Novo A/S

Annual Report of Proxy Voting Record of Registered Management Investment Company

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Report of Holders of Securities

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Report of Holders of Securities

Annual Report of Proxy Voting Record of Registered Management Investment Company

Annual Report of Proxy Voting Record of Registered Management Investment Company

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S

Novo Holdings A/S