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ELI LILLY & Co

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Exhibit 21 — List of Subsidiaries & Affiliates
The following are subsidiaries and affiliated companies of Eli Lilly and Company at December 31, 2025.
Certain subsidiaries have been omitted as they are not significant in the aggregate.

State or Jurisdiction
of Incorporation
or Organization
Adverum Biotechnologies, Inc.Delaware
Adverum NC, LLCDelaware
Akouos, Inc.Delaware
Alnara Pharmaceuticals, Inc.Delaware
Annapurna Therapeutics, Ltd. Ireland
Aparito Espanya S.L. Spain
Aparito Limited United Kingdom
Aparito LLCDelaware
ARMO Biosciences, Inc.Delaware
Avalanche Australia Pty Ltd.Australia
Avid Radiopharmaceuticals, Inc.Delaware
CoLucid Pharmaceuticals, Inc.Delaware
Compania Farmaceutica Eli Lilly de Centro America S.A.Guatemala
CPD 4, Inc.Delaware
Dermira, Inc.Delaware
DICE Alpha Inc.Delaware
DICE Molecules SV, Inc.Delaware
DICE Therapeutics, Inc.Delaware
Disarm Therapeutics Inc.Delaware
Dista Ilac Ticaret Limited SirketiTurkey
Dista, S.A.Spain
Dista-Produtos Quimicos & Farmaceuticos, LDAPortugal
ELC EHS, LLCIndiana
ELCO Dominicana S.R.L.Dominican Republic
ELCO for Trading and Marketing, S.A.E.Egypt
ELCO Insurance Company LimitedBermuda
ELCO Management, Inc.Delaware
ELGO Insurance Company LimitedBermuda
Eli Lilly (Malaysia) Sdn. Bhd.Malaysia
Eli Lilly (Philippines), IncorporatedPhilippines
Eli Lilly (S.A.) (Proprietary) LimitedSouth Africa
Eli Lilly (Singapore) Pte. Ltd.Singapore
Eli Lilly (Suisse) S.A.Switzerland
Eli Lilly and Company (India) Pvt. Ltd.India
Eli Lilly and Company (Ireland) LimitedIreland
Eli Lilly and Company (N.Z.) LimitedNew Zealand
Eli Lilly and Company (Taiwan), Inc.Taiwan
Eli Lilly and Company LimitedUnited Kingdom
Eli Lilly Asia Pacific SSC Sdn BhdMalaysia
Eli Lilly Asia, Inc.Delaware
Eli Lilly Australia Pty. LimitedAustralia


State or Jurisdiction
of Incorporation
or Organization
Eli Lilly Benelux S.A.Belgium
Eli Lilly B-H d.o.o.Bosnia
Eli Lilly Bienes y Servicios S. de R.L. de C.V.Mexico
Eli Lilly Canada Inc.Canada
Eli Lilly Clinical Diagnostics Laboratory LLCIndiana
Eli Lilly Cork LimitedIreland
Eli Lilly CR s.r.o.Czech Republic
Eli Lilly Danmark A/SDenmark
Eli Lilly de Costa Rica, S.R.L.Costa Rica
Eli Lilly do Brasil LimitadaBrazil
Eli Lilly Drug Store LLCUnited Arab Emirates
Eli Lilly Egypt for Trading Company S.A.E.Egypt
Eli Lilly European Clinical Trial Services S.A.Belgium
Eli Lilly Export S.A.Switzerland
Eli Lilly farmacevtska druzba, d.o.o.Slovenia
Eli Lilly Finance, S.A.Switzerland
Eli Lilly Ges.m.b.H.Austria
Eli Lilly Group LimitedUnited Kingdom
Eli Lilly Hrvatska d.o.o.Croatia
Eli Lilly Interamerica Inc., y Compania LimitadaChile
Eli Lilly Interamerica, Inc.Indiana
Eli Lilly International CorporationIndiana
Eli Lilly Ireland Holdings LimitedIreland
Eli Lilly Israel Ltd.Israel
Eli Lilly Italia S.p.A.Italy
Eli Lilly Japan K.K.Japan
Eli Lilly Kinsale LimitedIreland
Eli Lilly Nederland B.V.Netherlands
Eli Lilly Norge A.S.Norway
Eli Lilly Pakistan (Pvt.) Ltd.Pakistan
Eli Lilly Polska Sp. z.o.o. (Ltd.)Poland
Eli Lilly Regional Operations GmbHAustria
Eli Lilly Romania S.R.L.Romania
Eli Lilly S.A.Switzerland
Eli Lilly Saudi Arabia LimitedSaudi Arabia
Eli Lilly Services India Private LimitedIndia
Eli Lilly Services Peru S.A.CPeru
Eli Lilly Slovakia s.r.o.Slovakia
Eli Lilly Sweden ABSweden
Eli Lilly Vostok S.A.Switzerland
Eli Lilly y Compania de Mexico, S.A. de C.V.Mexico
Eli Lilly y Compania de Venezuela, S.A.Venezuela
Emergence Therapeutics France SASFrance
Glycostasis, Inc.Delaware
Greenfield-Produtos Farmaceuticos, Lda.Portugal


State or Jurisdiction
of Incorporation
or Organization
ICOS CorporationWashington
ImClone LLCDelaware
ImClone Systems Holdings, Inc.Delaware
Irisfarma S.A.Spain
Isopro Holdings LLCDelaware
LDH I CorporationDelaware
LDH II CorporationDelaware
LDH III CorporationDelaware
LDH IV CorporationDelaware
LDH V 2023 CorporationDelaware
LDH VI CorporationDelaware
LDH VII CorporationDelaware
LDH VIII CorporationDelaware
Lilly (Beijing) Medical Tech Innovation Co., Ltd.China
Lilly (Shanghai) Management Co., Ltd.China
Lilly Asia Ventures Fund I, L.P.Cayman Islands
Lilly Asia Ventures Fund II, L.P.Cayman Islands
Lilly Asian Ventures Fund III, L.P.Cayman Islands
Lilly Cayman HoldingsCayman Islands
Lilly Centre for Clinical Pharmacology PTE. LTD.Singapore
Lilly China Research and Development Co., LtdChina
Lilly del Caribe, Inc.Cayman Islands
Lilly Deutschland GmbHGermany
Lilly France S.A.S.France
Lilly Global Nederland Holdings B.V.Netherlands
Lilly Global Services, Inc.Indiana
Lilly Holding GmbHGermany
Lilly Holdings B.V.Netherlands
Lilly Hungaria KFTHungary
Lilly Ilac Ticaret Limited SirketiTurkey
Lilly Japan Financing G.K.Japan
Lilly Korea Ltd.Korea
Lilly Lebanon Advanced Therapies LLCIndiana
Lilly Nederland Finance B.V.Netherlands
Lilly Nederland Holding B.V.Netherlands
Lilly Pharma Ltd.Russia
Lilly Portugal - Produtos Farmaceuticos, Lda.Portugal
Lilly S.A.Spain
Lilly Suzhou Pharmaceutical Co. Ltd.China
Lilly Trading Co. LTDChina
Lilly USA, LLCIndiana
Lilly Ventures Fund I LLCDelaware
LillyDirect Pharmacy, LLCDelaware
Loxo Oncology, Inc.Delaware
Mablink Bioscience S.A.S.France


State or Jurisdiction
of Incorporation
or Organization
Manet Holdings LLCDelaware
Morphic Holding, Inc.Delaware
Morphic Therapeutic UK Ltd. United Kingdom
Morphic Therapeutic, Inc.Delaware
NexPharm Parent Holdco, LLCDelaware
OY Eli Lilly Finland ABFinland
Pandinus MSC, Inc.Massachusetts
Petra Pharma CorporationDelaware
Pharmaserve-Lilly S.A.C.I.Greece
Point Biopharma Corp.Canada
Point Biopharma Global Inc.Delaware
Point Biopharma Inc.Delaware
Point Biopharma USA Inc.Delaware
Prevail Therapeutics Inc.Delaware
Protomer Technologies, Inc.Delaware
Scorpion Therapeutics, Inc.Delaware
SGX Pharmaceuticals, Inc.Delaware
Sigilon Therapeutics Inc.Delaware
SiteOne Therapeutics, Inc. Delaware
Spaly Bioquimica, S.A.Spain
UAB Eli Lilly LietuvaLithuania
Valquifarma, S.A.Spain
Versanis Bio Australia PTY LTDAustralia
Versanis Bio, Inc.Delaware
Verve Therapeutics, Inc. Delaware
Victoria Holdco Corp.Delaware
Vitalfarma - Produtos Farmaceuticos, Lda.Portugal