Institutional HoldersBeta
Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.
Share classes (cover page of the 10-Q filed 2026-08-06, as of 2026-07-30)
| Class | Listed | Shares outstanding | Held by 13F filers | % of class | Holders | CUSIP |
|---|---|---|---|---|---|---|
| Common stock | ALXO · NASDAQ | 138,276,997 | 105,937,916 | 76.6% | 93 | 00166B105 |
Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.
Top holders (93 of 93 · 00166B105)
change vs 2026-03-31| # | Filer | Shares | % of class | Value | Change |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 13,011,849 | 9.41% | $26.9M | — |
| 2 | venBio Partners LLC | 12,884,638 | 9.32% | $26.7M | — |
| 3 | BlackRock, Inc. | 7,399,530 | 5.35% | $15.3M | +6,951,731 (+1552.4%) |
| 4 | Redmile Group, LLC | 7,392,504 | 5.35% | $15.3M | -571,684 (-7.2%) |
| 5 | Blackstone Inc. | 6,593,543 | 4.77% | $13.6M | +766,999 (+13.2%) |
| 6 | Driehaus Capital Management LLC | 6,025,240 | 4.36% | $12.5M | +290,620 (+5.1%) |
| 7 | SILVERARC CAPITAL MANAGEMENT, LLC | 5,744,757 | 4.15% | $11.9M | NEW |
| 8 | TCG Crossover Management, LLC | 5,655,487 | 4.09% | $11.7M | -7,356,362 (-56.5%) |
| 9 | VANGUARD CAPITAL MANAGEMENT LLC | 4,973,436 | 3.60% | $10.3M | +793,700 (+19.0%) |
| 10 | Vivo Capital, LLC | 3,184,713 | 2.30% | $6.6M | — |
| 11 | MARSHALL WACE, LLP | 3,071,496 | 2.22% | $6.4M | -685,720 (-18.3%) |
| 12 | 5AM Venture Management, LLC | 3,057,325 | 2.21% | $6.3M | — |
| 13 | Almitas Capital LLC | 2,938,431 | 2.13% | $6.1M | -235,403 (-7.4%) |
| 14 | ORBIMED ADVISORS LLC | 2,866,256 | 2.07% | $5.9M | — |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 2,787,809 | 2.02% | $5.8M | +2,294,372 (+465.0%) |
| 16 | TWO SIGMA INVESTMENTS, LP | 2,178,176 | 1.58% | $4.5M | +590,343 (+37.2%) |
| 17 | MILLENNIUM MANAGEMENT LLC | 1,543,594 | 1.12% | $3.2M | -444,965 (-22.4%) |
| 18 | Nantahala Capital Management, LLC | 1,500,000 | 1.08% | $3.1M | NEW |
| 19 | STATE STREET CORP | 1,498,905 | 1.08% | $3.1M | +1,323,077 (+752.5%) |
| 20 | ACADIAN ASSET MANAGEMENT LLC | 1,313,490 | 0.95% | $2.7M | +212,465 (+19.3%) |
| 21 | JPMORGAN CHASE & CO | 1,044,728 | 0.76% | $2.3M | +1,044,629 (+1055180.8%) |
| 22 | NORTHERN TRUST CORP | 935,669 | 0.68% | $1.9M | +798,705 (+583.1%) |
| 23 | Ensign Peak Advisors, Inc | 810,297 | 0.59% | $1.7M | -140,253 (-14.8%) |
| 24 | VANGUARD PORTFOLIO MANAGEMENT LLC | 749,229 | 0.54% | $1.6M | +651,348 (+665.4%) |
| 25 | VANGUARD FIDUCIARY TRUST CO | 743,491 | 0.54% | $1.5M | +449,013 (+152.5%) |
| 26 | GOLDMAN SACHS GROUP INC | 742,331 | 0.54% | $1.5M | +603,738 (+435.6%) |
| 27 | RENAISSANCE TECHNOLOGIES LLC | 603,797 | 0.44% | $1.2M | -128,802 (-17.6%) |
| 28 | ADAR1 Capital Management, LLC | 533,660 | 0.39% | $1.1M | NEW |
| 29 | UBS Group AG | 462,943 | 0.33% | $958K | -451,811 (-49.4%) |
| 30 | GSA CAPITAL PARTNERS LLP | 413,545 | 0.30% | $856K | +344,558 (+499.5%) |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 241,113 | 0.17% | $499K | NEW |
| 32 | Bank of New York Mellon Corp | 238,447 | 0.17% | $494K | NEW |
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 226,072 | 0.16% | $468K | +150,000 (+197.2%) |
| 34 | Atom Investors LP | 219,382 | 0.16% | $454K | NEW |
| 35 | IEQ CAPITAL, LLC | 175,382 | 0.13% | $363K | +83,149 (+90.2%) |
| 36 | MORGAN STANLEY | 157,873 | 0.11% | $327K | +59,038 (+59.7%) |
| 37 | Invesco Ltd. | 149,923 | 0.11% | $310K | +138,943 (+1265.4%) |
| 38 | Nuveen, LLC | 143,645 | 0.10% | $297K | NEW |
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,157 | 0.09% | $255K | -1,205,750 (-90.7%) |
| 40 | RHUMBLINE ADVISERS | 107,902 | 0.08% | $223K | NEW |
| 41 | DEUTSCHE BANK AG\ | 107,428 | 0.08% | $222K | NEW |
| 42 | WELLS FARGO & COMPANY/MN | 99,926 | 0.07% | $207K | NEW |
| 43 | PRICE T ROWE ASSOCIATES INC /MD/ | 89,779 | 0.06% | $186K | NEW |
| 44 | Verdad Advisers, LP | 82,200 | 0.06% | $170K | NEW |
| 45 | BANK OF AMERICA CORP /DE/ | 76,032 | 0.05% | $157K | -501,751 (-86.8%) |
| 46 | Graham Capital Management, L.P. | 74,821 | 0.05% | $155K | +37,082 (+98.3%) |
| 47 | XTX Topco Ltd | 69,657 | 0.05% | $144K | +25,516 (+57.8%) |
| 48 | MetLife Investment Management, LLC | 64,959 | 0.05% | $134K | NEW |
| 49 | CITIGROUP INC | 50,635 | 0.04% | $105K | +50,618 (+297752.9%) |
| 50 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 49,682 | 0.04% | $103K | NEW |
| 51 | Squarepoint Ops LLC | 46,869 | 0.03% | $97K | NEW |
| 52 | Vanguard Global Advisers, LLC | 43,038 | 0.03% | $89K | +33,070 (+331.8%) |
| 53 | AXQ CAPITAL, LP | 40,553 | 0.03% | $84K | NEW |
| 54 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 38,011 | 0.03% | $81K | +14 (+0.0%) |
| 55 | NEW YORK STATE COMMON RETIREMENT FUND | 33,100 | 0.02% | $69K | NEW |
| 56 | BARCLAYS PLC | 32,884 | 0.02% | $68K | +22,369 (+212.7%) |
| 57 | Police & Firemen's Retirement System of New Jersey | 31,822 | 0.02% | $66K | NEW |
| 58 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,997 | 0.02% | $64K | NEW |
| 59 | ALLIANCEBERNSTEIN L.P. | 26,340 | 0.02% | $53K | NEW |
| 60 | JACOBS LEVY EQUITY MANAGEMENT, INC | 25,507 | 0.02% | $53K | NEW |
| 61 | HC Advisors, LLC | 22,900 | 0.02% | $47K | — |
| 62 | Callan Family Office, LLC | 22,419 | 0.02% | $46K | — |
| 63 | VOYA INVESTMENT MANAGEMENT LLC | 21,461 | 0.02% | $44K | NEW |
| 64 | AMERICAN CENTURY COMPANIES INC | 21,434 | 0.02% | $44K | NEW |
| 65 | CAXTON CORP | 20,946 | 0.02% | $43K | — |
| 66 | INTECH INVESTMENT MANAGEMENT LLC | 19,424 | 0.01% | $40K | NEW |
| 67 | COMMONWEALTH EQUITY SERVICES, LLC | 18,451 | 0.01% | $38K | NEW |
| 68 | Bronte Capital Management Pty Ltd. | 18,095 | 0.01% | $37K | NEW |
| 69 | JSF Financial, LLC | 17,500 | 0.01% | $36K | — |
| 70 | BNP PARIBAS FINANCIAL MARKETS | 16,616 | 0.01% | $34K | +16,150 (+3465.7%) |
| 71 | PRUDENTIAL FINANCIAL INC | 16,385 | 0.01% | $34K | NEW |
| 72 | MONETA GROUP INVESTMENT ADVISORS LLC | 15,196 | 0.01% | $31K | — |
| 73 | ProShare Advisors LLC | 14,125 | 0.01% | $29K | NEW |
| 74 | FMR LLC | 13,242 | 0.01% | $27K | +256 (+2.0%) |
| 75 | Lido Advisors, LLC | 13,220 | 0.01% | $27K | — |
| 76 | Abel Hall, LLC | 12,731 | 0.01% | $26K | +133 (+1.1%) |
| 77 | Beacon Pointe Advisors, LLC | 12,500 | 0.01% | $26K | — |
| 78 | China Universal Asset Management Co., Ltd. | 12,500 | 0.01% | $26K | NEW |
| 79 | Legal & General Group Plc | 10,483 | 0.01% | $22K | NEW |
| 80 | Tower Research Capital LLC (TRC) | 10,397 | 0.01% | $22K | NEW |
| 81 | XPONANCE LLC | 10,179 | 0.01% | $21K | NEW |
| 82 | HSBC HOLDINGS PLC | 10,105 | 0.01% | $22K | — |
| 83 | Ameritas Investment Partners, Inc. | 9,792 | 0.01% | $20K | NEW |
| 84 | Russell Investments Group, Ltd. | 8,628 | 0.01% | $18K | NEW |
| 85 | ROYAL BANK OF CANADA | 6,156 | 0.00% | $13K | +4,277 (+227.6%) |
| 86 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,486 | 0.00% | $3K | NEW |
| 87 | NISA INVESTMENT ADVISORS, LLC | 1,106 | 0.00% | $2K | — |
| 88 | Bradley & Co. Private Wealth Management, LLC | 1,000 | 0.00% | $2K | — |
| 89 | EverSource Wealth Advisors, LLC | 905 | 0.00% | $2K | — |
| 90 | Sterling Capital Management LLC | 379 | 0.00% | $785 | NEW |
| 91 | PNC Financial Services Group, Inc. | 100 | 0.00% | $207 | — |
| 92 | Caitong International Asset Management Co., Ltd | 36 | 0.00% | $75 | +30 (+500.0%) |
| 93 | SBI Securities Co., Ltd. | 14 | 0.00% | $29 | — |
Exited since 2026-03-31 (12 filers; largest 12 shown)
| ADAGE CAPITAL PARTNERS GP, L.L.C. | −2,000,000 |
| Squadron Capital Management LLC | −1,460,000 |
| Qube Research & Technologies Ltd | −107,647 |
| BANK OF NOVA SCOTIA | −105,858 |
| JANE STREET GROUP, LLC | −95,101 |
| Brevan Howard Capital Management LP | −79,389 |
| OMERS ADMINISTRATION Corp | −75,000 |
| Point72 Asset Management, L.P. | −41,095 |
| NINE MASTS CAPITAL Ltd | −20,623 |
| TWO SIGMA SECURITIES, LLC | −10,993 |
| CWM, LLC | −65 |
| Optiver Holding B.V. | −27 |
Large holders from 13D/13G (latest per reporting person, last 2 years)
Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.
| Reporting person | Form | Filed | Event | Shares | % of class |
|---|---|---|---|---|---|
| TCG Crossover Fund III, L.P. | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 2,827,748 | 2.1% |
| TCG Crossover GP II, LLC | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 2,827,739 | 2.1% |
| Chen Yu | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 5,655,487 | 4.2% |
| TCG Crossover GP III, LLC | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 2,827,748 | 2.1% |
| TCG Crossover Fund II, L.P. | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 2,827,739 | 2.1% |
| BlackRock, Inc. | SCHEDULE 13G | 2026-07-27 | 2026-06-30 | 7,327,850 | 5.4% |
| Jean George | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 2,942,525 | 2.2% |
| Henry A. Plain Jr | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 2,942,525 | 2.2% |
| Michael A Carusi | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 2,942,525 | 2.2% |
| Lightstone Ventures (A), L.P. | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 185,870 | 0.1% |
| Lightstone Ventures II (A), L.P. | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 78,138 | 0.1% |
| Lightstone Ventures II, L.P. | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 1,315,255 | 1% |
| Lightstone Ventures, L.P. | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 1,363,262 | 1% |
| LSV Associates II, LLC | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 1,393,393 | 1% |
| LSV Associates, LLC | SCHEDULE 13D/A | 2026-05-27 | 2026-05-27 | 1,549,132 | 1.2% |
| HBM Healthcare Investments (Cayman) Ltd. | SCHEDULE 13G/A | 2026-05-15 | 2026-03-31 | 8,590,692 | 6.5% |
| Redmile Group, LLC | SCHEDULE 13G/A | 2026-05-15 | 2026-03-31 | 9,214,188 | 6.8% |
| Jeremy C. Green | SCHEDULE 13G/A | 2026-05-15 | 2026-03-31 | 9,214,188 | 6.8% |
| Redmile Biopharma Investments III, L.P. | SCHEDULE 13G/A | 2026-05-15 | 2026-03-31 | 5,267,838 | 3.9% |
| Millennium Group Management LLC | SCHEDULE 13G/A | 2026-04-28 | 2026-03-31 | 1,988,559 | 1.5% |
| Israel A. Englander | SCHEDULE 13G/A | 2026-04-28 | 2026-03-31 | 1,988,559 | 1.5% |
| Millennium Management LLC | SCHEDULE 13G/A | 2026-04-28 | 2026-03-31 | 1,988,559 | 1.5% |
| Integrated Core Strategies (US) LLC | SCHEDULE 13G/A | 2026-04-28 | 2026-03-31 | 730,528 | 0.5% |
| Peter Kolchinsky | SCHEDULE 13G | 2026-02-09 | 2026-02-02 | 13,117,106 | 9.9% |
| RA Capital Healthcare Fund, L.P. | SCHEDULE 13G | 2026-02-09 | 2026-02-02 | 13,117,106 | 9.9% |
| RA Capital Management, L.P. | SCHEDULE 13G | 2026-02-09 | 2026-02-02 | 13,117,106 | 9.9% |
| Rajeev Shah | SCHEDULE 13G | 2026-02-09 | 2026-02-02 | 13,117,106 | 9.9% |
| venBio Global Strategic GP, Ltd. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 4,431,600 | 3.4% |
| venBio Global Strategic GP, L.P. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 4,431,600 | 3.4% |
| venBio Global Strategic GP II, Ltd. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 8,453,038 | 6.4% |
| venBio Global Strategic GP II, L.P. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 8,453,038 | 6.4% |
| venBio Global Strategic Fund, L.P. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 4,431,600 | 3.4% |
| venBio Global Strategic Fund II L.P. | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 8,453,038 | 6.4% |
| Adelman Robert J | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 12,984,044 | 9.9% |
| GOODMAN COREY S | SCHEDULE 13D/A | 2026-02-04 | 2026-02-02 | 13,163,549 | 10% |
| TANG CAPITAL PARTNERS INTERNATIONAL, LP | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| TANG CAPITAL PARTNERS, LP | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| TANG CAPITAL PARTNERS IV, INC | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| TANG CAPITAL PARTNERS III, INC | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| TANG CAPITAL MANAGEMENT, LLC | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| KEVIN TANG | SCHEDULE 13G/A | 2025-11-14 | 2025-09-30 | 0 | 0% |
| FMR LLC | SCHEDULE 13G/A | 2024-12-06 | 2024-11-29 | 1,798,875 | 3.4% |
| Abigail P. Johnson | SCHEDULE 13G/A | 2024-12-06 | 2024-11-29 | 1,798,875 | 3.4% |
Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.