BVF INC/IL

Annual Report of Proxy Voting Record of Registered Management Investment Company

Report of Holders of Securities

Report of Holders of Securities

Report of Holders of Securities

Report of Holders of Securities

Annual Report of Proxy Voting Record of Registered Management Investment Company

Report of Holders of Securities

Annual Report of Proxy Voting Record of Registered Management Investment Company

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N

LAMPERT MARK N; BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; BVF GP HOLDINGS LLC; BVF Partners OS Ltd.; Biotechnology Value Trading Fund OS LP; BVF I GP LLC; BVF II GP LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

LAMPERT MARK N; BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N