Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

ARVINAS, INC.

CIK 0001655759ARVN· quarter ending 2026-06-30

Shares outstanding

65,386,191

as of 2026-07-31 · 10-Q cover page, filed 2026-08-04

Held by 13F filers

56,524,861

86.4% of shares outstanding

Holders

201

-6 vs 2026-03-31 · 35 new, 41 exited

Value

$476.6M

shares +4.3% vs prior quarter

Share classes (cover page of the 10-Q filed 2026-08-04, as of 2026-07-31)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	ARVN · NASDAQ	65,386,191	56,524,861	86.4%	201	04335A105

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	04335A105	COM	201	56,524,861	65,386,191	86.4%	$476.6M	3 call / 3 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (201 of 201 · 04335A105)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	BlackRock, Inc.	7,609,123	11.64%	$63.2M	+811,539 (+11.9%)
2	VANGUARD PORTFOLIO MANAGEMENT LLC	4,123,399	6.31%	$34.3M	+233,771 (+6.0%)
3	D. E. Shaw & Co., Inc.	3,495,153	5.35%	$29.0M	-143,414 (-3.9%)
4	Pfizer Inc	3,457,815	5.29%	$27.7M	—
5	ARMISTICE CAPITAL, LLC	2,796,000	4.28%	$23.2M	+818,000 (+41.4%)
6	VANGUARD CAPITAL MANAGEMENT LLC	2,714,163	4.15%	$22.6M	+24,801 (+0.9%)
7	TWO SIGMA INVESTMENTS, LP	2,573,447	3.94%	$21.4M	+741,333 (+40.5%)
8	STATE STREET CORP	2,196,872	3.36%	$18.3M	+368,400 (+20.1%)
9	GEODE CAPITAL MANAGEMENT, LLC	1,667,265	2.55%	$13.9M	+110,158 (+7.1%)
10	Qube Research & Technologies Ltd	1,592,276	2.44%	$13.2M	+390,641 (+32.5%)
11	JACOBS LEVY EQUITY MANAGEMENT, INC	1,412,643	2.16%	$11.7M	-28,878 (-2.0%)
12	FEDERATED HERMES, INC.	1,356,032	2.07%	$11.3M	+215,317 (+18.9%)
13	Nextech Invest Ltd.	1,122,713	1.72%	$17.1M	+583,319 (+108.1%)
14	Arbiter Partners Capital Management LLC	883,782	1.35%	$7.3M	NEW
15	ACADIAN ASSET MANAGEMENT LLC	848,382	1.30%	$7.0M	-101,492 (-10.7%)
16	Hillsdale Investment Management Inc.	750,900	1.15%	$6.2M	NEW
17	PRICE T ROWE ASSOCIATES INC /MD/	728,147	1.11%	$6.1M	+301,054 (+70.5%)
18	TCG Crossover Management, LLC	707,098	1.08%	$5.9M	-1,680,363 (-70.4%)
19	DIMENSIONAL FUND ADVISORS LP	654,909	1.00%	$5.4M	+169,145 (+34.8%)
20	GOLDMAN SACHS GROUP INC	640,811	0.98%	$5.3M	-116,064 (-15.3%)
21	CITADEL ADVISORS LLC	620,973	0.95%	$5.2M	-560,015 (-47.4%)
22	NORTHERN TRUST CORP	615,296	0.94%	$5.1M	+94,341 (+18.1%)
23	AQR CAPITAL MANAGEMENT LLC	601,873	0.92%	$5.0M	+316,755 (+111.1%)
24	Nantahala Capital Management, LLC	600,000	0.92%	$5.0M	+300,000 (+100.0%)
25	KENNEDY CAPITAL MANAGEMENT LLC	589,238	0.90%	$4.9M	+36,597 (+6.6%)
26	MILLENNIUM MANAGEMENT LLC	574,011	0.88%	$4.8M	-2,341 (-0.4%)
27	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	542,174	0.83%	$4.5M	+17,000 (+3.2%)
28	MORGAN STANLEY	502,755	0.77%	$4.2M	-171,963 (-25.5%)
29	NORDEA INVESTMENT MANAGEMENT AB	476,196	0.73%	$4.0M	+1,693 (+0.4%)
30	UBS Group AG	444,674	0.68%	$3.7M	+376,428 (+551.6%)
31	VANGUARD FIDUCIARY TRUST CO	427,224	0.65%	$3.6M	+14,628 (+3.5%)
32	ALGERT GLOBAL LLC	426,415	0.65%	$3.5M	+246,919 (+137.6%)
33	FRANKLIN RESOURCES INC	366,423	0.56%	$3.0M	+149,635 (+69.0%)
34	FMR LLC	365,206	0.56%	$3.0M	+276,974 (+313.9%)
35	Ikarian Capital, LLC	358,257	0.55%	$3.0M	—
36	Jump Financial, LLC	296,168	0.45%	$2.5M	+162,350 (+121.3%)
37	Man Group plc	256,104	0.39%	$2.1M	+165,135 (+181.5%)
38	Bank of New York Mellon Corp	254,997	0.39%	$2.1M	+18,283 (+7.7%)
39	BANK OF AMERICA CORP /DE/	252,939	0.39%	$2.1M	+136,139 (+116.6%)
40	Invesco Ltd.	247,920	0.38%	$2.1M	-68,734 (-21.7%)
41	RENAISSANCE TECHNOLOGIES LLC	215,345	0.33%	$1.8M	NEW
42	Squarepoint Ops LLC	201,822	0.31%	$1.7M	+178,362 (+760.3%)
43	AMERIPRISE FINANCIAL INC	185,347	0.28%	$1.5M	-148 (-0.1%)
44	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	180,000	0.28%	$1.5M	—
45	Rangeley Capital, LLC	175,590	0.27%	$1.5M	-48,400 (-21.6%)
46	Connor, Clark & Lunn Investment Management Ltd.	167,056	0.26%	$1.4M	+35,082 (+26.6%)
47	Russell Investments Group, Ltd.	166,222	0.25%	$1.4M	+29,037 (+21.2%)
48	Susquehanna Portfolio Strategies, LLC	158,285	0.24%	$1.3M	-142,960 (-47.5%)
49	DEUTSCHE BANK AG\	151,167	0.23%	$1.3M	+3,645 (+2.5%)
50	GSA CAPITAL PARTNERS LLP	142,214	0.22%	$1.2M	+8,962 (+6.7%)
51	Point72 Asset Management, L.P.	141,266	0.22%	$1.2M	-88,541 (-38.5%)
52	Nuveen, LLC	138,776	0.21%	$1.2M	-267,564 (-65.8%)
53	Assenagon Asset Management S.A.	136,912	0.21%	$1.1M	+108,176 (+376.4%)
54	OCCUDO QUANTITATIVE STRATEGIES LP	124,648	0.19%	$1.0M	NEW
55	LPL Financial LLC	113,664	0.17%	$945K	+2,970 (+2.7%)
56	AMERICAN CENTURY COMPANIES INC	110,771	0.17%	$921K	+25,279 (+29.6%)
57	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	109,966	0.17%	$914K	-1,008 (-0.9%)
58	Swiss National Bank	108,000	0.17%	$897K	—
59	WELLS FARGO & COMPANY/MN	106,411	0.16%	$884K	+52,748 (+98.3%)
60	HSBC HOLDINGS PLC	104,772	0.16%	$885K	+15,625 (+17.5%)
61	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	101,397	0.16%	$843K	+20,075 (+24.7%)
62	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	97,611	0.15%	$811K	—
63	LOS ANGELES CAPITAL MANAGEMENT LLC	94,817	0.15%	$788K	+81,692 (+622.4%)
64	Verition Fund Management LLC	84,477	0.13%	$702K	NEW
65	Tema ETFs LLC	84,124	0.13%	$699K	+543 (+0.6%)
66	Tidal Investments LLC	84,124	0.13%	$699K	+543 (+0.6%)
67	BARCLAYS PLC	83,925	0.13%	$697K	+27,568 (+48.9%)
68	HRT FINANCIAL LP	82,866	0.13%	$688K	-187,436 (-69.3%)
69	BOOTHBAY FUND MANAGEMENT, LLC	82,482	0.13%	$685K	—
70	CAXTON ASSOCIATES LLP	82,313	0.13%	$684K	-177,703 (-68.3%)
71	Graham Capital Management, L.P.	81,364	0.12%	$676K	+70,462 (+646.3%)
72	RHUMBLINE ADVISERS	78,147	0.12%	$649K	-2,345 (-2.9%)
73	MANGROVE PARTNERS IM, LLC	76,220	0.12%	$633K	+6,960 (+10.0%)
74	Engineers Gate Manager LP	72,321	0.11%	$601K	NEW
75	Quantinno Capital Management LP	66,796	0.10%	$555K	-7,744 (-10.4%)
76	ALLIANCEBERNSTEIN L.P.	63,820	0.10%	$676K	-9,900 (-13.4%)
77	Headlands Technologies LLC	60,436	0.09%	$502K	-12,607 (-17.3%)
78	Stonepine Capital Management, LLC	60,000	0.09%	$499K	+32,500 (+118.2%)
79	GLOBEFLEX CAPITAL L P	59,331	0.09%	$493K	—
80	CITIGROUP INC	58,263	0.09%	$484K	+33,141 (+131.9%)
81	ADAR1 Capital Management, LLC	57,591	0.09%	$479K	—
82	Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group	57,500	0.09%	$478K	—
83	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	55,093	0.08%	$458K	+11,752 (+27.1%)
84	Longaeva Partners L.P.	52,939	0.08%	$440K	+2,734 (+5.4%)
85	ExodusPoint Capital Management, LP	50,933	0.08%	$423K	-200,079 (-79.7%)
86	STRS OHIO	49,300	0.08%	$410K	+8,900 (+22.0%)
87	EntryPoint Capital, LLC	48,122	0.07%	$400K	NEW
88	FOX RUN MANAGEMENT, L.L.C.	47,916	0.07%	$398K	+37,277 (+350.4%)
89	Yelin Lapidot Holdings Management Ltd.	46,665	0.07%	$388K	—
90	Legal & General Group Plc	44,259	0.07%	$368K	+909 (+2.1%)
91	Virtus Investment Advisers, LLC	43,166	0.07%	$359K	+21,490 (+99.1%)
92	Schonfeld Strategic Advisors LLC	43,045	0.07%	$358K	NEW
93	IEQ CAPITAL, LLC	41,445	0.06%	$344K	+29,028 (+233.8%)
94	Quinn Opportunity Partners LLC	41,263	0.06%	$343K	—
95	SEI INVESTMENTS CO	40,372	0.06%	$335K	-38,215 (-48.6%)
96	VOYA INVESTMENT MANAGEMENT LLC	38,501	0.06%	$320K	+27,758 (+258.4%)
97	VIRGINIA RETIREMENT SYSTEMS ET Al	37,350	0.06%	$310K	-33,400 (-47.2%)
98	RAYMOND JAMES FINANCIAL INC	37,082	0.06%	$308K	+1,850 (+5.3%)
99	DRW Securities, LLC	36,309	0.06%	$302K	NEW
100	MetLife Investment Management, LLC	35,532	0.05%	$295K	+2,497 (+7.6%)
101	Creative Planning	35,029	0.05%	$291K	-23,091 (-39.7%)
102	Jain Global LLC	34,108	0.05%	$283K	NEW
103	VANGUARD ASSET MANAGEMENT, Ltd	33,536	0.05%	$279K	—
104	JPMORGAN CHASE & CO	31,028	0.05%	$257K	-112,285 (-78.3%)
105	AlphaCentric Advisors LLC	30,622	0.05%	$254K	+17,472 (+132.9%)
106	Brevan Howard Capital Management LP	30,599	0.05%	$254K	NEW
107	SUSQUEHANNA INTERNATIONAL GROUP, LLP	29,039	0.04%	$241K	-40,414 (-58.2%)
108	Dynamic Technology Lab Private Ltd	27,450	0.04%	$228K	NEW
109	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	27,384	0.04%	$228K	+1,322 (+5.1%)
110	Entropy Technologies, LP	27,319	0.04%	$227K	NEW
111	PROFUND ADVISORS LLC	26,135	0.04%	$217K	+10,930 (+71.9%)
112	Vanguard Global Advisers, LLC	25,894	0.04%	$215K	-3,929 (-13.2%)
113	Palumbo Wealth Management LLC	25,305	0.04%	$210K	NEW
114	Jupiter Topco LLC	23,365	0.04%	$194K	NEW
115	Zurcher Kantonalbank (Zurich Cantonalbank)	23,263	0.04%	$193K	-50,590 (-68.5%)
116	Mariner, LLC	21,914	0.03%	$182K	+1,868 (+9.3%)
117	Mitsubishi UFJ Trust & Banking Corp	21,788	0.03%	$181K	NEW
118	Rafferty Asset Management, LLC	19,535	0.03%	$162K	NEW
119	INTECH INVESTMENT MANAGEMENT LLC	18,106	0.03%	$150K	—
120	BNP PARIBAS FINANCIAL MARKETS	17,786	0.03%	$148K	-18,443 (-50.9%)
121	State of New Jersey Common Pension Fund D	17,579	0.03%	$146K	-1,078 (-5.8%)
122	Polymer Capital Management (US) LLC	16,974	0.03%	$141K	NEW
123	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	16,930	0.03%	$141K	—
124	MANUFACTURERS LIFE INSURANCE COMPANY, THE	16,481	0.03%	$137K	+1,321 (+8.7%)
125	Walleye Capital LLC	16,319	0.02%	$136K	NEW
126	VICTORY CAPITAL MANAGEMENT INC	16,170	0.02%	$134K	+2,970 (+22.5%)
127	Campbell & CO Investment Adviser LLC	15,981	0.02%	$133K	NEW
128	MERCER GLOBAL ADVISORS INC /ADV	15,935	0.02%	$132K	+3,689 (+30.1%)
129	Arax Advisory Partners	15,814	0.02%	$131K	+15,369 (+3453.7%)
130	Vanguard Investments Australia, Ltd.	15,727	0.02%	$131K	—
131	Y-Intercept (Hong Kong) Ltd	15,714	0.02%	$131K	-157,094 (-90.9%)
132	NEW YORK STATE COMMON RETIREMENT FUND	15,425	0.02%	$128K	-3,990 (-20.6%)
133	State of Wyoming	15,060	0.02%	$125K	NEW
134	ARIZONA STATE RETIREMENT SYSTEM	15,001	0.02%	$125K	+6 (+0.0%)
135	Police & Firemen's Retirement System of New Jersey	14,906	0.02%	$124K	—
136	PORTLAND INVESTMENT COUNSEL INC.	14,000	0.02%	$116K	—
137	CANADA PENSION PLAN INVESTMENT BOARD	13,500	0.02%	$112K	-1,000 (-6.9%)
138	KLP KAPITALFORVALTNING AS	13,300	0.02%	$111K	—
139	Aigen Investment Management, LP	13,152	0.02%	$109K	NEW
140	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	12,544	0.02%	$104K	NEW
141	Pale Fire Capital SE	11,951	0.02%	$99K	NEW
142	Corient Private Wealth LP	11,945	0.02%	$99K	+1,637 (+15.9%)
143	Ensign Peak Advisors, Inc	11,820	0.02%	$98K	+4,950 (+72.1%)
144	STATE OF WISCONSIN INVESTMENT BOARD	11,477	0.02%	$95K	+1,075 (+10.3%)
145	China Universal Asset Management Co., Ltd.	10,269	0.02%	$85K	-4,681 (-31.3%)
146	XTX Topco Ltd	10,224	0.02%	$85K	-32,433 (-76.0%)
147	Quantbot Technologies LP	10,197	0.02%	$85K	NEW
148	PRUDENTIAL FINANCIAL INC	10,050	0.02%	$84K	NEW
149	Balyasny Asset Management L.P.	6,273	0.01%	$52K	NEW
150	CANADA LIFE ASSURANCE Co	5,092	0.01%	$42K	—
151	Ameritas Investment Partners, Inc.	4,550	0.01%	$38K	—
152	PNC Financial Services Group, Inc.	3,379	0.01%	$28K	-179 (-5.0%)
153	ROYAL BANK OF CANADA	3,187	0.00%	$27K	+2,893 (+984.0%)
154	NISA INVESTMENT ADVISORS, LLC	2,927	0.00%	$24K	+169 (+6.1%)
155	Mirae Asset Global Investments Co., Ltd.	2,886	0.00%	$24K	-450 (-13.5%)
156	Tower Research Capital LLC (TRC)	2,351	0.00%	$20K	-684 (-22.5%)
157	EverSource Wealth Advisors, LLC	1,981	0.00%	$16K	+233 (+13.3%)
158	Steward Partners Investment Advisory, LLC	1,600	0.00%	$13K	—
159	Essential Partners LLC	1,554	0.00%	$13K	-361 (-18.9%)
160	Evelyn Partners Group Ltd	1,474	0.00%	$12K	NEW
161	GF FUND MANAGEMENT CO. LTD.	1,356	0.00%	$11K	-78 (-5.4%)
162	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	1,125	0.00%	$9K	+48 (+4.5%)
163	Sterling Capital Management LLC	1,102	0.00%	$9K	-590 (-34.9%)
164	Allworth Financial LP	1,019	0.00%	$8K	-112 (-9.9%)
165	Towne Trust Company, N.A	1,000	0.00%	$8K	—
166	Global Retirement Partners, LLC	1,000	0.00%	$8K	NEW
167	Nykredit A/S	982	0.00%	$8K	NEW
168	Versant Capital Management, Inc	925	0.00%	$8K	+274 (+42.1%)
169	ATLAS CAPITAL ADVISORS INC.	655	0.00%	$5K	—
170	GAMMA Investing LLC	640	0.00%	$5K	-382 (-37.4%)
171	Atlantic Private Wealth, LLC	577	0.00%	$5K	—
172	MassMutual Private Wealth & Trust, FSB	535	0.00%	$4K	-60 (-10.1%)
173	IFP Advisors, Inc	516	0.00%	$4K	+103 (+24.9%)
174	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	510	0.00%	$4K	NEW
175	Owl Creek Wealth Partners LLC	510	0.00%	$4K	-110 (-17.7%)
176	HUNTINGTON NATIONAL BANK	504	0.00%	$4K	—
177	Rockefeller Capital Management L.P.	420	0.00%	$3K	-5,245 (-92.6%)
178	SBI Securities Co., Ltd.	373	0.00%	$3K	+58 (+18.4%)
179	JONES FINANCIAL COMPANIES LLLP	371	0.00%	$3K	+215 (+137.8%)
180	ROTHSCHILD INVESTMENT LLC	311	0.00%	$3K	+49 (+18.7%)
181	OSAIC HOLDINGS, INC.	306	0.00%	$3K	-6,940 (-95.8%)
182	Farther Finance Advisors, LLC	304	0.00%	$3K	+121 (+66.1%)
183	SJS Investment Consulting Inc.	257	0.00%	$2K	NEW
184	US BANCORP \DE\	209	0.00%	$2K	-672 (-76.3%)
185	HARBOUR INVESTMENTS, INC.	200	0.00%	$2K	—
186	Parallel Advisors, LLC	157	0.00%	$1K	-1,364 (-89.7%)
187	True Wealth Design, LLC	146	0.00%	$1K	+6 (+4.3%)
188	Optiver Holding B.V.	136	0.00%	$1K	-160 (-54.1%)
189	Cornerstone Planning Group LLC	119	0.00%	$983	—
190	SIGNATUREFD, LLC	99	0.00%	$823	-436 (-81.5%)
191	Private Wealth Management Group, LLC	97	0.00%	$807	-61 (-38.6%)
192	FNY Investment Advisers, LLC	80	0.00%	$0	NEW
193	Parkside Financial Bank & Trust	75	0.00%	$624	—
194	Basecamp Wealth Advisors LLC	31	0.00%	$258	—
195	CHILTON CAPITAL MANAGEMENT LLC	27	0.00%	$225	—
196	Covestor Ltd	22	0.00%	$0	+16 (+266.7%)
197	Bell Investment Advisors, Inc	11	0.00%	$92	—
198	Clearstead Advisors, LLC	11	0.00%	$92	NEW
199	Silver Grove Financial Group, Inc.	7	0.00%	$58	NEW
200	Capital Advisors, Ltd. LLC	6	0.00%	$0	—
201	Leonteq Securities AG	2	0.00%	$17	—

Exited since 2026-03-31 (41 filers; largest 25 shown)

Vestal Point Capital, LP	−905,465
TANG CAPITAL MANAGEMENT LLC	−538,658
SUPERSTRING CAPITAL MANAGEMENT LP	−312,620
Brummer Multi-Strategy AB	−285,076
WASATCH ADVISORS LP	−281,857
NOMURA HOLDINGS INC	−253,609
JANE STREET GROUP, LLC	−199,908
J. Goldman & Co LP	−156,799
Trexquant Investment LP	−146,387
SG Americas Securities, LLC	−86,231
Voleon Capital Management LP	−75,537
MARSHALL WACE, LLP	−75,163
PLATINUM INVESTMENT MANAGEMENT LTD	−72,527
ZACKS INVESTMENT MANAGEMENT	−66,978
Allspring Global Investments Holdings, LLC	−51,923
Weiss Asset Management LP	−36,305
TUDOR INVESTMENT CORP ET AL	−34,298
VARCOV Co.	−30,591
JANUS HENDERSON GROUP PLC	−23,365
CWM, LLC	−20,167
Quantedge Capital Pte Ltd	−15,600
AXQ CAPITAL, LP	−14,073
Numerai GP LLC	−11,547
ProShare Advisors LLC	−10,920
Freestone Grove Partners LP	−4,517

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
David E. Shaw	SCHEDULE 13G/A	2026-08-14	2026-06-30	3,495,153	5.4%
D. E. Shaw & Co., L.L.C.	SCHEDULE 13G/A	2026-08-14	2026-06-30	3,050,971	4.7%
D. E. Shaw & Co., L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	3,495,153	5.4%
Vanguard Portfolio Management	SCHEDULE 13G	2026-04-28	2026-03-31	3,917,671	6.12%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Kenneth Griffin	SCHEDULE 13G/A	2025-11-14	2025-09-30	264,243	0.4%
Citadel Advisors Holdings LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	143,315	0.2%
Citadel Advisors LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	143,315	0.2%
Citadel GP LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	143,315	0.2%
Citadel Securities GP LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	120,928	0.2%
Citadel Securities Group LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	120,928	0.2%
Citadel Securities LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	120,928	0.2%
Logos GP LLC	SCHEDULE 13D/A	2025-10-15	2025-10-13	2,000,000	2.7%
Graham Walmsley	SCHEDULE 13D/A	2025-10-15	2025-10-13	500,000	0.7%
Logos Global Management GP LLC	SCHEDULE 13D/A	2025-10-15	2025-10-13	2,500,000	3.4%
Logos Global Management LP	SCHEDULE 13D/A	2025-10-15	2025-10-13	2,500,000	3.4%
Logos Global Master Fund LP	SCHEDULE 13D/A	2025-10-15	2025-10-13	2,000,000	2.7%
Arsani William	SCHEDULE 13D/A	2025-10-15	2025-10-13	2,500,000	3.4%
Logos Opportunities Fund IV GP LLC	SCHEDULE 13D/A	2025-10-15	2025-10-13	500,000	0.7%
Logos Opportunities Fund IV LP	SCHEDULE 13D/A	2025-10-15	2025-10-13	500,000	0.7%
T. Rowe Price Associates, Inc.	SCHEDULE 13G/A	2025-08-14	2025-06-30	1,333,977	1.9%
EcoR1 Capital, LLC	SCHEDULE 13G/A	2025-05-15	2025-03-31	0	0%
Oleg Nodelman	SCHEDULE 13G/A	2025-05-15	2025-03-31	0	0%
EcoR1 Capital Fund Qualified, L.P.	SCHEDULE 13G/A	2025-05-15	2025-03-31	0	0%
BlackRock, Inc.	SCHEDULE 13G/A	2025-04-17	2025-03-31	5,422,796	7.9%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.