Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

BIOCRYST PHARMACEUTICALS INC

CIK 0000882796BCRX· quarter ending 2026-06-30

Shares outstanding

255,535,105

as of 2026-07-31 · 10-Q cover page, filed 2026-08-05

Held by 13F filers

263,847,035

103.3% of shares outstanding

Holders

319

+16 vs 2026-03-31 · 56 new, 40 exited

Value

$2.6B

shares +5.8% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-08-05, as of 2026-07-31)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	BCRX · NASDAQ	255,535,105	263,847,035	103.3%	319	09058V103

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	09058V103	COM	319	263,847,035	255,535,105	103.3%	$2.6B	8 call / 6 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (250 of 319 · 09058V103)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	BlackRock, Inc.	23,893,036	9.35%	$238.9M	+1,242,048 (+5.5%)
2	RA CAPITAL MANAGEMENT, L.P.	15,827,186	6.19%	$158.3M	—
3	STATE STREET CORP	15,191,098	5.94%	$151.9M	+2,982,738 (+24.4%)
4	DEERFIELD MANAGEMENT COMPANY, L.P.	15,096,403	5.91%	$151.0M	+58,403 (+0.4%)
5	VANGUARD CAPITAL MANAGEMENT LLC	11,364,236	4.45%	$113.6M	+228,474 (+2.1%)
6	VANGUARD PORTFOLIO MANAGEMENT LLC	11,139,158	4.36%	$111.4M	-105,467 (-0.9%)
7	TCG Crossover Management, LLC	11,020,968	4.31%	$110.2M	—
8	PERCEPTIVE ADVISORS LLC	10,308,888	4.03%	$103.1M	+2,874,855 (+38.7%)
9	Jupiter Topco LLC	9,540,764	3.73%	$95.3M	NEW
10	Vestal Point Capital, LP	8,300,000	3.25%	$83.0M	+1,275,000 (+18.1%)
11	TWO SIGMA INVESTMENTS, LP	6,775,349	2.65%	$67.8M	+382,721 (+6.0%)
12	GEODE CAPITAL MANAGEMENT, LLC	6,248,046	2.45%	$62.5M	+465,270 (+8.0%)
13	Aberdeen Group plc	5,310,871	2.08%	$53.1M	+270,201 (+5.4%)
14	UBS Group AG	5,078,280	1.99%	$50.8M	+134,286 (+2.7%)
15	BANK OF AMERICA CORP /DE/	4,801,284	1.88%	$48.0M	-290,481 (-5.7%)
16	GOLDMAN SACHS GROUP INC	4,481,874	1.75%	$44.8M	+2,134,431 (+90.9%)
17	Frazier Life Sciences Management, L.P.	4,009,240	1.57%	$40.1M	—
18	Nuveen, LLC	4,007,237	1.57%	$40.1M	+187,974 (+4.9%)
19	Nantahala Capital Management, LLC	3,802,320	1.49%	$38.0M	+1,814,923 (+91.3%)
20	MILLENNIUM MANAGEMENT LLC	3,394,729	1.33%	$33.9M	+3,207,008 (+1708.4%)
21	GW&K Investment Management, LLC	3,171,113	1.24%	$31.7M	-69,349 (-2.1%)
22	JANE STREET GROUP, LLC	2,762,683	1.08%	$27.6M	+2,140,076 (+343.7%)
23	DIMENSIONAL FUND ADVISORS LP	2,718,781	1.06%	$27.2M	+28,130 (+1.0%)
24	Fisher Asset Management, LLC	2,604,027	1.02%	$26.0M	-129,226 (-4.7%)
25	RENAISSANCE TECHNOLOGIES LLC	2,530,290	0.99%	$25.3M	+1,753,300 (+225.7%)
26	Kynam Capital Management, LP	2,522,660	0.99%	$25.2M	-3,158,135 (-55.6%)
27	Candriam S.C.A.	2,514,949	0.98%	$25.1M	+228,108 (+10.0%)
28	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	2,353,291	0.92%	$23.5M	+2,886 (+0.1%)
29	RICE HALL JAMES & ASSOCIATES, LLC	2,332,043	0.91%	$23.3M	+101,938 (+4.6%)
30	NORTHERN TRUST CORP	2,255,731	0.88%	$22.6M	+151,006 (+7.2%)
31	AQR CAPITAL MANAGEMENT LLC	2,214,302	0.87%	$22.1M	+1,774,161 (+403.1%)
32	MORGAN STANLEY	1,999,684	0.78%	$20.0M	-23,304 (-1.2%)
33	Eversept Partners, LP	1,865,653	0.73%	$18.7M	-1,174,167 (-38.6%)
34	ORBIMED ADVISORS LLC	1,852,000	0.72%	$18.5M	+426,800 (+29.9%)
35	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	1,844,912	0.72%	$18.4M	+617,872 (+50.4%)
36	STIFEL FINANCIAL CORP	1,826,234	0.71%	$18.3M	+1,050 (+0.1%)
37	VANGUARD FIDUCIARY TRUST CO	1,759,573	0.69%	$17.6M	+95,276 (+5.7%)
38	CITADEL ADVISORS LLC	1,759,160	0.69%	$17.6M	+740,417 (+72.7%)
39	JUPITER ASSET MANAGEMENT LTD	1,642,874	0.64%	$16.4M	+446,503 (+37.3%)
40	IMC-Chicago, LLC	1,634,336	0.64%	$16.3M	+1,003,046 (+158.9%)
41	Parkman Healthcare Partners LLC	1,624,279	0.64%	$16.2M	-83,820 (-4.9%)
42	Legal & General Group Plc	1,455,514	0.57%	$14.6M	+44,315 (+3.1%)
43	OP Asset Management Ltd	1,340,990	0.52%	$13.4M	+88,127 (+7.0%)
44	Pictet Asset Management Holding SA	1,249,771	0.49%	$12.0M	+778,198 (+165.0%)
45	Invesco Ltd.	1,233,783	0.48%	$12.3M	-75,030 (-5.7%)
46	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1,195,651	0.47%	$12.0M	-1,619,653 (-57.5%)
47	BNP PARIBAS FINANCIAL MARKETS	1,174,052	0.46%	$11.7M	-128,205 (-9.8%)
48	FIRST TRUST ADVISORS LP	1,120,469	0.44%	$11.2M	+319,569 (+39.9%)
49	HRT FINANCIAL LP	1,081,523	0.42%	$10.8M	NEW
50	MOORE CAPITAL MANAGEMENT, LP	848,336	0.33%	$8.5M	NEW
51	FMR LLC	808,903	0.32%	$8.1M	+175,771 (+27.8%)
52	ExodusPoint Capital Management, LP	744,917	0.29%	$7.4M	+554,859 (+291.9%)
53	Man Group plc	732,867	0.29%	$7.3M	-560,433 (-43.3%)
54	Rosalind Advisors, Inc.	721,504	0.28%	$7.2M	-201,553 (-21.8%)
55	Schonfeld Strategic Advisors LLC	710,816	0.28%	$7.1M	-626,877 (-46.9%)
56	Assenagon Asset Management S.A.	706,088	0.28%	$7.1M	+473,141 (+203.1%)
57	Bank of New York Mellon Corp	680,481	0.27%	$6.8M	+42,823 (+6.7%)
58	Jump Financial, LLC	569,956	0.22%	$5.7M	+460,547 (+420.9%)
59	DEUTSCHE BANK AG\	563,361	0.22%	$5.6M	-258,006 (-31.4%)
60	VOYA INVESTMENT MANAGEMENT LLC	538,813	0.21%	$5.4M	+2,509 (+0.5%)
61	JPMORGAN CHASE & CO	525,449	0.21%	$5.1M	-1,016,529 (-65.9%)
62	Elmind Capital, LP	520,000	0.20%	$5.2M	-480,000 (-48.0%)
63	Bridgewater Associates, LP	491,057	0.19%	$4.9M	-146,997 (-23.0%)
64	FRANKLIN RESOURCES INC	480,364	0.19%	$4.8M	-42,917 (-8.2%)
65	PRINCIPAL FINANCIAL GROUP INC	468,785	0.18%	$4.7M	+38,227 (+8.9%)
66	NAN FUNG TRINITY (HK) LTD	450,000	0.18%	$4.5M	NEW
67	SPHERA FUNDS MANAGEMENT LTD.	422,051	0.17%	$4.2M	-444,413 (-51.3%)
68	Swiss National Bank	415,268	0.16%	$4.2M	+6,600 (+1.6%)
69	D. E. Shaw & Co., Inc.	408,529	0.16%	$4.1M	+106,428 (+35.2%)
70	Susquehanna Portfolio Strategies, LLC	404,704	0.16%	$4.0M	+30,688 (+8.2%)
71	DAFNA Capital Management LLC	400,248	0.16%	$4.0M	-30,000 (-7.0%)
72	Hudson Bay Capital Management LP	400,000	0.16%	$4.0M	-90,369 (-18.4%)
73	WEDGE CAPITAL MANAGEMENT L L P/NC	380,801	0.15%	$3.8M	NEW
74	DOLIVER ADVISORS, LP	374,328	0.15%	$3.7M	—
75	Aquatic Capital Management LLC	362,895	0.14%	$3.6M	NEW
76	CITIGROUP INC	360,189	0.14%	$3.6M	+289,025 (+406.1%)
77	MACKENZIE FINANCIAL CORP	347,299	0.14%	$3.5M	+103,883 (+42.7%)
78	Phocas Financial Corp.	340,541	0.13%	$3.4M	+145,001 (+74.2%)
79	ALLIANCEBERNSTEIN L.P.	327,909	0.13%	$3.1M	+64,240 (+24.4%)
80	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	320,566	0.13%	$3.2M	-48,412 (-13.1%)
81	ALPS ADVISORS INC	317,960	0.12%	$3.2M	+257,710 (+427.7%)
82	PRICE T ROWE ASSOCIATES INC /MD/	305,897	0.12%	$3.1M	+74,901 (+32.4%)
83	WELLINGTON MANAGEMENT GROUP LLP	293,925	0.12%	$2.9M	+195,042 (+197.2%)
84	RHUMBLINE ADVISERS	279,839	0.11%	$2.8M	+13,702 (+5.1%)
85	NFJ INVESTMENT GROUP, LLC	278,792	0.11%	$2.8M	NEW
86	Rafferty Asset Management, LLC	265,618	0.10%	$2.7M	-88,642 (-25.0%)
87	Point72 Asset Management, L.P.	260,917	0.10%	$2.6M	NEW
88	WINTON GROUP Ltd	255,600	0.10%	$2.6M	+202,384 (+380.3%)
89	MARSHALL WACE, LLP	252,764	0.10%	$2.5M	+6,287 (+2.6%)
90	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	251,230	0.10%	$2.5M	-7,115 (-2.8%)
91	MARTINGALE ASSET MANAGEMENT L P	242,508	0.09%	$2.4M	+185,979 (+329.0%)
92	IEQ CAPITAL, LLC	227,421	0.09%	$2.3M	NEW
93	WELLS FARGO & COMPANY/MN	222,894	0.09%	$2.2M	-14,047 (-5.9%)
94	HUSSMAN STRATEGIC ADVISORS, INC.	210,000	0.08%	$2.1M	NEW
95	PFM Health Sciences, LP	207,357	0.08%	$2.1M	NEW
96	VANGUARD ASSET MANAGEMENT, Ltd	196,280	0.08%	$2.0M	—
97	TUDOR INVESTMENT CORP ET AL	195,128	0.08%	$2.0M	NEW
98	Engineers Gate Manager LP	175,002	0.07%	$1.8M	-19,473 (-10.0%)
99	Squarepoint Ops LLC	174,714	0.07%	$1.7M	+134,949 (+339.4%)
100	Janney Montgomery Scott LLC	163,267	0.06%	$1.6M	+1 (+0.0%)
101	QTR Family Wealth, LLC	161,082	0.06%	$1.6M	+4,020 (+2.6%)
102	Gotham Asset Management, LLC	156,421	0.06%	$1.6M	-156,540 (-50.0%)
103	RAYMOND JAMES FINANCIAL INC	155,544	0.06%	$1.6M	-4,987 (-3.1%)
104	Corient Private Wealth LP	150,447	0.06%	$1.5M	+54,980 (+57.6%)
105	SEI INVESTMENTS CO	145,683	0.06%	$1.5M	-4,581 (-3.0%)
106	NEW YORK STATE COMMON RETIREMENT FUND	138,657	0.05%	$1.4M	+24,894 (+21.9%)
107	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	138,083	0.05%	$1.4M	+6,923 (+5.3%)
108	Quantinno Capital Management LP	137,453	0.05%	$1.4M	+57,392 (+71.7%)
109	MetLife Investment Management, LLC	135,670	0.05%	$1.4M	+5,499 (+4.2%)
110	PROFUND ADVISORS LLC	134,034	0.05%	$1.3M	-24,428 (-15.4%)
111	Virtus Investment Advisers, LLC	133,664	0.05%	$1.3M	+22,135 (+19.8%)
112	ADAR1 Capital Management, LLC	133,000	0.05%	$1.3M	+28,000 (+26.7%)
113	Voleon Capital Management LP	132,206	0.05%	$1.3M	NEW
114	XTX Topco Ltd	125,833	0.05%	$1.3M	+101,071 (+408.2%)
115	OSAIC HOLDINGS, INC.	120,528	0.05%	$1.2M	+45,059 (+59.7%)
116	FIFTH THIRD BANCORP	119,942	0.05%	$1.2M	+119,458 (+24681.4%)
117	MANUFACTURERS LIFE INSURANCE COMPANY, THE	119,516	0.05%	$1.2M	+17,474 (+17.1%)
118	CANADA PENSION PLAN INVESTMENT BOARD	115,805	0.05%	$1.2M	-2,200 (-1.9%)
119	Hennion & Walsh Asset Management, Inc.	112,893	0.04%	$1.1M	-988 (-0.9%)
120	Mariner, LLC	110,478	0.04%	$1.1M	NEW
121	HSBC HOLDINGS PLC	109,320	0.04%	$1.1M	+77,821 (+247.1%)
122	STATE OF WISCONSIN INVESTMENT BOARD	108,114	0.04%	$1.1M	-170,950 (-61.3%)
123	Cetera Investment Advisers	107,162	0.04%	$1.1M	+58,749 (+121.3%)
124	Brevan Howard Capital Management LP	96,574	0.04%	$966K	+77,686 (+411.3%)
125	Elo Mutual Pension Insurance Co	95,962	0.04%	$960K	+39,913 (+71.2%)
126	EntryPoint Capital, LLC	95,427	0.04%	$954K	+77,866 (+443.4%)
127	Vanguard Global Advisers, LLC	92,513	0.04%	$925K	-5,738 (-5.8%)
128	SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	91,228	0.04%	$912K	NEW
129	GSA CAPITAL PARTNERS LLP	90,210	0.04%	$902K	NEW
130	STRS OHIO	89,100	0.03%	$891K	NEW
131	BARCLAYS PLC	86,481	0.03%	$865K	-47,116 (-35.3%)
132	VICTORY CAPITAL MANAGEMENT INC	84,506	0.03%	$845K	+58,150 (+220.6%)
133	Creative Planning	83,683	0.03%	$837K	+22,007 (+35.7%)
134	Jain Global LLC	82,952	0.03%	$830K	NEW
135	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	81,719	0.03%	$817K	+25,358 (+45.0%)
136	Cerity Partners LLC	75,908	0.03%	$759K	+64,754 (+580.5%)
137	Russell Investments Group, Ltd.	74,699	0.03%	$747K	-196,969 (-72.5%)
138	Cresset Asset Management, LLC	74,074	0.03%	$741K	-740 (-1.0%)
139	DekaBank Deutsche Girozentrale	73,765	0.03%	$699K	—
140	GROUP ONE TRADING LLC	72,749	0.03%	$727K	-63,533 (-46.6%)
141	Inspire Investing, LLC	68,979	0.03%	$690K	+15,100 (+28.0%)
142	Police & Firemen's Retirement System of New Jersey	68,674	0.03%	$687K	+4,684 (+7.3%)
143	State of New Jersey Common Pension Fund D	66,903	0.03%	$669K	-3,927 (-5.5%)
144	COMMONWEALTH EQUITY SERVICES, LLC	66,855	0.03%	$669K	+352 (+0.5%)
145	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	65,149	0.03%	$681K	+52,827 (+428.7%)
146	FRED ALGER MANAGEMENT, LLC	64,112	0.03%	$641K	-59,849 (-48.3%)
147	ACADIAN ASSET MANAGEMENT LLC	62,657	0.02%	$625K	-117,353 (-65.2%)
148	Marble Bar Asset Management LLP	62,339	0.02%	$623K	-32,049 (-34.0%)
149	Counterweight Ventures, LLC	62,050	0.02%	$621K	-33,334 (-34.9%)
150	MERCER GLOBAL ADVISORS INC /ADV	61,472	0.02%	$615K	+51,453 (+513.6%)
151	Edgestream Partners, L.P.	61,446	0.02%	$614K	NEW
152	Cannon Global Investment Management, LLC	59,700	0.02%	$597K	+33,100 (+124.4%)
153	Zurcher Kantonalbank (Zurich Cantonalbank)	59,668	0.02%	$597K	-149,235 (-71.4%)
154	Sanctuary Advisors, LLC	58,673	0.02%	$587K	+2,995 (+5.4%)
155	LPL Financial LLC	58,394	0.02%	$584K	+29,823 (+104.4%)
156	State of Wyoming	58,264	0.02%	$583K	-45,598 (-43.9%)
157	ARIZONA STATE RETIREMENT SYSTEM	57,093	0.02%	$571K	+166 (+0.3%)
158	Quinn Opportunity Partners LLC	55,400	0.02%	$554K	-15,400 (-21.8%)
159	AXQ CAPITAL, LP	54,534	0.02%	$545K	+15,582 (+40.0%)
160	NewEdge Advisors, LLC	53,099	0.02%	$531K	+773 (+1.5%)
161	Vanguard Investments Australia, Ltd.	51,880	0.02%	$519K	—
162	Seven Fleet Capital Management LP	51,024	0.02%	$510K	-51,469 (-50.2%)
163	INTECH INVESTMENT MANAGEMENT LLC	47,763	0.02%	$478K	-2,315 (-4.6%)
164	GRIMES & Co WEALTH MANAGEMENT, LLC	46,850	0.02%	$469K	+8,898 (+23.4%)
165	ENVESTNET ASSET MANAGEMENT INC	46,137	0.02%	$461K	+3,715 (+8.8%)
166	KLP KAPITALFORVALTNING AS	45,900	0.02%	$459K	—
167	Headlands Technologies LLC	45,351	0.02%	$454K	-27,301 (-37.6%)
168	VIRGINIA RETIREMENT SYSTEMS ET Al	43,754	0.02%	$438K	-169,500 (-79.5%)
169	Virtu Financial LLC	43,204	0.02%	$432K	NEW
170	Fiduciary Trust Co	42,955	0.02%	$430K	—
171	Empirical Financial Services, LLC d.b.a. Empirical Wealth Management	41,730	0.02%	$417K	-2,507 (-5.7%)
172	ALLSTATE CORP	40,925	0.02%	$409K	NEW
173	China Universal Asset Management Co., Ltd.	40,450	0.02%	$405K	-4,057 (-9.1%)
174	Erste Asset Management GmbH	40,000	0.02%	$382K	—
175	Cambridge Investment Research Advisors, Inc.	39,706	0.02%	$398K	+16,283 (+69.5%)
176	PRUDENTIAL FINANCIAL INC	39,126	0.02%	$391K	-14,650 (-27.2%)
177	ProShare Advisors LLC	38,823	0.02%	$388K	-5,206 (-11.8%)
178	COMMERCE BANK	38,310	0.01%	$383K	—
179	E Fund Management Co., Ltd.	37,452	0.01%	$375K	-7,080 (-15.9%)
180	SIMPLEX TRADING, LLC	36,794	0.01%	$368K	-17,171 (-31.8%)
181	CAPTRUST FINANCIAL ADVISORS	35,218	0.01%	$352K	+19,331 (+121.7%)
182	Quantbot Technologies LP	34,296	0.01%	$343K	NEW
183	Rockefeller Capital Management L.P.	33,495	0.01%	$335K	-1,387 (-4.0%)
184	CAPITAL FUND MANAGEMENT S.A.	33,327	0.01%	$333K	-23,811 (-41.7%)
185	Universal- Beteiligungs- und Servicegesellschaft mbH	31,820	0.01%	$318K	+2,489 (+8.5%)
186	DRW Securities, LLC	31,234	0.01%	$312K	+9,389 (+43.0%)
187	Councilor Wealth, LLC	30,000	0.01%	$300K	—
188	Leisure Capital Management	28,000	0.01%	$280K	—
189	Bayforest Capital Ltd	27,728	0.01%	$277K	+27,725 (+924166.7%)
190	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO	27,713	0.01%	$277K	—
191	Csenge Advisory Group	25,000	0.01%	$250K	—
192	Focus Partners Wealth	24,877	0.01%	$249K	NEW
193	Mitsubishi UFJ Trust & Banking Corp	24,587	0.01%	$246K	NEW
194	PDT Partners, LLC	24,489	0.01%	$245K	-538,951 (-95.7%)
195	TEACHER RETIREMENT SYSTEM OF TEXAS	24,109	0.01%	$241K	-2,750 (-10.2%)
196	CANADA LIFE ASSURANCE Co	23,582	0.01%	$235K	+6,208 (+35.7%)
197	Rock Springs Capital Management LP	22,124	0.01%	$221K	+9,524 (+75.6%)
198	PERSONAL CFO SOLUTIONS, LLC	21,926	0.01%	$219K	+259 (+1.2%)
199	PNC Financial Services Group, Inc.	21,832	0.01%	$218K	+4,457 (+25.7%)
200	XPONANCE LLC	21,137	0.01%	$211K	—
201	Ameritas Investment Partners, Inc.	21,131	0.01%	$211K	+1,822 (+9.4%)
202	LAZARD ASSET MANAGEMENT LLC	21,000	0.01%	$210K	-15,360 (-42.2%)
203	Vanguard Personalized Indexing Management, LLC	20,967	0.01%	$210K	-1,200 (-5.4%)
204	Caitong International Asset Management Co., Ltd	20,925	0.01%	$209K	+20,786 (+14954.0%)
205	Walleye Capital LLC	20,878	0.01%	$209K	-5,915 (-22.1%)
206	Arax Advisory Partners	20,286	0.01%	$203K	+19,781 (+3917.0%)
207	R Squared Ltd	20,263	0.01%	$203K	NEW
208	denkapparat Operations GmbH	20,100	0.01%	$201K	NEW
209	HighTower Advisors, LLC	20,023	0.01%	$200K	+624 (+3.2%)
210	Cypress Wealth Services, LLC	20,000	0.01%	$200K	—
211	Merit Financial Group, LLC	19,185	0.01%	$192K	NEW
212	RHS Financial, LLC	19,018	0.01%	$190K	NEW
213	Abel Hall, LLC	18,994	0.01%	$190K	NEW
214	JONES FINANCIAL COMPANIES LLLP	17,894	0.01%	$178K	+1,012 (+6.0%)
215	OXFORD ASSET MANAGEMENT LLP	17,514	0.01%	$175K	-1,757 (-9.1%)
216	Ensign Peak Advisors, Inc	17,450	0.01%	$175K	+3,050 (+21.2%)
217	Amundi	16,944	0.01%	$169K	NEW
218	BRIGHTON JONES LLC	16,926	0.01%	$169K	NEW
219	Visionary Wealth Advisors	16,890	0.01%	$169K	-3,000 (-15.1%)
220	Ikarian Capital, LLC	16,756	0.01%	$168K	NEW
221	Magnetar Financial LLC	16,172	0.01%	$162K	NEW
222	J. Safra Sarasin Holding AG	15,700	0.01%	$157K	NEW
223	Swiss Life Asset Management Ltd	15,658	0.01%	$157K	+820 (+5.5%)
224	NEUBERGER BERMAN GROUP LLC	15,394	0.01%	$154K	+4,819 (+45.6%)
225	BHK Investment Advisors, LLC	15,000	0.01%	$150K	—
226	T3 Companies, LLC	15,000	0.01%	$150K	NEW
227	GABELLI FUNDS LLC	14,720	0.01%	$147K	NEW
228	Stratos Wealth Partners, LTD.	14,700	0.01%	$147K	—
229	INCEPTIONR LLC	14,624	0.01%	$146K	NEW
230	Chicago Partners Investment Group LLC	14,488	0.01%	$136K	NEW
231	DNB Asset Management AS	14,175	0.01%	$142K	-5,110 (-26.5%)
232	CHOREO, LLC	13,772	0.01%	$138K	+233 (+1.7%)
233	SteelPeak Wealth, LLC	13,741	0.01%	$137K	+51 (+0.4%)
234	Inscription Capital, LLC	13,706	0.01%	$137K	+210 (+1.6%)
235	Kestra Advisory Services, LLC	13,110	0.01%	$131K	-2,630 (-16.7%)
236	BANCO BILBAO VIZCAYA ARGENTARIA, S.A.	13,053	0.01%	$130K	-6,196 (-32.2%)
237	Pinnacle Wealth Planning Services, Inc.	13,040	0.01%	$130K	+262 (+2.1%)
238	CIBC Bancorp USA Inc.	12,883	0.01%	$129K	+1,485 (+13.0%)
239	ELEVATION POINT WEALTH PARTNERS, LLC	12,556	0.00%	$126K	-442 (-3.4%)
240	Vestmark Advisory Solutions, Inc.	12,462	0.00%	$125K	-536 (-4.1%)
241	Vident Advisory, LLC	12,324	0.00%	$123K	-2,469 (-16.7%)
242	Ethic Inc.	12,289	0.00%	$123K	NEW
243	ROYAL BANK OF CANADA	12,224	0.00%	$122K	-5,891 (-32.5%)
244	Atria Investments, Inc	12,046	0.00%	$120K	+1,171 (+10.8%)
245	State of Alaska, Department of Revenue	11,899	0.00%	$118K	—
246	Mirae Asset Global Investments Co., Ltd.	11,367	0.00%	$114K	-1,715 (-13.1%)
247	Integrated Wealth Concepts LLC	10,778	0.00%	$108K	NEW
248	CITIZENS FINANCIAL GROUP INC/RI	10,649	0.00%	$106K	NEW
249	Sumitomo Mitsui Trust Group, Inc.	10,557	0.00%	$106K	NEW
250	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	10,254	0.00%	$103K	+2,942 (+40.2%)

Exited since 2026-03-31 (40 filers; largest 25 shown)

JANUS HENDERSON GROUP PLC	−8,908,506
Royalty Pharma Sub-Manager, LLC	−3,846,154
RFG Advisory, LLC	−2,870,700
JACOBS LEVY EQUITY MANAGEMENT, INC	−1,004,373
Hillsdale Investment Management Inc.	−639,100
Capricorn Fund Managers Ltd	−202,900
Balyasny Asset Management L.P.	−186,125
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO	−90,977
PANAGORA ASSET MANAGEMENT INC	−88,876
Legato Capital Management LLC	−87,010
Weiss Asset Management LP	−82,100
DARK FOREST CAPITAL MANAGEMENT LP	−78,103
Entropy Technologies, LP	−75,908
Integrated Quantitative Investments LLC	−65,365
NAVELLIER & ASSOCIATES INC	−45,286
SummitTX Capital, L.P.	−41,165
Bridgefront Capital, LLC	−40,889
Vinva Investment Management Ltd	−40,321
CAPSTONE INVESTMENT ADVISORS, LLC	−29,554
Vontobel Holding Ltd.	−27,000
FARALLON CAPITAL MANAGEMENT LLC	−24,000
BENDER ROBERT & ASSOCIATES	−23,710
Deeter Investments LLP	−23,600
Polymer Capital Management (US) LLC	−21,353
SG Americas Securities, LLC	−20,649

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Peter Kolchinsky	SCHEDULE 13G/A	2026-08-14	2026-06-30	15,827,186	6.2%
Rajeev Shah	SCHEDULE 13G/A	2026-08-14	2026-06-30	15,827,186	6.2%
RA Capital Management, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	15,827,186	6.2%
RA Capital Healthcare Fund, L.P.	SCHEDULE 13G/A	2026-08-14	2026-06-30	15,827,186	6.2%
STATE STREET CORPORATION	SCHEDULE 13G	2026-08-07	2026-06-30	15,191,098	6%
Vanguard Capital Management	SCHEDULE 13G	2026-04-29	2026-03-31	12,961,172	5.16%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Deerfield Management Company, L.P.	SCHEDULE 13G/A	2026-02-12	2025-12-31	14,341,000	6.81%
James E. Flynn	SCHEDULE 13G/A	2026-02-12	2025-12-31	14,341,000	6.81%
Deerfield Partners, L.P.	SCHEDULE 13G/A	2026-02-12	2025-12-31	14,341,000	6.81%
Deerfield Mgmt, L.P.	SCHEDULE 13G/A	2026-02-12	2025-12-31	14,341,000	6.81%
Avoro Capital Advisors LLC	SCHEDULE 13G/A	2025-05-15	2025-03-31	8,700,000	4.2%
Behzad Aghazadeh	SCHEDULE 13G/A	2025-05-15	2025-03-31	8,700,000	4.2%
BlackRock, Inc.	SCHEDULE 13G/A	2025-04-17	2025-03-31	17,483,490	8.4%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.