| 1 | AyurMaya Capital Management Company, LP | 15,139,707 | — | $426.0M | — |
| 2 | BlackRock, Inc. | 8,218,151 | — | $231.3M | +1,047,283 (+14.6%) |
| 3 | FMR LLC | 6,769,170 | — | $190.5M | +5,795,388 (+595.1%) |
| 4 | Deep Track Capital, LP | 6,348,558 | — | $178.6M | -424,037 (-6.3%) |
| 5 | SAMSARA BIOCAPITAL, LLC | 6,345,219 | — | $178.6M | — |
| 6 | Foresite Capital Management V, LLC | 5,896,995 | — | $165.9M | — |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,199,838 | — | $146.3M | +1,913,085 (+58.2%) |
| 8 | venBio Partners LLC | 4,528,408 | — | $127.4M | — |
| 9 | Foresite Capital Management VI LLC | 4,247,670 | — | $119.5M | — |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 4,215,703 | — | $118.6M | +183,437 (+4.5%) |
| 11 | Nextech Invest Ltd. | 3,540,998 | — | $99.6M | — |
| 12 | Cormorant Asset Management, LP | 3,285,596 | — | $92.5M | -663,645 (-16.8%) |
| 13 | Saturn V Capital Management LP | 2,915,443 | — | $82.0M | -286,632 (-9.0%) |
| 14 | Octagon Capital Advisors LP | 2,830,700 | — | $79.7M | — |
| 15 | Jupiter Topco LLC | 2,355,122 | — | $66.2M | NEW |
| 16 | STATE STREET CORP | 2,187,266 | — | $61.5M | +385,454 (+21.4%) |
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 2,168,517 | — | $61.0M | +250,102 (+13.0%) |
| 18 | MPM BIOIMPACT LLC | 2,019,020 | — | $56.8M | -367,509 (-15.4%) |
| 19 | BAKER BROS. ADVISORS LP | 2,012,500 | — | $56.6M | — |
| 20 | SR One Capital Management, LP | 1,959,896 | — | $55.2M | — |
| 21 | Invesco Ltd. | 1,173,518 | — | $33.0M | -338,019 (-22.4%) |
| 22 | NOVO HOLDINGS A/S | 1,100,000 | — | $31.0M | NEW |
| 23 | PRINCIPAL FINANCIAL GROUP INC | 1,068,060 | — | $30.1M | +10,009 (+0.9%) |
| 24 | JPMORGAN CHASE & CO | 969,617 | — | $26.4M | +108,042 (+12.5%) |
| 25 | D. E. Shaw & Co., Inc. | 968,234 | — | $27.2M | +396,105 (+69.2%) |
| 26 | UBS Group AG | 951,796 | — | $26.8M | -2,103,069 (-68.8%) |
| 27 | VANGUARD PORTFOLIO MANAGEMENT LLC | 921,211 | — | $25.9M | +208,603 (+29.3%) |
| 28 | Ikarian Capital, LLC | 870,548 | — | $24.5M | -343,000 (-28.3%) |
| 29 | GREAT POINT PARTNERS LLC | 856,061 | — | $24.1M | — |
| 30 | GOLDMAN SACHS GROUP INC | 831,897 | — | $23.4M | +113,857 (+15.9%) |
| 31 | NORTHERN TRUST CORP | 723,849 | — | $20.4M | +160,327 (+28.5%) |
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 700,134 | — | $19.7M | +64,745 (+10.2%) |
| 33 | Integral Health Asset Management, LLC | 700,000 | — | $19.7M | -100,000 (-12.5%) |
| 34 | MILLENNIUM MANAGEMENT LLC | 660,142 | — | $18.6M | +53,858 (+8.9%) |
| 35 | VANGUARD FIDUCIARY TRUST CO | 612,010 | — | $17.2M | +84,705 (+16.1%) |
| 36 | Opaleye Management Inc. | 550,000 | — | $15.5M | — |
| 37 | ORBIMED ADVISORS LLC | 548,163 | — | $15.4M | — |
| 38 | ROYCE & ASSOCIATES LP | 525,303 | — | $14.8M | +48,911 (+10.3%) |
| 39 | Woodline Partners LP | 486,052 | — | $13.7M | NEW |
| 40 | Spruce Street Capital LP | 392,574 | — | $11.0M | — |
| 41 | Trium Capital LLP | 390,268 | — | $11.0M | +198,877 (+103.9%) |
| 42 | CITIGROUP INC | 385,400 | — | $10.8M | +286,476 (+289.6%) |
| 43 | TWO SIGMA INVESTMENTS, LP | 376,119 | — | $10.6M | -281,996 (-42.8%) |
| 44 | MARSHALL WACE, LLP | 368,014 | — | $10.4M | -804,735 (-68.6%) |
| 45 | MORGAN STANLEY | 321,163 | — | $9.0M | +96,091 (+42.7%) |
| 46 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 320,861 | — | $9.0M | -428,238 (-57.2%) |
| 47 | Weiss Asset Management LP | 311,371 | — | $8.8M | -786,046 (-71.6%) |
| 48 | Artia Global Partners LP | 278,546 | — | $7.8M | -46,500 (-14.3%) |
| 49 | BARCLAYS PLC | 273,716 | — | $7.7M | +51,058 (+22.9%) |
| 50 | Yu Fan | 252,672 | — | $7.1M | -524,173 (-67.5%) |
| 51 | Nuveen, LLC | 243,872 | — | $6.9M | -75,316 (-23.6%) |
| 52 | BOOTHBAY FUND MANAGEMENT, LLC | 242,538 | — | $6.8M | -103,593 (-29.9%) |
| 53 | Omega Fund Management, LLC | 241,255 | — | $6.8M | — |
| 54 | SCHRODER INVESTMENT MANAGEMENT GROUP | 236,841 | — | $6.4M | +99,494 (+72.4%) |
| 55 | Bank of New York Mellon Corp | 226,618 | — | $6.4M | +19,889 (+9.6%) |
| 56 | TOWERVIEW LLC | 222,294 | — | $6.3M | — |
| 57 | BANK OF AMERICA CORP /DE/ | 207,789 | — | $5.8M | +79,977 (+62.6%) |
| 58 | Exome Asset Management LLC | 204,418 | — | $5.8M | -74,758 (-26.8%) |
| 59 | HighVista Strategies LLC | 199,968 | — | $5.6M | +87,039 (+77.1%) |
| 60 | WELLINGTON MANAGEMENT GROUP LLP | 179,802 | — | $5.1M | -59,429 (-24.8%) |
| 61 | WELLS FARGO & COMPANY/MN | 174,912 | — | $4.9M | +88,194 (+101.7%) |
| 62 | Susquehanna Portfolio Strategies, LLC | 172,779 | — | $4.9M | — |
| 63 | PRUDENTIAL FINANCIAL INC | 162,583 | — | $4.6M | -376,150 (-69.8%) |
| 64 | Russell Investments Group, Ltd. | 153,906 | — | $4.3M | -8,274 (-5.1%) |
| 65 | Ensign Peak Advisors, Inc | 146,970 | — | $4.1M | -22,527 (-13.3%) |
| 66 | AQR CAPITAL MANAGEMENT LLC | 146,437 | — | $4.1M | -245 (-0.2%) |
| 67 | VOYA INVESTMENT MANAGEMENT LLC | 138,418 | — | $3.9M | +64,509 (+87.3%) |
| 68 | MOORE CAPITAL MANAGEMENT, LP | 136,803 | — | $3.8M | +95,433 (+230.7%) |
| 69 | Swiss National Bank | 135,900 | — | $3.8M | +8,100 (+6.3%) |
| 70 | STEMPOINT CAPITAL LP | 135,736 | — | $3.8M | -323,396 (-70.4%) |
| 71 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 134,850 | — | $3.8M | NEW |
| 72 | VICTORY CAPITAL MANAGEMENT INC | 132,331 | — | $3.7M | +49,677 (+60.1%) |
| 73 | Quantinno Capital Management LP | 131,092 | — | $3.7M | +3,997 (+3.1%) |
| 74 | Elmind Capital, LP | 130,000 | — | $3.7M | — |
| 75 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 112,129 | — | $3.2M | +30,055 (+36.6%) |
| 76 | STIFEL FINANCIAL CORP | 110,075 | — | $3.1M | -99,654 (-47.5%) |
| 77 | ALLIANCEBERNSTEIN L.P. | 104,394 | — | $2.3M | +36,300 (+53.3%) |
| 78 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,215 | — | $2.8M | -54,419 (-35.2%) |
| 79 | Ghisallo Capital Management LLC | 100,000 | — | $2.8M | — |
| 80 | TD Asset Management Inc | 97,002 | — | $2.7M | -94,200 (-49.3%) |
| 81 | RHUMBLINE ADVISERS | 96,767 | — | $2.7M | +12,475 (+14.8%) |
| 82 | FIRST TRUST ADVISORS LP | 94,046 | — | $2.6M | +27,947 (+42.3%) |
| 83 | Harvest Investment Services, LLC | 92,765 | — | $2.6M | -7,085 (-7.1%) |
| 84 | Caption Management, LLC | 90,000 | — | $2.5M | +70,000 (+350.0%) |
| 85 | DEUTSCHE BANK AG\ | 84,113 | — | $2.4M | +25,955 (+44.6%) |
| 86 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 78,818 | — | $2.2M | -2,027 (-2.5%) |
| 87 | Ally Bridge Group (NY) LLC | 76,459 | — | $2.2M | -90,500 (-54.2%) |
| 88 | Mariner, LLC | 71,726 | — | $2.0M | -1,397 (-1.9%) |
| 89 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,717 | — | $1.7M | -135,638 (-69.8%) |
| 90 | ALGERT GLOBAL LLC | 57,770 | — | $1.6M | -100,056 (-63.4%) |
| 91 | Legal & General Group Plc | 54,930 | — | $1.5M | +4,335 (+8.6%) |
| 92 | ACT CAPITAL MANAGEMENT, LLC | 51,600 | — | $1.5M | -122,650 (-70.4%) |
| 93 | VANGUARD ASSET MANAGEMENT, Ltd | 50,615 | — | $1.4M | +8,371 (+19.8%) |
| 94 | STATE OF WISCONSIN INVESTMENT BOARD | 50,413 | — | $1.4M | +5,903 (+13.3%) |
| 95 | Vanguard Global Advisers, LLC | 49,756 | — | $1.4M | +7,512 (+17.8%) |
| 96 | Squarepoint Ops LLC | 47,590 | — | $1.3M | -66,608 (-58.3%) |
| 97 | MetLife Investment Management, LLC | 46,312 | — | $1.3M | +8,754 (+23.3%) |
| 98 | FRED ALGER MANAGEMENT, LLC | 43,057 | — | $1.2M | NEW |
| 99 | Creative Planning | 41,818 | — | $1.2M | +735 (+1.8%) |
| 100 | Handelsbanken Fonder AB | 36,400 | — | $1.0M | NEW |
| 101 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 36,373 | — | $1.0M | +4,213 (+13.1%) |
| 102 | Corient Private Wealth LP | 35,144 | — | $989K | +16,458 (+88.1%) |
| 103 | Trexquant Investment LP | 34,137 | — | $961K | NEW |
| 104 | FRANKLIN RESOURCES INC | 32,634 | — | $918K | NEW |
| 105 | Zurcher Kantonalbank (Zurich Cantonalbank) | 31,377 | — | $883K | +12,991 (+70.7%) |
| 106 | NEW YORK STATE COMMON RETIREMENT FUND | 27,767 | — | $781K | +9,900 (+55.4%) |
| 107 | J. Goldman & Co LP | 25,846 | — | $727K | +2,398 (+10.2%) |
| 108 | Jain Global LLC | 25,256 | — | $711K | NEW |
| 109 | Y-Intercept (Hong Kong) Ltd | 25,236 | — | $710K | NEW |
| 110 | BNP PARIBAS FINANCIAL MARKETS | 24,078 | — | $678K | -11,068 (-31.5%) |
| 111 | FOX RUN MANAGEMENT, L.L.C. | 23,993 | — | $675K | NEW |
| 112 | Inscription Capital, LLC | 23,599 | — | $664K | -2,614 (-10.0%) |
| 113 | RENAISSANCE TECHNOLOGIES LLC | 23,335 | — | $657K | -51,832 (-69.0%) |
| 114 | Police & Firemen's Retirement System of New Jersey | 23,295 | — | $656K | +4,658 (+25.0%) |
| 115 | SG Americas Securities, LLC | 22,867 | — | $643K | +14,241 (+165.1%) |
| 116 | XTX Topco Ltd | 22,834 | — | $643K | +3,544 (+18.4%) |
| 117 | State of New Jersey Common Pension Fund D | 21,899 | — | $616K | -188 (-0.9%) |
| 118 | INTECH INVESTMENT MANAGEMENT LLC | 20,853 | — | $587K | -8,738 (-29.5%) |
| 119 | China Universal Asset Management Co., Ltd. | 19,644 | — | $553K | -2,792 (-12.4%) |
| 120 | ARIZONA STATE RETIREMENT SYSTEM | 18,688 | — | $526K | +937 (+5.3%) |
| 121 | Vanguard Investments Australia, Ltd. | 16,272 | — | $458K | — |
| 122 | Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 15,396 | — | $433K | +3,365 (+28.0%) |
| 123 | OCCUDO QUANTITATIVE STRATEGIES LP | 15,297 | — | $430K | +4,173 (+37.5%) |
| 124 | VIRGINIA RETIREMENT SYSTEMS ET Al | 15,000 | — | $422K | NEW |
| 125 | Brevan Howard Capital Management LP | 14,811 | — | $417K | -12,769 (-46.3%) |
| 126 | ProShare Advisors LLC | 14,393 | — | $405K | -1,198 (-7.7%) |
| 127 | PROFUND ADVISORS LLC | 14,251 | — | $401K | +4,230 (+42.2%) |
| 128 | OpenArc Corporate Advisory, LLC | 14,240 | — | $401K | — |
| 129 | KLP KAPITALFORVALTNING AS | 14,200 | — | $400K | — |
| 130 | STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 13,604 | — | $383K | — |
| 131 | Virtus Investment Advisers, LLC | 13,549 | — | $381K | -10,183 (-42.9%) |
| 132 | Verdad Advisers, LP | 12,187 | — | $343K | +3,014 (+32.9%) |
| 133 | MERCER GLOBAL ADVISORS INC /ADV | 11,447 | — | $322K | -1,318 (-10.3%) |
| 134 | SmartHarvest Portfolios, LLC | 10,771 | — | $303K | +1,164 (+12.1%) |
| 135 | Allianz Asset Management GmbH | 10,700 | — | $301K | -7,500 (-41.2%) |
| 136 | Vanguard Personalized Indexing Management, LLC | 10,667 | — | $300K | +247 (+2.4%) |
| 137 | Voleon Capital Management LP | 10,645 | — | $300K | NEW |
| 138 | Pictet Asset Management Holding SA | 10,491 | — | $295K | — |
| 139 | Rafferty Asset Management, LLC | 9,903 | — | $279K | NEW |
| 140 | CAPSTONE INVESTMENT ADVISORS, LLC | 8,421 | — | $237K | NEW |
| 141 | SEI INVESTMENTS CO | 8,337 | — | $235K | -981 (-10.5%) |
| 142 | Vident Advisory, LLC | 8,296 | — | $233K | NEW |
| 143 | TEACHER RETIREMENT SYSTEM OF TEXAS | 7,892 | — | $222K | NEW |
| 144 | Arax Advisory Partners | 7,885 | — | $222K | +7,519 (+2054.4%) |
| 145 | XPONANCE LLC | 7,751 | — | $218K | NEW |
| 146 | Abel Hall, LLC | 7,437 | — | $209K | NEW |
| 147 | Ameritas Investment Partners, Inc. | 7,168 | — | $202K | +1,559 (+27.8%) |
| 148 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 7,128 | — | $202K | NEW |
| 149 | Fulcrum Asset Management LLP | 7,116 | — | $193K | NEW |
| 150 | State of Wyoming | 6,712 | — | $189K | +4,122 (+159.2%) |
| 151 | Farther Finance Advisors, LLC | 6,215 | — | $175K | +205 (+3.4%) |
| 152 | Mirae Asset Global Investments Co., Ltd. | 5,520 | — | $155K | -1,074 (-16.3%) |
| 153 | Tower Research Capital LLC (TRC) | 5,447 | — | $153K | -3,428 (-38.6%) |
| 154 | SIMPLEX TRADING, LLC | 4,986 | — | $140K | -3,044 (-37.9%) |
| 155 | ASSETMARK, INC | 4,209 | — | $118K | +21 (+0.5%) |
| 156 | ACADIAN ASSET MANAGEMENT LLC | 3,696 | — | $103K | +3,108 (+528.6%) |
| 157 | GF FUND MANAGEMENT CO. LTD. | 2,677 | — | $75K | +494 (+22.6%) |
| 158 | STRS OHIO | 2,600 | — | $73K | +600 (+30.0%) |
| 159 | EverSource Wealth Advisors, LLC | 2,581 | — | $73K | -550 (-17.6%) |
| 160 | ROYAL BANK OF CANADA | 2,559 | — | $72K | +2,471 (+2808.0%) |
| 161 | Parallel Advisors, LLC | 2,059 | — | $58K | — |
| 162 | KBC Group NV | 1,929 | — | $54K | — |
| 163 | SIGNATUREFD, LLC | 1,286 | — | $36K | -327 (-20.3%) |
| 164 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,167 | — | $33K | NEW |
| 165 | JONES FINANCIAL COMPANIES LLLP | 1,055 | — | $28K | +511 (+93.9%) |
| 166 | GAMMA Investing LLC | 994 | — | $28K | -57 (-5.4%) |
| 167 | NISA INVESTMENT ADVISORS, LLC | 987 | — | $28K | -2,368 (-70.6%) |
| 168 | Kemnay Advisory Services Inc. | 912 | — | $26K | +84 (+10.1%) |
| 169 | Nykredit A/S | 776 | — | $22K | NEW |
| 170 | Versant Capital Management, Inc | 543 | — | $15K | — |
| 171 | Global Retirement Partners, LLC | 543 | — | $15K | NEW |
| 172 | Allworth Financial LP | 467 | — | $13K | -36 (-7.2%) |
| 173 | Essential Partners LLC | 440 | — | $12K | -2,452 (-84.8%) |
| 174 | ROTHSCHILD INVESTMENT LLC | 411 | — | $12K | +1 (+0.2%) |
| 175 | PNC Financial Services Group, Inc. | 392 | — | $11K | -25 (-6.0%) |
| 176 | Aster Capital Management (DIFC) Ltd | 329 | — | $9K | NEW |
| 177 | OSAIC HOLDINGS, INC. | 291 | — | $8K | -52 (-15.2%) |
| 178 | MassMutual Private Wealth & Trust, FSB | 279 | — | $8K | +63 (+29.2%) |
| 179 | Sterling Capital Management LLC | 277 | — | $8K | -1,994 (-87.8%) |
| 180 | US BANCORP \DE\ | 263 | — | $7K | -201 (-43.3%) |
| 181 | True Wealth Design, LLC | 232 | — | $7K | -12 (-4.9%) |
| 182 | BFSG, LLC | 192 | — | $5K | — |
| 183 | Larson Financial Group LLC | 154 | — | $4K | -96 (-38.4%) |
| 184 | Parkside Financial Bank & Trust | 142 | — | $4K | -8 (-5.3%) |
| 185 | Transamerica Financial Advisors, LLC | 97 | — | $3K | — |
| 186 | Quarry LP | 96 | — | $3K | NEW |
| 187 | Optiver Holding B.V. | 94 | — | $3K | -130 (-58.0%) |
| 188 | Decker Retirement Planning Inc. | 91 | — | $3K | — |
| 189 | Fortitude Family Office, LLC | 77 | — | $2K | +57 (+285.0%) |
| 190 | IFP Advisors, Inc | 55 | — | $2K | — |
| 191 | SBI Securities Co., Ltd. | 34 | — | $957 | +30 (+750.0%) |
| 192 | Silver Grove Financial Group, Inc. | 32 | — | $900 | NEW |
| 193 | Covestor Ltd | 28 | — | $1K | +23 (+460.0%) |
| 194 | CoreCap Advisors, LLC | 26 | — | $732 | — |
| 195 | NATIONAL BANK OF CANADA /FI/ | 25 | — | $703 | NEW |
| 196 | HARBOUR INVESTMENTS, INC. | 23 | — | $634 | +10 (+76.9%) |
| 197 | Stone House Investment Management, LLC | 22 | — | $619 | NEW |
| 198 | SALEM INVESTMENT COUNSELORS INC | 20 | — | $563 | — |