Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

Annexon, Inc.

CIK 0001528115ANNX· quarter ending 2026-06-30

Shares outstanding

204,444,933

as of 2026-08-10 · 10-Q cover page, filed 2026-08-12

Held by 13F filers

178,374,017

across share classes — see % per class below

Holders

216

-1 vs 2026-03-31 · 31 new, 32 exited

Value

$1.0B

shares +14.4% vs prior quarter

Share classes (cover page of the 10-Q filed 2026-08-12, as of 2026-08-10)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	CUSIP
Common Stock	—	189,579,134	—	—
Prefunded Warrant	—	14,865,799	—	—
Not matched to a class			178,374,017	—	03589W102

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	03589W102	COM	216	178,374,017	—	—	$1.0B	7 call / 3 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (216 of 216 · 03589W102)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	FMR LLC	19,518,496	—	$111.5M	+8,882,848 (+83.5%)
2	BlackRock, Inc.	13,539,744	—	$77.3M	+2,601,235 (+23.8%)
3	Redmile Group, LLC	11,869,877	—	$67.8M	-2,679,891 (-18.4%)
4	STATE STREET CORP	9,824,321	—	$56.1M	+2,905,066 (+42.0%)
5	BVF INC/IL	8,698,173	—	$49.7M	—
6	Woodline Partners LP	6,925,067	—	$39.5M	+4,587,930 (+196.3%)
7	VANGUARD CAPITAL MANAGEMENT LLC	6,871,015	—	$39.2M	+914,426 (+15.4%)
8	MAK CAPITAL ONE LLC	5,862,180	—	$33.5M	+1,138,137 (+24.1%)
9	GOLDMAN SACHS GROUP INC	5,825,579	—	$33.3M	+3,672,699 (+170.6%)
10	Siren, L.L.C.	4,458,646	—	$25.5M	+500,000 (+12.6%)
11	Bain Capital Life Sciences Investors, LLC	4,437,731	—	$25.3M	-774,943 (-14.9%)
12	Bellevue Group AG	4,100,016	—	$23.4M	-1,057,274 (-20.5%)
13	GEODE CAPITAL MANAGEMENT, LLC	4,037,193	—	$23.1M	+659,370 (+19.5%)
14	MPM BIOIMPACT LLC	3,544,354	—	$20.2M	NEW
15	AMERIPRISE FINANCIAL INC	3,509,623	—	$20.0M	+60,502 (+1.8%)
16	ADAGE CAPITAL PARTNERS GP, L.L.C.	3,500,000	—	$20.0M	-800,000 (-18.6%)
17	GREAT POINT PARTNERS LLC	3,500,000	—	$20.0M	+1,000,000 (+40.0%)
18	MORGAN STANLEY	3,144,453	—	$18.0M	+408,483 (+14.9%)
19	Palo Alto Investors LP	2,948,090	—	$16.8M	—
20	Balyasny Asset Management L.P.	2,830,976	—	$16.2M	-1,055,933 (-27.2%)
21	Nuveen, LLC	2,765,080	—	$15.8M	-1,481,250 (-34.9%)
22	Qube Research & Technologies Ltd	2,749,961	—	$15.7M	-364,353 (-11.7%)
23	VANGUARD PORTFOLIO MANAGEMENT LLC	2,246,800	—	$12.8M	+763,710 (+51.5%)
24	Opaleye Management Inc.	1,714,451	—	$9.8M	-617,310 (-26.5%)
25	Logos Global Management LP	1,500,000	—	$8.6M	NEW
26	DIMENSIONAL FUND ADVISORS LP	1,497,756	—	$8.6M	+573,678 (+62.1%)
27	Point72 Asset Management, L.P.	1,382,699	—	$7.9M	-489,096 (-26.1%)
28	NORTHERN TRUST CORP	1,352,046	—	$7.7M	+265,144 (+24.4%)
29	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,257,799	—	$7.2M	+155,354 (+14.1%)
30	Tetragon Partners GP Ltd	1,242,455	—	$7.1M	-50,000 (-3.9%)
31	Candriam S.C.A.	1,195,142	—	$6.8M	NEW
32	MILLENNIUM MANAGEMENT LLC	1,184,931	—	$6.8M	-53,747 (-4.3%)
33	VANGUARD FIDUCIARY TRUST CO	1,105,450	—	$6.3M	+216,898 (+24.4%)
34	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1,037,366	—	$5.9M	+133,998 (+14.8%)
35	JPMORGAN CHASE & CO	1,004,308	—	$5.6M	+680,414 (+210.1%)
36	WELLS FARGO & COMPANY/MN	978,055	—	$5.6M	+279,316 (+40.0%)
37	PANAGORA ASSET MANAGEMENT INC	967,926	—	$5.5M	NEW
38	KENNEDY CAPITAL MANAGEMENT LLC	898,394	—	$5.1M	-13,929 (-1.5%)
39	Ishara Investments LP	820,000	—	$4.7M	+645,750 (+370.6%)
40	Ensign Peak Advisors, Inc	800,516	—	$4.6M	+175,419 (+28.1%)
41	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	737,935	—	$4.2M	NEW
42	Y-Intercept (Hong Kong) Ltd	734,585	—	$4.2M	-585,328 (-44.3%)
43	Russell Investments Group, Ltd.	705,291	—	$4.0M	-6,089 (-0.9%)
44	AQR CAPITAL MANAGEMENT LLC	691,812	—	$4.0M	-85,441 (-11.0%)
45	Parkman Healthcare Partners LLC	641,029	—	$3.7M	-32,984 (-4.9%)
46	ACADIAN ASSET MANAGEMENT LLC	629,127	—	$3.6M	-129,105 (-17.0%)
47	UBS Group AG	623,094	—	$3.6M	-622,847 (-50.0%)
48	DEUTSCHE BANK AG\	616,489	—	$3.5M	+54,308 (+9.7%)
49	BANK OF AMERICA CORP /DE/	614,186	—	$3.5M	-3,645,809 (-85.6%)
50	CITADEL ADVISORS LLC	596,582	—	$3.4M	-3,553 (-0.6%)
51	DEERFIELD MANAGEMENT COMPANY, L.P.	583,913	—	$3.3M	—
52	SIRIOS CAPITAL MANAGEMENT L P	569,276	—	$3.3M	-5,787 (-1.0%)
53	Schonfeld Strategic Advisors LLC	533,567	—	$3.0M	+410,285 (+332.8%)
54	TWO SIGMA INVESTMENTS, LP	512,796	—	$2.9M	+41,405 (+8.8%)
55	Hennion & Walsh Asset Management, Inc.	507,050	—	$2.9M	-2,639 (-0.5%)
56	Bank of New York Mellon Corp	501,442	—	$2.9M	+106,423 (+26.9%)
57	Board of Trustees of The Leland Stanford Junior University	482,550	—	$2.8M	—
58	RENAISSANCE TECHNOLOGIES LLC	459,000	—	$2.6M	-85,300 (-15.7%)
59	Ikarian Capital, LLC	430,244	—	$2.5M	-150,000 (-25.9%)
60	MOORE CAPITAL MANAGEMENT, LP	425,332	—	$2.4M	NEW
61	Trexquant Investment LP	409,667	—	$2.3M	+6,010 (+1.5%)
62	WELLINGTON MANAGEMENT GROUP LLP	406,795	—	$2.3M	-114,584 (-22.0%)
63	Susquehanna Portfolio Strategies, LLC	395,230	—	$2.3M	+34,911 (+9.7%)
64	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	394,600	—	$2.3M	-22,098 (-5.3%)
65	Invesco Ltd.	330,729	—	$1.9M	-432,276 (-56.7%)
66	Engineers Gate Manager LP	319,057	—	$1.8M	+144,916 (+83.2%)
67	DAFNA Capital Management LLC	297,812	—	$1.7M	+180,000 (+152.8%)
68	Jump Financial, LLC	297,800	—	$1.7M	NEW
69	STATE OF WISCONSIN INVESTMENT BOARD	286,375	—	$1.6M	+236,629 (+475.7%)
70	D. E. Shaw & Co., Inc.	265,284	—	$1.5M	-437,515 (-62.3%)
71	VOLORIDGE INVESTMENT MANAGEMENT, LLC	250,025	—	$1.4M	-212,043 (-45.9%)
72	Swiss National Bank	244,600	—	$1.4M	+8,600 (+3.6%)
73	CITIGROUP INC	235,990	—	$1.3M	+205,173 (+665.8%)
74	Cinctive Capital Management LP	215,748	—	$1.2M	-52,892 (-19.7%)
75	MARSHALL WACE, LLP	210,607	—	$1.2M	-650,868 (-75.6%)
76	RHUMBLINE ADVISERS	189,578	—	$1.1M	+29,908 (+18.7%)
77	SEI INVESTMENTS CO	183,817	—	$1.0M	-19,419 (-9.6%)
78	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	180,647	—	$1.0M	+50,000 (+38.3%)
79	Squarepoint Ops LLC	173,285	—	$989K	+105,329 (+155.0%)
80	Rafferty Asset Management, LLC	173,279	—	$989K	-29,990 (-14.8%)
81	OSAIC HOLDINGS, INC.	147,624	—	$843K	+146,355 (+11533.1%)
82	ALLIANCEBERNSTEIN L.P.	147,240	—	$816K	+28,190 (+23.7%)
83	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	134,259	—	$767K	+127,086 (+1771.7%)
84	PRICE T ROWE ASSOCIATES INC /MD/	129,243	—	$738K	-299,477 (-69.9%)
85	VICTORY CAPITAL MANAGEMENT INC	127,338	—	$727K	+11,811 (+10.2%)
86	BOOTHBAY FUND MANAGEMENT, LLC	120,129	—	$686K	-46,035 (-27.7%)
87	IEQ CAPITAL, LLC	120,010	—	$685K	-75,754 (-38.7%)
88	J. Goldman & Co LP	116,046	—	$663K	-54,771 (-32.1%)
89	XTX Topco Ltd	112,147	—	$640K	+31,652 (+39.3%)
90	GSA CAPITAL PARTNERS LLP	104,378	—	$596K	+72,684 (+229.3%)
91	Vanguard Global Advisers, LLC	102,067	—	$583K	+48,013 (+88.8%)
92	Quarry LP	100,000	—	$571K	+78,750 (+370.6%)
93	SCS Capital Management LLC	99,000	—	$565K	—
94	Legal & General Group Plc	98,118	—	$560K	+18,072 (+22.6%)
95	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	91,661	—	$521K	+15,404 (+20.2%)
96	MetLife Investment Management, LLC	91,005	—	$520K	+18,561 (+25.6%)
97	J. Safra Sarasin Holding AG	90,487	—	$517K	—
98	Zurcher Kantonalbank (Zurich Cantonalbank)	88,518	—	$505K	+34,651 (+64.3%)
99	CAPTRUST FINANCIAL ADVISORS	87,909	—	$502K	+8,736 (+11.0%)
100	PROFUND ADVISORS LLC	87,509	—	$500K	-3,450 (-3.8%)
101	VANGUARD ASSET MANAGEMENT, Ltd	79,486	—	$454K	—
102	DNB Asset Management AS	73,147	—	$418K	-15,470 (-17.5%)
103	Virtus Investment Advisers, LLC	69,468	—	$397K	+14,602 (+26.6%)
104	Jain Global LLC	64,719	—	$370K	NEW
105	China Universal Asset Management Co., Ltd.	62,076	—	$354K	+4,393 (+7.6%)
106	LOS ANGELES CAPITAL MANAGEMENT LLC	62,073	—	$354K	—
107	DIVERSIFIED TRUST CO	61,797	—	$353K	NEW
108	Jupiter Topco LLC	59,100	—	$338K	NEW
109	VIRGINIA RETIREMENT SYSTEMS ET Al	54,300	—	$310K	NEW
110	WINTON GROUP Ltd	47,800	—	$273K	+23,700 (+98.3%)
111	JUPITER ASSET MANAGEMENT LTD	46,074	—	$263K	NEW
112	Creative Planning	45,950	—	$262K	+27 (+0.1%)
113	Police & Firemen's Retirement System of New Jersey	45,813	—	$262K	+9,785 (+27.2%)
114	Universal- Beteiligungs- und Servicegesellschaft mbH	44,706	—	$255K	NEW
115	JACOBS LEVY EQUITY MANAGEMENT, INC	44,485	—	$254K	-104,456 (-70.1%)
116	Allegheny Financial Group	42,900	—	$245K	—
117	SG Americas Securities, LLC	42,823	—	$245K	NEW
118	BARCLAYS PLC	41,715	—	$238K	+17,424 (+71.7%)
119	MANUFACTURERS LIFE INSURANCE COMPANY, THE	41,517	—	$237K	-93,269 (-69.2%)
120	DRW Securities, LLC	39,443	—	$225K	-15,041 (-27.6%)
121	State of New Jersey Common Pension Fund D	39,409	—	$225K	-1,344 (-3.3%)
122	SUSQUEHANNA INTERNATIONAL GROUP, LLP	39,394	—	$225K	-119,246 (-75.2%)
123	BNP PARIBAS FINANCIAL MARKETS	39,255	—	$224K	-216,116 (-84.6%)
124	FIFTH THIRD BANCORP	38,640	—	$221K	+3,242 (+9.2%)
125	CANADA PENSION PLAN INVESTMENT BOARD	38,600	—	$220K	-2,200 (-5.4%)
126	NEW YORK STATE COMMON RETIREMENT FUND	36,568	—	$209K	+7,000 (+23.7%)
127	Vanguard Investments Australia, Ltd.	35,034	—	$200K	—
128	ARIZONA STATE RETIREMENT SYSTEM	33,630	—	$192K	+877 (+2.7%)
129	Blueshift Asset Management, LLC	33,338	—	$190K	NEW
130	PRELUDE CAPITAL MANAGEMENT, LLC	31,642	—	$181K	+9,442 (+42.5%)
131	VOYA INVESTMENT MANAGEMENT LLC	30,870	—	$176K	+8,643 (+38.9%)
132	Lido Advisors, LLC	30,843	—	$176K	-157 (-0.5%)
133	EntryPoint Capital, LLC	30,787	—	$176K	-20,634 (-40.1%)
134	INTECH INVESTMENT MANAGEMENT LLC	29,929	—	$171K	—
135	Bridgefront Capital, LLC	28,528	—	$163K	NEW
136	Quadrature Capital Ltd	27,863	—	$159K	+10,960 (+64.8%)
137	DIADEMA PARTNERS LP	27,516	—	$157K	-105,400 (-79.3%)
138	KLP KAPITALFORVALTNING AS	26,300	—	$150K	—
139	ProShare Advisors LLC	25,711	—	$147K	+116 (+0.5%)
140	Verdad Advisers, LP	25,300	—	$144K	-27,977 (-52.5%)
141	Brevan Howard Capital Management LP	25,287	—	$144K	-33,146 (-56.7%)
142	AlphaCentric Advisors LLC	24,872	—	$142K	+354 (+1.4%)
143	PRUDENTIAL FINANCIAL INC	24,850	—	$142K	+4,670 (+23.1%)
144	E Fund Management Co., Ltd.	24,433	—	$140K	-1,119 (-4.4%)
145	Crown Wealth Group, LLC	23,763	—	$136K	NEW
146	SBI Securities Co., Ltd.	23,225	—	$133K	—
147	RAYMOND JAMES FINANCIAL INC	22,869	—	$131K	+3,500 (+18.1%)
148	CANADA LIFE ASSURANCE Co	21,646	—	$124K	—
149	Cygnus Capital Advisors, LLC	21,549	—	$123K	-651 (-2.9%)
150	STRS OHIO	21,200	—	$121K	-34,300 (-61.8%)
151	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	21,010	—	$120K	NEW
152	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	20,813	—	$119K	-699 (-3.2%)
153	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	20,253	—	$117K	-1,679 (-7.7%)
154	Cambridge Investment Research Advisors, Inc.	20,220	—	$116K	+10,110 (+100.0%)
155	Corient Private Wealth LP	19,704	—	$113K	—
156	State of Wyoming	19,479	—	$111K	NEW
157	MERCER GLOBAL ADVISORS INC /ADV	17,077	—	$98K	-1,637 (-8.7%)
158	Coastal Bridge Advisors, LLC	17,000	—	$97K	—
159	Pictet Asset Management Holding SA	16,701	—	$95K	—
160	Mariner, LLC	16,469	—	$94K	-36,773 (-69.1%)
161	LPL Financial LLC	15,809	—	$90K	+2,595 (+19.6%)
162	Balefire, LLC	15,011	—	$86K	+11 (+0.1%)
163	DLD Asset Management, LP	15,000	—	$86K	NEW
164	XPONANCE LLC	14,865	—	$85K	+3,659 (+32.7%)
165	Forefront Analytics, LLC	14,240	—	$81K	—
166	TEACHER RETIREMENT SYSTEM OF TEXAS	14,233	—	$81K	-866 (-5.7%)
167	Ameritas Investment Partners, Inc.	14,097	—	$80K	+3,307 (+30.6%)
168	Private Advisor Group, LLC	14,020	—	$80K	NEW
169	Cerity Partners LLC	13,867	—	$79K	-4,112 (-22.9%)
170	BRIDGEWAY CAPITAL MANAGEMENT, LLC	12,800	—	$73K	-85,000 (-86.9%)
171	Tower Research Capital LLC (TRC)	12,786	—	$73K	+109 (+0.9%)
172	Vanguard Personalized Indexing Management, LLC	12,488	—	$71K	-448 (-3.5%)
173	Quantinno Capital Management LP	12,263	—	$70K	NEW
174	PRINCIPAL FINANCIAL GROUP INC	11,876	—	$68K	NEW
175	Merit Financial Group, LLC	11,103	—	$63K	+358 (+3.3%)
176	FOX RUN MANAGEMENT, L.L.C.	10,920	—	$62K	-6,758 (-38.2%)
177	NISA INVESTMENT ADVISORS, LLC	10,779	—	$62K	+3,366 (+45.4%)
178	MOUNT VERNON ASSOCIATES INC /MD/	10,500	—	$60K	—
179	GROUP ONE TRADING LLC	10,087	—	$58K	NEW
180	Fulcrum Asset Management LLP	10,070	—	$56K	NEW
181	Shay Capital LLC	10,000	—	$57K	—
182	Harbor Advisors LLC	10,000	—	$57K	—
183	Arax Advisory Partners	7,684	—	$44K	+7,096 (+1206.8%)
184	Mirae Asset Global Investments Co., Ltd.	7,328	—	$42K	-221 (-2.9%)
185	Persistent Asset Partners Ltd	6,825	—	$39K	-26,800 (-79.7%)
186	Geneos Wealth Management Inc.	6,000	—	$34K	—
187	ROYAL BANK OF CANADA	5,395	—	$31K	+4,235 (+365.1%)
188	JONES FINANCIAL COMPANIES LLLP	3,565	—	$20K	—
189	GF FUND MANAGEMENT CO. LTD.	3,065	—	$18K	-169 (-5.2%)
190	Pacer Advisors, Inc.	2,894	—	$17K	NEW
191	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	2,024	—	$12K	-343 (-14.5%)
192	Larson Financial Group LLC	2,000	—	$11K	-16 (-0.8%)
193	Quantbot Technologies LP	1,562	—	$9K	+1,254 (+407.1%)
194	PNC Financial Services Group, Inc.	1,246	—	$7K	+114 (+10.1%)
195	Burnham & Co LLC	1,000	—	$6K	NEW
196	Allworth Financial LP	836	—	$5K	-225 (-21.2%)
197	Rockefeller Capital Management L.P.	786	—	$4K	-876 (-52.7%)
198	Farther Finance Advisors, LLC	738	—	$4K	-627 (-45.9%)
199	Essential Partners LLC	674	—	$4K	-418 (-38.3%)
200	GAMMA Investing LLC	570	—	$3K	+254 (+80.4%)
201	IFP Advisors, Inc	569	—	$3K	-76 (-11.8%)
202	EverSource Wealth Advisors, LLC	559	—	$3K	-32 (-5.4%)
203	Sterling Capital Management LLC	545	—	$3K	-3,823 (-87.5%)
204	Caitong International Asset Management Co., Ltd	497	—	$3K	-338 (-40.5%)
205	Fortitude Family Office, LLC	483	—	$3K	+396 (+455.2%)
206	Optiver Holding B.V.	406	—	$2K	-716 (-63.8%)
207	HighMark Wealth Management LLC	300	—	$2K	—
208	True Wealth Design, LLC	283	—	$2K	-39 (-12.1%)
209	Physician Wealth Advisors, Inc.	269	—	$2K	—
210	ROTHSCHILD INVESTMENT LLC	249	—	$1K	-188 (-43.0%)
211	Global Retirement Partners, LLC	181	—	$1K	NEW
212	NATIONAL BANK OF CANADA /FI/	67	—	$383	NEW
213	SJS Investment Consulting Inc.	20	—	$115	+3 (+17.6%)
214	Stone House Investment Management, LLC	16	—	$91	-4 (-20.0%)
215	Clearstead Advisors, LLC	15	—	$86	NEW
216	Silver Grove Financial Group, Inc.	1	—	$6	NEW

Exited since 2026-03-31 (32 filers; largest 25 shown)

Longaeva Partners L.P.	−620,401
SILVERARC CAPITAL MANAGEMENT, LLC	−496,461
Rosalind Advisors, Inc.	−200,000
ALGERT GLOBAL LLC	−154,840
Man Group plc	−109,222
Connor, Clark & Lunn Investment Management Ltd.	−92,707
POLEN CAPITAL MANAGEMENT LLC	−70,152
JANUS HENDERSON GROUP PLC	−59,100
AXQ CAPITAL, LP	−58,185
ADAR1 Capital Management, LLC	−55,000
BIT Capital GmbH	−50,000
JANE STREET GROUP, LLC	−47,120
CWM, LLC	−39,652
MIRABELLA FINANCIAL SERVICES LLP	−28,739
Virtu Financial LLC	−28,450
TD Asset Management Inc	−22,760
Scientech Research LLC	−17,316
ExodusPoint Capital Management, LP	−14,938
Vontobel Holding Ltd.	−14,511
Magnetar Financial LLC	−14,205
AMERICAN CENTURY COMPANIES INC	−12,463
nVerses Capital, LLC	−11,897
Abel Hall, LLC	−10,921
Integrated Wealth Concepts LLC	−10,232
Trask Adam Roland	−1,000

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
STATE STREET CORPORATION	SCHEDULE 13G	2026-08-07	2026-06-30	9,824,321	6%
BlackRock, Inc.	SCHEDULE 13G/A	2026-07-27	2026-06-30	13,128,281	8%
Redmile Group, LLC	SCHEDULE 13G/A	2026-07-08	2026-07-01	17,918,459	9.9%
RedCo II Offshore SPV LLC	SCHEDULE 13G/A	2026-07-08	2026-07-01	9,802,458	5.5%
Jeremy C. Green	SCHEDULE 13G/A	2026-07-08	2026-07-01	17,918,459	9.9%
FMR LLC	SCHEDULE 13G/A	2026-07-08	2026-06-30	19,518,496.35	11.9%
Abigail P. Johnson	SCHEDULE 13G/A	2026-07-08	2026-06-30	19,518,496.35	11.9%
BVF Partners OS Ltd.	SCHEDULE 13G/A	2026-05-15	2026-03-31	522,906	0.3%
BVF GP HOLDINGS LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	8,044,673	5%
BVF I GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,644,823	2.9%
BVF II GP LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,399,850	2.1%
BVF INC/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	8,698,173	5.4%
BVF PARTNERS L P/IL	SCHEDULE 13G/A	2026-05-15	2026-03-31	8,698,173	5.4%
BIOTECHNOLOGY VALUE FUND L P	SCHEDULE 13G/A	2026-05-15	2026-03-31	4,644,823	2.9%
BIOTECHNOLOGY VALUE FUND II LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	3,399,850	2.1%
LAMPERT MARK N	SCHEDULE 13G/A	2026-05-15	2026-03-31	8,698,173	5.4%
Biotechnology Value Trading Fund OS LP	SCHEDULE 13G/A	2026-05-15	2026-03-31	522,906	0.3%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Redmile Biopharma Investments II, L.P.	SCHEDULE 13G/A	2026-02-17	2025-12-31	7,288,917	4.7%
Satter Muneer A	SCHEDULE 13D/A	2025-11-21	2025-11-19	10,444,134	7.2%
Logos Global Management GP LLC	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
Logos GP LLC	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
Logos Global Master Fund LP	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
Logos Global Management LP	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
Arsani William	SCHEDULE 13G/A	2025-08-14	2025-06-30	0	0%
Point72 Asset Management, L.P.	SCHEDULE 13G/A	2025-05-15	2025-03-31	95,430	0.1%
Point72 Capital Advisors, Inc.	SCHEDULE 13G/A	2025-05-15	2025-03-31	95,430	0.1%
Steven A. Cohen	SCHEDULE 13G/A	2025-05-15	2025-03-31	95,430	0.1%
BCIP Life Sciences Associates, LP	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%
Bain Capital Life Sciences Fund, L.P.	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%
BCLS I Investco, LP	SCHEDULE 13G/A	2025-02-14	2024-12-31	5,249,069	4.9%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.