Prime Medicine, Inc.

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Other Events

Submission of Matters to a Vote of Security Holders

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Annual Report Scanned (Paper)

Additional Information for Proxy Statement/ Votes

Definitive Proxy Statement

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Notice of Effectiveness

Annual report pursuant to Section 13 or 15(d)

Results of Operations and Financial Condition

Post-effective amendment to an automatic shelf registration statement

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Post-effective amendment to a registration statement

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Regulation FD Disclosure

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Automatic Shelf Registration

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Regulation FD Disclosure

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Entry into a Material Definitive Agreement

Prospectus Supplement for Primary Offering

Results of Operations and Financial Condition

Prospectus Supplement for Primary Offering

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Definitive Proxy Statement

Preliminary Proxy Statement

Submission of Matters to a Vote of Security Holders

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Additional Information for Proxy Statement/ Votes

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Annual Report Scanned (Paper)

Additional Information for Proxy Statement/ Votes

Definitive Proxy Statement

Regulation FD Disclosure

Annual report pursuant to Section 13 or 15(d)

Results of Operations and Financial Condition

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

7.01,9.01

Notice of Effectiveness

Correspondence with the SEC

Letter from the SEC

Registration statement under Securities Act of 1933

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Additional Information for Proxy Statement/ Votes

General form for quarterly reports under Section 13 or 15(d)

Annual Report Scanned (Paper)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Preliminary Proxy Statement

Annual report pursuant to Section 13 or 15(d)

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Prospectus Supplement for Primary Offering

Free Writing Prospectus

Prospectus Supplement for Primary Offering

Notice of Effectiveness

Correspondence with the SEC

Letter from the SEC

General form for quarterly reports under Section 13 or 15(d)

Registration statement under Securities Act of 1933

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Additional Information for Proxy Statement/ Votes

Annual Report Scanned (Paper)

Additional Information for Proxy Statement/ Votes

Definitive Proxy Statement

Annual report pursuant to Section 13 or 15(d)

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

General form for quarterly reports under Section 13 or 15(d)

Prospectus Supplement with Pricing Information

Free Writing Prospectus

No description available

No description available

Certification of approval for listing and registration on a national securities exchange

Correspondence with the SEC

Correspondence with the SEC

Correspondence with the SEC

Letter from the SEC

Correspondence with the SEC

Correspondence with the SEC

Letter from the SEC

Draft registration statement (confidential submission) (amendment)

Draft registration statement (confidential submission) (amendment)

No description available

Schenkein David P

Marrazzo Jeffrey D

NELSEN ROBERT

Kelly Michael Aaron

Foster-Cheek Kaye I

Chung Wendy

Cahill Thomas

Makhni Svetlana Ni

Makhni Svetlana Ni

Reine Allan

Alenson Carman

LEE ANN L.

LEE ANN L.

Schenkein David P

Cahill Thomas