Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

ARROWHEAD PHARMACEUTICALS, INC.

CIK 0000879407ARWR· quarter ending 2026-06-30

Shares outstanding

141,254,467

as of 2026-07-30 · 10-Q cover page, filed 2026-08-04

Held by 13F filers

119,539,570

84.6% of shares outstanding

Holders

502

+64 vs 2026-03-31 · 127 new, 63 exited

Value

$9.7B

shares -1.1% vs prior quarter

Share classes (cover page of the 10-Q filed 2026-08-04, as of 2026-07-30)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	ARWR · NASDAQ	141,254,467	119,539,570	84.6%	502	04280A100

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	04280A100	COM	502	119,539,570	141,254,467	84.6%	$9.7B	12 call / 10 put	13DG	holders →
	04280AAC4	NOTE 1/1not common	52	5,516,633 $643.1M principal	—	—	$758.2M	—	NPORT	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (250 of 502 · 04280A100)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	BlackRock, Inc.	14,830,553	10.50%	$1.2B	-3,330,966 (-18.3%)
2	Avoro Capital Advisors LLC	11,355,555	8.04%	$925.6M	+655,556 (+6.1%)
3	FMR LLC	8,039,804	5.69%	$655.3M	+773,152 (+10.6%)
4	VANGUARD PORTFOLIO MANAGEMENT LLC	6,351,355	4.50%	$517.7M	-794,781 (-11.1%)
5	VANGUARD CAPITAL MANAGEMENT LLC	6,110,953	4.33%	$498.1M	+78,537 (+1.3%)
6	STATE STREET CORP	5,694,640	4.03%	$464.2M	-801,490 (-12.3%)
7	NORGES BANK	3,896,536	2.76%	$317.6M	NEW
8	Invesco Ltd.	3,883,976	2.75%	$316.6M	+603,329 (+18.4%)
9	GEODE CAPITAL MANAGEMENT, LLC	3,530,612	2.50%	$298.8M	-748,216 (-17.5%)
10	FRED ALGER MANAGEMENT, LLC	3,301,919	2.34%	$269.1M	-40,574 (-1.2%)
11	BAKER BROS. ADVISORS LP	1,992,783	1.41%	$162.4M	—
12	Siren, L.L.C.	1,715,476	1.21%	$139.8M	+100,000 (+6.2%)
13	Vestal Point Capital, LP	1,575,000	1.12%	$128.4M	-700,000 (-30.8%)
14	DEERFIELD MANAGEMENT COMPANY, L.P.	1,389,055	0.98%	$113.2M	-184,242 (-11.7%)
15	FIRST TRUST ADVISORS LP	1,352,918	0.96%	$110.3M	+1,203,770 (+807.1%)
16	Driehaus Capital Management LLC	1,350,556	0.96%	$110.1M	+160,221 (+13.5%)
17	Jupiter Topco LLC	1,221,596	0.86%	$99.6M	NEW
18	NORTHERN TRUST CORP	1,192,868	0.84%	$97.2M	-462,969 (-28.0%)
19	DIMENSIONAL FUND ADVISORS LP	1,181,608	0.84%	$96.3M	+573,077 (+94.2%)
20	GOLDMAN SACHS GROUP INC	1,150,007	0.81%	$93.7M	-589,916 (-33.9%)
21	BANK OF AMERICA CORP /DE/	1,139,810	0.81%	$92.9M	+75,355 (+7.1%)
22	Hood River Capital Management LLC	1,120,747	0.79%	$91.4M	+64,213 (+6.1%)
23	Holocene Advisors, LP	1,106,177	0.78%	$90.2M	NEW
24	MORGAN STANLEY	1,084,835	0.77%	$88.4M	+124,328 (+12.9%)
25	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	964,479	0.68%	$78.6M	-366,517 (-27.5%)
26	Fisher Asset Management, LLC	957,691	0.68%	$78.1M	-155,877 (-14.0%)
27	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	923,927	0.65%	$75.3M	-268,158 (-22.5%)
28	VANGUARD FIDUCIARY TRUST CO	896,738	0.63%	$73.1M	-69,037 (-7.1%)
29	UBS Group AG	861,520	0.61%	$70.2M	-474,751 (-35.5%)
30	Bank of New York Mellon Corp	859,538	0.61%	$70.1M	-100,606 (-10.5%)
31	PRICE T ROWE ASSOCIATES INC /MD/	853,360	0.60%	$69.6M	-190,372 (-18.2%)
32	SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	830,247	0.59%	$67.7M	+290,103 (+53.7%)
33	Western Financial Corp/CA	820,239	0.58%	$66.9M	—
34	JPMORGAN CHASE & CO	637,399	0.45%	$51.8M	-45,669 (-6.7%)
35	Connor, Clark & Lunn Investment Management Ltd.	625,569	0.44%	$51.0M	-211,412 (-25.3%)
36	SUSQUEHANNA INTERNATIONAL GROUP, LLP	596,573	0.42%	$48.6M	+217,740 (+57.5%)
37	TWO SIGMA INVESTMENTS, LP	580,609	0.41%	$47.3M	+544,809 (+1521.8%)
38	Pictet Asset Management Holding SA	573,419	0.41%	$46.7M	-699,847 (-55.0%)
39	BNP PARIBAS FINANCIAL MARKETS	558,643	0.40%	$45.5M	-91,956 (-14.1%)
40	LORD, ABBETT & CO. LLC	540,466	0.38%	$44.1M	+227,642 (+72.8%)
41	1832 Asset Management L.P.	538,500	0.38%	$43.9M	NEW
42	PRINCIPAL FINANCIAL GROUP INC	514,658	0.36%	$41.9M	+24,536 (+5.0%)
43	HRT FINANCIAL LP	498,655	0.35%	$40.6M	NEW
44	VOYA INVESTMENT MANAGEMENT LLC	483,495	0.34%	$39.4M	-172,634 (-26.3%)
45	Balyasny Asset Management L.P.	470,754	0.33%	$38.4M	+264,342 (+128.1%)
46	RENAISSANCE TECHNOLOGIES LLC	468,921	0.33%	$38.2M	-567,574 (-54.8%)
47	FRANKLIN RESOURCES INC	462,133	0.33%	$37.7M	-574 (-0.1%)
48	D. E. Shaw & Co., Inc.	431,560	0.31%	$35.2M	-752,278 (-63.5%)
49	Nuveen, LLC	415,883	0.29%	$33.9M	-83,954 (-16.8%)
50	Assenagon Asset Management S.A.	403,854	0.29%	$32.9M	+345,119 (+587.6%)
51	RHUMBLINE ADVISERS	374,897	0.27%	$30.6M	-29,539 (-7.3%)
52	EVENTIDE ASSET MANAGEMENT, LLC	370,000	0.26%	$30.2M	—
53	AMERICAN CENTURY COMPANIES INC	364,211	0.26%	$29.7M	-287,333 (-44.1%)
54	MILLENNIUM MANAGEMENT LLC	329,337	0.23%	$26.8M	NEW
55	LPL Financial LLC	310,761	0.22%	$25.3M	+181,262 (+140.0%)
56	Artisan Partners Limited Partnership	310,706	0.22%	$25.3M	NEW
57	MARSHALL WACE, LLP	305,031	0.22%	$24.9M	+125,458 (+69.9%)
58	SEI INVESTMENTS CO	300,619	0.21%	$24.5M	+97,399 (+47.9%)
59	NORDEA INVESTMENT MANAGEMENT AB	284,175	0.20%	$23.6M	-22,264 (-7.3%)
60	Russell Investments Group, Ltd.	284,096	0.20%	$23.2M	+110,101 (+63.3%)
61	CITIGROUP INC	264,678	0.19%	$21.6M	+13,110 (+5.2%)
62	California Public Employees Retirement System	256,314	0.18%	$20.9M	-819 (-0.3%)
63	Squarepoint Ops LLC	255,907	0.18%	$20.9M	NEW
64	ENVESTNET ASSET MANAGEMENT INC	254,228	0.18%	$20.7M	+187,478 (+280.9%)
65	Aberdeen Group plc	251,968	0.18%	$20.5M	-112,004 (-30.8%)
66	Swiss National Bank	238,900	0.17%	$19.5M	-3,100 (-1.3%)
67	Legal & General Group Plc	237,216	0.17%	$19.3M	+8,119 (+3.5%)
68	Privium Fund Management B.V.	234,222	0.17%	$19.1M	-132,714 (-36.2%)
69	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	218,133	0.15%	$17.8M	-368,992 (-62.8%)
70	Life Cycle Investment Partners Ltd	209,068	0.15%	$17.0M	NEW
71	HSBC HOLDINGS PLC	203,800	0.14%	$16.8M	+52,754 (+34.9%)
72	Woodline Partners LP	200,184	0.14%	$16.3M	—
73	Integral Health Asset Management, LLC	200,000	0.14%	$16.3M	-100,000 (-33.3%)
74	AQR CAPITAL MANAGEMENT LLC	198,842	0.14%	$15.8M	+31,632 (+18.9%)
75	JANE STREET GROUP, LLC	196,205	0.14%	$16.0M	+180,430 (+1143.8%)
76	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	191,432	0.14%	$15.6M	+7,128 (+3.9%)
77	ALLIANCEBERNSTEIN L.P.	173,265	0.12%	$10.9M	-107,129 (-38.2%)
78	WCM INVESTMENT MANAGEMENT, LLC	171,232	0.12%	$13.8M	-343 (-0.2%)
79	PINNACLE ASSOCIATES LTD	170,131	0.12%	$13.9M	-5,325 (-3.0%)
80	RAYMOND JAMES FINANCIAL INC	169,913	0.12%	$13.8M	-12,642 (-6.9%)
81	SEB Asset Management AB	158,205	0.11%	$12.9M	—
82	Clearbridge Investments, LLC	157,110	0.11%	$12.8M	-45,237 (-22.4%)
83	AMERIPRISE FINANCIAL INC	155,908	0.11%	$12.7M	-35,146 (-18.4%)
84	Affinity Asset Advisors, LLC	150,000	0.11%	$12.2M	-50,000 (-25.0%)
85	DEUTSCHE BANK AG\	149,240	0.11%	$12.2M	-110,723 (-42.6%)
86	WEALTH EFFECTS LLC	147,300	0.10%	$12.0M	+4,000 (+2.8%)
87	Retirement Systems of Alabama	145,687	0.10%	$11.9M	-25,985 (-15.1%)
88	TORONTO DOMINION BANK	144,928	0.10%	$11.8M	-5,350 (-3.6%)
89	HighTower Advisors, LLC	140,394	0.10%	$11.4M	-6,068 (-4.1%)
90	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	139,826	0.10%	$11.4M	-4,487 (-3.1%)
91	Weiss Asset Management LP	134,014	0.09%	$10.9M	NEW
92	BANK OF NOVA SCOTIA	133,805	0.09%	$10.9M	-2,155 (-1.6%)
93	PFM Health Sciences, LP	131,667	0.09%	$10.7M	+67,388 (+104.8%)
94	Tetragon Partners GP Ltd	130,484	0.09%	$10.6M	+3,286 (+2.6%)
95	WELLS FARGO & COMPANY/MN	128,789	0.09%	$10.5M	-29,609 (-18.7%)
96	Rhenman & Partners Asset Management AB	128,000	0.09%	$10.4M	-16,500 (-11.4%)
97	VANGUARD ASSET MANAGEMENT, Ltd	119,102	0.08%	$9.7M	+6,131 (+5.4%)
98	Catalyst Funds Management Pty Ltd	117,600	0.08%	$9.6M	NEW
99	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	116,948	0.08%	$9.5M	-7,905 (-6.3%)
100	Universal- Beteiligungs- und Servicegesellschaft mbH	116,393	0.08%	$9.5M	-3,845 (-3.2%)
101	MANUFACTURERS LIFE INSURANCE COMPANY, THE	111,955	0.08%	$9.1M	-48,467 (-30.2%)
102	VAN ECK ASSOCIATES CORP	111,500	0.08%	$9.1M	+92,610 (+490.3%)
103	ACT CAPITAL MANAGEMENT, LLC	110,100	0.08%	$9.0M	+27,600 (+33.5%)
104	Empowered Funds, LLC	108,041	0.08%	$8.8M	-29,179 (-21.3%)
105	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	104,322	0.07%	$8.5M	+74,673 (+251.9%)
106	SILVERCREST ASSET MANAGEMENT GROUP LLC	103,616	0.07%	$8.4M	-4,797 (-4.4%)
107	VICTORY CAPITAL MANAGEMENT INC	100,717	0.07%	$8.2M	+11,431 (+12.8%)
108	Creative Planning	100,290	0.07%	$8.2M	+12,034 (+13.6%)
109	NEUBERGER BERMAN GROUP LLC	98,467	0.07%	$8.0M	-105,447 (-51.7%)
110	Dorsey Wright & Associates	97,466	0.07%	$7.9M	NEW
111	NEW YORK STATE COMMON RETIREMENT FUND	95,515	0.07%	$7.8M	+53,636 (+128.1%)
112	KEYSTONE INVESTORS PTE LTD	94,661	0.07%	$7.7M	NEW
113	FEDERATED HERMES, INC.	89,365	0.06%	$7.3M	+75,253 (+533.3%)
114	BARCLAYS PLC	86,776	0.06%	$7.1M	-28,567 (-24.8%)
115	PRUDENTIAL FINANCIAL INC	85,710	0.06%	$7.0M	+15,570 (+22.2%)
116	CANADA LIFE ASSURANCE Co	82,488	0.06%	$6.7M	+1,681 (+2.1%)
117	BESSEMER GROUP INC	79,140	0.06%	$6.5M	—
118	Transamerica Financial Advisors, LLC	77,403	0.05%	$6.3M	+77,398 (+1547960.0%)
119	Allianz Asset Management GmbH	75,353	0.05%	$6.1M	+19,731 (+35.5%)
120	Pinion Investment Advisors, LLC	75,000	0.05%	$6.1M	—
121	STIFEL FINANCIAL CORP	73,294	0.05%	$6.0M	+61,598 (+526.7%)
122	Erste Asset Management GmbH	73,000	0.05%	$5.9M	—
123	STATE OF WISCONSIN INVESTMENT BOARD	71,181	0.05%	$5.8M	-6,666 (-8.6%)
124	MetLife Investment Management, LLC	71,062	0.05%	$5.8M	-69,342 (-49.4%)
125	ADAR1 Capital Management, LLC	69,800	0.05%	$5.7M	-500 (-0.7%)
126	Orion Investment Co	65,831	0.05%	$5.4M	+3,296 (+5.3%)
127	PLATINUM INVESTMENT MANAGEMENT LTD	64,752	0.05%	$5.3M	—
128	AMALGAMATED BANK	64,447	0.05%	$5.3M	+4,140 (+6.9%)
129	Jain Global LLC	61,895	0.04%	$5.0M	NEW
130	Police & Firemen's Retirement System of New Jersey	61,104	0.04%	$5.0M	+24,229 (+65.7%)
131	Vanguard Global Advisers, LLC	61,098	0.04%	$5.0M	-2,026 (-3.2%)
132	ROYAL BANK OF CANADA	60,957	0.04%	$5.0M	-359 (-0.6%)
133	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	60,466	0.04%	$4.9M	-79,132 (-56.7%)
134	Ghisallo Capital Management LLC	60,000	0.04%	$4.9M	NEW
135	Brevan Howard Capital Management LP	58,923	0.04%	$4.8M	NEW
136	Alyeska Investment Group, L.P.	58,722	0.04%	$4.8M	-414,148 (-87.6%)
137	Treasurer of the State of North Carolina	57,530	0.04%	$4.7M	NEW
138	COMMONWEALTH EQUITY SERVICES, LLC	55,170	0.04%	$4.5M	+94 (+0.2%)
139	KING LUTHER CAPITAL MANAGEMENT CORP	53,725	0.04%	$4.4M	—
140	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	52,344	0.04%	$4.3M	+9,590 (+22.4%)
141	OSTERWEIS CAPITAL MANAGEMENT INC	50,315	0.04%	$4.1M	NEW
142	WELLINGTON MANAGEMENT GROUP LLP	50,081	0.04%	$4.1M	-4,437 (-8.1%)
143	Cormorant Asset Management, LP	50,000	0.04%	$4.1M	-50,000 (-50.0%)
144	GUGGENHEIM CAPITAL LLC	46,565	0.03%	$3.8M	-44,898 (-49.1%)
145	State of Tennessee, Department of Treasury	44,756	0.03%	$3.6M	+11,899 (+36.2%)
146	Zurcher Kantonalbank (Zurich Cantonalbank)	44,360	0.03%	$3.6M	-4,012 (-8.3%)
147	Shay Capital LLC	44,000	0.03%	$3.6M	NEW
148	VIRGINIA RETIREMENT SYSTEMS ET Al	43,350	0.03%	$3.5M	+11,300 (+35.3%)
149	TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY	43,261	0.03%	$3.5M	—
150	Allspring Global Investments Holdings, LLC	43,243	0.03%	$3.5M	-11,936 (-21.6%)
151	Handelsbanken Fonder AB	42,800	0.03%	$3.5M	—
152	Rafferty Asset Management, LLC	41,246	0.03%	$3.4M	-38,359 (-48.2%)
153	BOOTHBAY FUND MANAGEMENT, LLC	41,242	0.03%	$3.4M	-5,746 (-12.2%)
154	Louisiana State Employees Retirement System	41,200	0.03%	$3.4M	+600 (+1.5%)
155	Y-Intercept (Hong Kong) Ltd	40,231	0.03%	$3.3M	NEW
156	YOUSIF CAPITAL MANAGEMENT, LLC	40,203	0.03%	$3.3M	-2,387 (-5.6%)
157	Edgestream Partners, L.P.	39,489	0.03%	$3.2M	-52,508 (-57.1%)
158	STEMPOINT CAPITAL LP	39,198	0.03%	$3.2M	NEW
159	PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO	38,507	0.03%	$3.1M	NEW
160	State of New Jersey Common Pension Fund D	38,486	0.03%	$3.1M	-3,308 (-7.9%)
161	ALGERT GLOBAL LLC	38,340	0.03%	$3.1M	-21,680 (-36.1%)
162	Ikarian Capital, LLC	38,278	0.03%	$3.1M	NEW
163	US BANCORP \DE\	38,226	0.03%	$3.1M	+3,543 (+10.2%)
164	EP Wealth Advisors, LLC	38,135	0.03%	$3.1M	-271 (-0.7%)
165	DekaBank Deutsche Girozentrale	37,844	0.03%	$2.2M	—
166	M28 Capital Management LP	36,851	0.03%	$3.0M	—
167	Polymer Capital Management (HK) LTD	36,800	0.03%	$3.0M	NEW
168	Engineers Gate Manager LP	36,495	0.03%	$3.0M	-8,361 (-18.6%)
169	KORNITZER CAPITAL MANAGEMENT INC /KS	35,780	0.03%	$2.9M	—
170	PANAGORA ASSET MANAGEMENT INC	35,103	0.02%	$2.9M	-426,090 (-92.4%)
171	Tower Research Capital LLC (TRC)	34,537	0.02%	$2.8M	+22,283 (+181.8%)
172	COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS	33,721	0.02%	$2.7M	-1,365 (-3.9%)
173	Alpine Global Management, LLC	33,339	0.02%	$2.7M	NEW
174	STATE OF MICHIGAN RETIREMENT SYSTEM	32,900	0.02%	$2.7M	-800 (-2.4%)
175	ARIZONA STATE RETIREMENT SYSTEM	32,843	0.02%	$2.7M	-748 (-2.2%)
176	Exome Asset Management LLC	32,214	0.02%	$2.6M	-13,507 (-29.5%)
177	KLP KAPITALFORVALTNING AS	32,200	0.02%	$2.6M	+5,300 (+19.7%)
178	OAK RIDGE INVESTMENTS LLC	31,910	0.02%	$2.6M	+796 (+2.6%)
179	NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC	31,685	0.02%	$2.6M	+314 (+1.0%)
180	Thrivent Financial for Lutherans	31,279	0.02%	$2.5M	-271 (-0.9%)
181	Vanguard Investments Australia, Ltd.	30,828	0.02%	$2.5M	—
182	FIFTH THIRD BANCORP	30,534	0.02%	$2.5M	-2,913 (-8.7%)
183	Focus Partners Wealth	30,510	0.02%	$2.5M	+16,818 (+122.8%)
184	Private Advisor Group, LLC	30,352	0.02%	$2.5M	+14,926 (+96.8%)
185	BANK OF HAWAII	29,276	0.02%	$2.4M	+9,151 (+45.5%)
186	Cetera Investment Advisers	29,241	0.02%	$2.4M	+19,817 (+210.3%)
187	OREGON PUBLIC EMPLOYEES RETIREMENT FUND	29,155	0.02%	$2.4M	+455 (+1.6%)
188	SIMPLEX TRADING, LLC	29,002	0.02%	$2.4M	+14,721 (+103.1%)
189	NEW MEXICO EDUCATIONAL RETIREMENT BOARD	29,000	0.02%	$2.4M	—
190	Mediolanum International Funds Ltd	28,940	0.02%	$2.3M	NEW
191	Ensign Peak Advisors, Inc	28,714	0.02%	$2.3M	-30,407 (-51.4%)
192	XTX Topco Ltd	28,590	0.02%	$2.3M	NEW
193	NATIXIS ADVISORS, LLC	27,872	0.02%	$2.3M	+9,702 (+53.4%)
194	TD Asset Management Inc	26,920	0.02%	$2.2M	-17,800 (-39.8%)
195	B. Metzler seel. Sohn & Co. AG	26,338	0.02%	$2.1M	—
196	SBI Okasan Asset Management Co.Ltd.	26,300	0.02%	$2.1M	—
197	Washington Trust Advisors, Inc.	26,185	0.02%	$2.1M	+911 (+3.6%)
198	Ameritas Investment Partners, Inc.	25,923	0.02%	$2.1M	-11,051 (-29.9%)
199	LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	25,623	0.02%	$2.1M	NEW
200	Hudson Bay Capital Management LP	25,620	0.02%	$2.1M	-38,523 (-60.1%)
201	EDGEWOOD MANAGEMENT LLC	25,000	0.02%	$2.0M	—
202	XPONANCE LLC	24,473	0.02%	$2.0M	+5,162 (+26.7%)
203	Jump Financial, LLC	23,464	0.02%	$1.9M	NEW
204	Pine Valley Investments Ltd Liability Co	23,248	0.02%	$1.9M	+4,434 (+23.6%)
205	Pacer Advisors, Inc.	22,957	0.02%	$1.9M	-965 (-4.0%)
206	China Universal Asset Management Co., Ltd.	22,417	0.02%	$1.8M	-2,433 (-9.8%)
207	PROFUND ADVISORS LLC	22,190	0.02%	$1.8M	-17,568 (-44.2%)
208	BANK OF MONTREAL /CAN/	22,186	0.02%	$1.8M	+58 (+0.3%)
209	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	21,689	0.02%	$1.7M	+202 (+0.9%)
210	HUSSMAN STRATEGIC ADVISORS, INC.	21,000	0.01%	$1.7M	NEW
211	Sanctuary Advisors, LLC	20,830	0.01%	$1.7M	-6,494 (-23.8%)
212	Calamos Advisors LLC	20,612	0.01%	$1.7M	+5,216 (+33.9%)
213	LMR Partners LLP	20,123	0.01%	$1.6M	NEW
214	CenterBook Partners LP	19,728	0.01%	$1.6M	NEW
215	SG Americas Securities, LLC	19,109	0.01%	$1.6M	-31,241 (-62.0%)
216	Voleon Capital Management LP	18,618	0.01%	$1.5M	-50,572 (-73.1%)
217	Atria Investments, Inc	18,578	0.01%	$1.5M	NEW
218	Vestmark Advisory Solutions, Inc.	18,449	0.01%	$1.5M	+5,459 (+42.0%)
219	MACKENZIE FINANCIAL CORP	18,363	0.01%	$1.5M	-9,452 (-34.0%)
220	FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A.	17,859	0.01%	$1.5M	-26,186 (-59.5%)
221	Pathstone Holdings, LLC	17,801	0.01%	$1.5M	+728 (+4.3%)
222	MYECFO, LLC	17,497	0.01%	$1.4M	-1,000 (-5.4%)
223	Advisory Services Network, LLC	17,371	0.01%	$1.4M	+17,110 (+6555.6%)
224	ELEVATION POINT WEALTH PARTNERS, LLC	16,991	0.01%	$1.4M	+5,014 (+41.9%)
225	EXCHANGE TRADED CONCEPTS, LLC	16,688	0.01%	$1.4M	-2,091 (-11.1%)
226	Corient Private Wealth LP	15,769	0.01%	$1.3M	-344 (-2.1%)
227	Virtus Investment Advisers, LLC	15,605	0.01%	$1.3M	+3,560 (+29.6%)
228	Prime Capital Investment Advisors, LLC	15,336	0.01%	$1.3M	-490 (-3.1%)
229	New York Life Investment Management LLC	15,089	0.01%	$1.2M	+850 (+6.0%)
230	TRUIST FINANCIAL CORP	14,755	0.01%	$1.2M	+4,247 (+40.4%)
231	INDEPENDENT FINANCIAL GROUP, LLC	14,410	0.01%	$1.2M	-965 (-6.3%)
232	Evolutionary Tree Capital Management, LLC	14,368	0.01%	$1.2M	NEW
233	Vanguard Personalized Indexing Management, LLC	14,336	0.01%	$1.2M	+2,106 (+17.2%)
234	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO	14,208	0.01%	$1.2M	—
235	Trexquant Investment LP	13,952	0.01%	$1.1M	-263,162 (-95.0%)
236	TEACHER RETIREMENT SYSTEM OF TEXAS	13,897	0.01%	$1.1M	-1,932 (-12.2%)
237	State of Alaska, Department of Revenue	13,802	0.01%	$1.1M	-218 (-1.6%)
238	Amundi	13,650	0.01%	$1.1M	-3,651 (-21.1%)
239	ACADIAN ASSET MANAGEMENT LLC	13,211	0.01%	$1.1M	-7,324 (-35.7%)
240	Quantinno Capital Management LP	13,199	0.01%	$1.1M	+409 (+3.2%)
241	VestGen Advisors, LLC	13,126	0.01%	$1.1M	NEW
242	JUPITER ASSET MANAGEMENT LTD	12,989	0.01%	$1.1M	NEW
243	Harvest Investment Services, LLC	12,946	0.01%	$1.1M	+3,184 (+32.6%)
244	Aster Capital Management (DIFC) Ltd	12,667	0.01%	$1.0M	+12,423 (+5091.4%)
245	OSAIC HOLDINGS, INC.	12,458	0.01%	$1.0M	+1,544 (+14.1%)
246	Wealth Architects, LLC	12,249	0.01%	$998K	+2 (+0.0%)
247	Farther Finance Advisors, LLC	12,088	0.01%	$985K	+117 (+1.0%)
248	CAPTRUST FINANCIAL ADVISORS	11,960	0.01%	$975K	+665 (+5.9%)
249	HOLLENCREST CAPITAL MANAGEMENT	11,374	0.01%	$927K	NEW
250	ALLSTATE CORP	11,370	0.01%	$927K	-4,935 (-30.3%)

Exited since 2026-03-31 (63 filers; largest 25 shown)

JANUS HENDERSON GROUP PLC	−1,436,990
RTW INVESTMENTS, LP	−585,682
CANADA PENSION PLAN INVESTMENT BOARD	−325,700
Longaeva Partners L.P.	−194,589
SCHRODER INVESTMENT MANAGEMENT GROUP	−162,005
CITADEL ADVISORS LLC	−98,194
Bridgewater Associates, LP	−95,552
Aquatic Capital Management LLC	−80,227
PDT Partners, LLC	−70,048
Quadrature Capital Ltd	−55,546
Ishara Investments LP	−55,350
Cinctive Capital Management LP	−49,068
J. Goldman & Co LP	−41,210
INTECH INVESTMENT MANAGEMENT LLC	−35,848
Diversified Trust Co	−34,553
SECTOR GAMMA AS	−30,000
Soleus Capital Management, L.P.	−28,479
FORA Capital, LLC	−23,625
Campbell & CO Investment Adviser LLC	−18,936
FARALLON CAPITAL MANAGEMENT LLC	−15,800
Capstone Capital Management Ltd	−15,740
PRELUDE CAPITAL MANAGEMENT, LLC	−15,217
SIERRA SUMMIT ADVISORS LLC	−14,353
Havemeyer Place LP	−13,276
Ares Systematic Credit Ltd	−13,169

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Avoro Capital Advisors LLC	SCHEDULE 13G/A	2026-08-14	2026-06-30	13,823,383	9.64%
Behzad Aghazadeh	SCHEDULE 13G/A	2026-08-14	2026-06-30	13,823,383	9.64%
Vanguard Portfolio Management	SCHEDULE 13G/A	2026-07-31	2026-06-30	6,384,903	4.53%
BlackRock, Inc.	SCHEDULE 13G/A	2026-07-27	2026-06-30	14,232,545	10.1%
Abigail P. Johnson	SCHEDULE 13G	2026-05-06	2026-03-31	7,349,106.75	5.2%
FMR LLC	SCHEDULE 13G	2026-05-06	2026-03-31	7,349,106.75	5.2%
Vanguard Capital Management	SCHEDULE 13G	2026-04-29	2026-03-31	7,081,293	5.05%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Sarepta Therapeutics, Inc.	SCHEDULE 13D/A	2025-08-15	2025-08-13	0	0%
Sarepta Therapeutics Investments, Inc.	SCHEDULE 13D/A	2025-08-15	2025-08-13	0	0%
STATE STREET CORPORATION	SCHEDULE 13G	2025-08-11	2025-06-30	6,371,056	4.6%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.