BIOTECHNOLOGY VALUE FUND L P

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Beneficial ownership report for a passive holder of more than 5% (Schedule 13G) (amendment)

Rule 506(b) provides a "safer harbor" for a private offering

<ITEMS>06b

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06b,3C,3C.1

06,3C,3C.1

06,3C,3C.1

06,3C,3C.7

06,3C,3C.7

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

No description available

No description available

Correspondence with the SEC

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

Additional proxy soliciting materials filed by a non-management party

No description available

No description available

Correspondence with the SEC

06

FILED AS OF DATE: 20030213

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; LAMPERT MARK N; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; BVF II GP LLC; BVF GP HOLDINGS LLC

BIOTECHNOLOGY VALUE FUND L P; BVF PARTNERS L P/IL; BVF INC/IL; BIOTECHNOLOGY VALUE FUND II LP; BVF II GP LLC; BVF GP HOLDINGS LLC; Biotechnology Value Trading Fund OS LP; BVF Partners OS Ltd.; BVF I GP LLC; LAMPERT MARK N