Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

Compass Therapeutics, Inc.

CIK 0001738021CMPX· quarter ending 2026-06-30

Shares outstanding

180,087,915

as of 2026-07-28 · 10-Q cover page, filed 2026-08-06

Held by 13F filers

165,699,030

92.0% of shares outstanding

Holders

215

+14 vs 2026-03-31 · 64 new, 50 exited

Value

$363.4M

shares -4.4% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-08-06, as of 2026-07-28)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	CMPX · NASDAQ	180,087,915	257,060,055	142.7%	—	20451W101, 20454B104

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	20451W101	SPONSORED ADS	224	91,361,025	180,087,915	50.7%	$1.3B	12 call / 6 put	13DG	holders →
	20454B104	COM	215	165,699,030	180,087,915	92.0%	$363.4M	3 call / 2 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (215 of 215 · 20454B104)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	TANG CAPITAL MANAGEMENT LLC	17,990,782	9.99%	$39.4M	+1,199,973 (+7.1%)
2	ORBIMED ADVISORS LLC	15,219,994	8.45%	$33.3M	—
3	MONTANOVA CAPITAL, LLC	14,101,159	7.83%	$30.9M	-206,220 (-1.4%)
4	BlackRock, Inc.	11,281,781	6.26%	$24.7M	+1,775,701 (+18.7%)
5	STATE STREET CORP	9,953,653	5.53%	$21.8M	+3,258,677 (+48.7%)
6	ENAVATE SCIENCES GP, LLC	7,788,150	4.32%	$17.1M	—
7	Vivo Capital, LLC	7,757,060	4.31%	$17.0M	-1,788,406 (-18.7%)
8	VANGUARD CAPITAL MANAGEMENT LLC	6,118,782	3.40%	$13.4M	+81,607 (+1.4%)
9	Palo Alto Investors LP	5,831,813	3.24%	$12.8M	+4,317,309 (+285.1%)
10	MILLENNIUM MANAGEMENT LLC	4,713,247	2.62%	$10.3M	+3,867,027 (+457.0%)
11	GEODE CAPITAL MANAGEMENT, LLC	3,815,189	2.12%	$8.4M	+249,419 (+7.0%)
12	VANGUARD PORTFOLIO MANAGEMENT LLC	3,771,032	2.09%	$8.3M	+2,688,381 (+248.3%)
13	Qube Research & Technologies Ltd	3,687,489	2.05%	$8.1M	+1,137,133 (+44.6%)
14	Blue Owl Capital Holdings LP	3,624,076	2.01%	$7.9M	+682,551 (+23.2%)
15	CITADEL ADVISORS LLC	3,570,674	1.98%	$7.8M	+2,849,264 (+395.0%)
16	GOLDMAN SACHS GROUP INC	3,531,000	1.96%	$7.7M	+1,535,606 (+77.0%)
17	Rock Springs Capital Management LP	3,524,929	1.96%	$7.7M	+219,621 (+6.6%)
18	AQR CAPITAL MANAGEMENT LLC	3,509,137	1.95%	$7.7M	+3,308,709 (+1650.8%)
19	Birchview Capital, LP	1,675,000	0.93%	$3.7M	+209,133 (+14.3%)
20	KINGDON CAPITAL MANAGEMENT, L.L.C.	1,400,000	0.78%	$3.1M	NEW
21	Fisher Asset Management, LLC	1,391,890	0.77%	$3.0M	+43,631 (+3.2%)
22	ROYCE & ASSOCIATES LP	1,336,780	0.74%	$2.9M	-283,018 (-17.5%)
23	FMR LLC	1,212,196	0.67%	$2.7M	-589,525 (-32.7%)
24	ADAGE CAPITAL PARTNERS GP, L.L.C.	1,186,500	0.66%	$2.6M	-7,300,000 (-86.0%)
25	ACADIAN ASSET MANAGEMENT LLC	1,161,231	0.64%	$2.5M	NEW
26	NORTHERN TRUST CORP	1,140,914	0.63%	$2.5M	+92,356 (+8.8%)
27	Atle Fund Management AB	1,048,593	0.58%	$2.3M	+1,006,762 (+2406.7%)
28	Nuveen, LLC	1,010,562	0.56%	$2.2M	+719,590 (+247.3%)
29	Squarepoint Ops LLC	1,007,507	0.56%	$2.2M	+957,305 (+1906.9%)
30	VANGUARD FIDUCIARY TRUST CO	1,000,938	0.56%	$2.2M	+2,798 (+0.3%)
31	Blackstone Inc.	899,936	0.50%	$2.0M	-957,912 (-51.6%)
32	FIRST TRUST ADVISORS LP	807,004	0.45%	$1.8M	NEW
33	JPMORGAN CHASE & CO	789,399	0.44%	$1.7M	-58,303 (-6.9%)
34	KVP Capital Advisors, LP	771,000	0.43%	$1.7M	+271,000 (+54.2%)
35	MORGAN STANLEY	735,186	0.41%	$1.6M	+374,814 (+104.0%)
36	CITIGROUP INC	713,907	0.40%	$1.6M	+115,669 (+19.3%)
37	UBS Group AG	712,763	0.40%	$1.6M	-1,678,570 (-70.2%)
38	Burkehill Global Management, LP	700,000	0.39%	$1.5M	—
39	Point72 Asset Management, L.P.	686,577	0.38%	$1.5M	NEW
40	ACUTA CAPITAL PARTNERS, LLC	595,213	0.33%	$1.3M	-253,863 (-29.9%)
41	BANK OF AMERICA CORP /DE/	566,919	0.31%	$1.2M	-298,694 (-34.5%)
42	CM Management, LLC	550,000	0.31%	$1.2M	NEW
43	DIMENSIONAL FUND ADVISORS LP	541,178	0.30%	$1.2M	+101,394 (+23.1%)
44	Connor, Clark & Lunn Investment Management Ltd.	523,777	0.29%	$1.1M	+25,959 (+5.2%)
45	Artia Global Partners LP	383,200	0.21%	$839K	NEW
46	WELLINGTON MANAGEMENT GROUP LLP	378,687	0.21%	$829K	+18,562 (+5.2%)
47	ArrowMark Colorado Holdings LLC	364,742	0.20%	$799K	-150,051 (-29.1%)
48	Bank of New York Mellon Corp	351,032	0.19%	$769K	+53,731 (+18.1%)
49	MARSHALL WACE, LLP	334,869	0.19%	$733K	NEW
50	TWO SIGMA INVESTMENTS, LP	320,312	0.18%	$701K	+287,212 (+867.7%)
51	SUSQUEHANNA INTERNATIONAL GROUP, LLP	308,295	0.17%	$675K	+151,270 (+96.3%)
52	ALGERT GLOBAL LLC	308,110	0.17%	$675K	+271,330 (+737.7%)
53	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	303,139	0.17%	$664K	-67,919 (-18.3%)
54	NATIXIS	297,715	0.17%	$652K	NEW
55	Exome Asset Management LLC	276,165	0.15%	$605K	NEW
56	Caption Management, LLC	263,577	0.15%	$577K	NEW
57	DV EQUITIES, LLC	233,066	0.13%	$510K	NEW
58	Seven Fleet Capital Management LP	233,066	0.13%	$510K	-283,906 (-54.9%)
59	PANAGORA ASSET MANAGEMENT INC	222,179	0.12%	$487K	NEW
60	XTX Topco Ltd	217,485	0.12%	$476K	+147,364 (+210.2%)
61	Orion Porfolio Solutions, LLC	213,863	0.12%	$468K	NEW
62	D. E. Shaw & Co., Inc.	204,487	0.11%	$448K	+138,520 (+210.0%)
63	Rafferty Asset Management, LLC	190,126	0.11%	$416K	-5,741 (-2.9%)
64	Creative Planning	182,841	0.10%	$400K	+76,650 (+72.2%)
65	ALPS ADVISORS INC	182,777	0.10%	$400K	+36,170 (+24.7%)
66	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	177,814	0.10%	$389K	+38,172 (+27.3%)
67	Mariner, LLC	172,821	0.10%	$378K	NEW
68	Swiss National Bank	171,700	0.10%	$376K	-49,000 (-22.2%)
69	HRT FINANCIAL LP	170,102	0.09%	$372K	+150,251 (+756.9%)
70	ALLIANCEBERNSTEIN L.P.	161,880	0.09%	$856K	+77,940 (+92.9%)
71	Virtus Investment Advisers, LLC	161,181	0.09%	$353K	+108,335 (+205.0%)
72	CANADA PENSION PLAN INVESTMENT BOARD	160,900	0.09%	$352K	+135,800 (+541.0%)
73	RHUMBLINE ADVISERS	158,444	0.09%	$347K	+11,428 (+7.8%)
74	DEUTSCHE BANK AG\	134,350	0.07%	$294K	+998 (+0.7%)
75	IEQ CAPITAL, LLC	122,948	0.07%	$269K	NEW
76	ADAR1 Capital Management, LLC	122,132	0.07%	$267K	-16,868 (-12.1%)
77	WELLS FARGO & COMPANY/MN	109,793	0.06%	$240K	+62,053 (+130.0%)
78	Quadrature Capital Ltd	108,250	0.06%	$237K	+94,405 (+681.9%)
79	MERCER GLOBAL ADVISORS INC /ADV	106,570	0.06%	$233K	NEW
80	LOS ANGELES CAPITAL MANAGEMENT LLC	105,113	0.06%	$230K	NEW
81	PRICE T ROWE ASSOCIATES INC /MD/	104,251	0.06%	$229K	+4,729 (+4.8%)
82	PROFUND ADVISORS LLC	95,209	0.05%	$209K	+7,528 (+8.6%)
83	Schonfeld Strategic Advisors LLC	92,227	0.05%	$202K	-983,777 (-91.4%)
84	TUDOR INVESTMENT CORP ET AL	90,044	0.05%	$197K	+1,113 (+1.3%)
85	Jain Global LLC	88,302	0.05%	$193K	NEW
86	SmartHarvest Portfolios, LLC	86,508	0.05%	$189K	+51,795 (+149.2%)
87	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	83,567	0.05%	$195K	NEW
88	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	82,459	0.05%	$180K	+8,375 (+11.3%)
89	GROUP ONE TRADING LLC	81,557	0.05%	$179K	+51,328 (+169.8%)
90	Cerity Partners LLC	80,973	0.04%	$177K	NEW
91	OPTIMIZE FINANCIAL INC.	80,160	0.04%	$176K	-279 (-0.3%)
92	Sound Capital Solutions LLC	80,160	0.04%	$176K	NEW
93	SG Americas Securities, LLC	76,355	0.04%	$167K	+28,685 (+60.2%)
94	Legal & General Group Plc	75,103	0.04%	$164K	—
95	VANGUARD ASSET MANAGEMENT, Ltd	74,689	0.04%	$164K	—
96	MetLife Investment Management, LLC	71,421	0.04%	$156K	+7,216 (+11.2%)
97	GSA CAPITAL PARTNERS LLP	70,179	0.04%	$154K	NEW
98	Invesco Ltd.	69,818	0.04%	$153K	-31,389 (-31.0%)
99	MANUFACTURERS LIFE INSURANCE COMPANY, THE	68,217	0.04%	$149K	+751 (+1.1%)
100	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	67,713	0.04%	$148K	-44,603 (-39.7%)
101	ExodusPoint Capital Management, LP	67,478	0.04%	$148K	+23,448 (+53.3%)
102	Vanguard Global Advisers, LLC	61,158	0.03%	$134K	-33,760 (-35.6%)
103	Wealthcare Advisory Partners LLC	60,962	0.03%	$134K	NEW
104	Quantbot Technologies LP	60,826	0.03%	$133K	+60,106 (+8348.1%)
105	JANE STREET GROUP, LLC	59,955	0.03%	$131K	NEW
106	SIMPLEX TRADING, LLC	57,790	0.03%	$127K	+31,939 (+123.6%)
107	Jupiter Topco LLC	55,600	0.03%	$121K	NEW
108	Focus Partners Wealth	53,121	0.03%	$116K	+38,829 (+271.7%)
109	Russell Investments Group, Ltd.	50,505	0.03%	$111K	+39,605 (+363.3%)
110	BARCLAYS PLC	50,397	0.03%	$110K	-739,644 (-93.6%)
111	Sequoia Financial Advisors, LLC	44,980	0.02%	$99K	+29,445 (+189.5%)
112	Zurcher Kantonalbank (Zurich Cantonalbank)	43,914	0.02%	$96K	—
113	STATE OF WISCONSIN INVESTMENT BOARD	43,579	0.02%	$95K	-156,700 (-78.2%)
114	AXQ CAPITAL, LP	42,118	0.02%	$92K	+17,060 (+68.1%)
115	OSAIC HOLDINGS, INC.	41,965	0.02%	$92K	+27,287 (+185.9%)
116	Simplicity Wealth,LLC	36,480	0.02%	$80K	+8,130 (+28.7%)
117	BNP PARIBAS FINANCIAL MARKETS	35,631	0.02%	$78K	-137 (-0.4%)
118	Police & Firemen's Retirement System of New Jersey	35,503	0.02%	$78K	—
119	Vanguard Investments Australia, Ltd.	33,422	0.02%	$73K	—
120	CAPTRUST FINANCIAL ADVISORS	32,609	0.02%	$71K	+10,933 (+50.4%)
121	VIRGINIA RETIREMENT SYSTEMS ET Al	32,300	0.02%	$71K	NEW
122	Independent Advisor Alliance	31,587	0.02%	$69K	+13,693 (+76.5%)
123	LPL Financial LLC	31,470	0.02%	$69K	-4,000 (-11.3%)
124	NEW YORK STATE COMMON RETIREMENT FUND	30,407	0.02%	$67K	—
125	Betterment LLC	30,143	0.02%	$66K	NEW
126	TWO SIGMA SECURITIES, LLC	29,451	0.02%	$64K	NEW
127	FLORIDA FINANCIAL ADVISORS, LLC	28,586	0.02%	$63K	NEW
128	Strategic Wealth Partners, Ltd.	28,575	0.02%	$63K	+11,750 (+69.8%)
129	INTECH INVESTMENT MANAGEMENT LLC	27,910	0.02%	$61K	-1,893 (-6.4%)
130	State of New Jersey Common Pension Fund D	27,659	0.02%	$61K	-10,454 (-27.4%)
131	VOYA INVESTMENT MANAGEMENT LLC	27,069	0.02%	$59K	-348,251 (-92.8%)
132	E Fund Management Co., Ltd.	26,808	0.01%	$59K	+2,186 (+8.9%)
133	Engineers Gate Manager LP	26,335	0.01%	$58K	-45,418 (-63.3%)
134	Walleye Trading LLC	25,000	0.01%	$55K	—
135	WINTON GROUP Ltd	24,900	0.01%	$55K	NEW
136	KLP KAPITALFORVALTNING AS	24,600	0.01%	$54K	—
137	Merit Financial Group, LLC	23,674	0.01%	$52K	NEW
138	ARIZONA STATE RETIREMENT SYSTEM	23,604	0.01%	$52K	-7,028 (-22.9%)
139	nVerses Capital, LLC	23,330	0.01%	$51K	NEW
140	Graham Capital Management, L.P.	22,857	0.01%	$50K	-694 (-2.9%)
141	INDEPENDENT FINANCIAL GROUP, LLC	22,779	0.01%	$50K	—
142	PRUDENTIAL FINANCIAL INC	21,720	0.01%	$48K	-472,580 (-95.6%)
143	SEI INVESTMENTS CO	21,552	0.01%	$47K	NEW
144	Arkadios Wealth Advisors	21,464	0.01%	$47K	NEW
145	ACT Advisors, LLC.	20,613	0.01%	$45K	NEW
146	NEUBERGER BERMAN GROUP LLC	19,792	0.01%	$43K	+3,439 (+21.0%)
147	Apollon Wealth Management, LLC	19,687	0.01%	$43K	NEW
148	Wealthcare Capital Partners, LLC	19,654	0.01%	$43K	NEW
149	Caitong International Asset Management Co., Ltd	19,301	0.01%	$42K	+18,582 (+2584.4%)
150	Welch & Forbes LLC	19,000	0.01%	$42K	—
151	BRIGHTON JONES LLC	18,317	0.01%	$40K	NEW
152	M&T Bank Corp	18,198	0.01%	$40K	+3,155 (+21.0%)
153	Ikarian Capital, LLC	18,000	0.01%	$39K	—
154	ProShare Advisors LLC	17,167	0.01%	$38K	-1,536 (-8.2%)
155	McAdam, LLC	16,494	0.01%	$36K	NEW
156	Virtu Financial LLC	16,394	0.01%	$36K	-26,672 (-61.9%)
157	JUPITER ASSET MANAGEMENT LTD	16,270	0.01%	$36K	NEW
158	Chicago Partners Investment Group LLC	16,257	0.01%	$34K	NEW
159	StoneX Group Inc.	15,000	0.01%	$31K	NEW
160	VICTORY CAPITAL MANAGEMENT INC	14,806	0.01%	$32K	+1,077 (+7.8%)
161	SIG BROKERAGE, LP	14,496	0.01%	$32K	—
162	Pictet Asset Management Holding SA	14,432	0.01%	$32K	—
163	Centiva Capital, LP	14,432	0.01%	$32K	NEW
164	STIFEL FINANCIAL CORP	14,211	0.01%	$31K	-13,286 (-48.3%)
165	MAI Capital Management	14,189	0.01%	$31K	+13,575 (+2210.9%)
166	State of Wyoming	14,065	0.01%	$31K	NEW
167	HB Wealth Management, LLC	13,058	0.01%	$29K	NEW
168	Belpointe Asset Management LLC	13,025	0.01%	$29K	NEW
169	Fortis Capital Advisors, LLC	13,025	0.01%	$29K	NEW
170	XPONANCE LLC	12,550	0.01%	$27K	+714 (+6.0%)
171	North Star Investment Management Corp.	12,500	0.01%	$27K	—
172	BLAIR WILLIAM & CO/IL	12,186	0.01%	$27K	-18,574 (-60.4%)
173	SummitTX Capital, L.P.	12,000	0.01%	$26K	NEW
174	Crewe Advisors LLC	11,696	0.01%	$26K	NEW
175	PNC Financial Services Group, Inc.	10,939	0.01%	$24K	-99 (-0.9%)
176	Ameritas Investment Partners, Inc.	10,621	0.01%	$23K	—
177	Brevan Howard Capital Management LP	10,202	0.01%	$22K	+2 (+0.0%)
178	TEACHER RETIREMENT SYSTEM OF TEXAS	10,167	0.01%	$22K	-4,297 (-29.7%)
179	Allworth Financial LP	10,084	0.01%	$22K	+9,492 (+1603.4%)
180	Prestige Wealth Management Group LLC	7,750	0.00%	$17K	NEW
181	FEDERATED HERMES, INC.	7,522	0.00%	$16K	NEW
182	Tower Research Capital LLC (TRC)	7,474	0.00%	$16K	-15,778 (-67.9%)
183	Operose Advisors LLC	6,274	0.00%	$14K	NEW
184	VSM Wealth Advisory, LLC	6,100	0.00%	$13K	+3,100 (+103.3%)
185	Arax Advisory Partners	5,725	0.00%	$13K	NEW
186	MCF Advisors LLC	5,540	0.00%	$12K	—
187	NISA INVESTMENT ADVISORS, LLC	5,456	0.00%	$12K	+208 (+4.0%)
188	Rockefeller Capital Management L.P.	4,814	0.00%	$11K	-5,368 (-52.7%)
189	ROYAL BANK OF CANADA	4,048	0.00%	$9K	+4,042 (+67366.7%)
190	Federation des caisses Desjardins du Quebec	4,000	0.00%	$9K	+3,000 (+300.0%)
191	Pacer Advisors, Inc.	3,175	0.00%	$7K	NEW
192	Silver Grove Financial Group, Inc.	3,004	0.00%	$7K	NEW
193	Sterling Capital Management LLC	2,642	0.00%	$6K	+198 (+8.1%)
194	True Wealth Design, LLC	1,557	0.00%	$3K	NEW
195	Essential Partners LLC	1,516	0.00%	$3K	+1,507 (+16744.4%)
196	Fortitude Family Office, LLC	1,481	0.00%	$3K	-434 (-22.7%)
197	Farther Finance Advisors, LLC	1,264	0.00%	$3K	+609 (+93.0%)
198	EverSource Wealth Advisors, LLC	1,114	0.00%	$2K	-5,028 (-81.9%)
199	SJS Investment Consulting Inc.	812	0.00%	$2K	+785 (+2907.4%)
200	Clearstead Advisors, LLC	783	0.00%	$2K	NEW
201	ROTHSCHILD INVESTMENT LLC	765	0.00%	$2K	+486 (+174.2%)
202	Wealth Enhancement Trust Services, Inc.	740	0.00%	$2K	NEW
203	Truvestments Capital LLC	614	0.00%	$1K	NEW
204	Optiver Holding B.V.	568	0.00%	$1K	-768 (-57.5%)
205	PICTON MAHONEY ASSET MANAGEMENT	467	0.00%	$1K	NEW
206	GAMMA Investing LLC	442	0.00%	$968	+218 (+97.3%)
207	NATIONAL BANK OF CANADA /FI/	300	0.00%	$654	+65 (+27.7%)
208	ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/	288	0.00%	$631	NEW
209	Marshall & Sterling Wealth Advisors Inc.	200	0.00%	$438	—
210	SBI Securities Co., Ltd.	180	0.00%	$394	-4 (-2.2%)
211	Larson Financial Group LLC	93	0.00%	$204	+70 (+304.3%)
212	JPL Wealth Management, LLC	89	0.00%	$195	NEW
213	Smartleaf Asset Management LLC	69	0.00%	$149	—
214	Steward Partners Investment Advisory, LLC	2	0.00%	$4	NEW
215	Freestone Grove Partners LP	1	0.00%	$2	NEW

Exited since 2026-03-31 (50 filers; largest 25 shown)

BVF INC/IL	−7,764,842
RTW INVESTMENTS, LP	−4,186,599
DEERFIELD MANAGEMENT COMPANY, L.P.	−3,606,000
Logos Global Management LP	−3,150,000
Sofinnova Investments, Inc.	−2,056,161
BRAIDWELL LP	−1,965,106
AMERIPRISE FINANCIAL INC	−1,596,815
GREAT POINT PARTNERS LLC	−1,350,000
Balyasny Asset Management L.P.	−1,119,090
SILVERARC CAPITAL MANAGEMENT, LLC	−859,049
NEXTBio Capital Management LP	−848,204
Y-Intercept (Hong Kong) Ltd	−828,879
DV Trading LLC	−423,566
Trexquant Investment LP	−421,831
Jump Financial, LLC	−371,400
Atom Investors LP	−344,933
Monashee Investment Management LLC	−258,865
Tema ETFs LLC	−138,276
Tidal Investments LLC	−138,276
RAYMOND JAMES FINANCIAL INC	−121,889
Rhenman & Partners Asset Management AB	−115,113
Harvest Investment Services, LLC	−87,652
AMERICAN CENTURY COMPANIES INC	−78,328
DRW Securities, LLC	−76,493
Aquatic Capital Management LLC	−73,338

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Vivo Opportunity Cayman Fund, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
Vivo Opportunity, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Fund Holdings, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Cayman, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
STATE STREET CORPORATION	SCHEDULE 13G	2026-08-07	2026-06-30	9,953,653	5.5%
Biotechnology Value Trading Fund OS LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF I GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND L P	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND II LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
LAMPERT MARK N	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF Partners OS Ltd.	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF PARTNERS L P/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF INC/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF II GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
BVF GP HOLDINGS LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,170,971	4%
Blackstone Holdings II L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Annex Master Fund L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	2,447,820	1.4%
Blackstone Holdings I/II GP L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Group Management L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Inc.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Stephen A. Schwarzman	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Alternative Asset Management Associates LLC	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Spruce Street Aggregator L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	3,678,362	2.1%
BlackRock, Inc.	SCHEDULE 13G	2026-01-21	2025-12-31	9,271,644	5.2%
TANG CAPITAL PARTNERS III, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	999,750	0.58%
TANG CAPITAL PARTNERS, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	10,274,944	5.98%
TANG CAPITAL PARTNERS IV, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	333,250	0.19%
TANG CAPITAL PARTNERS INTERNATIONAL, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	5,568,566	3.24%
KEVIN TANG	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
TANG CAPITAL MANAGEMENT, LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
Suvretta Capital Management, LLC	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Averill Master Fund, Ltd.	SCHEDULE 13G/A	2025-08-21	2025-08-13	12,229,050	7.1%
Aaron Cowen	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Commander Aggregator, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences GP, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences Holdings, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
ORBIMED CAPITAL GP V LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
ORBIMED ADVISORS LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
Roderick Wong	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
RTW Investments, LP	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
MPM BioImpact LLC	SCHEDULE 13G/A	2025-08-12	2025-06-30	5,622,505	4.1%
OrbiMed Genesis GP LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
ORBIMED CAPITAL LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
Robert Atchinson	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Phillip Gross	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Adage Capital Partners GP, L.L.C.	SCHEDULE 13G/A	2025-02-12	2024-12-31	0	0%
Adage Capital Management, L.P.	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.