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MARGIN-BOTTOM: 0px; TEXT-INDENT: 8%" align="justify"><font face="Times New Roman" size="2">The 2032 Modified Convertible Notes were issued in 2005 in exchange for zero-coupon, 30-year convertible notes that we issued in 2002. Like the notes for which they were exchanged, no interest is currently payable on the 2032 Modified Convertible Notes. These notes were issued at a discount from their principal amount (prior to the adoption of FSP APB 14-1). The reduced carrying value resulting from issuing these notes at a discount is being accreted back to the principal amount based on a contractual interest rate of 1.125% over the life of the notes. In March 2007, substantially all of the holders of the 2032 Modified Convertible Notes exercised their option to put these convertible notes to us. The additional discount on the 2032 Modified Convertible Notes recognized pursuant to the retrospective application of FSP APB 14-1 (in excess of the discount recognized under the contractual</font> <font face= "Times New Roman" size="2">terms of these securities) was amortized as non-cash interest expense prior to the holders putting these convertible notes to us. We continue to recognize interest expense for the amortization of the discount based on the contractual rate for the 2032 Modified Convertible Notes that remain outstanding. Such amounts were not material for the three and six months ended June&#160;30, 2009 and 2008.</font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px; TEXT-INDENT: 8%" align="justify"><font face="Times New Roman" size="2">Holders of the remaining outstanding 2032 Modified Convertible Notes may, subject to certain conditions, convert each of their notes based on a conversion rate of 8.8601 shares of common stock. The conversion price per share of the convertible notes as of any day will equal the accreted value on that day, divided by the conversion rate, or $87.52, as of June&#160;30, 2009. If converted, the 2032 Modified Convertible Notes will be settled in cash for an amount equal to the lesser of the accreted value of the 2032 Modified Convertible Notes at the conversion date or the conversion value, as defined, and shares of common stock, if any, to the extent the conversion value exceeds the amount paid in cash. As of June&#160;30, 2009, these notes were not convertible and the accreted value exceeded the amount that would have been received upon conversion. 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We do not use derivatives for speculative trading purposes and are not a party to any leveraged derivatives.</font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px; TEXT-INDENT: 8%" align="justify"><font face="Times New Roman" size="2">We recognize all of our derivative instruments as either assets or liabilities at fair value in the Condensed Consolidated Balance Sheets. Fair value is determined in accordance with SFAS 157 (see Note 11, &#8220;<i>Fair value measurement</i>&#8221;). The accounting for changes in the fair value of a derivative instrument depends on whether it has been designated and qualifies as part of a hedging relationship and, further, on the type of hedging relationship. For derivatives designated as hedges under SFAS No.&#160;133 &#8220;<i>Accounting for Derivative Instruments and Hedging Activities&#8221;</i> (&#8220;SFAS 133&#8221;), we formally assess, both at inception and periodically thereafter, whether the hedging derivatives are highly effective in offsetting changes in either the fair value or cash flows of the hedged item. Our derivatives that are not designated and do not qualify as hedges under SFAS 133 are adjusted to fair value through current earnings.</font></p> <p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px; TEXT-INDENT: 8%" align="justify"><font face="Times New Roman" size="2">We enter into foreign currency forward and option contracts to reduce our exposure to possible changes in values of certain anticipated foreign currency cash flows resulting from changes in foreign currency exchange rates, primarily associated with sales denominated in Euros. Increases or decreases in the cash flows associated with our international product sales due to movements in foreign currency exchange rates are partially offset by the corresponding increases and decreases in our international operating expenses resulting from these foreign currency exchange rate movements. To further reduce our exposure to foreign currency exchange rate fluctuations on our international product sales, we enter into foreign currency forward and option contracts to hedge a portion of our projected international product sales over a three-year time horizon. 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(&#8220;Ortho Biotech&#8221;)), a subsidiary of Johnson&#160;&amp; Johnson (&#8220;J&amp;J&#8221;), a license relating to Epoetin alfa for sales in the United States for all human uses except dialysis and diagnostics. This license agreement, which is perpetual, may be terminated for various reasons, including upon mutual agreement of the parties, or default. The parties are required to compensate each other for Epoetin alfa sales that either party makes into the other party&#8217;s exclusive market, sometimes referred to as &#8220;spillover.&#8221; Accordingly, we do not recognize product sales we make into the exclusive market of J&amp;J and do recognize the product sales made by J&amp;J into our exclusive market. Sales in our exclusive market are derived from our sales to our customers, as adjusted for spillover. 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R&amp;D expenses also include costs incurred under R&amp;D arrangements with our corporate partners, such as activities performed on behalf of Kirin-Amgen Inc. (&#8220;KA&#8221;), and costs and cost recoveries associated with collaborative R&amp;D and in-licensing arrangements, including upfront fees and milestones paid to collaboration partners in connection with technologies that have no alternative future use. 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MARGIN-BOTTOM: 0px; TEXT-INDENT: 8%" align="justify"><font face="Times New Roman" size="2">For the three and six months ended June&#160;30, 2009, there were employee stock options, calculated on a weighted average basis, to purchase 51&#160;million and 48&#160;million shares, respectively, with exercise prices greater than the average market prices of common stock for these periods that are not included in the computation of diluted EPS as their impact would have been anti-dilutive. 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