Exhibit 21.1
Significant Subsidiaries of the Company
Listed below are the significant subsidiaries (as defined in Rule 1-02(w) of Regulation S-X) of UnitedHealth Group Incorporated as of December 31, 2025. This list does not include Company subsidiaries that did not meet the conditions required to be deemed a significant subsidiary as of December 31, 2025.
| Name of Entity | State of Jurisdiction or Domicile | Doing Business As | ||||||
| Collaborative Care Holdings, LLC | Delaware | |||||||
| Optum, Inc. | Delaware | |||||||
| OptumHealth Holdings, LLC | Delaware | |||||||
| OptumRx Administrative Services, LLC | Texas | Alaska Business License #2143946 | ||||||
| OptumRx Group Holdings, Inc. | Delaware | |||||||
| OptumRx Holdings I, LLC | Delaware | |||||||
| UHIC Holdings, Inc. | Delaware | OneNet PPO | ||||||
| United HealthCare Services, Inc. | Minnesota | AmeriChoice EverCare Health Professionals Review Healthmarc HealthPro Institute for Human Resources UHC Management Company UHC Management Company, Inc. United Health Care United HealthCare United HealthCare Corporation United HealthCare Management Company, Inc. United HealthCare Management Services United HealthCare Services of Minnesota United HealthCare Services of Minnesota, Inc. United Resource Networks United Resource Networks, Inc. UnitedHealthcare UnitedHealthcare Medicare Customer Service Center UnitedHealthcare MedicareStore | ||||||
| UnitedHealthcare Insurance Company | Connecticut | UnitedHealthcare Community Plan | ||||||
| UnitedHealthcare, Inc. | Delaware | |||||||