Institutional HoldersBeta
Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.
Share classes (cover page of the 10-Q filed 2026-08-05, as of 2026-08-03)
| Class | Listed | Shares outstanding | Held by 13F filers | % of class | Holders | CUSIP |
|---|---|---|---|---|---|---|
| Common stock | ACET · NASDAQ | 9,361,490 | 6,109,856 | 65.3% | 56 | 007002207 |
Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.
Top holders (56 of 56 · 007002207)
change vs 2026-03-31| # | Filer | Shares | % of class | Value | Change |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 932,624 | 9.96% | $8.1M | -250,000 (-21.1%) |
| 2 | ORBIMED ADVISORS LLC | 844,787 | 9.02% | $7.3M | -183,157 (-17.8%) |
| 3 | FRANKLIN RESOURCES INC | 626,571 | 6.69% | $5.4M | — |
| 4 | CITADEL ADVISORS LLC | 432,738 | 4.62% | $3.7M | +50,915 (+13.3%) |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 343,228 | 3.67% | $3.0M | +6,704 (+2.0%) |
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 274,375 | 2.93% | $2.4M | — |
| 7 | RENAISSANCE TECHNOLOGIES LLC | 265,945 | 2.84% | $2.3M | +33,354 (+14.3%) |
| 8 | Stonepine Capital Management, LLC | 245,518 | 2.62% | $2.1M | +23,563 (+10.6%) |
| 9 | Alyeska Investment Group, L.P. | 203,799 | 2.18% | $1.8M | — |
| 10 | Schonfeld Strategic Advisors LLC | 195,514 | 2.09% | $1.7M | NEW |
| 11 | Carlyle Group Inc. | 184,295 | 1.97% | $1.6M | — |
| 12 | NEXTBio Capital Management LP | 157,827 | 1.69% | $1.4M | — |
| 13 | ACADIAN ASSET MANAGEMENT LLC | 124,832 | 1.33% | $1.1M | +6,694 (+5.7%) |
| 14 | TWO SIGMA INVESTMENTS, LP | 96,839 | 1.03% | $837K | +53,733 (+124.7%) |
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 95,634 | 1.02% | $827K | -5,501 (-5.4%) |
| 16 | DAFNA Capital Management LLC | 93,812 | 1.00% | $811K | — |
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,959 | 0.92% | $743K | NEW |
| 18 | MARSHALL WACE, LLP | 79,488 | 0.85% | $687K | NEW |
| 19 | Trexquant Investment LP | 78,002 | 0.83% | $674K | +34,336 (+78.6%) |
| 20 | JANE STREET GROUP, LLC | 70,561 | 0.75% | $610K | +33,477 (+90.3%) |
| 21 | Burkehill Global Management, LP | 62,500 | 0.67% | $540K | — |
| 22 | BlackRock, Inc. | 62,126 | 0.66% | $537K | +25,541 (+69.8%) |
| 23 | REGENERON PHARMACEUTICALS, INC. | 60,511 | 0.65% | $523K | NEW |
| 24 | Rangeley Capital, LLC | 50,892 | 0.54% | $440K | -5,108 (-9.1%) |
| 25 | VANGUARD FIDUCIARY TRUST CO | 50,670 | 0.54% | $438K | +336 (+0.7%) |
| 26 | RBF Capital, LLC | 38,582 | 0.41% | $333K | — |
| 27 | STATE STREET CORP | 36,222 | 0.39% | $313K | — |
| 28 | Quadrature Capital Ltd | 36,193 | 0.39% | $313K | NEW |
| 29 | DIMENSIONAL FUND ADVISORS LP | 31,603 | 0.34% | $273K | +20,825 (+193.2%) |
| 30 | UBS Group AG | 29,817 | 0.32% | $258K | -8,551 (-22.3%) |
| 31 | Verdad Advisers, LP | 25,200 | 0.27% | $218K | NEW |
| 32 | XTX Topco Ltd | 24,284 | 0.26% | $210K | +5,158 (+27.0%) |
| 33 | JOHNSON & JOHNSON | 22,779 | 0.24% | $197K | — |
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,650 | 0.22% | $178K | NEW |
| 35 | PRELUDE CAPITAL MANAGEMENT, LLC | 18,550 | 0.20% | $160K | NEW |
| 36 | NORTHERN TRUST CORP | 18,436 | 0.20% | $159K | -764 (-4.0%) |
| 37 | OCCUDO QUANTITATIVE STRATEGIES LP | 16,636 | 0.18% | $144K | +1,536 (+10.2%) |
| 38 | Squarepoint Ops LLC | 15,254 | 0.16% | $132K | NEW |
| 39 | Vontobel Holding Ltd. | 13,776 | 0.15% | $119K | -471 (-3.3%) |
| 40 | AXQ CAPITAL, LP | 10,991 | 0.12% | $95K | NEW |
| 41 | Jump Financial, LLC | 10,942 | 0.12% | $95K | NEW |
| 42 | Arax Advisory Partners | 6,000 | 0.06% | $52K | NEW |
| 43 | Vanguard Global Advisers, LLC | 5,221 | 0.06% | $45K | — |
| 44 | SIMPLEX TRADING, LLC | 4,814 | 0.05% | $42K | +3,421 (+245.6%) |
| 45 | MORGAN STANLEY | 2,291 | 0.02% | $20K | -1,202 (-34.4%) |
| 46 | ROYAL BANK OF CANADA | 1,701 | 0.02% | $15K | +2 (+0.1%) |
| 47 | Tower Research Capital LLC (TRC) | 277 | 0.00% | $2K | -1,144 (-80.5%) |
| 48 | Avion Wealth | 246 | 0.00% | $2K | — |
| 49 | JPMORGAN CHASE & CO | 196 | 0.00% | $2K | +188 (+2350.0%) |
| 50 | BNP PARIBAS FINANCIAL MARKETS | 50 | 0.00% | $432 | — |
| 51 | Caitong International Asset Management Co., Ltd | 47 | 0.00% | $406 | +44 (+1466.7%) |
| 52 | SBI Securities Co., Ltd. | 24 | 0.00% | $207 | +5 (+26.3%) |
| 53 | NATIONAL BANK OF CANADA /FI/ | 17 | 0.00% | $146 | — |
| 54 | FMR LLC | 6 | 0.00% | $52 | NEW |
| 55 | TD Waterhouse Canada Inc. | 3 | 0.00% | $26 | NEW |
| 56 | DANSKE BANK A/S | 1 | 0.00% | $9 | — |
Exited since 2026-03-31 (6 filers; largest 6 shown)
| Woodline Partners LP | −313,124 |
| Prosight Management, LP | −250,244 |
| ADAR1 Capital Management, LLC | −53,827 |
| BARCLAYS PLC | −25,000 |
| NewEdge Advisors, LLC | −3,854 |
| FNY Investment Advisers, LLC | −3,200 |
Large holders from 13D/13G (latest per reporting person, last 2 years)
Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.
| Reporting person | Form | Filed | Event | Shares | % of class |
|---|---|---|---|---|---|
| Peter Kolchinsky | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 935,486 | 9.9% |
| Rajeev Shah | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 935,486 | 9.9% |
| RA Capital Management, L.P. | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 935,486 | 9.9% |
| RA Capital Healthcare Fund, L.P. | SCHEDULE 13G/A | 2026-08-14 | 2026-06-30 | 935,486 | 9.9% |
| Woodline Partners LP | SCHEDULE 13G/A | 2026-05-15 | 2026-03-31 | 313,124 | 3.3% |
| ORBIMED ADVISORS LLC | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 844,787 | 8.8% |
| ORBIMED ADVISORS ISRAEL II LTD | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 0 | 0% |
| ORBIMED CAPITAL GP V LLC | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 564,147 | 5.9% |
| OrbiMed Genesis GP LLC | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 0 | 0% |
| ORBIMED ISRAEL BIOFUND GP LIMITED PARTNERSHIP | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 0 | 0% |
| ORBIMED ISRAEL GP II, L.P. | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 0 | 0% |
| ORBIMED ISRAEL GP LTD. | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 0 | 0% |
| ORBIMED CAPITAL GP VI LLC | SCHEDULE 13D/A | 2026-04-10 | 2026-04-08 | 280,640 | 2.9% |
| KEVIN TANG | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 6,158 | 0.1% |
| TANG CAPITAL MANAGEMENT, LLC | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 6,158 | 0.1% |
| TANG CAPITAL PARTNERS III, INC | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 0 | 0% |
| TANG CAPITAL PARTNERS INTERNATIONAL, LP | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 6,158 | 0.1% |
| TANG CAPITAL PARTNERS IV, INC | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 0 | 0% |
| TANG CAPITAL PARTNERS, LP | SCHEDULE 13G/A | 2026-02-17 | 2025-12-31 | 0 | 0% |
| Charles B. Johnson | SCHEDULE 13G | 2026-01-29 | 2025-12-31 | 0 | 0% |
| Franklin Resources, Inc. | SCHEDULE 13G | 2026-01-29 | 2025-12-31 | 626,571 | 6.5% |
| Rupert H. Johnson, Jr. | SCHEDULE 13G | 2026-01-29 | 2025-12-31 | 0 | 0% |
| Franklin Advisers, Inc. | SCHEDULE 13G | 2026-01-29 | 2025-12-31 | 626,571 | 6.5% |
Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.