Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

Nautilus Biotechnology, Inc.

CIK 0001808805NAUT· quarter ending 2026-06-30

Shares outstanding

127,255,223

as of 2026-07-24 · 10-Q cover page, filed 2026-07-28

Held by 13F filers

50,144,583

39.4% of shares outstanding

Holders

+12 vs 2026-03-31 · 30 new, 18 exited

Value

$93.7M

shares -7.7% vs prior quarter

Share classes (cover page of the 10-Q filed 2026-07-28, as of 2026-07-24)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	NAUT · NASDAQ	127,255,223	50,144,583	39.4%	93	63909J108

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	63909J108	COM	93	50,144,583	127,255,223	39.4%	$93.7M	1 call / 1 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (93 of 93 · 63909J108)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	PERCEPTIVE ADVISORS LLC	11,634,211	9.14%	$21.8M	-960,000 (-7.6%)
2	a16z Capital Management, L.L.C.	9,063,054	7.12%	$16.9M	-8,590,863 (-48.7%)
3	Cercano Management LLC	7,172,985	5.64%	$13.4M	—
4	BlackRock, Inc.	2,687,226	2.11%	$5.0M	+2,499,555 (+1331.9%)
5	VANGUARD CAPITAL MANAGEMENT LLC	2,549,979	2.00%	$4.8M	+4,382 (+0.2%)
6	Comprehensive Financial Management LLC	2,207,619	1.73%	$4.1M	—
7	CITADEL ADVISORS LLC	1,896,192	1.49%	$3.5M	NEW
8	GEODE CAPITAL MANAGEMENT, LLC	1,265,535	0.99%	$2.4M	+662,011 (+109.7%)
9	ACADIAN ASSET MANAGEMENT LLC	1,055,461	0.83%	$2.0M	+314,215 (+42.4%)
10	Clearstead Advisors, LLC	892,787	0.70%	$1.7M	-1,436,997 (-61.7%)
11	SUSQUEHANNA INTERNATIONAL GROUP, LLP	890,949	0.70%	$1.7M	NEW
12	SENTINEL TRUST CO LBA	750,000	0.59%	$1.4M	—
13	BARCLAYS PLC	725,321	0.57%	$1.4M	+651,996 (+889.2%)
14	RENAISSANCE TECHNOLOGIES LLC	690,514	0.54%	$1.3M	+424,814 (+159.9%)
15	JPMORGAN CHASE & CO	614,177	0.48%	$1.1M	NEW
16	STATE STREET CORP	559,508	0.44%	$1.0M	+343,238 (+158.7%)
17	DIMENSIONAL FUND ADVISORS LP	475,844	0.37%	$889K	+146,721 (+44.6%)
18	NORTHERN TRUST CORP	381,234	0.30%	$713K	+274,223 (+256.3%)
19	HRT FINANCIAL LP	361,073	0.28%	$675K	+295,819 (+453.3%)
20	VANGUARD FIDUCIARY TRUST CO	353,093	0.28%	$660K	+47,567 (+15.6%)
21	VANGUARD PORTFOLIO MANAGEMENT LLC	337,748	0.27%	$632K	NEW
22	MARSHALL WACE, LLP	265,582	0.21%	$497K	-54,300 (-17.0%)
23	Qube Research & Technologies Ltd	257,346	0.20%	$481K	+177,723 (+223.2%)
24	GOLDMAN SACHS GROUP INC	252,751	0.20%	$473K	-138,017 (-35.3%)
25	HILLMAN CO	200,000	0.16%	$374K	—
26	MILLENNIUM MANAGEMENT LLC	188,730	0.15%	$353K	-1,084,653 (-85.2%)
27	BRIDGEWAY CAPITAL MANAGEMENT, LLC	180,000	0.14%	$337K	+50,000 (+38.5%)
28	Corient Private Wealth LP	164,788	0.13%	$308K	+50,000 (+43.6%)
29	Crewe Advisors LLC	136,052	0.11%	$254K	—
30	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	123,684	0.10%	$231K	NEW
31	Bank of New York Mellon Corp	122,570	0.10%	$229K	NEW
32	GSA CAPITAL PARTNERS LLP	101,112	0.08%	$189K	+46,413 (+84.9%)
33	MORGAN STANLEY	98,212	0.08%	$184K	+48,709 (+98.4%)
34	BANK OF AMERICA CORP /DE/	77,058	0.06%	$144K	+13,911 (+22.0%)
35	Point72 Asset Management, L.P.	67,938	0.05%	$127K	-15,105 (-18.2%)
36	Palumbo Wealth Management LLC	66,232	0.05%	$124K	+1,001 (+1.5%)
37	Nuveen, LLC	66,202	0.05%	$124K	NEW
38	Quadrature Capital Ltd	58,559	0.05%	$110K	NEW
39	Y-Intercept (Hong Kong) Ltd	58,152	0.05%	$109K	NEW
40	AMERICAN CENTURY COMPANIES INC	52,689	0.04%	$99K	NEW
41	CITIZENS FINANCIAL GROUP INC/RI	50,000	0.04%	$94K	—
42	Virtu Financial LLC	49,943	0.04%	$93K	NEW
43	HSBC HOLDINGS PLC	49,449	0.04%	$91K	—
44	DEUTSCHE BANK AG\	48,518	0.04%	$91K	NEW
45	Caprock Group, LLC	47,090	0.04%	$88K	+3,000 (+6.8%)
46	Ashton Thomas Private Wealth, LLC	45,000	0.04%	$84K	—
47	Fayez Sarofim & Co	45,000	0.04%	$84K	—
48	WELLS FARGO & COMPANY/MN	42,268	0.03%	$79K	+42,008 (+16156.9%)
49	PRICE T ROWE ASSOCIATES INC /MD/	40,760	0.03%	$77K	NEW
50	SEI INVESTMENTS CO	38,643	0.03%	$72K	—
51	RHUMBLINE ADVISERS	36,567	0.03%	$68K	NEW
52	Invesco Ltd.	35,200	0.03%	$66K	NEW
53	Presidio Capital Management, LLC	34,664	0.03%	$65K	—
54	AXQ CAPITAL, LP	34,147	0.03%	$64K	NEW
55	CAPTRUST FINANCIAL ADVISORS	34,000	0.03%	$64K	-3 (-0.0%)
56	Squarepoint Ops LLC	33,746	0.03%	$63K	NEW
57	Badgley Phelps Wealth Managers, LLC	30,000	0.02%	$56K	—
58	Catalyst Funds Management Pty Ltd	26,340	0.02%	$49K	-19,988 (-43.1%)
59	Callan Family Office, LLC	25,970	0.02%	$49K	—
60	CITIGROUP INC	23,072	0.02%	$43K	+1,930 (+9.1%)
61	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	22,898	0.02%	$43K	NEW
62	Police & Firemen's Retirement System of New Jersey	18,983	0.01%	$35K	NEW
63	Engineers Gate Manager LP	17,980	0.01%	$34K	+4,102 (+29.6%)
64	UBS Group AG	17,110	0.01%	$32K	-9,793 (-36.4%)
65	Vanguard Global Advisers, LLC	16,607	0.01%	$31K	—
66	TD Waterhouse Canada Inc.	16,000	0.01%	$29K	+15,000 (+1500.0%)
67	FNY Investment Advisers, LLC	14,000	0.01%	$26K	—
68	NEW YORK STATE COMMON RETIREMENT FUND	14,000	0.01%	$26K	NEW
69	Balyasny Asset Management L.P.	13,184	0.01%	$25K	NEW
70	Vanguard Capital Wealth Advisors	13,000	0.01%	$24K	—
71	INTECH INVESTMENT MANAGEMENT LLC	11,857	0.01%	$22K	NEW
72	BNP PARIBAS FINANCIAL MARKETS	11,494	0.01%	$21K	-1,878 (-14.0%)
73	ROYAL BANK OF CANADA	11,207	0.01%	$21K	+11,116 (+12215.4%)
74	Garde Capital, Inc.	11,000	0.01%	$21K	—
75	BLAIR WILLIAM & CO/IL	10,000	0.01%	$19K	-5,000 (-33.3%)
76	Rockefeller Capital Management L.P.	9,400	0.01%	$18K	+3,200 (+51.6%)
77	GROUP ONE TRADING LLC	8,197	0.01%	$15K	NEW
78	BFSG, LLC	6,700	0.01%	$13K	—
79	Legal & General Group Plc	4,844	0.00%	$9K	NEW
80	Ameritas Investment Partners, Inc.	4,513	0.00%	$8K	NEW
81	Russell Investments Group, Ltd.	3,976	0.00%	$7K	NEW
82	FMR LLC	3,583	0.00%	$7K	+240 (+7.2%)
83	OSAIC HOLDINGS, INC.	3,078	0.00%	$6K	+2,783 (+943.4%)
84	Federation des caisses Desjardins du Quebec	3,000	0.00%	$6K	+2,000 (+200.0%)
85	Tower Research Capital LLC (TRC)	2,827	0.00%	$5K	NEW
86	SIMPLEX TRADING, LLC	1,090	0.00%	$2K	NEW
87	Sterling Capital Management LLC	922	0.00%	$2K	NEW
88	GILL CAPITAL PARTNERS, LLC	250	0.00%	$468	—
89	Caitong International Asset Management Co., Ltd	119	0.00%	$223	+118 (+11800.0%)
90	SBI Securities Co., Ltd.	100	0.00%	$187	—
91	Allworth Financial LP	72	0.00%	$135	NEW
92	Optiver Holding B.V.	40	0.00%	$75	—
93	Covestor Ltd	8	0.00%	$0	—

Exited since 2026-03-31 (18 filers; largest 18 shown)

AMAZON COM INC	−1,457,055
Tikvah Management LLC	−726,895
CROWN ADVISORS MANAGEMENT, INC.	−100,000
JANE STREET GROUP, LLC	−61,802
Brevan Howard Capital Management LP	−60,501
JACOBS LEVY EQUITY MANAGEMENT, INC	−46,394
POLEN CAPITAL MANAGEMENT LLC	−40,345
Hudson Bay Capital Management LP	−29,594
OMERS ADMINISTRATION Corp	−24,500
Diametric Capital, LP	−22,806
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	−19,300
CTC Alternative Strategies, Ltd.	−12,397
Schonfeld Strategic Advisors LLC	−12,010
NINE MASTS CAPITAL Ltd	−10,395
NATIONAL BANK OF CANADA /FI/	−300
Your Advocates Ltd., LLP	−150
CWM, LLC	−29
EverSource Wealth Advisors, LLC	−18

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
AH Bio Fund II, L.P.	SCHEDULE 13D/A	2026-09-11	2026-09-09	5,782,188	4.5%
AH Equity Partners Bio II, L.L.C.	SCHEDULE 13D/A	2026-09-11	2026-09-09	5,782,188	4.5%
AH Equity Partners LSV II, L.L.C.	SCHEDULE 13D/A	2026-09-11	2026-09-09	481,047	0.4%
Andreessen Horowitz LSV Fund II, L.P.	SCHEDULE 13D/A	2026-09-11	2026-09-09	481,047	0.4%
Benjamin A. Horowitz	SCHEDULE 13D/A	2026-09-11	2026-09-09	6,263,235	4.9%
Marc L. Andreessen	SCHEDULE 13D/A	2026-09-11	2026-09-09	6,263,235	4.9%
C2 Life Sciences LLC	SCHEDULE 13D/A	2026-08-14	2026-06-30	165,860	0.1%
Joseph Edelman	SCHEDULE 13D/A	2026-08-14	2026-06-30	11,634,211	9.1%
Perceptive Advisors LLC	SCHEDULE 13D/A	2026-08-14	2026-06-30	11,634,211	9.1%
Perceptive Life Sciences Master Fund, Ltd.	SCHEDULE 13D/A	2026-08-14	2026-06-30	11,468,351	9.1%
Parag Mallick	SCHEDULE 13D/A	2026-03-04	2026-03-02	22,557,411	17.6%
Sujal Patel	SCHEDULE 13D/A	2026-03-04	2026-03-02	21,249,965	16.3%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.