Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

ESTABLISHMENT LABS HOLDINGS INC.

CIK 0001688757ESTA· quarter ending 2026-06-30

Shares outstanding

29,801,891

as of 2026-08-06 · 10-Q cover page, filed 2026-08-07

Held by 13F filers

28,547,039

95.8% of shares outstanding

Holders

196

+20 vs 2026-03-31 · 56 new, 36 exited

Value

$2.4B

shares +6.6% vs prior quarter

Share classes (cover page of the 10-Q filed 2026-08-07, as of 2026-08-06)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	ESTA · NASDAQ	29,801,891	28,547,039	95.8%	196	G31249108

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	G31249108	COM	196	28,547,039	29,801,891	95.8%	$2.4B	5 call / 6 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (196 of 196 · G31249108)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	JW Asset Management, LLC	2,692,856	9.04%	$231.1M	-368,838 (-12.0%)
2	RTW INVESTMENTS, LP	2,655,695	8.91%	$227.9M	—
3	BlackRock, Inc.	1,582,005	5.31%	$135.8M	+1,454,482 (+1140.6%)
4	PRICE T ROWE ASSOCIATES INC /MD/	1,533,497	5.15%	$131.6M	NEW
5	BROWN ADVISORY INC	1,313,148	4.41%	$112.7M	-213,724 (-14.0%)
6	FINDELL CAPITAL MANAGEMENT LLC	1,096,000	3.68%	$94.0M	+98,253 (+9.8%)
7	Mudita Advisors LLP	723,063	2.43%	$62.0M	-41,500 (-5.4%)
8	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	714,051	2.40%	$61.3M	+25,124 (+3.6%)
9	Rubric Capital Management LP	688,325	2.31%	$59.1M	NEW
10	Nantahala Capital Management, LLC	671,660	2.25%	$57.6M	-161,296 (-19.4%)
11	FRANKLIN RESOURCES INC	613,698	2.06%	$52.7M	+374,484 (+156.5%)
12	BANK OF AMERICA CORP /DE/	608,040	2.04%	$52.2M	+191,200 (+45.9%)
13	Tyro Capital Management LLC	605,559	2.03%	$52.0M	-545,750 (-47.4%)
14	D. E. Shaw & Co., Inc.	566,910	1.90%	$48.6M	+159,129 (+39.0%)
15	RICE HALL JAMES & ASSOCIATES, LLC	560,935	1.88%	$48.1M	+12,261 (+2.2%)
16	UBS Group AG	548,960	1.84%	$47.1M	+401,303 (+271.8%)
17	TORONTO DOMINION BANK	540,024	1.81%	$46.3M	—
18	SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	491,486	1.65%	$42.2M	+98,681 (+25.1%)
19	ROYCE & ASSOCIATES LP	472,316	1.58%	$40.5M	+44,844 (+10.5%)
20	STATE STREET CORP	455,315	1.53%	$39.1M	+410,185 (+908.9%)
21	TWO SIGMA INVESTMENTS, LP	448,425	1.50%	$38.5M	+16,940 (+3.9%)
22	GEODE CAPITAL MANAGEMENT, LLC	386,142	1.30%	$33.1M	+358,144 (+1279.2%)
23	JANE STREET GROUP, LLC	361,302	1.21%	$31.0M	-266,398 (-42.4%)
24	GILDER GAGNON HOWE & CO LLC	342,033	1.15%	$29.3M	+73,500 (+27.4%)
25	Nuveen, LLC	321,498	1.08%	$27.6M	-1,177 (-0.4%)
26	MORGAN STANLEY	299,347	1.00%	$25.7M	-106,990 (-26.3%)
27	BAMCO INC /NY/	286,098	0.96%	$24.6M	-678,069 (-70.3%)
28	BNP PARIBAS FINANCIAL MARKETS	279,169	0.94%	$24.0M	+72,413 (+35.0%)
29	Woodson Capital Management, LP	275,000	0.92%	$23.6M	-75,000 (-21.4%)
30	Assenagon Asset Management S.A.	271,794	0.91%	$23.3M	+220,489 (+429.8%)
31	BOOTHBAY FUND MANAGEMENT, LLC	253,091	0.85%	$21.7M	+21,111 (+9.1%)
32	First Light Asset Management, LLC	246,577	0.83%	$21.2M	-61,161 (-19.9%)
33	VANGUARD PORTFOLIO MANAGEMENT LLC	242,438	0.81%	$20.8M	+190,162 (+363.8%)
34	HRT FINANCIAL LP	235,980	0.79%	$20.2M	+127,178 (+116.9%)
35	NORTHERN TRUST CORP	235,169	0.79%	$20.2M	+153,285 (+187.2%)
36	RAYMOND JAMES FINANCIAL INC	200,694	0.67%	$17.2M	-14,940 (-6.9%)
37	Capital Research Global Investors	189,029	0.63%	$16.2M	+86,134 (+83.7%)
38	ADAR1 Capital Management, LLC	185,619	0.62%	$15.9M	-27,854 (-13.0%)
39	JPMORGAN CHASE & CO	181,748	0.61%	$16.0M	-181,151 (-49.9%)
40	Voleon Capital Management LP	173,778	0.58%	$14.9M	+45,134 (+35.1%)
41	GARNET EQUITY CAPITAL HOLDINGS, INC.	170,490	0.57%	$14.6M	-93,952 (-35.5%)
42	GOLDMAN SACHS GROUP INC	167,277	0.56%	$14.4M	-465,003 (-73.5%)
43	Affinity Asset Advisors, LLC	148,013	0.50%	$12.7M	+48,013 (+48.0%)
44	HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND	145,300	0.49%	$12.5M	NEW
45	Granite Investment Partners, LLC	143,485	0.48%	$12.3M	-64 (-0.0%)
46	Pier Capital, LLC	133,810	0.45%	$11.5M	+243 (+0.2%)
47	BARCLAYS PLC	131,867	0.44%	$11.3M	+23,000 (+21.1%)
48	Tejara Capital Ltd	130,979	0.44%	$11.2M	-177,644 (-57.6%)
49	DEUTSCHE BANK AG\	128,138	0.43%	$11.0M	+26,607 (+26.2%)
50	STATE OF WISCONSIN INVESTMENT BOARD	125,967	0.42%	$10.8M	-12,553 (-9.1%)
51	Hood River Capital Management LLC	117,321	0.39%	$10.1M	+30,142 (+34.6%)
52	KORNITZER CAPITAL MANAGEMENT INC /KS	115,530	0.39%	$9.9M	-1,116 (-1.0%)
53	Divisadero Street Capital Management, LP	106,675	0.36%	$9.2M	NEW
54	Union Square Park Capital Management, LLC	105,000	0.35%	$9.0M	—
55	CITADEL ADVISORS LLC	100,838	0.34%	$8.7M	-448,449 (-81.6%)
56	FIRST TRUST ADVISORS LP	99,004	0.33%	$8.5M	NEW
57	Trexquant Investment LP	97,791	0.33%	$8.4M	-38,076 (-28.0%)
58	Redmile Group, LLC	88,964	0.30%	$7.6M	-14,500 (-14.0%)
59	RENAISSANCE TECHNOLOGIES LLC	82,300	0.28%	$7.1M	+26,500 (+47.5%)
60	Walleye Capital LLC	80,123	0.27%	$6.9M	NEW
61	Bank of New York Mellon Corp	68,145	0.23%	$5.8M	NEW
62	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	65,816	0.22%	$5.6M	NEW
63	Simplify Asset Management Inc.	60,540	0.20%	$5.2M	+7,531 (+14.2%)
64	Strategic Wealth Partners, Ltd.	56,533	0.19%	$4.9M	-1,524 (-2.6%)
65	Invesco Ltd.	56,212	0.19%	$4.8M	NEW
66	SEI INVESTMENTS CO	51,879	0.17%	$4.5M	+4,619 (+9.8%)
67	PURA VIDA INVESTMENTS, LLC	45,000	0.15%	$3.9M	—
68	WELLS FARGO & COMPANY/MN	42,745	0.14%	$3.7M	+30,798 (+257.8%)
69	Squarepoint Ops LLC	40,784	0.14%	$3.5M	-18,751 (-31.5%)
70	SummitTX Capital, L.P.	40,400	0.14%	$3.5M	-4,523 (-10.1%)
71	AQR CAPITAL MANAGEMENT LLC	39,321	0.13%	$3.4M	+6,178 (+18.6%)
72	NorthRock Partners, LLC	36,931	0.12%	$3.2M	-2,000 (-5.1%)
73	Swiss National Bank	36,800	0.12%	$3.2M	+2,600 (+7.6%)
74	Jump Financial, LLC	36,150	0.12%	$3.1M	-51,926 (-59.0%)
75	NEW YORK STATE COMMON RETIREMENT FUND	34,888	0.12%	$3.0M	+9,600 (+38.0%)
76	RHUMBLINE ADVISERS	33,118	0.11%	$2.8M	NEW
77	Engineers Gate Manager LP	31,458	0.11%	$2.7M	+2,191 (+7.5%)
78	ALLIANCEBERNSTEIN L.P.	29,955	0.10%	$1.7M	NEW
79	Guided Capital Wealth Management, LLC	28,361	0.10%	$2.4M	-6 (-0.0%)
80	Dauntless Investment Group, LLC	25,728	0.09%	$2.2M	+16,300 (+172.9%)
81	VANGUARD FIDUCIARY TRUST CO	25,642	0.09%	$2.2M	NEW
82	ExodusPoint Capital Management, LP	25,461	0.09%	$2.2M	-53,566 (-67.8%)
83	Buckley Capital Advisors, LLC	25,000	0.08%	$2.1M	-69,000 (-73.4%)
84	LPL Financial LLC	24,638	0.08%	$2.1M	+2,923 (+13.5%)
85	AMERIPRISE FINANCIAL INC	24,253	0.08%	$2.1M	-6,878 (-22.1%)
86	Qube Research & Technologies Ltd	23,100	0.08%	$2.0M	-205,465 (-89.9%)
87	POLEN CAPITAL MANAGEMENT LLC	22,541	0.08%	$1.9M	-1,783 (-7.3%)
88	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	22,493	0.08%	$1.9M	+373 (+1.7%)
89	SIT INVESTMENT ASSOCIATES INC	21,600	0.07%	$1.9M	—
90	Kerrisdale Advisers, LLC	20,390	0.07%	$1.7M	NEW
91	ADAGE CAPITAL PARTNERS GP, L.L.C.	18,079	0.06%	$1.6M	NEW
92	Legal & General Group Plc	16,839	0.06%	$1.4M	+4,430 (+35.7%)
93	XTX Topco Ltd	16,002	0.05%	$1.4M	-35,353 (-68.8%)
94	MetLife Investment Management, LLC	15,868	0.05%	$1.4M	NEW
95	STABLEFORD CAPITAL II LLC	15,395	0.05%	$1.3M	-6,964 (-31.1%)
96	NewEdge Advisors, LLC	13,871	0.05%	$1.2M	+3,587 (+34.9%)
97	AlTi Global, Inc.	13,829	0.05%	$1.2M	-996 (-6.7%)
98	Headlands Technologies LLC	13,681	0.05%	$1.2M	NEW
99	CITIGROUP INC	13,432	0.05%	$1.2M	+5,716 (+74.1%)
100	Exome Asset Management LLC	13,100	0.04%	$1.1M	—
101	HCR Wealth Advisors	12,639	0.04%	$1.1M	—
102	MANUFACTURERS LIFE INSURANCE COMPANY, THE	12,429	0.04%	$1.1M	+6,828 (+121.9%)
103	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	12,428	0.04%	$1.1M	NEW
104	VANGUARD ASSET MANAGEMENT, Ltd	12,146	0.04%	$1.0M	—
105	Roehl & Yi Investment Advisors, LLC	11,774	0.04%	$1.0M	-5,373 (-31.3%)
106	Pathstone Holdings, LLC	11,023	0.04%	$946K	—
107	Handelsbanken Fonder AB	9,800	0.03%	$841K	+1,000 (+11.4%)
108	HighTower Advisors, LLC	9,517	0.03%	$817K	+293 (+3.2%)
109	Jefferies Financial Group Inc.	8,739	0.03%	$750K	+1,239 (+16.5%)
110	Jupiter Topco LLC	8,376	0.03%	$719K	NEW
111	Police & Firemen's Retirement System of New Jersey	7,994	0.03%	$686K	NEW
112	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	7,644	0.03%	$656K	NEW
113	ENVESTNET ASSET MANAGEMENT INC	7,494	0.03%	$643K	+1,279 (+20.6%)
114	TOTH FINANCIAL ADVISORY CORP	7,400	0.02%	$635K	NEW
115	SATOVSKY ASSET MANAGEMENT LLC	7,075	0.02%	$607K	—
116	Quantbot Technologies LP	6,997	0.02%	$600K	+3,082 (+78.7%)
117	Aquatic Capital Management LLC	6,724	0.02%	$577K	NEW
118	GSA CAPITAL PARTNERS LLP	6,301	0.02%	$541K	-435 (-6.5%)
119	Zurcher Kantonalbank (Zurich Cantonalbank)	6,226	0.02%	$534K	+3,053 (+96.2%)
120	SIMPLEX TRADING, LLC	5,780	0.02%	$496K	NEW
121	BigSur Wealth Management LLC	5,590	0.02%	$480K	-14,392 (-72.0%)
122	KLP KAPITALFORVALTNING AS	5,300	0.02%	$455K	+1,500 (+39.5%)
123	STRS OHIO	5,300	0.02%	$455K	NEW
124	MARSHALL WACE, LLP	5,231	0.02%	$449K	-226,197 (-97.7%)
125	VOYA INVESTMENT MANAGEMENT LLC	5,200	0.02%	$446K	NEW
126	Penserra Capital Management LLC	5,123	0.02%	$439K	NEW
127	PRINCIPAL FINANCIAL GROUP INC	5,094	0.02%	$437K	NEW
128	ARIZONA STATE RETIREMENT SYSTEM	5,057	0.02%	$434K	+268 (+5.6%)
129	INTECH INVESTMENT MANAGEMENT LLC	5,015	0.02%	$430K	NEW
130	Private Advisor Group, LLC	4,950	0.02%	$425K	—
131	SUSQUEHANNA INTERNATIONAL GROUP, LLP	4,864	0.02%	$417K	NEW
132	OCCUDO QUANTITATIVE STRATEGIES LP	4,793	0.02%	$411K	NEW
133	Vanguard Investments Australia, Ltd.	4,663	0.02%	$400K	—
134	PRUDENTIAL FINANCIAL INC	4,505	0.02%	$387K	NEW
135	CIBC Bancorp USA Inc.	4,472	0.02%	$384K	NEW
136	BRIAN LOW FINANCIAL GROUP, LLC	4,362	0.01%	$374K	-236 (-5.1%)
137	CenterBook Partners LP	4,034	0.01%	$346K	-130,939 (-97.0%)
138	ELEVATION POINT WEALTH PARTNERS, LLC	3,933	0.01%	$337K	+246 (+6.7%)
139	Vise Technologies, Inc.	3,815	0.01%	$327K	NEW
140	ProShare Advisors LLC	3,548	0.01%	$304K	NEW
141	Amundi	3,396	0.01%	$291K	NEW
142	TWO SIGMA SECURITIES, LLC	3,235	0.01%	$278K	NEW
143	VICTORY CAPITAL MANAGEMENT INC	3,113	0.01%	$267K	NEW
144	Schonfeld Strategic Advisors LLC	3,086	0.01%	$265K	-65,402 (-95.5%)
145	Colter Lewis Investment Partners LLC	3,000	0.01%	$257K	NEW
146	Twin Lakes Capital Management, LLC	2,931	0.01%	$252K	—
147	CAPTRUST FINANCIAL ADVISORS	2,851	0.01%	$245K	NEW
148	Verdence Capital Advisors LLC	2,850	0.01%	$245K	NEW
149	Pictet Asset Management Holding SA	2,802	0.01%	$240K	NEW
150	LANARK FINANCIAL, INC.	2,550	0.01%	$219K	-3 (-0.1%)
151	ROYAL BANK OF CANADA	2,476	0.01%	$213K	+1,308 (+112.0%)
152	Ameritas Investment Partners, Inc.	2,460	0.01%	$211K	NEW
153	TRUIST FINANCIAL CORP	2,418	0.01%	$207K	NEW
154	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	2,400	0.01%	$211K	NEW
155	Clearstead Advisors, LLC	2,303	0.01%	$198K	+2,233 (+3190.0%)
156	Russell Investments Group, Ltd.	2,249	0.01%	$193K	+2,212 (+5978.4%)
157	MV CAPITAL MANAGEMENT, INC.	2,000	0.01%	$172K	—
158	ROTHSCHILD INVESTMENT LLC	1,513	0.01%	$130K	+1,512 (+151200.0%)
159	Ensign Peak Advisors, Inc	1,474	0.00%	$126K	+100 (+7.3%)
160	Tower Research Capital LLC (TRC)	1,233	0.00%	$106K	+160 (+14.9%)
161	State of Wyoming	1,018	0.00%	$87K	-261 (-20.4%)
162	ANTIPODES PARTNERS Ltd	964	0.00%	$83K	NEW
163	China Universal Asset Management Co., Ltd.	800	0.00%	$69K	NEW
164	Larson Financial Group LLC	769	0.00%	$66K	—
165	JONES FINANCIAL COMPANIES LLLP	761	0.00%	$67K	+302 (+65.8%)
166	IFG Advisory, LLC	650	0.00%	$56K	NEW
167	Eurizon Capital SGR S.p.A.	586	0.00%	$51K	-626 (-51.7%)
168	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	500	0.00%	$43K	NEW
169	KBC Group NV	487	0.00%	$42K	—
170	BESSEMER GROUP INC	430	0.00%	$37K	-33 (-7.1%)
171	US BANCORP \DE\	358	0.00%	$31K	+1 (+0.3%)
172	LOS ANGELES CAPITAL MANAGEMENT LLC	356	0.00%	$31K	NEW
173	NISA INVESTMENT ADVISORS, LLC	329	0.00%	$28K	NEW
174	OSAIC HOLDINGS, INC.	297	0.00%	$25K	+200 (+206.2%)
175	Kemnay Advisory Services Inc.	190	0.00%	$16K	NEW
176	Essential Partners LLC	146	0.00%	$13K	+120 (+461.5%)
177	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	139	0.00%	$12K	-48,276 (-99.7%)
178	Arax Advisory Partners	138	0.00%	$12K	NEW
179	Private Wealth Asset Management, LLC	125	0.00%	$11K	—
180	Parallel Advisors, LLC	123	0.00%	$11K	+32 (+35.2%)
181	SIGNATUREFD, LLC	102	0.00%	$9K	+31 (+43.7%)
182	Richardson Capital Management LLC	100	0.00%	$9K	—
183	Sterling Capital Management LLC	95	0.00%	$8K	NEW
184	Allworth Financial LP	89	0.00%	$8K	+52 (+140.5%)
185	PNC Financial Services Group, Inc.	87	0.00%	$7K	+71 (+443.8%)
186	HARBOUR INVESTMENTS, INC.	80	0.00%	$7K	—
187	Smartleaf Asset Management LLC	76	0.00%	$7K	—
188	TRUST CO OF TOLEDO NA /OH/	64	0.00%	$5K	-21 (-24.7%)
189	EverSource Wealth Advisors, LLC	58	0.00%	$5K	+9 (+18.4%)
190	Farther Finance Advisors, LLC	47	0.00%	$4K	-9 (-16.1%)
191	FMR LLC	28	0.00%	$2K	+7 (+33.3%)
192	Global Retirement Partners, LLC	10	0.00%	$858	NEW
193	Bayforest Capital Ltd	7	0.00%	$601	NEW
194	GAMMA Investing LLC	6	0.00%	$515	+2 (+50.0%)
195	JPL Wealth Management, LLC	3	0.00%	$258	NEW
196	Rockefeller Capital Management L.P.	2	0.00%	$172	—

Exited since 2026-03-31 (36 filers; largest 25 shown)

BRAIDWELL LP	−463,600
MILLENNIUM MANAGEMENT LLC	−368,298
TUDOR INVESTMENT CORP ET AL	−171,430
Brevan Howard Capital Management LP	−43,726
SG Americas Securities, LLC	−37,928
Sofinnova Investments, Inc.	−33,930
Campbell & CO Investment Adviser LLC	−28,625
Sigma Planning Corp	−20,424
Hudson Bay Capital Management LP	−16,205
CAPITAL FUND MANAGEMENT S.A.	−13,701
Cannon Global Investment Management, LLC	−13,000
FOX RUN MANAGEMENT, L.L.C.	−11,575
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.	−11,422
Marex Group plc	−10,600
Catalyst Funds Management Pty Ltd	−10,300
Portolan Capital Management, LLC	−9,573
JANUS HENDERSON GROUP PLC	−8,376
VOLORIDGE INVESTMENT MANAGEMENT, LLC	−8,156
Diametric Capital, LP	−7,885
Centiva Capital, LP	−7,288
Legato Capital Management LLC	−6,363
Stonepine Capital Management, LLC	−6,000
Y-Intercept (Hong Kong) Ltd	−5,864
SkyView Investment Advisors, LLC	−5,500
Patriot Financial Group Insurance Agency, LLC	−5,450

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
JW Partners, LP	SCHEDULE 13G	2026-07-31	2026-06-30	2,006,252	6.82%
Jason G. Wild	SCHEDULE 13G	2026-07-31	2026-06-30	2,692,856	9.15%
JW Asset Management, LLC	SCHEDULE 13G	2026-07-31	2026-06-30	2,692,856	9.15%
JW GP, LLC	SCHEDULE 13G	2026-07-31	2026-06-30	2,692,856	9.15%
JW Opportunities Fund, LLC	SCHEDULE 13G	2026-07-31	2026-06-30	686,604	2.33%
BlackRock, Inc.	SCHEDULE 13G	2026-07-28	2026-06-30	1,576,071	5.4%
BROWN ADVISORY INC	SCHEDULE 13G/A	2026-05-15	2025-12-31	1,578,119	5.38%
BROWN ADVISORY LLC	SCHEDULE 13G/A	2026-05-15	2025-12-31	1,568,983	5.35%
BROWN INVESTMENT ADVISORY & TRUST CO	SCHEDULE 13G/A	2026-05-15	2025-12-31	8,333	0.03%
SIGNATURE FINANCIAL MANAGEMENT, INC.	SCHEDULE 13G/A	2026-05-15	2025-12-31	803	0.003%
Juan Jose Chacon Quiros	SCHEDULE 13G/A	2026-02-19	2025-12-31	1,424,300	4.9%
Nantahala Capital Management, LLC	SCHEDULE 13G/A	2026-02-13	2025-12-31	987,689	3.4%
Daniel Mack	SCHEDULE 13G/A	2026-02-13	2025-12-31	987,689	3.5%
Wilmot B. Harkey	SCHEDULE 13G/A	2026-02-13	2025-12-31	987,689	3.4%
Capital Research Global Investors	SCHEDULE 13G/A	2025-08-13	2025-06-30	1,024,417	3.5%
Qatar Investment Authority	SCHEDULE 13G/A	2025-05-13	2025-03-31	2,390,951	8.27%
Roderick Wong, M.D.	SCHEDULE 13G/A	2025-02-14	2024-12-31	2,822,216	9.99%
RTW Investments, LP	SCHEDULE 13G/A	2025-02-14	2024-12-31	2,822,216	9.99%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.