ALNYLAM PHARMACEUTICALS, INC.

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Annual Report Scanned (Paper)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Annual report pursuant to Section 13 or 15(d)

Results of Operations and Financial Condition

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Results of Operations and Financial Condition

Other Events

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Entry into a Material Definitive Agreement

Entry into a Material Definitive Agreement

Other Events

General form for quarterly reports under Section 13 or 15(d)

Results of Operations and Financial Condition

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Letter from the SEC

Correspondence with the SEC

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year

Letter from the SEC

General form for quarterly reports under Section 13 or 15(d)

Financial Statements and Exhibits

Additional Information for Proxy Statement/ Votes

Annual Report Scanned (Paper)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Other Events

Preliminary Proxy Statement

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers

Annual report pursuant to Section 13 or 15(d)

Financial Statements and Exhibits

2.02

General form for quarterly reports under Section 13 or 15(d)

Letter from the SEC

Correspondence with the SEC

Letter from the SEC

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Annual Report Scanned (Paper)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Annual report pursuant to Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Annual Report Scanned (Paper)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Annual report pursuant to Section 13 or 15(d)

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

No description available

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

Annual report pursuant to Section 13 or 15(d)

General form for quarterly reports under Section 13 or 15(d)

Definitive Proxy Statement

Additional Information for Proxy Statement/ Votes

No description available

No description available

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Automatic Shelf Registration

Additional Information for Proxy Statement/ Votes

Definitive Proxy Statement

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

No description available

No description available

No description available

No description available

No description available

Additional Information for Proxy Statement/ Votes

Additional Information for Proxy Statement/ Votes

Letter from the SEC

Definitive Proxy Statement

No description available

Prospectus Supplement for Primary Offering

Prospectus Supplement for Primary Offering

No description available

Post Effective Amendment to S-8

Post Effective Amendment to S-8

Post Effective Amendment to S-8

Post Effective Amendment to S-8

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Prospectus Supplement for Primary Offering

Prospectus Supplement for Primary Offering

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Prospectus Supplement for Primary Offering

Prospectus Supplement for Primary Offering

Automatic Shelf Registration

Registration statement under Securities Act of 1933 to be offered to employees pursuant to certain plans

Certification of termination of registration of a class of securities (Section 12(b))

SUPRAN BRYAN

SUPRAN BRYAN

Greenstreet Yvonne

Cravatt Benjamin

PYOTT DAVID E I

Cravatt Benjamin

PYOTT DAVID E I

PYOTT DAVID E I

SCHULMAN AMY W

Reitan Colleen F

Sigal Charles Elliott

KELLOGG PETER N

HAMBURG MARGARET A

BRANDICOURT OLIVIER

Ausiello Dennis A

Arbuckle Stuart A

SCHULMAN AMY W