CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Revenue:
Total revenue	$ 1,944,000	$ 3,236,000	$ 6,848,000
Operating expenses:
Cost of sales	868,000	1,464,000	4,693,000
Research and development	3,132,000	4,543,000	4,845,000
Selling, general and administrative	1,018,000	1,174,000	1,549,000
Total operating expenses	5,018,000	7,181,000	11,087,000
Loss from operations	(3,074,000)	(3,945,000)	(4,239,000)
Interest income	314,000	425,000	421,000
Other expense, net	(8,000)	(87,000)	(124,000)
Loss before income taxes	(2,768,000)	(3,607,000)	(3,942,000)
Provision for (benefit from) tax provision	54,000	(46,000)	772,000
Net loss	$ (2,822,000)	$ (3,561,000)	$ (4,714,000)
Net loss per share
Basic (in usd per share)	$ (7.26)	$ (9.28)	$ (12.33)
Diluted (in usd per share)	$ (7.26)	$ (9.28)	$ (12.33)
Weighted average common shares used in calculation of loss per share:
Basic (in shares)	389,000	384,000	382,000
Diluted (in shares)	389,000	384,000	382,000
Net product sales
Revenue:
Total revenue	$ 1,818,000	$ 3,109,000	$ 6,671,000
Other revenue
Revenue:
Total revenue	$ 126,000	$ 127,000	$ 177,000

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Operating activities
Net loss	$ (2,822)	$ (3,561)	$ (4,714)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	483	429	305
Depreciation and amortization	215	189	621
Amortization/accretion of investments	(67)	(95)	(61)
Loss on equity investments, net	8	52	35
Other non-cash items	77	60	7
Changes in assets and liabilities:
Accounts receivable, net	156	534	493
Prepaid expenses and other assets	153	145	1,802
Inventory	(34)	83	747
Right-of-use assets, operating leases	38	(53)	(605)
Accounts payable	(92)	(69)	13
Accrued liabilities	(2)	(385)	(340)
Deferred revenue	41	(439)	(2,060)
Operating lease liabilities	(21)	28	551
Other liabilities	(6)	78	88
Net cash used in operating activities	(1,873)	(3,004)	(3,118)
Investing activities
Purchases of marketable securities	(5,768)	(6,529)	(3,760)
Proceeds from maturities of marketable securities	5,563	5,562	5,575
Proceeds from sales of marketable securities	2,353	3,967	3,206
Purchases of property, plant and equipment	(192)	(1,051)	(707)
Acquisition of business, net of cash acquired	0	0	(85)
Purchase of intangible asset	(10)	0	0
Investment in convertible notes and equity securities	0	0	(23)
Net cash provided by investing activities	1,946	1,949	4,206
Financing activities
Proceeds from credit facility	600	0	0
Payment of credit facility issuance costs	(22)	0	0
Proceeds from issuance of common stock through equity plans	35	66	46
Tax payments related to net share settlements on equity awards	(2)	0	(1,153)
Changes in financing lease liabilities	(18)	(10)	(270)
Net cash provided by (used in) financing activities	593	56	(1,377)
Effect of changes in exchange rates on cash and cash equivalents	2	0	0
Net increase (decrease) in cash, cash equivalents and restricted cash	668	(999)	(289)
Cash, cash equivalents and restricted cash, beginning of year	1,929	2,928	3,217
Cash, cash equivalents and restricted cash, end of year	2,597	1,929	2,928
Supplemental cash flow information
Cash paid (received) for income taxes	26	197	(357)
Cash paid for interest	10	24	39
Non-cash investing and financing activities
Purchases of property, plant and equipment included in accounts payable and accrued liabilities	$ 83	$ 97	$ 130

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Millions	Dec. 31, 2025	Dec. 31, 2024
Current assets:
Cash and cash equivalents	$ 2,595	$ 1,927
Investments	3,204	5,098
Accounts receivable, net	184	358
Inventory	153	117
Prepaid expenses and other current assets	408	599
Total current assets	6,544	8,099
Investments, non-current	2,336	2,494
Property, plant and equipment, net	2,134	2,196
Right-of-use assets, operating leases	719	759
Other non-current assets	605	594
Total assets	12,338	14,142
Current liabilities:
Accounts payable	317	405
Accrued liabilities	1,386	1,427
Deferred revenue	99	153
Other current liabilities	185	221
Total current liabilities	1,987	2,206
Deferred revenue, non-current	153	58
Operating lease liabilities, non-current	653	671
Financing lease liabilities, non-current	20	39
Long-term debt	590	0
Other non-current liabilities	285	267
Total liabilities	3,688	3,241
Commitments and contingencies (Note 12)
Stockholders’ equity:
Preferred stock, $0.0001; 162 shares authorized as of December 31, 2025 and 2024; no shares issued or outstanding at December 31, 2025 and 2024	0	0
Common stock, par value $0.0001; 1,600 shares authorized as of December 31, 2025 and 2024; 394 and 386 shares issued and outstanding as of December 31, 2025 and 2024, respectively	0	0
Additional paid-in capital	1,382	866
Accumulated other comprehensive income (loss)	45	(10)
Retained earnings	7,223	10,045
Total stockholders’ equity	8,650	10,901
Total liabilities and stockholders’ equity	$ 12,338	$ 14,142