DEERFIELD MANAGEMENT CO

Annual Report of Proxy Voting Record of Registered Management Investment Company

Report of Holders of Securities

Report of Holders of Securities

Report of Holders of Securities

Report of Holders of Securities

Annual Report of Proxy Voting Record of Registered Management Investment Company

Report of Holders of Securities

Report of Holders of Securities

Annual Report of Proxy Voting Record of Registered Management Investment Company

DEERFIELD MANAGEMENT COMPANY, L.P.; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, L.P.; Flynn James E; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Private Design Fund IV, L.P.; Deerfield Mgmt IV, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P.; Flynn James E

DEERFIELD MANAGEMENT COMPANY, L.P.; Flynn James E; Deerfield Private Design Fund III, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt III, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P.; Flynn James E; Deerfield Private Design Fund III, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt III, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P.; Flynn James E

DEERFIELD MANAGEMENT COMPANY, L.P.; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, L.P.; Flynn James E; Deerfield Private Design Fund III, L.P.; Deerfield Mgmt IV, L.P.; Deerfield Mgmt III, L.P.; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Private Design Fund IV, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P.; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, L.P.; Flynn James E; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Private Design Fund IV, L.P.; Deerfield Mgmt IV, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P.; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, L.P.; Flynn James E; Deerfield Private Design Fund III, L.P.; Deerfield Mgmt IV, L.P.; Deerfield Mgmt III, L.P.; Deerfield Healthcare Innovations Fund, L.P.; Deerfield Mgmt HIF, L.P.; Deerfield Private Design Fund IV, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E; Deerfield Private Design Fund III, L.P.; Deerfield Mgmt IV, L.P.; Deerfield Mgmt III, L.P.; Deerfield Private Design Fund IV, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E; Deerfield Mgmt HIF, L.P.; Deerfield Mgmt V, L.P.; Deerfield Healthcare Innovations Fund II, L.P.; Deerfield Private Design Fund V, L.P.

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E

DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C); Flynn James E; Deerfield Mgmt HIF, L.P.; Deerfield Mgmt V, L.P.; Deerfield Healthcare Innovations Fund II, L.P.; Deerfield Private Design Fund V, L.P.