BAKER BROS. ADVISORS LP

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Annual Report of Proxy Voting Record of Registered Management Investment Company

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Report of Holders of Securities

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Annual Report of Proxy Voting Record of Registered Management Investment Company

Annual Report of Proxy Voting Record of Registered Management Investment Company

BAKER BROS. ADVISORS LP; BAKER JULIAN; BAKER FELIX; Baker Bros. Advisors (GP) LLC; Baker Brothers Life Sciences LP; 667, L.P.

BAKER JULIAN; BAKER FELIX; BAKER BROS. ADVISORS LP; Baker Bros. Advisors (GP) LLC; Baker Brothers Life Sciences LP; 667, L.P.

BAKER JULIAN; BAKER FELIX; BAKER BROS. ADVISORS LP; Baker Bros. Advisors (GP) LLC; Baker Brothers Life Sciences LP; 667, L.P.

BAKER JULIAN; BAKER FELIX; BAKER BROS. ADVISORS LP; Baker Bros. Advisors (GP) LLC; Baker Brothers Life Sciences LP; 667, L.P.

BAKER JULIAN; BAKER FELIX; BAKER BROS. ADVISORS LP; Baker Brothers Life Sciences LP; 667, L.P.; Baker Bros. Advisors (GP) LLC