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For subsidiaries operating outside the U.S., the financial information is included as of and for the year ended November&#160;30 for each year presented. Substantially all unremitted earnings of international subsidiaries are free of legal and contractual restrictions. All significant transactions among our businesses have been eliminat ed. We made certain reclassifications to prior-period amounts to conform to the December&#160;31, 2009 presentations related to the presentation of noncontrolling interests as a result of adopting a new accounting standard. Subsequent events have been evaluated through the time of our filing on February&#160;26, 2010. </font></p> <p style="MARGIN-TOP: 10px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">On October&#160;15, 2009, we completed our acquisition of Wyeth in a cash-and-stock transaction valued at approximately $68 billion. Commencing from the acquisition date, our financial statements reflect the assets, liabilities and operating results of Wyeth. In accordance with our domestic and international fiscal year-ends, approximately two-and-a-half months of the fourth calendar quarter of 2009 in the case of Wyeth&#8217;s U.S. operations and approximately one-and-a-half months of the fourth calendar quarter of 2009 in the case of Wyeth&#8217;s international operations are included in our consolidated financial statements for the year ended December&#160;31, 2009. For additional information, see <i>Note 2. Acquisition of Wyeth</i>. </font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>B. 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We applied these provisions in our accounting for our new equity method investment, ViiV Healthcare Limited (see <i>Note 3A. Other Significant Transactions and Events: Formation of ViiV, an Equity-Method Investment</i>). </font></p></td></tr></table> <p style="MARGIN-TOP: 0px; FONT-SIZE: 10px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Clarify the accounting for certain separately identifiable assets, which an acquirer does not intend to actively use but intends to hold to prevent its competitors from obtaining access to them. These provisions require an acquirer to account for a defensive intangible asset as a separate unit of accounting, which should be amortized to expense over the period the asset diminishes in value (as of January&#160;1, 2009). We applied these provisions in our accounting for the acquisition of Wyeth in 2009. </font></p></td></tr></table> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>C. Estimates and Assumptions </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In preparing the consolidated financial statements, we use certain estimates and assumptions that affect reported amounts and disclosures, including amounts recorded in connection with acquisitions, such as our acquisition of Wyeth on October&#160;15, 2009. These estimates and underlying assumptions can impact all elements of our financial statements. For example, in the consolidated statements of income, estimates are used when accounting for deductions from revenues (such as rebates, chargebacks, sales returns and sales allowances), determining cost of sales, allocating cost in the form of depreciation and amortization, and estimating restructuring charges and the impact of contingencies. On the consolidated balance sheets, estimates are used in determining the valuation and recoverability of assets, such as accounts receivables, investments, inventories, fixed assets and intangible assets (including ac quired in-process research&#160;&amp; development (IPR&amp;D) assets, beginning in 2009, and goodwill), and estimates are used in determining the reported amounts of liabilities, such as taxes payable, benefit obligations, the impact of contingencies, rebates, chargebacks, sales returns and sales allowances, and restructuring reserves, all of which also will impact the consolidated statements of income. </font></p> <p style="MARGIN-TOP: 10px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">We regularly evaluate our estimates and assumptions using historical experience and other factors, including the economic environment. Our estimates often are based on complex judgments, probabilities and assumptions that we believe to be reasonable but that are inherently uncertain and unpredictable. </font></p> <p style="MARGIN-TOP: 10px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">As future events and their effects cannot be determined with precision, our estimates and assumptions may prove to be incomplete or inaccurate, or unanticipated events and circumstances may occur that might cause us to change those estimates and assumptions. Market conditions, such as illiquid credit markets, volatile equity markets, dramatic fluctuations in foreign currency rates and economic downturn, can increase the uncertainty already inherent in our estimates and assumptions. We adjust our estimates and assumptions when facts and circumstances indicate the need for change. Those changes generally will be reflected in our financial statements on a prospective basis unless they are required to be treated retrospectively under the relevant accounting standard. It is possible that other professionals, applying reasonable judgment to the same facts and circumstances, could develop and support a range of alt ernative estimated amounts. We also are subject to other risks and uncertainties that may cause actual results to differ from estimated amounts, such as changes in the healthcare environment, competition, litigation, legislation and regulations. These and other risks and uncertainties are discussed in the accompanying Financial Review, which is unaudited, under the headings &#8220;Our Operating Environment, Strategy and Response to Key Opportunities and Challenges&#8221; and &#8220;Forward-Looking Information and Factors That May Affect Future Results&#8221; and in our 2009 Annual Report on Form 10-K under the caption, Part 1 Item&#160;1A. &#8220;Risk Factors.&#8221; </font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>D. Contingencies </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">We and certain of our subsidiaries are involved in various patent, product liability, consumer, commercial, securities, environmental and tax litigations and claims; government investigations; and other legal proceedings that arise from time to time in the ordinary course of our business. Except for income tax contingencies, we record accruals for contingencies to the extent that we conclude their occurrence is probable and that the related liabilities are estimable, and we record anticipated recoveries under existing insurance contracts when assured of recovery. For tax matters, we record accruals for income tax contingencies to the extent that we conclude that a tax position is not sustainable under a &#8220;more-likely-than-not&#8221; standard, and we record our estimate of the potential tax benefits in one tax jurisdiction that could result from the payment of income taxes in another tax jurisdict ion when we conclude that the potential recovery is more likely than not (see <i>Note 7D. Taxes on Income: Tax Contingencies). </i>We consider many factors in making these assessments. Because litigation and other contingencies are inherently unpredictable and excessive verdicts do occur, these assessments can involve a series of complex judgments about future events and can rely heavily on estimates and assumptions (see <i>Note 1C. Significant Accounting Policies: Estimates and Assumptions</i>). </font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>E. Acquisitions </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Our consolidated financial statements include the operations of an acquired business after the completion of the acquisition. We account for acquired businesses using the acquisition method of accounting. The acquisition method of accounting for acquired businesses requires, among other things, that most assets acquired and liabilities assumed be recognized at their estimated fair values as of the acquisition date and that the fair value of acquired IPR&amp;D be recorded on the balance sheet. Also, transaction costs are expensed as incurred. Any excess of the purchase price over the assigned values of the net assets acquired is recorded as goodwill. For acquisitions consummated prior to January&#160;1, 2009, amounts allocated to IPR&amp;D were expensed at the date of acquisition. When we have acquired net assets that do not constitute a business under U.S. GAAP, no goodwill has been recognized. &l t;/font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>F. 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Before a compound receives regulatory approval, we record upfront and milestone payments made by us to third parties under licensing arrangements as expense. Upfront payments are recorded when incurred, and milestone payments are recorded when the specific milestone has been achieved. Once a compound receives regulatory approval, we record any milestone payments in <i>Identifiable intangible assets, less accumulated amortization </i>and, unless the assets are determined to have an indefinite life, we amortize them evenly over the remaining agreement term or the expected product life cycle, whichever is shorter. </font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>L. 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Income Tax Contingencies </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">We account for income tax contingencies using a benefit recognition model. If we consider that a tax position is more likely than not to be sustained upon audit, based solely on the technical merits of the position, we recognize the benefit. We measure the benefit by determining the amount that is greater than 50% likely of being realized upon settlement, presuming that the tax position is examined by the appropriate taxing authority that has full knowledge of all relevant information. Under the benefit recognition model, if our initial assessment fails to result in the recognition of a tax benefit, we regularly monitor our position and subsequently recognize the tax benefit: (i)&#160;if there are changes in tax law, analogous case law or there is new information that sufficiently raise the likelihood of prevailing on the technical merits of the position to more likely than not; (ii)&#160;if the statu te of limitations expires; or (iii)&#160;if there is a completion of an audit resulting in a favorable settlement of that tax year with the appropriate agency. We regularly re-evaluate our tax positions based on the results of audits of federal, state and foreign income tax filings, statute of limitations expirations, changes in tax law or receipt of new information that would either increase or decrease the technical merits of a position relative to the &#8220;more-likely-than-not&#8221; standard. 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For our pension plans, the obligation may also include assumptions as to future compensation levels. For our other postretirement bene fit plans, the obligation may include assumptions as to the expected cost of providing the healthcare and life insurance benefits, as well as the extent to which those costs are shared with the employee or others (such as governmental programs). Plan assets are measured at fair value. Net periodic benefit costs are recognized, as required, into <i>Cost of sales, Selling, informational and administrative expenses </i>and<i> Research and development expenses</i>, as appropriate. </font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>R. Share-Based Payments </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Our compensation programs can include share-based payments. 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FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1"><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">(a)</font></font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Legacy Wyeth products and operations. In accordance with Pfizer&#8217;s domestic and international year-ends, includes approximately two-and-a-half months of Wyeth&#8217;s U.S. operations and approximately one-and-a-half months of Wyeth&#8217;s international operations in 2009. </font></p></td></tr></table> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1"><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">(b)</font></font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Represents direct sales under license agreement with Eisai. </font></p></td></tr></table> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1"><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">(c)</font></font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Outside the U.S. and Canada. </font></p></td></tr></table> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1"><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">(d)</font></font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Includes legacy Pfizer and legacy Wyeth products in 2009. </font></p></td></tr></table> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1"><font style="DISPLAY: inline; FONT-SIZE: 70%; VERTICAL-ALIGN: text-top">(e)</font></font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Prior-period amounts for Capsugel, which were previously classified in <i>Corporate/Other</i> are now classified in <i>Diversified</i>. </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="3"><b>19. Legal Proceedings and Contingencies </b></font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">We and certain of our subsidiaries are involved in various patent, product liability, consumer, commercial, securities, environmental and tax litigations and claims; government investigations; and other legal proceedings that arise from time to time in the ordinary course of our business. We do not believe any of them will have a material adverse effect on our financial position. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Beginning in 2007 upon the adoption of a new accounting standard, we record accruals for income tax contingencies to the extent that we conclude that a tax position is not sustainable under a &#8220;more likely than not&#8221; standard and we record our estimate of the potential tax benefits in one tax jurisdiction that could result from the payment of income taxes in another tax jurisdiction when we conclude that the potential recovery is more likely than not (see <i>Note 1P. Significant Accounting Policies: Income Tax Contingencies</i>). We record accruals for all other contingencies to the extent that we conclude their occurrence is probable and the related damages are estimable, and we record anticipated recoveries under existing insurance contracts when assured of recovery. If a range of liability is probable and estimable and some amount within the range appears to be a better estima te than any other amount within the range, we accrue that amount. If a range of liability is probable and estimable and no amount within the range appears to be a better estimate than any other amount within the range, we accrue the minimum of such probable range. Many claims involve highly complex issues relating to causation, label warnings, scientific evidence, actual damages and other matters. Often these issues are subject to substantial uncertainties and, therefore, the probability of loss and an estimation of damages are difficult to ascertain. Consequently, we cannot reasonably estimate the maximum potential exposure or the range of possible loss in excess of amounts accrued for these contingencies. These assessments can involve a series of complex judgments about future events and can rely heavily on estimates and assumptions (see <i>Note 1C. Significant Accounting Policies: Estimates and Assumptions</i>). Our assessments are based on estimates and assumptions that have been deemed reaso nable by management. Litigation is inherently unpredictable, and excessive verdicts do occur. Although we believe we have substantial defenses in these matters, we could in the future incur judgments or enter into settlements of claims that could have a material adverse effect on our results of operations in any particular period. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Patent claims include challenges to the coverage and/or validity of our patents on various products or processes. Although we believe we have substantial defenses to these challenges with respect to all our material patents, there can be no assurance as to the outcome of these matters, and a loss in any of these cases could result in a loss of patent protection for the drug at issue, which could lead to a significant loss of sales of that drug and could materially affect future results of operations. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Among the principal matters pending to which we are a party are the following: </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>A. Patent Matters </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Like other pharmaceutical companies, we are involved in numerous suits relating to our patents, including but not limited to those discussed below. Most of the suits involve claims by generic drug manufacturers that patents covering our products, processes or dosage forms are invalid and/or do not cover the product of the generic manufacturer. Also, counterclaims as well as various independent actions have been filed claiming that our assertions of, or attempts to enforce, our patent rights with respect to certain products constitute unfair competition and/or violations of the antitrust laws. In addition to the challenges to the U.S. patents on a number of our products that are discussed below, we note that the patent rights to certain of our products, including without limitation Lipitor, are being challenged in various other countries. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Lipitor (atorvastatin) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In November 2008, Apotex Inc. (Apotex) notified us that it had filed an abbreviated new drug application with the U.S. Food and Drug Administration (FDA) seeking approval to market a generic version of Lipitor. Apotex asserts the invalidity of our enantiomer patent, which (including the six-month pediatric exclusivity period) expires in June 2011, and the non-infringement of certain later-expiring patents. In December 2008, we filed suit against Apotex in the U.S. District Court for the District of Delaware and the U.S. District Court for the Northern District of Illinois asserting the validity and infringement of the enantiomer patent. In August 2009, our action in the District of Delaware was transferred to the Northern District of Illinois and consolidated with our pending action there.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In May 2009, Matrix Laboratories Limited&#160;(Matrix), a subsidiary of Mylan Inc. (Mylan), notified us that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Lipitor. Matrix asserts the non-infringement of our patent covering the crystalline form of atorvastatin, which (including the six-month pediatric exclusivity period) expires in 2017, and the non-infringement of two formulation patents. Matrix is not challenging our enantiomer patent. In June 2009, we filed actions against Matrix, Mylan and another Mylan subsidiary in the U.S. District Court for the District of Delaware and the U.S. District Court for the Northern District of West Virginia asserting the infringement of the crystalline patent and two process patents that expire in 2016.&#160;In&#160;November 2009, our action in the Northern District of West Virginia was transferred t o the District of Delaware and consolidated with our pending action there. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In October 2009, Dr.&#160;Reddy&#8217;s Laboratories Ltd. and Dr.&#160;Reddy&#8217;s Laboratories, Inc. (collectively, Dr.&#160;Reddy&#8217;s) and KUDCO Ireland, Ltd. and Kremers Urban LLC (collectively, KUDCO) notified us that they had filed abbreviated new drug applications with the FDA seeking approval to market generic versions of Lipitor. They assert the invalidity and/or non-infringement of our patent covering the crystalline form of atorvastatin and two other Lipitor patents. They are not challenging our enantiomer patent. In December 2009, we filed actions against Dr.&#160;Reddy&#8217;s and KUDCO in the U.S. District Court for the District of Delaware asserting the infringement of our crystalline patent. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Caduet (atorvastatin/amlodipine combination) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In August 2009, Sandoz Inc., a division of Novartis AG (Sandoz), notified us that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Caduet. In that filing and in a declaratory judgment action brought by Sandoz in October 2009 in the U.S. District Court for the District of Colorado, collectively, Sandoz asserts the invalidity of our patent covering the atorvastatin/amlodipine combination, which expires in 2018, and the invalidity and non-infringement of three patents for Lipitor, which (including the six-month pediatric exclusivity period) expire between 2013 and 2017. Sandoz is not challenging our enantiomer patent for Lipitor. In October 2009, we filed suit against Sandoz in the U.S. District Court for the District of Delaware and the U.S. District Court for the District of Colorado asserting the infringement of the atorvastatin/amlodipine combinati on patent. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In December 2009, Mylan Pharmaceuticals, Inc. notified us that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Caduet. Mylan asserts the invalidity of our patent covering the atorvastatin/ amlodipine combination and the non-infringement of three patents for Lipitor, which (including the six-month pediatric exclusivity period) expire between 2013 and 2017. Mylan Pharmaceuticals, Inc. is not challenging our enantiomer patent for Lipitor. In February 2010, we filed suit against Mylan Pharmaceuticals, Inc. in the U.S. District Court for the District of Delaware asserting the infringement of the atorvastatin/amlodipine combination patent. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Detrol (tolterodine) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In March 2004, we brought a patent infringement suit in the U.S. District Court for the District of New Jersey against Teva Pharmaceuticals USA, Inc. (Teva USA), which had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Detrol. In January 2007, Teva USA withdrew its challenge to our patent, and the patent infringement suit was dismissed. Also in January 2007, Ivax Pharmaceuticals, Inc. (Ivax), a wholly owned subsidiary of Teva USA, amended its previously filed abbreviated new drug application for tolterodine to challenge our basic patent for Detrol, and we brought a patent infringement action against Ivax in the U.S. District Court for the District of New Jersey. The basic patent (including the six-month pediatric exclusivity period) expires in September 2012. In January 2010, the court issued a decision in our favor, upholding the basic patent. The court entered an order preventing the FDA from approving Ivax&#8217;s abbreviated new drug application for Detrol before the expiration of the basic patent in September 2012. Ivax and Teva have filed a notice of appeal. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Detrol LA (tolterodine) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In October 2007 and January 2008, respectively, Teva USA and Impax Laboratories, Inc. notified us that they had filed abbreviated new drug applications with the FDA challenging on various grounds four patents relating to Detrol LA, an extended-release formulation of Detrol (tolterodine), and seeking approval to market their generic versions of Detrol LA. We filed suit against each of them in the U.S. District Court for the Southern District of New York asserting the infringement of three of the patents relating to Detrol LA., which (including the six-month pediatric exclusivity period) expire between 2012 (the basic patent) and 2020. Each of these actions subsequently was transferred to the U.S. District Court for the District of New Jersey. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Vfend (voriconazole) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In October 2009, we settled a challenge by Matrix and Mylan to four of our patents relating to Vfend by entering into an agreement granting Matrix and another subsidiary of Mylan the right to market voriconazole tablets in the U.S. beginning in the first quarter of 2011<b>. </b></font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Lyrica (pregabalin) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In March and April 2009, several generic manufacturers notified us that they had filed abbreviated new drug applications with the FDA seeking approval to market generic versions of Lyrica. Each of the generic manufacturers is challenging one or more of three patents for Lyrica: the basic patent, which expires in 2018, and two other patents, which expire in 2013 and 2018. Each of the generic manufacturers asserts the invalidity and/or the non-infringement of the patents subject to challenge. In April 2009, we filed an action against each of the generic manufacturers in the U.S. District Court for the District of Delaware asserting the infringement and validity of our patents for Lyrica. In October 2009, all of these cases were consolidated in the District of Delaware. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Zyvox (linezolid) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In December 2009, Teva Parenteral Medicines Inc. (Teva Parenteral) notified us that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Zyvox. Teva Parenteral asserts the invalidity and non-infringement of the basic Zyvox patent, which (including the six-month pediatric exclusivity period) expires in 2015, and another patent that expires in 2021. In January 2010, we filed suit against Teva Parenteral in the U.S. District Court for the District of Delaware asserting the infringement of the basic patent.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Aricept (donepezil hydrochloride) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In October 2005, Teva USA notified Eisai Co., Ltd. (Eisai) that Teva USA had filed an abbreviated new drug application with the FDA challenging on various grounds Eisai&#8217;s basic patent for Aricept, which expires in November 2010, and seeking approval to market a generic version of Aricept. In December 2005, Eisai filed suit against Teva USA in the U.S. District Court for the District of New Jersey asserting infringement of that patent. While Teva USA has received final approval from the FDA for its generic product, it is subject to a preliminary injunction prohibiting the marketing of its product pending the outcome of Eisai&#8217;s patent infringement action. We co-promote Aricept with Eisai in the U.S. but are not a party to Eisai&#8217;s patent infringement action. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Neurontin (gabapentin) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In August 2005, the U.S. District Court for the District of New Jersey held that the generic gabapentin (Neurontin) products of a number of generic manufacturers did not infringe our gabapentin low-lactam patent, which expires in 2017, and it granted summary judgment in their favor. Several generic manufacturers launched their gabapentin products in 2004 and 2005. In September 2007, the U.S. Court of Appeals for the Federal Circuit reversed the District Court&#8217;s summary judgment decision and remanded the case to the District Court for trial on the patent infringement issue. If successful at trial, we intend to seek compensation from the generic manufacturers for damages resulting from their at-risk launches of generic gabapentin. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Protonix (pantoprazole sodium) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Wyeth has an exclusive license to market Protonix in the U.S. from Nycomed GmbH (Nycomed), which owns the patents relating to Protonix. The basic patent (including the six-month pediatric exclusivity period) for Protonix expires in January 2011. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Following their respective filings of abbreviated new drug applications with the FDA, Teva USA and Teva Pharmaceutical Industries, Ltd. (Teva Industries), Sun Pharmaceutical Advanced Research Centre Ltd. and Sun Pharmaceutical Industries Ltd. (collectively, Sun) and KUDCO Ireland, Ltd. (KUDCO Ireland) received final FDA approval to market their generic versions of Protonix 20 mg and 40 mg delayed release tablets. Wyeth and Nycomed filed actions against Teva USA and Teva Industries, Sun and KUDCO Ireland in the U.S. District Court for the District of New Jersey, which subsequently were consolidated into a single proceeding, alleging infringement of the basic patent and seeking declaratory and injunctive relief. Following the court&#8217;s denial of a preliminary injunction sought by Wyeth and Nycomed, Teva USA and Teva Industries and Sun launched their generic versions of Protonix tablets at risk in Decemb er 2007 and January 2008, respectively. Wyeth launched its own generic version of Protonix tablets in January 2008, and Wyeth and Nycomed filed amended complaints in the pending patent infringement action seeking to recover lost profits and other damages resulting from Teva USA&#8217;s and Teva Industries&#8217; and Sun&#8217;s at-risk launches. To Wyeth&#8217;s knowledge, KUDCO Ireland has not launched its generic product to date. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In July 2009, Apotex notified Wyeth that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Protonix 20 mg and 40 mg delayed release tablets and asserting the invalidity of the basic patent for Protonix. In August 2009, Wyeth and Nycomed filed suit against Apotex in the U.S. District Court for the Northern District of Illinois alleging infringement of the basic patent. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Wyeth and Nycomed are defendants in purported class actions brought by direct and indirect purchasers of Protonix in the U.S. District Court for the District of New Jersey. Plaintiffs seek damages, on behalf of the respective putative classes, for the alleged violation of antitrust laws in connection with the procurement and enforcement of the patents for Protonix. These purported class actions have been stayed pending resolution of the underlying patent litigation in the U.S. District Court for the District of New Jersey. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Effexor XR (venlafaxine HCl (extended release capsules)) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2005, Wyeth entered into a settlement of patent litigation against Teva USA and Teva Industries pursuant to which they are permitted to launch generic versions of Effexor XR (extended release capsules) in the U.S. beginning on July&#160;1, 2010, subject to possible earlier launch based on specified market conditions or developments regarding the applicable patent rights, including the outcome of other generic challenges to such patent rights. Since the settlement with Teva USA and Teva Industries, Wyeth has settled patent suits against certain other generic companies that generally grant licenses permitting the generic companies to launch generic versions of Effexor XR (extended release capsules) in the U.S. on or after June&#160;1, 2011, subject to possible earlier launch in limited circumstances but in no event earlier than January&#160;1, 2011. Wyeth has patent infringement actions pending a gainst several other generic companies that have filed abbreviated new drug applications with the FDA seeking approval to market generic versions of Effexor XR (extended release capsules) in the U.S. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>ReFacto and Xyntha </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In February 2008, Novartis Vaccines and Diagnostics, Inc. (Novartis) filed suit against Wyeth and a subsidiary of Wyeth in the U.S. District Court for the Eastern District of Texas alleging that Wyeth&#8217;s ReFacto and Xyntha products infringe two Novartis patents. Novartis&#8217; complaint seeks damages, including treble damages, for alleged willful infringement. Wyeth and its subsidiary assert, among other things, the invalidity and non-infringement of the Novartis patents. In November 2009, Novartis added a third patent to its infringement claim against Wyeth and its subsidiary. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In May 2008, a subsidiary of Wyeth filed suit in the U.S. District Court for the District of Delaware against Novartis seeking a&#160;declaration that the two Novartis patents initially asserted against Wyeth and its subsidiary in the action referred to in the preceding paragraph are invalid on the ground that the Wyeth subsidiary was the first to invent the subject matter. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Tygacil (tigecycline) </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In October 2009, Sandoz notified Wyeth that it had filed an abbreviated new drug application with the FDA seeking approval to market a generic version of Tygacil. Sandoz asserts the invalidity and non-infringement of two of Wyeth&#8217;s patents relating to Tygacil, including the basic patent, which expires in 2016. In December 2009, Wyeth filed suit against Sandoz in the U.S. District Court for the District of Delaware asserting infringement of the basic patent. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>B. Product Litigation </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Like other pharmaceutical companies, we are defendants in numerous cases, including but not limited to those discussed below, related to our pharmaceutical and other products. Plaintiffs in these cases seek damages and other relief on various grounds for alleged personal injury and economic loss. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Asbestos </b></font></p> <p style="MARGIN-TOP: 0px; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" style="BORDER-COLLAPSE: collapse" cellspacing="0" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Quigley </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Quigley Company, Inc. (Quigley), a wholly owned subsidiary, was acquired by Pfizer in 1968 and sold small amounts of products containing asbestos until the early 1970s. In September 2004, Pfizer and Quigley took steps that were intended to resolve all pending and future claims against Pfizer and Quigley in which the claimants allege personal injury from exposure to Quigley products containing asbestos, silica or mixed dust. We recorded a charge of $369 million before-tax ($229 million after-tax) in the third quarter of 2004 in connection with these matters. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In September 2004, Quigley filed a petition in the U.S. Bankruptcy Court for the Southern District of New York seeking reorganization under Chapter 11 of the U.S. Bankruptcy Code. In March 2005, Quigley filed a reorganization plan in the Bankruptcy Court that needed the approval of both the Bankruptcy Court and the U.S. District Court for the Southern District of New York after receipt of the vote of 75% of the claimants. In connection with that filing, Pfizer entered into settlement agreements with lawyers representing more than 80% of the individuals with claims related to Quigley products against Quigley and Pfizer. The agreements provide for a total of $430 million in payments, of which $215 million became due in December 2005 and is being paid to claimants upon receipt by the Company of certain required documentation from each of the claimants. The reorganization plan provided for the establishment of a Trust (the Trust) for the payment of all remaining pending claims as well as any future claims alleging injury from exposure to Quigley products. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">As certified by the balloting agent in May 2006, more than 75% of Quigley&#8217;s claimants holding claims that represented more than two-thirds in value of claims against Quigley voted to accept Quigley&#8217;s plan of reorganization. In August 2006, in reviewing the voting tabulation methodology, the Bankruptcy Court ruled that certain votes that accepted the plan were not predicated upon the actual value of the claim. As a result, the reorganization plan was not accepted. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In June 2007, Quigley filed an amended plan of reorganization that was intended to address the Bankruptcy Court&#8217;s concerns regarding the voting tabulation methodology. In February 2008, the Bankruptcy Court authorized Quigley to solicit its amended reorganization plan for acceptance by claimants. According to the official report filed with the court by the balloting agent in July 2008, the requisite number of votes was cast in favor of the amended plan of reorganization. The Bankruptcy Court held a confirmation hearing, which concluded in December 2009, at which objections to the plan&#8217;s confirmation were presented. Briefing on legal issues related to the confirmation hearing will conclude in February 2010, and thereafter the Bankruptcy Court will determine whether to approve the plan. If approved by the claimants and the courts, the amended reorganization plan will result in a permanent in junction directing all pending and future claims alleging personal injury from exposure to Quigley products to the Trust. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Under the amended reorganization plan, Pfizer will contribute to the Trust $405 million through a note as well as approximately $100 million in cash and insurance, and will forgive a $76 million secured loan to Quigley. In addition, Pfizer entered into an agreement with the representative of future claimants that provides for the contribution to the Trust of an additional amount with a present value of $88.4 million. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In a separately negotiated transaction with an insurance company in August 2004, we agreed to a settlement related to certain insurance coverage that provides for payments to us over a 10-year period of amounts totaling $405 million. </font></p> <p style="MARGIN-TOP: 0px; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Other Matters </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Between 1967 and 1982, Warner-Lambert owned American Optical Corporation (American Optical), which manufactured and sold respiratory protective devices and asbestos safety clothing. In connection with the sale of American Optical in 1982, Warner-Lambert agreed to indemnify the purchaser for certain liabilities, including certain asbestos-related and other claims. As of December&#160;31, 2009, approximately 100,000 claims naming American Optical and numerous other defendants were pending in various federal and state courts seeking damages for alleged personal injury from exposure to asbestos and other allegedly hazardous materials. Warner-Lambert is actively engaged in the defense of, and will continue to explore various means to resolve, these claims. Several of the insurance carriers that provided coverage for the American Optical asbestos and other allegedly hazardous materials claims have denied covera ge. Warner-Lambert believes that these carriers&#8217; position is without merit and is pursuing legal proceedings against such carriers. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Numerous lawsuits are pending against Pfizer in various federal and state courts seeking damages for alleged personal injury from exposure to products containing asbestos and other allegedly hazardous materials sold by Gibsonburg Lime Products Company (Gibsonburg). Gibsonburg was acquired by Pfizer in the 1960s and sold small amounts of products containing asbestos until the early 1970s. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">There also is a small number of lawsuits pending in various federal and state courts seeking damages for alleged exposure to asbestos in facilities owned or formerly owned by Pfizer or its subsidiaries. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Celebrex and Bextra </b></font></p> <p style="MARGIN-TOP: 0px; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Securities and ERISA Actions </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Beginning in late 2004, actions, including purported class actions, have been filed in various federal and state courts against Pfizer, Pharmacia and certain current and former officers, directors and employees of Pfizer and Pharmacia. These actions include (i)&#160;purported class actions alleging that Pfizer and certain current and former officers of Pfizer violated federal securities laws by misrepresenting the safety of Celebrex and Bextra and (ii)&#160;purported class actions filed by persons who claim to be participants in the Pfizer or Pharmacia Savings Plan alleging that Pfizer and certain current and former officers, directors and employees of Pfizer or, where applicable, Pharmacia and certain former officers, directors and employees of Pharmacia, violated certain provisions of the Employee Retirement Income Security Act of 1974 (ERISA) by selecting and maintaining Pfizer stock as an investme nt alternative when it allegedly no longer was a suitable or prudent investment option. In June 2005, the federal securities and ERISA actions were transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Pfizer Inc. Securities, Derivative and &#8220;ERISA&#8221; Litigation MDL-1688</i>) in the U.S. District Court for the Southern District of New York. </font></p> <p style="MARGIN-TOP: 0px; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" style="BORDER-COLLAPSE: collapse" cellspacing="0" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Securities Action in New Jersey </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2003, several purported class action complaints were filed in the U.S. District Court for the District of New Jersey against Pharmacia, Pfizer and certain former officers of Pharmacia. The complaints allege that the defendants violated federal securities laws by misrepresenting the data from a study concerning the gastrointestinal effects of Celebrex. These cases were consolidated for pre-trial proceedings in the District of New Jersey (<i>Alaska Electrical Pension Fund et al. v. Pharmacia Corporation et al</i>.). In January 2007, the court certified a class consisting of all persons who purchased Pharmacia securities from April&#160;17, 2000 through February&#160;6, 2001 and were damaged as a result of the decline in the price of Pharmacia&#8217;s securities allegedly attributable to the misrepresentations. Plaintiffs seek damages in an unspecified amount. In October 2007, the cour t granted defendants&#8217; motion for summary judgment and dismissed the plaintiffs&#8217; claims. In November 2007, the plaintiffs appealed the decision to the U.S. Court of Appeals for the Third Circuit. In January 2009, the Third Circuit vacated the District Court&#8217;s grant of summary judgment in favor of defendants and remanded the case to the District Court for further proceedings. The Third Circuit also held that the District Court erred in determining that the class period ended on February&#160;6, 2001, and directed that the class period end on August&#160;5, 2001. In June 2009, the District Court stayed proceedings in the case pending a determination by the U.S. Supreme Court with regard to defendants&#8217; petition for certiorari seeking reversal of the Third Circuit&#8217;s decision, as well as the decision by the U.S. Supreme Court in a case involving another company that presents questions of law and fact that are similar to those in this case. </font>< /p> <p style="MARGIN-TOP: 0px; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px">&#160;</p> <table cellpadding="0" cellspacing="0" style="BORDER-COLLAPSE: collapse" border="0" width="100%"> <tr> <td valign="top" align="left" width="1%"><font style="FONT-FAMILY: ARIAL" size="1">&#8226;</font></td> <td valign="top" width="1%"><font size="1">&#160;</font></td> <td valign="top" align="left"> <p align="left"><font style="FONT-FAMILY: ARIAL" size="1">Other </font></p></td></tr></table> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Pfizer and several predecessor and affiliated companies, including Monsanto Company (Monsanto), are defendants in an action brought by Brigham Young University (BYU) and a BYU professor in the U.S. District Court for the District of Utah alleging, among other things, breach by Monsanto of a 1991 research agreement with BYU. Plaintiffs claim that research under that agreement led to the discovery of Celebrex and that, as a result, they are entitled to a share of the profits from Celebrex sales. Plaintiffs seek, among other things, compensatory and punitive damages. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Bextra and Certain Other Drugs </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Beginning in September 2009, a number of shareholder derivative actions were filed in the U.S. District Court for the Southern District of New York and in the Supreme Court of the State of New York, County of New York, against certain current and former Pfizer officers and directors.&#160;Pfizer is named as a nominal defendant.&#160;These actions allege that the individual defendants breached fiduciary duties by causing or allowing Pfizer to engage in off-label&#160;promotion of certain drugs, including Bextra. Damages in unspecified amounts are sought on behalf of Pfizer. In November 2009, the federal cases were consolidated in the Southern District of New York (<i>In re Pfizer Inc. Shareholder Derivative Litigation</i>). </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Various Drugs </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In September 2009, a number of purported nationwide class actions were filed against us in the U.S. District Court for the District of Massachusetts and the U.S. District Court for the Eastern District of Pennsylvania alleging off-label promotion of certain drugs. In each case, the plaintiffs seek monetary and injunctive relief on behalf of the purported class, including the recovery of amounts paid for the drugs, treble damages and punitive damages. </font></p> <p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Hormone-Replacement Therapy </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Pfizer and certain wholly owned subsidiaries and limited liability companies, including Wyeth, along with several other pharmaceutical manufacturers, have been named as defendants in numerous lawsuits in various federal and state courts alleging personal injury resulting from the use of certain estrogen and progestin medications primarily prescribed for women to treat the symptoms of menopause. Plaintiffs in these suits allege a variety of personal injuries, including breast cancer, ovarian cancer, stroke and heart disease. Certain co-defendants in some of these actions have asserted indemnification rights against Pfizer and its affiliated companies. The cases against Pfizer and its affiliated companies involve one or more of the following products, all of which remain approved by the FDA: femhrt (which Pfizer divested in 2003); Activella and Vagifem (which are Novo Nordisk products that were marketed by a Pf izer affiliate from 2000 to 2004); Premarin, Prempro, Aygestin, Cycrin and Premphase (which are legacy Wyeth products); and Provera, Ogen, Depo-Estradiol, Estring and generic MPA (which are legacy Pharmacia&#160;&amp; Upjohn products). The federal cases have been transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Prempro Products Liability Litigation MDL-1507</i>) in the U.S. District Court for the Eastern District of Arkansas. Certain of the federal cases have been remanded to their respective District Courts for further proceedings, including, if necessary, trial. </font></p> <p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">This litigation originally included both individual actions as well as various purported nationwide and statewide class actions. However, as a result of the denial of class certification by the courts in certain actions, the voluntary dismissal by the plaintiffs of certain purported class actions and the withdrawal of the class action allegations by the plaintiffs in certain other actions, this litigation now consists of individual actions, a few purported statewide class actions and a purported nationwide class action in Canada.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Pfizer and its affiliated companies, including Wyeth, have prevailed in many of the hormone-replacement therapy actions that have been resolved to date, whether by voluntary dismissal by the plaintiffs, summary judgment, defense verdict or judgment notwithstanding the verdict; a number of these cases have been appealed by the plaintiffs. Certain other hormone-replacement therapy actions have resulted in verdicts for the plaintiffs and have included the award of compensatory and, in some instances, punitive damages; each of these cases has been appealed by Pfizer and/or its affiliated companies. Some of the cases that had been appealed by Pfizer and/or its affiliated companies or by the plaintiffs have been sent back by the appellate courts to their respective trial courts for further proceedings, and certain other cases have been settled by the parties in advance of trial. Trials of additional hormone-replace ment therapy actions are scheduled for 2010. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Pfizer and/or its affiliated companies also have received inquiries from various federal and state agencies and officials relating to the marketing of their hormone-replacement products. In November 2008, the State of Nevada filed an action against Pfizer, Pharmacia&#160;&amp; Upjohn Company and Wyeth in state court in Nevada alleging that they had engaged in deceptive marketing of their respective hormone-replacement therapy medications in Nevada in violation of the Nevada Deceptive Trade Practices Act. The action seeks monetary relief, including civil penalties and treble damages. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Viagra </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of lawsuits, including purported class actions, have been filed against us in various federal and state courts alleging that Viagra causes certain types of visual injuries. The plaintiffs in the purported class actions seek to represent nationwide and certain statewide classes of Viagra users. All of the actions seek damages for personal injury, and the purported class actions also seek medical monitoring. In January 2006, the federal cases were transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Viagra Products Liability Litigation MDL-1724</i>) in the U.S. District Court for the District of Minnesota. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Zoloft and Effexor </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of individual lawsuits, as well as a multi-plaintiff lawsuit with respect to Effexor, have been filed against us and/or our subsidiaries in various federal and state courts alleging personal injury as a result of the purported ingesting of Zoloft or Effexor. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Neurontin </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of lawsuits, including purported class actions, have been filed against us in various federal and state courts alleging claims arising from the promotion and sale of Neurontin. The plaintiffs in the purported class actions seek to represent nationwide and certain statewide classes consisting of persons, including individuals, health insurers, employee benefit plans and other third-party payers, who purchased or reimbursed patients for the purchase of Neurontin that allegedly was used for indications other than those included in the product labeling approved by the FDA. In October 2004, many of the suits pending in federal courts, including individual actions as well as purported class actions, were transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Neurontin Marketing, Sales Practices and Product Liability Litigation MDL-1629</i>) in the U.S. Distr ict Court for the District of Massachusetts. Purported class actions also have been filed against us in various Canadian provincial courts alleging claims arising from the promotion and sale of Neurontin and generic gabapentin. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In the Multi-District Litigation, in August 2007, the court denied without prejudice plaintiffs&#8217; motion to certify a nationwide class of all consumers and third-party payers who allegedly purchased or reimbursed patients for the purchase of Neurontin for off-label uses from 1994 through 2004. In December 2007, plaintiffs filed a renewed motion for class certification. In May 2009, the court denied plaintiffs&#8217; renewed motion for class certification. Plaintiffs have filed a motion for reconsideration. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In June 2007, a Pennsylvania state court certified a class of all individuals in Pennsylvania who allegedly purchased Neurontin for off-label uses since 1995. The court subsequently expanded the class to include purchasers of generic gabapentin. However, in February 2009, the court determined that class certification was not appropriate and entered an order decertifying the class. The plaintiffs appealed and, in January 2010, the appellate court affirmed the trial court&#8217;s order decertifying the class. Other plaintiffs are seeking certification of statewide classes of Neurontin purchasers in actions pending in California, Illinois, Indiana, Missouri and Oklahoma. State courts in New York and New Mexico have declined to certify statewide classes of Neurontin purchasers.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of individual lawsuits have been filed against us in various U.S. federal and state courts and in certain other countries alleging suicide, attempted suicide and other personal injuries as a result of the purported ingesting of Neurontin. Certain of the U.S. federal actions have been transferred for consolidated pre-trial proceedings to the same Multi-District Litigation referred to in the first paragraph of this section. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Lipitor </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2006, a purported class action was filed against us alleging, among other things, violation of the federal Racketeer Influenced and Corrupt Organizations (RICO) Act and certain state consumer fraud statutes primarily related to the promotion of Lipitor. In 2008, the action was transferred to the U.S. District Court for the Southern District of New York. In September 2009, the court dismissed the action, but granted the plaintiffs leave to amend certain of their claims. In November 2009, the plaintiffs filed a voluntary dismissal of the action, with prejudice. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2004, a former employee filed a whistleblower action against us in the U.S. District Court for the Eastern District of New York. The complaint remained under seal until September 2007, at which time the U.S. Attorney for the Eastern District of New York declined to intervene in the case. We were served with the complaint in December 2007. Plaintiff alleges that, through patient and medical education programs, written materials and other actions aimed at doctors, consumers, payers and investors, the Company promoted Lipitor for use by certain patients contrary to national cholesterol guidelines that plaintiff claims are a part of the labeled indications for the product. Plaintiff alleges violations of the Federal Civil False Claims Act and the false claims acts of certain states and seeks treble damages and civil penalties on behalf of the federal government and the specified states as the result of their p urchase, or reimbursement of patients for the purchase, of Lipitor allegedly for such off-label uses. Plaintiff also seeks compensation as a whistleblower under those federal and state statutes. In addition, plaintiff alleges that he was wrongfully terminated, in violation of the anti-retaliation provisions of the Federal Civil False Claims Act, the Civil Rights Act of 1964 and applicable New York law, for raising concerns about the alleged off-label promotion of Lipitor and about alleged instances of sexual harassment in the workplace, and he seeks damages and the reinstatement of his employment. In May 2009, the court dismissed without prejudice the claims alleging violations of the Federal Civil False Claims Act and the false claims acts of certain states. In February 2010, plaintiff filed an amended complaint containing allegations concerning violations of the Federal Civil False Claims Act and false claims acts of certain states that are substantially similar to the allegations in the original complaint . </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Chantix/Champix </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of individual lawsuits have been filed against us in various federal and state courts alleging suicide, attempted suicide and other personal injuries as a result of the purported ingesting of Chantix, as well as economic loss. Plaintiffs in these actions seek compensatory and punitive damages and the disgorgement of profits resulting from the sale of Chantix. In October 2009, the federal cases were transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Chantix (Varenicline) Products Liability Litigation MDL-2092</i>) in the U.S. District Court for the Northern District of Alabama. </font></p> <p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In December 2008, a purported class action was filed against us in the Ontario Superior Court of Justice (Toronto Region) on behalf of all individuals and third-party payers in Canada who have purchased and ingested Champix or reimbursed patients for the purchase of Champix. This action asserts claims under Canadian product liability law, including with respect to the safety and efficacy of Champix, and, on behalf of the putative class, seeks monetary relief, including punitive damages. In April and October 2009 and February 2010, respectively, substantially similar purported class actions were filed against us in the Superior Court of Quebec (District of Montreal), the Court of Queen&#8217;s Bench of Alberta, Judicial District of Calgary, and the Superior Court of British Columbia (Vancouver Registry). </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Zosyn </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In April 2006, Wyeth filed a citizen petition with the FDA asking it to refrain from approving any application for a generic product that references Zosyn (piperacillin and tazobactam) unless the generic product complies with the U.S. Pharmacopeia standards on particulate matter in injectable drugs and exhibits the same compatibility profile as Zosyn. Wyeth further requested that, in the event the FDA chose to approve a generic product that did not exhibit the same compatibility profile as Zosyn, the FDA condition such approval upon the applicant&#8217;s implementation of a risk-minimization action plan to address the confusion that would necessarily arise as a result of such difference. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In September 2009, the FDA denied the principal requests in Wyeth&#8217;s citizen petition and approved applications by Orchid Healthcare for a generic piperacillin/tazobactam product that does not exhibit the same compatibility profile as Zosyn. Following the FDA&#8217;s decision, in September 2009, Wyeth brought suit in the U.S. District Court for the District of Columbia against the FDA and its parent agency, the U.S. Department of Health and Human Services, seeking to overturn the FDA&#8217;s ruling on Wyeth&#8217;s citizen petition and to have the generic approvals suspended and/or withdrawn. Orchid Healthcare and its U.S. marketing partner, Apotex Corp., intervened in the case. In September 2009, the court denied Wyeth&#8217;s motion for a temporary restraining order. Pending action by the courts, the generic approvals granted by the FDA in September remain in effect. Wyeth understan ds that generic piperacillin/tazobactam is currently being marketed in the U.S. pursuant to those approvals. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Thimerosal </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Wyeth is a defendant in a number of suits by or on behalf of vaccine recipients alleging that exposure through vaccines to cumulative doses of thimerosal, a preservative used in certain childhood vaccines formerly manufactured and distributed by Wyeth and other vaccine manufacturers, causes severe neurological damage and/or autism in children. While several suits were filed as purported nationwide or statewide class actions, all but one of the purported class actions have been dismissed, either by the courts or voluntarily by plaintiffs. In the one remaining purported class action, the U.S. District Court for the Eastern District of Kentucky dismissed all claims except plaintiffs&#8217; fraud claim, which has been stayed. In addition to the suits alleging injury from exposure to thimerosal, certain of the cases were brought by parents in their individual capacities for, among other things, loss of service s and loss of consortium of the injured child. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">The National Childhood Vaccine Injury Act (the Vaccine Act) requires that plaintiffs alleging injury from childhood vaccines first bring a claim under the Vaccine Act in the U.S. Court of Federal Claims. At the conclusion of that proceeding, plaintiffs may bring a lawsuit against the manufacturer in federal or state court, provided that they have satisfied certain procedural requirements. Also under the terms of the Vaccine Act, if a claim has not been adjudicated by the U.S. Court of Federal Claims within a specified time period after filing, the claimant may opt out of the proceeding and pursue a lawsuit against the manufacturer by following certain procedures. Some of the vaccine recipients who have sued Wyeth to date may not have satisfied the conditions to filing a lawsuit that are mandated by the Vaccine Act. The claims brought by parents for, among other things, loss of services and loss of consortium of the injured child are not covered by the Vaccine Act. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In July 2002, the U.S. Court of Federal Claims established an Omnibus Autism Proceeding with jurisdiction over petitions in which vaccine recipients claim to suffer from autism or autism spectrum disorder as a result of receiving thimerosal-containing childhood vaccines or the measles, mumps and rubella (MMR) vaccine. There currently are several thousand petitions pending in the Omnibus Autism Proceeding. The court heard six test cases on claimants&#8217; theories that either thimerosal-containing vaccines in combination with the MMR vaccine or thimerosal-containing vaccines alone can cause autism or autism spectrum disorder. In February 2009, the court rejected the three cases brought on the theory that a combination of MMR and thimerosal-containing vaccines caused claimants&#8217; conditions. The court in each case found that the scientific evidence against a connection between the vaccines and auti sm was significantly stronger than the evidence presented by the claimants. Two of these cases have been appealed by the plaintiffs to the U.S. Court of Appeals for the Federal Circuit. Decisions on the three test cases involving thimerosal-containing vaccines alone are pending. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Pristiq </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In late 2007 and early 2008, the following actions were filed in various federal courts and remain pending: (i)&#160;a purported class action alleging that Wyeth and certain former officers of Wyeth violated federal securities laws by misrepresenting the safety of Pristiq during the period before the FDA&#8217;s issuance on July&#160;24, 2007 of an &#8220;approvable&#8221; letter for Pristiq for the treatment of vasomotor symptoms, which allegedly caused a decline in the price of Wyeth stock; (ii)&#160;a shareholder derivative action alleging that certain former officers of Wyeth and certain former directors of Wyeth, two of whom are now directors of Pfizer, breached fiduciary duties and violated federal securities laws by virtue of the aforementioned alleged misrepresentation; and (iii)&#160;a purported class action against Wyeth, the Wyeth Savings Plan Committee, the Wyeth Saving s Plan-Puerto Rico Committee, the Wyeth Retirement Committee and certain former Wyeth officers and committee members alleging that they violated certain provisions of ERISA by maintaining Wyeth stock as an investment alternative under certain Wyeth plans notwithstanding their alleged knowledge of the aforementioned alleged misrepresentation. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="2"><b>C. Commercial and Other Matters </b></font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Acquisition of Wyeth </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Beginning in late January 2009, several purported class action complaints were filed by Wyeth shareholders challenging Wyeth&#8217;s proposed merger with Pfizer. The actions were filed in federal court in New Jersey (the Federal Action) and in state courts in New Jersey and Delaware.&#160;Subsequently, the actions filed in state court in New Jersey were consolidated (the New Jersey Action), and the actions filed in state court in Delaware were consolidated (the Delaware Action). The complaints in all of the actions name as defendants Wyeth and the individuals who served as the members of Wyeth&#8217;s Board of Directors prior to the consummation of the merger, two of whom are now directors of Pfizer. The complaints in the Federal Action and the Delaware Action also name Pfizer as a defendant.&#160;The plaintiffs allege that (i)&#160;each of the members of Wyeth&#8217;s pre-merger Board of Directors breached his or her fiduciary duties to Wyeth and its shareholders by authorizing the sale of Wyeth to Pfizer for what plaintiffs deem &#8220;inadequate&#8221; consideration; (ii)&#160;Wyeth directly breached and/or aided and abetted the other defendants&#8217; alleged breaches of fiduciary duties; and (iii)&#160;in the actions in which Pfizer is a defendant, Pfizer aided and abetted the alleged breaches of fiduciary duties by Wyeth and its pre-merger directors.&#160;The plaintiffs sought, among other things, to enjoin the defendants from consummating the merger on the agreed-upon terms. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">On June&#160;10, 2009, Wyeth, Wyeth&#8217;s directors and Pfizer entered into a memorandum of understanding with the plaintiffs in the Delaware Action reflecting an agreement-in-principle to settle the Delaware Action based on their agreement to include in the Pfizer/Wyeth registration statement/proxy statement on Form S-4 certain additional disclosures relating to the transaction. Wyeth, Wyeth&#8217;s pre-merger directors and Pfizer each have denied that they committed or aided and abetted in the commission of any violation of law or engaged in any of the wrongful acts alleged in the Delaware Action and expressly maintain that they diligently and scrupulously complied with their fiduciary and other legal duties.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">If the settlement is consummated, the Delaware Action will be dismissed with prejudice, and the defendants will receive&#8212;from or on behalf of all persons who were Wyeth shareholders at any time between the announcement of the merger agreement on January&#160;26, 2009 and the closing of the merger&#8212;a release of all claims related to the merger, including the claims asserted in the Federal Action and the New Jersey Action.&#160;Members of the purported plaintiff class will be sent notice of the proposed settlement, and a hearing before the Delaware Court of Chancery will be scheduled regarding approval of the proposed settlement.</font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Separately, in August 2009, a number of retail pharmacies in California brought an action against Pfizer and Wyeth in the U.S. District Court for the Northern District of California. The plaintiffs allege, among other things, that our acquisition of Wyeth violates various federal antitrust laws by creating a monopoly in the manufacture, distribution and sale of prescription drugs in the U.S. The plaintiffs&#8217; request for a temporary restraining order preventing consummation of the acquisition was denied, and the court granted our motion to dismiss the case, on October&#160;14, 2009. On the day following the consummation of the acquisition, October&#160;16, 2009, the plaintiffs filed an amended complaint containing allegations substantially similar to those in the original complaint and renewing the request for a temporary restraining order. In December 2009, the court granted our motion to dis miss the amended complaint and denied the plaintiffs&#8217; renewed request for a temporary restraining order. In January 2010, the plaintiffs filed a second amended complaint containing allegations substantially similar to those in the original complaint. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Average Wholesale Price Litigation </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">A number of states, as well as most counties in New York, have sued Pharmacia, Pfizer and other pharmaceutical manufacturers alleging that they provided average wholesale price (AWP) information for certain of their products that was higher than the actual prices at which those products were sold. The AWP is used to determine reimbursement levels under Medicare Part B and Medicaid and in many private-sector insurance policies and medical plans. The plaintiffs claim that the alleged spread between the AWPs at which purchasers were reimbursed and the actual sale prices was promoted by the defendants as an incentive to purchase certain of their products. In addition to suing on their own behalf, many of the plaintiff states seek to recover on behalf of individual Medicare Part B co-payers and private-sector insurance companies and medical plans in their states. These various actions generally assert fraud claims , as well as claims under state deceptive trade practice laws, and seek monetary and other relief, including civil penalties and treble damages. Several of the suits also allege that Pharmacia and/or Pfizer did not report to the states their best price for certain products under the Medicaid program. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In addition, Pharmacia, Pfizer and other pharmaceutical manufacturers are defendants in a number of purported class action suits in various federal and state courts brought by employee benefit plans and other third-party payers that assert claims similar to those in the state and county actions. These suits allege, among other things, fraud, unfair competition and unfair trade practices and seek monetary and other relief, including civil penalties and treble damages. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">All of these state, county and purported class action suits were transferred for consolidated pre-trial proceedings to a Multi-District Litigation (<i>In re Pharmaceutical Industry Average Wholesale Price Litigation MDL-1456</i>) in the U.S. District Court for the District of Massachusetts. Certain of the state and private suits have been remanded to their respective state courts. In November 2006, the claims against Pfizer in the Multi-District Litigation were dismissed with prejudice; the claims against Pharmacia are still pending. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In April 2008, the court in the Multi-District Litigation granted preliminary approval with respect to the fairness of a proposed settlement of the claims against 11 defendants, including Pharmacia, for a total of $125 million. It is expected that the court will schedule a hearing for later this year to consider final approval of the settlement. If the settlement is approved, Pharmacia&#8217;s contribution would be immaterial. </font></p> <p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In addition, Wyeth is a defendant in AWP actions brought by certain states, which are not included in the Multi-District Litigation, as well as AWP actions brought by most counties in New York, almost all of which are included in the Multi-District Litigation. Wyeth also is a defendant in a purported class action in state court in New Jersey brought by a third-party payer. These actions against Wyeth would not be included in the proposed settlement referred to in the previous paragraph. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Monsanto-Related Matters </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 1997, Monsanto Company (Former Monsanto) contributed certain chemical manufacturing operations and facilities to a newly formed corporation, Solutia Inc. (Solutia), and spun off the shares of Solutia. In 2000, Former Monsanto merged with Pharmacia&#160;&amp; Upjohn Company to form Pharmacia Corporation (Pharmacia). Pharmacia then transferred its agricultural operations to a newly created subsidiary, named Monsanto Company (New Monsanto), which it spun off in a two-stage process that was completed in 2002. Pharmacia was acquired by Pfizer in 2003 and is now a wholly owned subsidiary of Pfizer. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In connection with its spin-off that was completed in 2002, New Monsanto assumed, and agreed to indemnify Pharmacia for, any liabilities related to Pharmacia&#8217;s former agricultural business. New Monsanto is defending and indemnifying Pharmacia for various claims and litigation arising out of, or related to, the agricultural business. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In connection with its spin-off in 1997, Solutia assumed, and agreed to indemnify Pharmacia for, liabilities related to Former Monsanto&#8217;s chemical businesses. As the result of its reorganization under Chapter 11 of the U.S. Bankruptcy Code, Solutia&#8217;s indemnification obligations related to Former Monsanto&#8217;s chemical businesses are limited to sites that Solutia has owned or operated. In addition, in connection with its spin-off that was completed in 2002, New Monsanto assumed, and agreed to indemnify Pharmacia for, any liabilities primarily related to Former Monsanto&#8217;s chemical businesses, including, but not limited to, any such liabilities that Solutia assumed. Solutia&#8217;s and New Monsanto&#8217;s assumption of and agreement to indemnify Pharmacia for these liabilities apply to pending actions and any future actions related to Former Monsanto&#8217;s chem ical businesses in which Pharmacia is named as a defendant, including, without limitation, actions asserting environmental claims, including alleged exposure to polychlorinated biphenyls. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Pharmacia Cash Balance Pension Plan </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2006, several current and former employees of Pharmacia Corporation filed a purported class action in the U.S. District Court for the Southern District of Illinois against the Pharmacia Cash Balance Pension Plan (the Plan), Pharmacia Corporation, Pharmacia&#160;&amp; Upjohn Company and Pfizer Inc. Plaintiffs seek monetary and injunctive relief on behalf of a class consisting of certain current and former participants in the Plan who accrued a benefit in the Monsanto Company Pension Plan prior to its conversion to a cash balance plan in 1997. In January 2002, after various corporate reorganizations, certain of the assets and liabilities of the Monsanto Company Pension Plan were transferred to the Plan. Plaintiffs claim that the Plan violates the age-discrimination provisions of ERISA by providing certain credits to such participants only to age 55. This action has been consolidated in the U.S. Distr ict Court for the Southern District of Illinois <i>(Walker, et al., v. The Monsanto Company Pension Plan et al.</i>) with purported class actions pending in that court that make largely similar claims against substantially similar cash balance plans sponsored by Monsanto Company and Solutia, each of which was spun off by Pharmacia Corporation or a predecessor of Pharmacia Corporation. In May 2008, at the request of the parties, the court issued an order permitting the case to proceed as a class action. In June 2009, the court granted our motion for summary judgment and dismissed the claims against the Plan, Pfizer and the two Pfizer subsidiaries. In October 2009, the plaintiffs filed a notice of appeal to the U.S. Court of Appeals for the Seventh Circuit. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Trade Secrets Action in California </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">In 2004, Ischemia Research and Education Foundation (IREF) and its chief executive officer brought an action in California Superior Court, Santa Clara County, against a former IREF employee and Pfizer. Plaintiffs allege that defendants conspired to misappropriate certain information from IREF&#8217;s allegedly proprietary database in order to assist Pfizer in designing and executing a clinical study of a Pfizer drug. In December 2008, the jury returned a verdict for compensatory damages of approximately $38.7 million. In March 2009, the court awarded prejudgment interest but declined to award punitive damages. In July 2009, the court granted our motion for a new trial and vacated the jury verdict. </font></p> <p style="MARGIN-TOP: 9px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1"><b>Trimegestone </b></font></p> <p style="MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px"><font style="FONT-FAMILY: ARIAL" size="1">Aventis filed a breach of contract action against Wyeth in the Commercial Court of Nanterre in France arising out of the December 2003 termination by Wyeth of an October&#160;2000 agreement between Wyeth and Aventis relating to the development of hormone-therapy drugs utilizing Aventis&#8217; trimegestone (TMG) progestin. Aventis alleges that the termination was improper and seeks monetary&#160;damages and injunctive relief. In January 2009, a three-judge tribunal rendered its decision in favor of Wyeth, denying all of the relief sought by Aventis. 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Because tax laws and regulations are subject to interpretation and tax litigation inherently is uncertain, these evaluations can involve a series of complex judgments about future events and can rely heavily on estimates and assumptions. Our evaluations are based on estimates and assumptions that have been deemed reasonable by management. However, if our estimates and assumptions are not representative of actual outcomes, our results could be materially impacted. For a description of our accounting policies associated with accounting for income tax c ontingencies, see <i>Note 1P. Significant Accounting Policies: Income Tax Contingencies </i>and <i>Note 1C. 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