Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

Compass Therapeutics, Inc.

CIK 0001738021CMPX· quarter ending 2026-06-30

Shares outstanding

180,087,915

as of 2026-07-28 · 10-Q cover page, filed 2026-08-06

Held by 13F filers

257,060,055

142.7% of shares outstanding

Holders

362

+47 vs 2026-03-31 · 100 new, 53 exited

Value

$1.7B

shares -3.6% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-08-06, as of 2026-07-28)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	CMPX · NASDAQ	180,087,915	257,060,055	142.7%	—	20451W101, 20454B104

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	20451W101	SPONSORED ADS	224	91,361,025	180,087,915	50.7%	$1.3B	12 call / 6 put	13DG	holders →
	20454B104	COM	215	165,699,030	180,087,915	92.0%	$363.4M	3 call / 2 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (250 of 362 · 20451W101, 20454B104)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	TANG CAPITAL MANAGEMENT LLC	22,990,782	12.77%	$110.1M	+2,197,773 (+10.6%)
2	ORBIMED ADVISORS LLC	15,219,994	8.45%	$33.3M	-1,150,646 (-7.0%)
3	MONTANOVA CAPITAL, LLC	14,101,159	7.83%	$30.9M	-206,220 (-1.4%)
4	BlackRock, Inc.	12,207,172	6.78%	$37.8M	+2,017,851 (+19.8%)
5	Deep Track Capital, LP	12,161,496	6.75%	$172.1M	—
6	RTW INVESTMENTS, LP	10,700,974	5.94%	$151.4M	-4,118,015 (-27.8%)
7	STATE STREET CORP	10,034,932	5.57%	$22.9M	+3,259,514 (+48.1%)
8	ENAVATE SCIENCES GP, LLC	7,788,150	4.32%	$17.1M	—
9	Vivo Capital, LLC	7,757,060	4.31%	$17.0M	-1,988,406 (-20.4%)
10	BIT Capital GmbH	6,348,797	3.53%	$89.8M	+2,857,563 (+81.8%)
11	VANGUARD CAPITAL MANAGEMENT LLC	6,118,782	3.40%	$13.4M	+81,607 (+1.4%)
12	Palo Alto Investors LP	5,947,429	3.30%	$14.4M	+4,317,309 (+264.8%)
13	MILLENNIUM MANAGEMENT LLC	5,484,234	3.05%	$21.2M	+1,499,492 (+37.6%)
14	TWO SIGMA INVESTMENTS, LP	4,790,797	2.66%	$64.0M	+2,174,198 (+83.1%)
15	MARSHALL WACE, LLP	4,663,551	2.59%	$62.0M	+625,216 (+15.5%)
16	CITADEL ADVISORS LLC	4,575,554	2.54%	$22.0M	+3,584,655 (+361.8%)
17	Qube Research & Technologies Ltd	4,187,165	2.33%	$15.1M	+688,255 (+19.7%)
18	Blue Owl Capital Holdings LP	4,074,076	2.26%	$14.3M	+1,132,551 (+38.5%)
19	GOLDMAN SACHS GROUP INC	3,922,587	2.18%	$13.3M	+1,555,496 (+65.7%)
20	GEODE CAPITAL MANAGEMENT, LLC	3,890,376	2.16%	$9.4M	+261,644 (+7.2%)
21	VANGUARD PORTFOLIO MANAGEMENT LLC	3,771,032	2.09%	$8.3M	+2,688,381 (+248.3%)
22	Rock Springs Capital Management LP	3,524,929	1.96%	$7.7M	+219,621 (+6.6%)
23	AQR CAPITAL MANAGEMENT LLC	3,509,137	1.95%	$7.7M	+3,308,709 (+1650.8%)
24	ARK Investment Management LLC	3,451,965	1.92%	$48.8M	+150,915 (+4.6%)
25	Point72 Asset Management, L.P.	3,307,455	1.84%	$38.6M	NEW
26	BANK OF AMERICA CORP /DE/	2,586,267	1.44%	$29.8M	+1,688,322 (+188.0%)
27	Logos Global Management LP	2,250,000	1.25%	$31.8M	-900,000 (-28.6%)
28	UBS Group AG	2,195,233	1.22%	$22.5M	-2,051,170 (-48.3%)
29	Eagle Health Investments LP	2,060,427	1.14%	$29.2M	—
30	DAFNA Capital Management LLC	2,011,952	1.12%	$28.5M	-406,930 (-16.8%)
31	NEXTBio Capital Management LP	1,775,759	0.99%	$25.1M	-1,093,852 (-38.1%)
32	Birchview Capital, LP	1,705,000	0.95%	$4.1M	-135,867 (-7.4%)
33	Kalehua Capital Management LLC	1,639,384	0.91%	$23.2M	—
34	ROYCE & ASSOCIATES LP	1,603,839	0.89%	$6.7M	-398,045 (-19.9%)
35	ADAGE CAPITAL PARTNERS GP, L.L.C.	1,486,500	0.83%	$6.8M	-7,300,000 (-83.1%)
36	Aisling Capital Management LP	1,432,336	0.80%	$20.3M	—
37	RENAISSANCE TECHNOLOGIES LLC	1,431,889	0.80%	$20.3M	+566,535 (+65.5%)
38	KINGDON CAPITAL MANAGEMENT, L.L.C.	1,400,000	0.78%	$3.1M	NEW
39	Fisher Asset Management, LLC	1,391,890	0.77%	$3.0M	+43,631 (+3.2%)
40	MORGAN STANLEY	1,330,092	0.74%	$10.0M	-236,167 (-15.1%)
41	Candriam S.C.A.	1,274,278	0.71%	$18.0M	NEW
42	FMR LLC	1,212,196	0.67%	$2.7M	-589,525 (-32.7%)
43	ACADIAN ASSET MANAGEMENT LLC	1,198,816	0.67%	$3.1M	NEW
44	Squarepoint Ops LLC	1,146,178	0.64%	$4.2M	+1,079,683 (+1623.7%)
45	NORTHERN TRUST CORP	1,140,914	0.63%	$2.5M	+92,356 (+8.8%)
46	Woodline Partners LP	1,086,004	0.60%	$15.4M	+910,565 (+519.0%)
47	Atle Fund Management AB	1,048,593	0.58%	$2.3M	+1,006,762 (+2406.7%)
48	Caption Management, LLC	1,019,693	0.57%	$11.3M	-590,437 (-36.7%)
49	Nuveen, LLC	1,010,562	0.56%	$2.2M	+719,590 (+247.3%)
50	VANGUARD FIDUCIARY TRUST CO	1,000,938	0.56%	$2.2M	+2,798 (+0.3%)
51	Jefferies Financial Group Inc.	994,393	0.55%	$14.1M	-472,969 (-32.2%)
52	Blackstone Inc.	899,936	0.50%	$2.0M	-957,912 (-51.6%)
53	Trexquant Investment LP	860,158	0.48%	$12.2M	+129,044 (+17.7%)
54	JPMORGAN CHASE & CO	808,453	0.45%	$2.0M	-49,198 (-5.7%)
55	FIRST TRUST ADVISORS LP	807,004	0.45%	$1.8M	NEW
56	KVP Capital Advisors, LP	771,000	0.43%	$1.7M	+271,000 (+54.2%)
57	Axxion S.A.	727,556	0.40%	$10.3M	NEW
58	CITIGROUP INC	724,661	0.40%	$1.7M	+96,771 (+15.4%)
59	Occam Crest Management LP	710,000	0.39%	$7.7M	NEW
60	Burkehill Global Management, LP	700,000	0.39%	$1.5M	-250,000 (-26.3%)
61	Eversept Partners, LP	672,825	0.37%	$9.5M	-5,099 (-0.8%)
62	ACUTA CAPITAL PARTNERS, LLC	595,213	0.33%	$1.3M	-253,863 (-29.9%)
63	Propel Bio Management, LLC	573,086	0.32%	$8.1M	-168,963 (-22.8%)
64	Creek Drive Management Group LLC	572,000	0.32%	$8.1M	-253,000 (-30.7%)
65	JANE STREET GROUP, LLC	561,885	0.31%	$7.2M	+220,064 (+64.4%)
66	CM Management, LLC	550,000	0.31%	$1.2M	NEW
67	DIMENSIONAL FUND ADVISORS LP	541,178	0.30%	$1.2M	+101,394 (+23.1%)
68	Connor, Clark & Lunn Investment Management Ltd.	523,777	0.29%	$1.1M	+25,959 (+5.2%)
69	SILVERARC CAPITAL MANAGEMENT, LLC	503,382	0.28%	$7.1M	-655,667 (-56.6%)
70	Walleye Capital LLC	487,165	0.27%	$6.9M	+125,013 (+34.5%)
71	Ensign Peak Advisors, Inc	474,653	0.26%	$6.7M	+435,428 (+1110.1%)
72	D. E. Shaw & Co., Inc.	445,361	0.25%	$3.9M	+143,014 (+47.3%)
73	AdvisorShares Investments LLC	421,347	0.23%	$6.0M	+174,608 (+70.8%)
74	Hennion & Walsh Asset Management, Inc.	417,833	0.23%	$5.9M	-69,841 (-14.3%)
75	Legal & General Group Plc	407,309	0.23%	$4.9M	+100,821 (+32.9%)
76	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	384,351	0.21%	$5.4M	+279,943 (+268.1%)
77	Artia Global Partners LP	383,200	0.21%	$839K	NEW
78	WELLINGTON MANAGEMENT GROUP LLP	378,687	0.21%	$829K	+18,562 (+5.2%)
79	SUSQUEHANNA INTERNATIONAL GROUP, LLP	374,857	0.21%	$1.6M	-904,756 (-70.7%)
80	HighVista Strategies LLC	371,120	0.21%	$5.3M	+6,760 (+1.9%)
81	ArrowMark Colorado Holdings LLC	364,742	0.20%	$799K	-150,051 (-29.1%)
82	Bank of New York Mellon Corp	351,032	0.19%	$769K	+53,731 (+18.1%)
83	Sumitomo Mitsui Trust Group, Inc.	323,209	0.18%	$4.6M	-45,619 (-12.4%)
84	Amova Asset Management Americas, Inc.	319,472	0.18%	$4.5M	-49,356 (-13.4%)
85	ALPS ADVISORS INC	319,239	0.18%	$2.3M	+172,632 (+117.8%)
86	HRT FINANCIAL LP	316,229	0.18%	$2.4M	+250,492 (+381.1%)
87	ALGERT GLOBAL LLC	308,110	0.17%	$675K	+271,330 (+737.7%)
88	ROYAL BANK OF CANADA	303,856	0.17%	$4.3M	+59,324 (+24.3%)
89	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	303,139	0.17%	$664K	-67,919 (-18.3%)
90	Affinity Asset Advisors, LLC	301,183	0.17%	$4.3M	-807,300 (-72.8%)
91	Squadron Capital Management LLC	300,000	0.17%	$4.2M	NEW
92	SEVEN GRAND MANAGERS, LLC	300,000	0.17%	$4.2M	—
93	NATIXIS	297,715	0.17%	$652K	NEW
94	AMERIPRISE FINANCIAL INC	291,950	0.16%	$4.1M	-1,875,361 (-86.5%)
95	STEMPOINT CAPITAL LP	284,769	0.16%	$4.0M	NEW
96	TORONTO DOMINION BANK	277,755	0.15%	$3.9M	—
97	Exome Asset Management LLC	276,165	0.15%	$605K	NEW
98	Jump Financial, LLC	261,616	0.15%	$3.7M	-564,784 (-68.3%)
99	PFM Health Sciences, LP	247,589	0.14%	$3.5M	-1,119,510 (-81.9%)
100	WELLS FARGO & COMPANY/MN	245,424	0.14%	$2.2M	+57,297 (+30.5%)
101	Seven Fleet Capital Management LP	233,066	0.13%	$510K	-441,927 (-65.5%)
102	DV EQUITIES, LLC	233,066	0.13%	$510K	NEW
103	PANAGORA ASSET MANAGEMENT INC	222,179	0.12%	$487K	NEW
104	XTX Topco Ltd	217,485	0.12%	$476K	+147,364 (+210.2%)
105	Brown University	214,200	0.12%	$3.0M	—
106	Orion Porfolio Solutions, LLC	213,863	0.12%	$468K	NEW
107	HEIGHTS CAPITAL MANAGEMENT, INC	205,932	0.11%	$2.9M	-1,286,483 (-86.2%)
108	Engineers Gate Manager LP	198,232	0.11%	$2.5M	-91,513 (-31.6%)
109	Rafferty Asset Management, LLC	190,126	0.11%	$416K	-5,741 (-2.9%)
110	Virtus Investment Advisers, LLC	188,267	0.10%	$736K	+94,964 (+101.8%)
111	Creative Planning	182,841	0.10%	$400K	+76,650 (+72.2%)
112	GROUP ONE TRADING LLC	179,855	0.10%	$1.6M	-40,127 (-18.2%)
113	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	177,814	0.10%	$389K	+38,172 (+27.3%)
114	IQ EQ FUND MANAGEMENT (IRELAND) Ltd	175,373	0.10%	$2.5M	+27,783 (+18.8%)
115	Mariner, LLC	172,821	0.10%	$378K	NEW
116	Swiss National Bank	171,700	0.10%	$376K	-49,000 (-22.2%)
117	Y-Intercept (Hong Kong) Ltd	168,090	0.09%	$2.4M	-705,767 (-80.8%)
118	RHUMBLINE ADVISERS	166,241	0.09%	$457K	+12,006 (+7.8%)
119	ALLIANCEBERNSTEIN L.P.	161,880	0.09%	$856K	+77,940 (+92.9%)
120	CANADA PENSION PLAN INVESTMENT BOARD	160,900	0.09%	$352K	+135,800 (+541.0%)
121	DISCOVERY CAPITAL MANAGEMENT, LLC / CT	150,000	0.08%	$2.1M	-29,716 (-16.5%)
122	LPL Financial LLC	141,038	0.08%	$1.6M	+78,571 (+125.8%)
123	Balyasny Asset Management L.P.	138,480	0.08%	$2.0M	-980,610 (-87.6%)
124	K2 PRINCIPAL FUND, L.P.	135,100	0.08%	$1.9M	NEW
125	DEUTSCHE BANK AG\	134,350	0.07%	$294K	+998 (+0.7%)
126	Quadrature Capital Ltd	128,656	0.07%	$526K	+96,920 (+305.4%)
127	CenterBook Partners LP	125,594	0.07%	$1.8M	-283,643 (-69.3%)
128	IEQ CAPITAL, LLC	122,948	0.07%	$269K	NEW
129	ADAR1 Capital Management, LLC	122,132	0.07%	$267K	-16,868 (-12.1%)
130	BANK OF MONTREAL /CAN/	119,222	0.07%	$1.7M	NEW
131	ENVESTNET ASSET MANAGEMENT INC	115,839	0.06%	$1.6M	NEW
132	Simplify Asset Management Inc.	114,281	0.06%	$1.6M	-44,771 (-28.1%)
133	Jain Global LLC	112,039	0.06%	$529K	NEW
134	FLAX POND CAPITAL, LLC	109,182	0.06%	$1.0M	+56,616 (+107.7%)
135	Schonfeld Strategic Advisors LLC	107,088	0.06%	$412K	-1,071,744 (-90.9%)
136	MERCER GLOBAL ADVISORS INC /ADV	106,570	0.06%	$233K	NEW
137	LOS ANGELES CAPITAL MANAGEMENT LLC	105,113	0.06%	$230K	NEW
138	GSA CAPITAL PARTNERS LLP	104,496	0.06%	$640K	+74,290 (+245.9%)
139	PRICE T ROWE ASSOCIATES INC /MD/	104,251	0.06%	$229K	+4,729 (+4.8%)
140	PROFUND ADVISORS LLC	95,209	0.05%	$209K	+7,528 (+8.6%)
141	Susquehanna Portfolio Strategies, LLC	94,802	0.05%	$1.3M	-180,971 (-65.6%)
142	CreativeOne Wealth, LLC	94,439	0.05%	$1.3M	NEW
143	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	93,234	0.05%	$327K	NEW
144	STABLEFORD CAPITAL II LLC	91,873	0.05%	$1.3M	-69,266 (-43.0%)
145	TUDOR INVESTMENT CORP ET AL	90,044	0.05%	$197K	+1,113 (+1.3%)
146	SmartHarvest Portfolios, LLC	86,508	0.05%	$189K	+51,795 (+149.2%)
147	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	82,459	0.05%	$180K	+8,375 (+11.3%)
148	Cerity Partners LLC	80,973	0.04%	$177K	+70,769 (+693.5%)
149	MANUFACTURERS LIFE INSURANCE COMPANY, THE	80,657	0.04%	$325K	-882 (-1.1%)
150	Sound Capital Solutions LLC	80,160	0.04%	$176K	NEW
151	OPTIMIZE FINANCIAL INC.	80,160	0.04%	$176K	-279 (-0.3%)
152	Lion Point Capital, LP	80,000	0.04%	$1.1M	—
153	SG Americas Securities, LLC	76,355	0.04%	$167K	+28,685 (+60.2%)
154	VANGUARD ASSET MANAGEMENT, Ltd	74,689	0.04%	$164K	—
155	STIFEL FINANCIAL CORP	74,680	0.04%	$887K	+18,183 (+32.2%)
156	MetLife Investment Management, LLC	71,421	0.04%	$156K	+7,216 (+11.2%)
157	Invesco Ltd.	69,818	0.04%	$153K	-31,389 (-31.0%)
158	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	67,713	0.04%	$148K	-44,603 (-39.7%)
159	ExodusPoint Capital Management, LP	67,478	0.04%	$148K	+23,448 (+53.3%)
160	Aquatic Capital Management LLC	65,180	0.04%	$922K	-71,691 (-52.4%)
161	Dorsey Wright & Associates	62,449	0.03%	$884K	NEW
162	Campbell & CO Investment Adviser LLC	61,816	0.03%	$875K	NEW
163	Merit Financial Group, LLC	61,521	0.03%	$587K	NEW
164	Quantbot Technologies LP	61,422	0.03%	$142K	+60,702 (+8430.8%)
165	Vanguard Global Advisers, LLC	61,158	0.03%	$134K	-33,760 (-35.6%)
166	Wealthcare Advisory Partners LLC	60,962	0.03%	$134K	NEW
167	BARCLAYS PLC	59,505	0.03%	$239K	-734,399 (-92.5%)
168	Intellectus Partners, LLC	59,500	0.03%	$842K	-1,500 (-2.5%)
169	SIMPLEX TRADING, LLC	57,790	0.03%	$127K	-235,526 (-80.3%)
170	OSAIC HOLDINGS, INC.	56,078	0.03%	$292K	+32,703 (+139.9%)
171	Jupiter Topco LLC	55,600	0.03%	$121K	NEW
172	AXQ CAPITAL, LP	54,809	0.03%	$272K	+13,835 (+33.8%)
173	DCF Advisers, LLC	54,250	0.03%	$768K	+11,750 (+27.6%)
174	Focus Partners Wealth	53,121	0.03%	$116K	+38,829 (+271.7%)
175	CIBC WORLD MARKET INC.	52,110	0.03%	$737K	NEW
176	NATIONAL BANK OF CANADA /FI/	52,027	0.03%	$732K	+51,243 (+6536.1%)
177	Russell Investments Group, Ltd.	50,505	0.03%	$111K	+39,605 (+363.3%)
178	EXCHANGE TRADED CONCEPTS, LLC	50,102	0.03%	$709K	NEW
179	QRG CAPITAL MANAGEMENT, INC.	48,657	0.03%	$688K	NEW
180	Zurcher Kantonalbank (Zurich Cantonalbank)	48,073	0.03%	$155K	+1,967 (+4.3%)
181	Fore Capital, LLC	45,000	0.02%	$637K	—
182	Sequoia Financial Advisors, LLC	44,980	0.02%	$99K	+29,445 (+189.5%)
183	FLAGSHIP HARBOR ADVISORS, LLC	44,599	0.02%	$631K	+2,000 (+4.7%)
184	STATE OF WISCONSIN INVESTMENT BOARD	43,579	0.02%	$95K	-156,700 (-78.2%)
185	WINTON GROUP Ltd	42,800	0.02%	$308K	+27,900 (+187.2%)
186	HighTower Advisors, LLC	40,727	0.02%	$576K	+10,086 (+32.9%)
187	Forum Finance Group S.A.	39,745	0.02%	$454K	—
188	BNP PARIBAS FINANCIAL MARKETS	38,671	0.02%	$121K	+884 (+2.3%)
189	Corient Private Wealth LP	38,130	0.02%	$540K	-1,043 (-2.7%)
190	MOUNT VERNON ASSOCIATES INC /MD/	38,000	0.02%	$538K	NEW
191	Walleye Trading LLC	36,498	0.02%	$217K	+11,498 (+46.0%)
192	Simplicity Wealth,LLC	36,480	0.02%	$80K	+8,130 (+28.7%)
193	Entropy Technologies, LP	36,480	0.02%	$516K	+16,510 (+82.7%)
194	Gladstone Institutional Advisory LLC	35,589	0.02%	$504K	+18,645 (+110.0%)
195	Police & Firemen's Retirement System of New Jersey	35,503	0.02%	$78K	—
196	Caitong International Asset Management Co., Ltd	34,879	0.02%	$263K	+33,991 (+3827.8%)
197	Vanguard Investments Australia, Ltd.	33,422	0.02%	$73K	—
198	Ikarian Capital, LLC	33,000	0.02%	$252K	-660,000 (-95.2%)
199	Atom Investors LP	32,885	0.02%	$465K	-360,108 (-91.6%)
200	Burns Matteson Capital Management, LLC	32,861	0.02%	$465K	NEW
201	RAYMOND JAMES FINANCIAL INC	32,642	0.02%	$462K	-106,676 (-76.6%)
202	CAPTRUST FINANCIAL ADVISORS	32,609	0.02%	$71K	+10,933 (+50.4%)
203	VIRGINIA RETIREMENT SYSTEMS ET Al	32,300	0.02%	$71K	NEW
204	Independent Advisor Alliance	31,587	0.02%	$69K	+13,693 (+76.5%)
205	NEW YORK STATE COMMON RETIREMENT FUND	30,407	0.02%	$67K	—
206	TD Waterhouse Canada Inc.	30,306	0.02%	$402K	+29,616 (+4292.2%)
207	FOX RUN MANAGEMENT, L.L.C.	30,208	0.02%	$427K	+17,150 (+131.3%)
208	Betterment LLC	30,143	0.02%	$66K	NEW
209	ACT CAPITAL MANAGEMENT, LLC	30,000	0.02%	$425K	+14,500 (+93.5%)
210	TWO SIGMA SECURITIES, LLC	29,451	0.02%	$64K	NEW
211	FLORIDA FINANCIAL ADVISORS, LLC	28,586	0.02%	$63K	NEW
212	Strategic Wealth Partners, Ltd.	28,575	0.02%	$63K	+11,750 (+69.8%)
213	Rockefeller Capital Management L.P.	28,458	0.02%	$345K	+17,000 (+148.4%)
214	EntryPoint Capital, LLC	28,375	0.02%	$402K	-17,502 (-38.1%)
215	INTECH INVESTMENT MANAGEMENT LLC	27,910	0.02%	$61K	-1,893 (-6.4%)
216	Atria Investments, Inc	27,732	0.02%	$392K	NEW
217	State of New Jersey Common Pension Fund D	27,659	0.02%	$61K	-10,454 (-27.4%)
218	VOYA INVESTMENT MANAGEMENT LLC	27,069	0.02%	$59K	-348,251 (-92.8%)
219	E Fund Management Co., Ltd.	26,808	0.01%	$59K	+2,186 (+8.9%)
220	SIG BROKERAGE, LP	26,786	0.01%	$206K	+12,290 (+84.8%)
221	Conservest Capital Advisors, Inc.	25,005	0.01%	$354K	-358 (-1.4%)
222	Scientech Research LLC	24,846	0.01%	$352K	-4,860 (-16.4%)
223	Integrated Wealth Concepts LLC	24,792	0.01%	$351K	NEW
224	KLP KAPITALFORVALTNING AS	24,600	0.01%	$54K	—
225	Cetera Investment Advisers	24,561	0.01%	$348K	NEW
226	ARIZONA STATE RETIREMENT SYSTEM	23,604	0.01%	$52K	-7,028 (-22.9%)
227	nVerses Capital, LLC	23,330	0.01%	$51K	NEW
228	Graham Capital Management, L.P.	22,857	0.01%	$50K	-694 (-2.9%)
229	INDEPENDENT FINANCIAL GROUP, LLC	22,779	0.01%	$50K	—
230	PRUDENTIAL FINANCIAL INC	21,720	0.01%	$48K	-472,580 (-95.6%)
231	SEI INVESTMENTS CO	21,552	0.01%	$47K	NEW
232	Arkadios Wealth Advisors	21,464	0.01%	$47K	NEW
233	Janney Montgomery Scott LLC	21,196	0.01%	$300K	NEW
234	China Universal Asset Management Co., Ltd.	21,183	0.01%	$300K	+4,448 (+26.6%)
235	Arax Advisory Partners	20,965	0.01%	$228K	+20,725 (+8635.4%)
236	ACT Advisors, LLC.	20,613	0.01%	$45K	NEW
237	North Star Investment Management Corp.	20,017	0.01%	$134K	—
238	FNY Investment Advisers, LLC	20,000	0.01%	$283K	—
239	NEUBERGER BERMAN GROUP LLC	19,792	0.01%	$43K	+3,439 (+21.0%)
240	Apollon Wealth Management, LLC	19,687	0.01%	$43K	NEW
241	Wealthcare Capital Partners, LLC	19,654	0.01%	$43K	NEW
242	MML INVESTORS SERVICES, LLC	19,006	0.01%	$269K	+9,002 (+90.0%)
243	Welch & Forbes LLC	19,000	0.01%	$42K	—
244	BRIGHTON JONES LLC	18,317	0.01%	$40K	NEW
245	M&T Bank Corp	18,198	0.01%	$40K	+3,155 (+21.0%)
246	PSP Research LLC	18,000	0.01%	$255K	-83,000 (-82.2%)
247	PERSONAL CFO SOLUTIONS, LLC	17,180	0.01%	$243K	NEW
248	ProShare Advisors LLC	17,167	0.01%	$38K	-1,536 (-8.2%)
249	McAdam, LLC	16,494	0.01%	$36K	NEW
250	Virtu Financial LLC	16,394	0.01%	$36K	-109,672 (-87.0%)

Exited since 2026-03-31 (53 filers; largest 25 shown)

BVF INC/IL	−7,764,842
DEERFIELD MANAGEMENT COMPANY, L.P.	−3,606,000
GMT Capital Corp	−3,078,536
BAKER BROS. ADVISORS LP	−2,344,720
Sofinnova Investments, Inc.	−2,056,161
BRAIDWELL LP	−1,965,106
Sio Capital Management, LLC	−1,506,525
GREAT POINT PARTNERS LLC	−1,350,000
Ally Bridge Group (NY) LLC	−1,045,000
Alyeska Investment Group, L.P.	−1,000,000
Parkman Healthcare Partners LLC	−554,411
DV Trading LLC	−423,566
SCHRODER INVESTMENT MANAGEMENT GROUP	−300,000
Monashee Investment Management LLC	−258,865
BOOTHBAY FUND MANAGEMENT, LLC	−191,305
Saba Capital Management, L.P.	−151,033
Tema ETFs LLC	−138,276
Tidal Investments LLC	−138,276
Rhenman & Partners Asset Management AB	−115,113
Harvest Investment Services, LLC	−87,652
AMERICAN CENTURY COMPANIES INC	−78,328
DRW Securities, LLC	−76,493
Polar Asset Management Partners Inc.	−75,000
FRANKLIN RESOURCES INC	−66,607
JANUS HENDERSON GROUP PLC	−55,600

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Vivo Opportunity Cayman Fund, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
Vivo Opportunity, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Fund Holdings, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Cayman, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
STATE STREET CORPORATION	SCHEDULE 13G	2026-08-07	2026-06-30	9,953,653	5.5%
Biotechnology Value Trading Fund OS LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF I GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND L P	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND II LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
LAMPERT MARK N	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF Partners OS Ltd.	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF PARTNERS L P/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF INC/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF II GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
BVF GP HOLDINGS LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,170,971	4%
Blackstone Holdings II L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Annex Master Fund L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	2,447,820	1.4%
Blackstone Holdings I/II GP L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Group Management L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Inc.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Stephen A. Schwarzman	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Alternative Asset Management Associates LLC	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Spruce Street Aggregator L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	3,678,362	2.1%
BlackRock, Inc.	SCHEDULE 13G	2026-01-21	2025-12-31	9,271,644	5.2%
TANG CAPITAL PARTNERS III, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	999,750	0.58%
TANG CAPITAL PARTNERS, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	10,274,944	5.98%
TANG CAPITAL PARTNERS IV, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	333,250	0.19%
TANG CAPITAL PARTNERS INTERNATIONAL, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	5,568,566	3.24%
KEVIN TANG	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
TANG CAPITAL MANAGEMENT, LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
Suvretta Capital Management, LLC	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Averill Master Fund, Ltd.	SCHEDULE 13G/A	2025-08-21	2025-08-13	12,229,050	7.1%
Aaron Cowen	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Commander Aggregator, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences GP, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences Holdings, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
ORBIMED CAPITAL GP V LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
ORBIMED ADVISORS LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
Roderick Wong	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
RTW Investments, LP	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
MPM BioImpact LLC	SCHEDULE 13G/A	2025-08-12	2025-06-30	5,622,505	4.1%
OrbiMed Genesis GP LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
ORBIMED CAPITAL LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
Robert Atchinson	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Phillip Gross	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Adage Capital Partners GP, L.L.C.	SCHEDULE 13G/A	2025-02-12	2024-12-31	0	0%
Adage Capital Management, L.P.	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.