ORBIMED ADVISORS LLC

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Beneficial ownership report for a holder of more than 5% (Schedule 13D) (amendment)

Annual Report of Proxy Voting Record of Registered Management Investment Company

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a holder of more than 5% (Schedule 13D)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Annual Report of Proxy Voting Record of Registered Management Investment Company

Annual Report of Proxy Voting Record of Registered Management Investment Company

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

No description available

No description available

No description available

Shareholder Letter

Shareholder Letter

Shareholder Letter

Shareholder Letter

Shareholder Letter

Shareholder Letter

ORBIMED ADVISORS LLC; OrbiMed Israel GP II, L.P.; OrbiMed Genesis GP LLC; OrbiMed Capital GP VII LLC; OrbiMed Advisors Israel II Ltd

ORBIMED ADVISORS LLC; OrbiMed Israel GP II, L.P.; OrbiMed Advisors Israel II Ltd; OrbiMed Capital GP VII LLC

ORBIMED ADVISORS LLC; OrbiMed Capital GP VII LLC; OrbiMed Genesis GP LLC

ORBIMED ADVISORS LLC; OrbiMed Capital GP VII LLC; OrbiMed Genesis GP LLC