Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

Compass Therapeutics, Inc.

CIK 0001738021CMPX· quarter ending 2026-06-30

Shares outstanding

180,087,915

as of 2026-07-28 · 10-Q cover page, filed 2026-08-06

Held by 13F filers

91,361,025

50.7% of shares outstanding

Holders

224

+30 vs 2026-03-31 · 62 new, 32 exited

Value

$1.3B

shares -2.1% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-08-06, as of 2026-07-28)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	CMPX · NASDAQ	180,087,915	257,060,055	142.7%	—	20451W101, 20454B104

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	20451W101	SPONSORED ADS	224	91,361,025	180,087,915	50.7%	$1.3B	12 call / 6 put	13DG	holders →
	20454B104	COM	215	165,699,030	180,087,915	92.0%	$363.4M	3 call / 2 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (224 of 224 · 20451W101)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	Deep Track Capital, LP	12,161,496	6.75%	$172.1M	—
2	RTW INVESTMENTS, LP	10,700,974	5.94%	$151.4M	+68,584 (+0.6%)
3	BIT Capital GmbH	6,348,797	3.53%	$89.8M	+2,857,563 (+81.8%)
4	TANG CAPITAL MANAGEMENT LLC	5,000,000	2.78%	$70.8M	+997,800 (+24.9%)
5	TWO SIGMA INVESTMENTS, LP	4,470,485	2.48%	$63.3M	+1,886,986 (+73.0%)
6	MARSHALL WACE, LLP	4,328,682	2.40%	$61.3M	+290,347 (+7.2%)
7	ARK Investment Management LLC	3,451,965	1.92%	$48.8M	+150,915 (+4.6%)
8	Point72 Asset Management, L.P.	2,620,878	1.46%	$37.1M	NEW
9	Logos Global Management LP	2,250,000	1.25%	$31.8M	NEW
10	Eagle Health Investments LP	2,060,427	1.14%	$29.2M	—
11	BANK OF AMERICA CORP /DE/	2,019,348	1.12%	$28.6M	+1,987,016 (+6145.7%)
12	DAFNA Capital Management LLC	2,011,952	1.12%	$28.5M	-406,930 (-16.8%)
13	NEXTBio Capital Management LP	1,775,759	0.99%	$25.1M	-245,648 (-12.2%)
14	Kalehua Capital Management LLC	1,639,384	0.91%	$23.2M	—
15	UBS Group AG	1,482,470	0.82%	$21.0M	-372,600 (-20.1%)
16	Aisling Capital Management LP	1,432,336	0.80%	$20.3M	—
17	RENAISSANCE TECHNOLOGIES LLC	1,431,889	0.80%	$20.3M	+566,535 (+65.5%)
18	Candriam S.C.A.	1,274,278	0.71%	$18.0M	NEW
19	Woodline Partners LP	1,086,004	0.60%	$15.4M	+910,565 (+519.0%)
20	CITADEL ADVISORS LLC	1,004,880	0.56%	$14.2M	+735,391 (+272.9%)
21	Jefferies Financial Group Inc.	994,393	0.55%	$14.1M	-472,969 (-32.2%)
22	BlackRock, Inc.	925,391	0.51%	$13.1M	+242,150 (+35.4%)
23	Trexquant Investment LP	860,158	0.48%	$12.2M	+550,875 (+178.1%)
24	MILLENNIUM MANAGEMENT LLC	770,987	0.43%	$10.9M	-2,367,535 (-75.4%)
25	Caption Management, LLC	756,116	0.42%	$10.7M	-854,014 (-53.0%)
26	Axxion S.A.	727,556	0.40%	$10.3M	NEW
27	Occam Crest Management LP	710,000	0.39%	$7.7M	NEW
28	Eversept Partners, LP	672,825	0.37%	$9.5M	-5,099 (-0.8%)
29	MORGAN STANLEY	594,906	0.33%	$8.4M	-610,981 (-50.7%)
30	Propel Bio Management, LLC	573,086	0.32%	$8.1M	-168,963 (-22.8%)
31	Creek Drive Management Group LLC	572,000	0.32%	$8.1M	-253,000 (-30.7%)
32	SILVERARC CAPITAL MANAGEMENT, LLC	503,382	0.28%	$7.1M	+203,382 (+67.8%)
33	JANE STREET GROUP, LLC	501,930	0.28%	$7.1M	+160,109 (+46.8%)
34	Qube Research & Technologies Ltd	499,676	0.28%	$7.1M	-448,878 (-47.3%)
35	Walleye Capital LLC	487,165	0.27%	$6.9M	+125,013 (+34.5%)
36	Ensign Peak Advisors, Inc	474,653	0.26%	$6.7M	+435,428 (+1110.1%)
37	Blue Owl Capital Holdings LP	450,000	0.25%	$6.4M	NEW
38	AdvisorShares Investments LLC	421,347	0.23%	$6.0M	+174,608 (+70.8%)
39	Hennion & Walsh Asset Management, Inc.	417,833	0.23%	$5.9M	-69,841 (-14.3%)
40	GOLDMAN SACHS GROUP INC	391,587	0.22%	$5.5M	+19,890 (+5.4%)
41	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	384,351	0.21%	$5.4M	+315,866 (+461.2%)
42	HighVista Strategies LLC	371,120	0.21%	$5.3M	+6,760 (+1.9%)
43	Legal & General Group Plc	332,206	0.18%	$4.7M	+100,821 (+43.6%)
44	Sumitomo Mitsui Trust Group, Inc.	323,209	0.18%	$4.6M	-45,619 (-12.4%)
45	Amova Asset Management Americas, Inc.	319,472	0.18%	$4.5M	-49,356 (-13.4%)
46	Affinity Asset Advisors, LLC	301,183	0.17%	$4.3M	-807,300 (-72.8%)
47	ADAGE CAPITAL PARTNERS GP, L.L.C.	300,000	0.17%	$4.2M	—
48	Squadron Capital Management LLC	300,000	0.17%	$4.2M	NEW
49	SEVEN GRAND MANAGERS, LLC	300,000	0.17%	$4.2M	—
50	ROYAL BANK OF CANADA	299,808	0.17%	$4.2M	+55,282 (+22.6%)
51	AMERIPRISE FINANCIAL INC	291,950	0.16%	$4.1M	-278,546 (-48.8%)
52	STEMPOINT CAPITAL LP	284,769	0.16%	$4.0M	NEW
53	TORONTO DOMINION BANK	277,755	0.15%	$3.9M	—
54	ROYCE & ASSOCIATES LP	267,059	0.15%	$3.8M	-115,027 (-30.1%)
55	Jump Financial, LLC	261,616	0.15%	$3.7M	-193,384 (-42.5%)
56	PFM Health Sciences, LP	247,589	0.14%	$3.5M	-1,119,510 (-81.9%)
57	D. E. Shaw & Co., Inc.	240,874	0.13%	$3.4M	+4,494 (+1.9%)
58	Brown University	214,200	0.12%	$3.0M	—
59	HEIGHTS CAPITAL MANAGEMENT, INC	205,932	0.11%	$2.9M	-1,286,483 (-86.2%)
60	IQ EQ FUND MANAGEMENT (IRELAND) Ltd	175,373	0.10%	$2.5M	+27,783 (+18.8%)
61	Engineers Gate Manager LP	171,897	0.10%	$2.4M	-46,095 (-21.1%)
62	Y-Intercept (Hong Kong) Ltd	168,090	0.09%	$2.4M	+123,112 (+273.7%)
63	DISCOVERY CAPITAL MANAGEMENT, LLC / CT	150,000	0.08%	$2.1M	-29,716 (-16.5%)
64	HRT FINANCIAL LP	146,127	0.08%	$2.1M	+100,241 (+218.5%)
65	Squarepoint Ops LLC	138,671	0.08%	$2.0M	+122,378 (+751.1%)
66	Balyasny Asset Management L.P.	138,480	0.08%	$2.0M	NEW
67	ALPS ADVISORS INC	136,462	0.08%	$1.9M	NEW
68	WELLS FARGO & COMPANY/MN	135,631	0.08%	$1.9M	-4,756 (-3.4%)
69	K2 PRINCIPAL FUND, L.P.	135,100	0.08%	$1.9M	NEW
70	CenterBook Partners LP	125,594	0.07%	$1.8M	-283,643 (-69.3%)
71	BANK OF MONTREAL /CAN/	119,222	0.07%	$1.7M	NEW
72	ENVESTNET ASSET MANAGEMENT INC	115,839	0.06%	$1.6M	NEW
73	Palo Alto Investors LP	115,616	0.06%	$1.6M	—
74	Simplify Asset Management Inc.	114,281	0.06%	$1.6M	-44,771 (-28.1%)
75	LPL Financial LLC	109,568	0.06%	$1.6M	+82,571 (+305.9%)
76	FLAX POND CAPITAL, LLC	109,182	0.06%	$1.0M	+56,616 (+107.7%)
77	GROUP ONE TRADING LLC	98,298	0.05%	$1.4M	-91,455 (-48.2%)
78	Susquehanna Portfolio Strategies, LLC	94,802	0.05%	$1.3M	-180,971 (-65.6%)
79	CreativeOne Wealth, LLC	94,439	0.05%	$1.3M	NEW
80	STABLEFORD CAPITAL II LLC	91,873	0.05%	$1.3M	-69,266 (-43.0%)
81	STATE STREET CORP	81,279	0.05%	$1.2M	+837 (+1.0%)
82	Lion Point Capital, LP	80,000	0.04%	$1.1M	—
83	GEODE CAPITAL MANAGEMENT, LLC	75,187	0.04%	$1.1M	+12,225 (+19.4%)
84	SUSQUEHANNA INTERNATIONAL GROUP, LLP	66,562	0.04%	$942K	-1,056,026 (-94.1%)
85	Aquatic Capital Management LLC	65,180	0.04%	$922K	+1,647 (+2.6%)
86	Dorsey Wright & Associates	62,449	0.03%	$884K	NEW
87	Campbell & CO Investment Adviser LLC	61,816	0.03%	$875K	NEW
88	STIFEL FINANCIAL CORP	60,469	0.03%	$856K	+31,469 (+108.5%)
89	Intellectus Partners, LLC	59,500	0.03%	$842K	-1,500 (-2.5%)
90	DCF Advisers, LLC	54,250	0.03%	$768K	+11,750 (+27.6%)
91	CIBC WORLD MARKET INC.	52,110	0.03%	$737K	NEW
92	NATIONAL BANK OF CANADA /FI/	51,727	0.03%	$731K	+51,178 (+9322.0%)
93	EXCHANGE TRADED CONCEPTS, LLC	50,102	0.03%	$709K	NEW
94	QRG CAPITAL MANAGEMENT, INC.	48,657	0.03%	$688K	NEW
95	Fore Capital, LLC	45,000	0.02%	$637K	—
96	FLAGSHIP HARBOR ADVISORS, LLC	44,599	0.02%	$631K	+2,000 (+4.7%)
97	HighTower Advisors, LLC	40,727	0.02%	$576K	+10,086 (+32.9%)
98	Forum Finance Group S.A.	39,745	0.02%	$454K	—
99	Corient Private Wealth LP	38,130	0.02%	$540K	-1,043 (-2.7%)
100	MOUNT VERNON ASSOCIATES INC /MD/	38,000	0.02%	$538K	NEW
101	Merit Financial Group, LLC	37,847	0.02%	$536K	NEW
102	ACADIAN ASSET MANAGEMENT LLC	37,585	0.02%	$531K	NEW
103	Entropy Technologies, LP	36,480	0.02%	$516K	+16,510 (+82.7%)
104	Gladstone Institutional Advisory LLC	35,589	0.02%	$504K	+18,645 (+110.0%)
105	GSA CAPITAL PARTNERS LLP	34,317	0.02%	$486K	+4,111 (+13.6%)
106	Atom Investors LP	32,885	0.02%	$465K	-15,175 (-31.6%)
107	Burns Matteson Capital Management, LLC	32,861	0.02%	$465K	NEW
108	RAYMOND JAMES FINANCIAL INC	32,642	0.02%	$462K	+15,213 (+87.3%)
109	TD Waterhouse Canada Inc.	30,306	0.02%	$402K	+29,616 (+4292.2%)
110	FOX RUN MANAGEMENT, L.L.C.	30,208	0.02%	$427K	+17,150 (+131.3%)
111	ACT CAPITAL MANAGEMENT, LLC	30,000	0.02%	$425K	+14,500 (+93.5%)
112	Birchview Capital, LP	30,000	0.02%	$425K	-345,000 (-92.0%)
113	EntryPoint Capital, LLC	28,375	0.02%	$402K	+11,763 (+70.8%)
114	Atria Investments, Inc	27,732	0.02%	$392K	NEW
115	Virtus Investment Advisers, LLC	27,086	0.02%	$383K	-13,371 (-33.0%)
116	Conservest Capital Advisors, Inc.	25,005	0.01%	$354K	-358 (-1.4%)
117	Scientech Research LLC	24,846	0.01%	$352K	+11,809 (+90.6%)
118	Integrated Wealth Concepts LLC	24,792	0.01%	$351K	NEW
119	Cetera Investment Advisers	24,561	0.01%	$348K	NEW
120	Jain Global LLC	23,737	0.01%	$336K	NEW
121	Rockefeller Capital Management L.P.	23,644	0.01%	$335K	+22,368 (+1753.0%)
122	Janney Montgomery Scott LLC	21,196	0.01%	$300K	NEW
123	China Universal Asset Management Co., Ltd.	21,183	0.01%	$300K	+4,448 (+26.6%)
124	Quadrature Capital Ltd	20,406	0.01%	$289K	+2,515 (+14.1%)
125	FNY Investment Advisers, LLC	20,000	0.01%	$283K	—
126	JPMORGAN CHASE & CO	19,054	0.01%	$287K	+9,105 (+91.5%)
127	MML INVESTORS SERVICES, LLC	19,006	0.01%	$269K	+9,002 (+90.0%)
128	PSP Research LLC	18,000	0.01%	$255K	-53,000 (-74.6%)
129	WINTON GROUP Ltd	17,900	0.01%	$253K	+3,000 (+20.1%)
130	PERSONAL CFO SOLUTIONS, LLC	17,180	0.01%	$243K	NEW
131	Caitong International Asset Management Co., Ltd	15,578	0.01%	$220K	+15,409 (+9117.8%)
132	OLD NATIONAL BANCORP /IN/	15,265	0.01%	$216K	—
133	Arax Advisory Partners	15,240	0.01%	$216K	+15,000 (+6250.0%)
134	CHIRON CAPITAL MANAGEMENT, LLC	15,086	0.01%	$213K	NEW
135	ACORN FINANCIAL ADVISORY SERVICES INC /ADV	15,000	0.01%	$212K	—
136	Ikarian Capital, LLC	15,000	0.01%	$212K	-660,000 (-97.8%)
137	Schonfeld Strategic Advisors LLC	14,861	0.01%	$210K	-87,967 (-85.5%)
138	LGT Financial Advisors LLC	14,700	0.01%	$208K	—
139	OSAIC HOLDINGS, INC.	14,113	0.01%	$200K	+5,416 (+62.3%)
140	IFG Advisory, LLC	13,845	0.01%	$196K	NEW
141	Ethos Financial Group, LLC	13,532	0.01%	$191K	—
142	COMMONWEALTH EQUITY SERVICES, LLC	12,972	0.01%	$184K	NEW
143	AXQ CAPITAL, LP	12,691	0.01%	$180K	-3,225 (-20.3%)
144	MANUFACTURERS LIFE INSURANCE COMPANY, THE	12,440	0.01%	$176K	-1,633 (-11.6%)
145	SIG BROKERAGE, LP	12,290	0.01%	$174K	NEW
146	Summit Financial, LLC	12,194	0.01%	$173K	—
147	B. Riley Wealth Advisors, Inc.	11,900	0.01%	$179K	—
148	Persistent Asset Partners Ltd	11,845	0.01%	$168K	+3,785 (+47.0%)
149	Walleye Trading LLC	11,498	0.01%	$163K	NEW
150	CITIGROUP INC	10,754	0.01%	$152K	-18,898 (-63.7%)
151	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	9,667	0.01%	$132K	NEW
152	BARCLAYS PLC	9,108	0.01%	$129K	+5,245 (+135.8%)
153	GAMMA Investing LLC	8,760	0.00%	$124K	-267 (-3.0%)
154	Parallel Advisors, LLC	8,183	0.00%	$116K	+915 (+12.6%)
155	RHUMBLINE ADVISERS	7,797	0.00%	$110K	+578 (+8.0%)
156	North Star Investment Management Corp.	7,517	0.00%	$106K	—
157	Mirae Asset Global Investments Co., Ltd.	5,953	0.00%	$84K	+1,034 (+21.0%)
158	Zurcher Kantonalbank (Zurich Cantonalbank)	4,159	0.00%	$59K	+1,967 (+89.7%)
159	TrinityBridge Ltd	3,900	0.00%	$55K	—
160	Ancora Advisors LLC	3,070	0.00%	$43K	—
161	BNP PARIBAS FINANCIAL MARKETS	3,040	0.00%	$43K	+1,021 (+50.6%)
162	GF FUND MANAGEMENT CO. LTD.	2,631	0.00%	$37K	+527 (+25.0%)
163	EverSource Wealth Advisors, LLC	2,436	0.00%	$34K	-2,318 (-48.8%)
164	State of Wyoming	2,318	0.00%	$33K	NEW
165	Farther Finance Advisors, LLC	2,060	0.00%	$30K	+232 (+12.7%)
166	MCDONALD PARTNERS LLC	2,040	0.00%	$29K	NEW
167	Crewe Advisors LLC	1,945	0.00%	$28K	—
168	DT Investment Partners, LLC	1,590	0.00%	$22K	NEW
169	HOEY INVESTMENTS, INC	1,500	0.00%	$21K	NEW
170	JONES FINANCIAL COMPANIES LLLP	1,450	0.00%	$21K	NEW
171	Federation des caisses Desjardins du Quebec	1,025	0.00%	$15K	+850 (+485.7%)
172	FIDUCIARY FINANCIAL ADVISORS	1,000	0.00%	$14K	NEW
173	Colonial Trust Advisors	1,000	0.00%	$14K	-1,000 (-50.0%)
174	Bullock Wealth Management Group	1,000	0.00%	$13K	—
175	Westside Investment Management, Inc.	900	0.00%	$13K	—
176	Steward Partners Investment Advisory, LLC	822	0.00%	$12K	-998 (-54.8%)
177	Legacies Wealth LLC	695	0.00%	$10K	NEW
178	Quantbot Technologies LP	596	0.00%	$8K	NEW
179	Blue Trust, Inc.	555	0.00%	$8K	+245 (+79.0%)
180	Anchor Investment Management, LLC	550	0.00%	$8K	—
181	SBI Securities Co., Ltd.	518	0.00%	$7K	+78 (+17.7%)
182	ADIRONDACK TRUST CO	505	0.00%	$7K	—
183	PNC Financial Services Group, Inc.	503	0.00%	$7K	+303 (+151.5%)
184	HUNTINGTON NATIONAL BANK	501	0.00%	$7K	+500 (+50000.0%)
185	Global Retirement Partners, LLC	500	0.00%	$7K	NEW
186	Larson Financial Group LLC	500	0.00%	$7K	+300 (+150.0%)
187	Pacifica Partners Inc.	420	0.00%	$6K	—
188	IFP Advisors, Inc	400	0.00%	$6K	+350 (+700.0%)
189	TSFG, LLC	350	0.00%	$5K	+250 (+250.0%)
190	Ascentis Wealth Management, LLC	320	0.00%	$5K	NEW
191	ROTHSCHILD INVESTMENT LLC	304	0.00%	$4K	—
192	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	280	0.00%	$4K	NEW
193	Sankala Group LLC	251	0.00%	$3K	—
194	GHP Investment Advisors, Inc.	250	0.00%	$4K	—
195	Silver Grove Financial Group, Inc.	233	0.00%	$3K	NEW
196	TD PRIVATE CLIENT WEALTH LLC	232	0.00%	$3K	NEW
197	Tower Research Capital LLC (TRC)	219	0.00%	$3K	-14,854 (-98.5%)
198	CoreCap Advisors, LLC	205	0.00%	$3K	NEW
199	NVWM, LLC	202	0.00%	$3K	—
200	CREATIVE FINANCIAL DESIGNS INC /ADV	200	0.00%	$3K	NEW
201	SOUTHERN MICHIGAN BANK & TRUST	196	0.00%	$3K	—
202	Triumph Capital Management	114	0.00%	$2K	+11 (+10.7%)
203	New England Capital Financial Advisors LLC	104	0.00%	$1K	-196 (-65.3%)
204	LANARK FINANCIAL, INC.	100	0.00%	$1K	NEW
205	Basepoint Wealth LLC	100	0.00%	$1K	—
206	CENTRAL TRUST Co	100	0.00%	$1K	—
207	SJS Investment Consulting Inc.	95	0.00%	$1K	—
208	Retirement Wealth Solutions LLC	89	0.00%	$1K	NEW
209	MANNING & NAPIER ADVISORS LLC	86	0.00%	$1K	NEW
210	Signature Equity Partners, LLC	76	0.00%	$1K	NEW
211	THOMPSON INVESTMENT MANAGEMENT, INC.	75	0.00%	$1K	NEW
212	IMA Advisory Services, Inc.	58	0.00%	$821	NEW
213	TFC Financial Management, Inc.	52	0.00%	$736	—
214	Western Pacific Wealth Management, LP	50	0.00%	$708	—
215	First Command Advisory Services, Inc.	34	0.00%	$481	NEW
216	HARBOUR INVESTMENTS, INC.	32	0.00%	$447	-14 (-30.4%)
217	COMPASS FINANCIAL MANAGEMENT LLC	27	0.00%	$382	NEW
218	Optiver Holding B.V.	25	0.00%	$354	NEW
219	Essential Investment Partners LLC	25	0.00%	$354	—
220	Allworth Financial LP	25	0.00%	$354	NEW
221	BEACON INVESTMENT ADVISORY SERVICES, INC.	20	0.00%	$283	NEW
222	US BANCORP \DE\	17	0.00%	$240	NEW
223	Smartleaf Asset Management LLC	15	0.00%	$229	—
224	SIGNATUREFD, LLC	1	0.00%	$14	—

Exited since 2026-03-31 (32 filers; largest 25 shown)

GMT Capital Corp	−3,078,536
BAKER BROS. ADVISORS LP	−2,344,720
Sio Capital Management, LLC	−1,506,525
ORBIMED ADVISORS LLC	−1,150,646
Ally Bridge Group (NY) LLC	−1,045,000
Alyeska Investment Group, L.P.	−1,000,000
Parkman Healthcare Partners LLC	−554,411
SCHRODER INVESTMENT MANAGEMENT GROUP	−300,000
SIMPLEX TRADING, LLC	−267,465
Burkehill Global Management, LP	−250,000
Vivo Capital, LLC	−200,000
BOOTHBAY FUND MANAGEMENT, LLC	−191,305
Seven Fleet Capital Management LP	−158,021
Saba Capital Management, L.P.	−151,033
Virtu Financial LLC	−83,000
Polar Asset Management Partners Inc.	−75,000
DIADEMA PARTNERS LP	−31,885
Shay Capital LLC	−27,600
Zhang Financial LLC	−19,037
CWM, LLC	−15,540
U.S. Capital Wealth Advisors, LLC	−15,000
Aigen Investment Management, LP	−11,153
Cerity Partners LLC	−10,204
Vontobel Holding Ltd.	−10,100
Advisory Services Network, LLC	−7,124

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Vivo Opportunity Cayman Fund, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
Vivo Opportunity, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Fund Holdings, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	7,207,573	4%
Vivo Opportunity Cayman, LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	549,487	0.3%
STATE STREET CORPORATION	SCHEDULE 13G	2026-08-07	2026-06-30	9,953,653	5.5%
Biotechnology Value Trading Fund OS LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF I GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND L P	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,142,020	2.3%
BIOTECHNOLOGY VALUE FUND II LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
LAMPERT MARK N	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF Partners OS Ltd.	SCHEDULE 13G/A	2026-05-15	2026-03-31	476,311	0.3%
BVF PARTNERS L P/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF INC/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,764,842	4.3%
BVF II GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,028,951	1.7%
BVF GP HOLDINGS LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	7,170,971	4%
Blackstone Holdings II L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Annex Master Fund L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	2,447,820	1.4%
Blackstone Holdings I/II GP L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Group Management L.L.C.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Inc.	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Stephen A. Schwarzman	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Blackstone Alternative Asset Management Associates LLC	SCHEDULE 13G/A	2026-02-13	2025-12-31	6,126,182	3.4%
Spruce Street Aggregator L.P.	SCHEDULE 13G/A	2026-02-13	2025-12-31	3,678,362	2.1%
BlackRock, Inc.	SCHEDULE 13G	2026-01-21	2025-12-31	9,271,644	5.2%
TANG CAPITAL PARTNERS III, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	999,750	0.58%
TANG CAPITAL PARTNERS, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	10,274,944	5.98%
TANG CAPITAL PARTNERS IV, INC	SCHEDULE 13G/A	2025-11-14	2025-09-30	333,250	0.19%
TANG CAPITAL PARTNERS INTERNATIONAL, LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	5,568,566	3.24%
KEVIN TANG	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
TANG CAPITAL MANAGEMENT, LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	17,176,510	9.99%
Suvretta Capital Management, LLC	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Averill Master Fund, Ltd.	SCHEDULE 13G/A	2025-08-21	2025-08-13	12,229,050	7.1%
Aaron Cowen	SCHEDULE 13G/A	2025-08-21	2025-08-13	14,101,159	8.2%
Commander Aggregator, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences GP, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences, LP	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
Enavate Sciences Holdings, LLC	SCHEDULE 13D/A	2025-08-18	2025-08-14	7,788,150	4.5%
ORBIMED CAPITAL GP V LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
ORBIMED ADVISORS LLC	SCHEDULE 13D/A	2025-08-15	2025-08-13	15,219,994	8.9%
Roderick Wong	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
RTW Investments, LP	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
MPM BioImpact LLC	SCHEDULE 13G/A	2025-08-12	2025-06-30	5,622,505	4.1%
OrbiMed Genesis GP LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
ORBIMED CAPITAL LLC	SCHEDULE 13D/A	2025-04-11	2024-04-09	0	0%
Robert Atchinson	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Phillip Gross	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%
Adage Capital Partners GP, L.L.C.	SCHEDULE 13G/A	2025-02-12	2024-12-31	0	0%
Adage Capital Management, L.P.	SCHEDULE 13G/A	2025-02-12	2024-12-31	5,994,810	4.36%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.