Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

AGIOS PHARMACEUTICALS, INC.

CIK 0001439222AGIO· quarter ending 2026-06-30

Shares outstanding

59,701,882

as of 2026-07-24 · 10-Q cover page, filed 2026-07-30

Held by 13F filers

66,107,502

110.7% of shares outstanding

Holders

238

+4 vs 2026-03-31 · 38 new, 34 exited

Value

$2.5B

shares +4.8% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-07-30, as of 2026-07-24)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	AGIO · NASDAQ	59,701,882	66,107,502	110.7%	238	00847X104

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	00847X104	COM	238	66,107,502	59,701,882	110.7%	$2.5B	9 call / 4 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (238 of 238 · 00847X104)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	BlackRock, Inc.	6,455,997	10.81%	$239.6M	+701,040 (+12.2%)
2	FARALLON CAPITAL MANAGEMENT, L.L.C.	5,917,400	9.91%	$219.6M	+233,400 (+4.1%)
3	STATE STREET CORP	3,533,633	5.92%	$131.1M	+168,754 (+5.0%)
4	Lynx1 Capital Management LP	3,408,937	5.71%	$126.5M	+797,369 (+30.5%)
5	D. E. Shaw & Co., Inc.	3,107,005	5.20%	$115.3M	+425,836 (+15.9%)
6	VANGUARD PORTFOLIO MANAGEMENT LLC	2,898,197	4.85%	$107.6M	+287,162 (+11.0%)
7	VANGUARD CAPITAL MANAGEMENT LLC	2,681,845	4.49%	$99.5M	+49,529 (+1.9%)
8	ARMISTICE CAPITAL, LLC	2,400,000	4.02%	$89.1M	-316,000 (-11.6%)
9	Erste Asset Management GmbH	2,154,900	3.61%	$82.0M	-550,000 (-20.3%)
10	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	2,110,809	3.54%	$78.3M	+616,374 (+41.2%)
11	GEODE CAPITAL MANAGEMENT, LLC	1,574,268	2.64%	$58.4M	+106,358 (+7.2%)
12	SUSQUEHANNA INTERNATIONAL GROUP, LLP	1,375,558	2.30%	$51.0M	+30,605 (+2.3%)
13	ADAR1 Capital Management, LLC	1,288,053	2.16%	$47.8M	+1,147,381 (+815.6%)
14	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	1,280,044	2.14%	$47.5M	-300,796 (-19.0%)
15	DIMENSIONAL FUND ADVISORS LP	1,248,738	2.09%	$46.3M	+97,124 (+8.4%)
16	GW&K Investment Management, LLC	1,206,615	2.02%	$44.8M	-8,286 (-0.7%)
17	GOLDMAN SACHS GROUP INC	1,150,932	1.93%	$42.7M	+345,156 (+42.8%)
18	UBS Group AG	985,831	1.65%	$36.6M	+853,291 (+643.8%)
19	MORGAN STANLEY	963,256	1.61%	$35.7M	-4,269 (-0.4%)
20	Nuveen, LLC	873,560	1.46%	$32.4M	+151,212 (+20.9%)
21	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	810,530	1.36%	$30.1M	+560,069 (+223.6%)
22	Foresite Capital Management VI LLC	785,000	1.31%	$29.1M	+260,000 (+49.5%)
23	CITADEL ADVISORS LLC	732,687	1.23%	$27.2M	+113,074 (+18.2%)
24	AQR CAPITAL MANAGEMENT LLC	684,340	1.15%	$25.4M	+647,930 (+1779.5%)
25	Parkman Healthcare Partners LLC	669,046	1.12%	$24.8M	+265,521 (+65.8%)
26	SCS Capital Management LLC	612,850	1.03%	$22.7M	—
27	Qube Research & Technologies Ltd	597,638	1.00%	$22.2M	+409,971 (+218.5%)
28	NORTHERN TRUST CORP	554,709	0.93%	$20.6M	+45,437 (+8.9%)
29	Defilade Capital Management, L.P.	546,848	0.92%	$20.3M	NEW
30	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	538,128	0.90%	$20.0M	+61,096 (+12.8%)
31	TWO SIGMA INVESTMENTS, LP	536,380	0.90%	$19.9M	+284,744 (+113.2%)
32	Rock Springs Capital Management LP	532,563	0.89%	$19.8M	-266,600 (-33.4%)
33	Schonfeld Strategic Advisors LLC	520,083	0.87%	$19.3M	+320,022 (+160.0%)
34	BANK OF AMERICA CORP /DE/	507,869	0.85%	$18.8M	-31 (-0.0%)
35	Point72 Asset Management, L.P.	506,344	0.85%	$18.8M	NEW
36	JANE STREET GROUP, LLC	492,598	0.83%	$18.3M	-192,642 (-28.1%)
37	Legal & General Group Plc	434,719	0.73%	$16.1M	+10,804 (+2.5%)
38	VANGUARD FIDUCIARY TRUST CO	395,868	0.66%	$14.7M	+13,847 (+3.6%)
39	PANAGORA ASSET MANAGEMENT INC	373,931	0.63%	$13.9M	+135,463 (+56.8%)
40	KENNEDY CAPITAL MANAGEMENT LLC	373,230	0.63%	$13.9M	+97,774 (+35.5%)
41	JPMORGAN CHASE & CO	359,756	0.60%	$13.8M	+208,198 (+137.4%)
42	Connor, Clark & Lunn Investment Management Ltd.	359,550	0.60%	$13.3M	-90,543 (-20.1%)
43	Squarepoint Ops LLC	321,138	0.54%	$11.9M	+112,250 (+53.7%)
44	Ensign Peak Advisors, Inc	297,630	0.50%	$11.0M	+291,060 (+4430.1%)
45	BNP PARIBAS FINANCIAL MARKETS	269,383	0.45%	$10.0M	-58,074 (-17.7%)
46	ALGERT GLOBAL LLC	248,007	0.42%	$9.2M	-20,428 (-7.6%)
47	PRICE T ROWE ASSOCIATES INC /MD/	218,966	0.37%	$8.1M	-79,817 (-26.7%)
48	Palo Alto Investors LP	213,601	0.36%	$7.9M	—
49	Assenagon Asset Management S.A.	207,910	0.35%	$7.7M	+140,757 (+209.6%)
50	Tetragon Partners GP Ltd	205,579	0.34%	$7.6M	+40,740 (+24.7%)
51	Bank of New York Mellon Corp	198,685	0.33%	$7.4M	+11,894 (+6.4%)
52	Jump Financial, LLC	182,773	0.31%	$6.8M	NEW
53	Invesco Ltd.	168,153	0.28%	$6.2M	+16,723 (+11.0%)
54	FIRST TRUST ADVISORS LP	165,587	0.28%	$6.1M	NEW
55	Ishara Investments LP	164,000	0.27%	$6.1M	NEW
56	HRT FINANCIAL LP	160,759	0.27%	$6.0M	-34,673 (-17.7%)
57	GROUP ONE TRADING LLC	151,994	0.25%	$5.6M	-21,285 (-12.3%)
58	BOOTHBAY FUND MANAGEMENT, LLC	149,886	0.25%	$5.6M	NEW
59	MARSHALL WACE, LLP	138,800	0.23%	$5.2M	-309,318 (-69.0%)
60	AMERICAN CENTURY COMPANIES INC	134,512	0.23%	$5.0M	+14,259 (+11.9%)
61	Man Group plc	124,466	0.21%	$4.6M	-19,831 (-13.7%)
62	ArrowMark Colorado Holdings LLC	117,714	0.20%	$4.4M	-285,876 (-70.8%)
63	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	116,909	0.20%	$4.3M	+6,230 (+5.6%)
64	Pictet Asset Management Holding SA	111,861	0.19%	$4.2M	-16,953 (-13.2%)
65	Swiss National Bank	111,660	0.19%	$4.1M	+2,800 (+2.6%)
66	CAPITAL FUND MANAGEMENT S.A.	104,080	0.17%	$3.9M	-25,451 (-19.6%)
67	Universal- Beteiligungs- und Servicegesellschaft mbH	99,726	0.17%	$3.7M	+39,047 (+64.4%)
68	Knott David M Jr	95,058	0.16%	$3.5M	+2,000 (+2.1%)
69	Trexquant Investment LP	93,539	0.16%	$3.5M	+18,241 (+24.2%)
70	Jain Global LLC	91,647	0.15%	$3.4M	NEW
71	CITIGROUP INC	89,167	0.15%	$3.3M	+72,071 (+421.6%)
72	RHUMBLINE ADVISERS	79,441	0.13%	$2.9M	+6,072 (+8.3%)
73	Campbell & CO Investment Adviser LLC	73,095	0.12%	$2.7M	NEW
74	Exome Asset Management LLC	70,500	0.12%	$2.6M	-54,560 (-43.6%)
75	Edgestream Partners, L.P.	70,195	0.12%	$2.6M	-73,536 (-51.2%)
76	Russell Investments Group, Ltd.	66,856	0.11%	$2.5M	+27,146 (+68.4%)
77	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	66,796	0.11%	$2.5M	-1,768 (-2.6%)
78	TUDOR INVESTMENT CORP ET AL	65,779	0.11%	$2.4M	+7,628 (+13.1%)
79	DEUTSCHE BANK AG\	62,228	0.10%	$2.3M	+11,844 (+23.5%)
80	ALLIANCEBERNSTEIN L.P.	61,864	0.10%	$2.1M	+370 (+0.6%)
81	ALPS ADVISORS INC	60,059	0.10%	$2.2M	+12,358 (+25.9%)
82	Seven Fleet Capital Management LP	56,900	0.10%	$2.1M	-152,647 (-72.8%)
83	Rafferty Asset Management, LLC	55,580	0.09%	$2.1M	-47,161 (-45.9%)
84	Engineers Gate Manager LP	53,912	0.09%	$2.0M	+24,992 (+86.4%)
85	WELLS FARGO & COMPANY/MN	53,240	0.09%	$2.0M	+30,477 (+133.9%)
86	VANGUARD ASSET MANAGEMENT, Ltd	52,050	0.09%	$1.9M	-6,598 (-11.3%)
87	XTX Topco Ltd	50,366	0.08%	$1.9M	-110,514 (-68.7%)
88	DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main	49,764	0.08%	$1.8M	NEW
89	BARCLAYS PLC	48,300	0.08%	$1.8M	-4,138 (-7.9%)
90	HARBOR CAPITAL ADVISORS, INC.	46,550	0.08%	$1.7M	+3,545 (+8.2%)
91	Quantinno Capital Management LP	43,514	0.07%	$1.6M	+15,923 (+57.7%)
92	MARTINGALE ASSET MANAGEMENT L P	43,009	0.07%	$1.6M	+7,195 (+20.1%)
93	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	41,455	0.07%	$1.5M	-616 (-1.5%)
94	IEQ CAPITAL, LLC	40,404	0.07%	$1.5M	NEW
95	Virtus Investment Advisers, LLC	39,473	0.07%	$1.5M	+8,514 (+27.5%)
96	Caption Management, LLC	39,249	0.07%	$1.5M	+26,900 (+217.8%)
97	FMR LLC	39,072	0.07%	$1.4M	+29,951 (+328.4%)
98	Aquatic Capital Management LLC	38,627	0.06%	$1.4M	+27,305 (+241.2%)
99	MANUFACTURERS LIFE INSURANCE COMPANY, THE	37,727	0.06%	$1.4M	-12,319 (-24.6%)
100	SEI INVESTMENTS CO	35,089	0.06%	$1.3M	-28,461 (-44.8%)
101	EDGEWOOD MANAGEMENT LLC	35,000	0.06%	$1.3M	—
102	MetLife Investment Management, LLC	34,470	0.06%	$1.3M	+1,612 (+4.9%)
103	SG Americas Securities, LLC	34,348	0.06%	$1.3M	-22,899 (-40.0%)
104	Hennion & Walsh Asset Management, Inc.	33,574	0.06%	$1.2M	-294 (-0.9%)
105	STATE OF WISCONSIN INVESTMENT BOARD	32,235	0.05%	$1.2M	+4,425 (+15.9%)
106	Bridgefront Capital, LLC	31,097	0.05%	$1.2M	+24,546 (+374.7%)
107	Mariner, LLC	29,139	0.05%	$1.1M	NEW
108	PROFUND ADVISORS LLC	28,260	0.05%	$1.0M	-17,534 (-38.3%)
109	Quadrature Capital Ltd	28,111	0.05%	$1.0M	NEW
110	VIRGINIA RETIREMENT SYSTEMS ET Al	27,761	0.05%	$1.0M	-11,300 (-28.9%)
111	AXQ CAPITAL, LP	27,656	0.05%	$1.0M	NEW
112	Handelsbanken Fonder AB	26,123	0.04%	$969K	+6,800 (+35.2%)
113	OAK RIDGE INVESTMENTS LLC	25,649	0.04%	$952K	+784 (+3.2%)
114	GSA CAPITAL PARTNERS LLP	25,113	0.04%	$932K	-11,359 (-31.1%)
115	DIVERSIFIED TRUST CO	23,948	0.04%	$889K	+8,629 (+56.3%)
116	Jupiter Topco LLC	23,797	0.04%	$883K	NEW
117	Zurcher Kantonalbank (Zurich Cantonalbank)	23,620	0.04%	$877K	—
118	Vanguard Global Advisers, LLC	23,317	0.04%	$865K	-35 (-0.1%)
119	JACOBS LEVY EQUITY MANAGEMENT, INC	22,938	0.04%	$851K	-5,592 (-19.6%)
120	CenterBook Partners LP	21,885	0.04%	$812K	+4,440 (+25.5%)
121	Creative Planning	21,604	0.04%	$802K	+8,271 (+62.0%)
122	MERCER GLOBAL ADVISORS INC /ADV	21,295	0.04%	$790K	NEW
123	WELLINGTON MANAGEMENT GROUP LLP	20,875	0.03%	$775K	-620,611 (-96.7%)
124	Headlands Technologies LLC	20,805	0.03%	$772K	-38,452 (-64.9%)
125	NEW YORK STATE COMMON RETIREMENT FUND	20,768	0.03%	$771K	-30,939 (-59.8%)
126	Cerity Partners LLC	20,229	0.03%	$751K	NEW
127	Quarry LP	20,147	0.03%	$748K	NEW
128	Inspire Investing, LLC	18,269	0.03%	$678K	+3,529 (+23.9%)
129	LOS ANGELES CAPITAL MANAGEMENT LLC	18,028	0.03%	$669K	+17,078 (+1797.7%)
130	State of New Jersey Common Pension Fund D	17,998	0.03%	$668K	-866 (-4.6%)
131	WEALTH ENHANCEMENT ADVISORY SERVICES, LLC	17,959	0.03%	$740K	NEW
132	Police & Firemen's Retirement System of New Jersey	17,444	0.03%	$647K	+1,804 (+11.5%)
133	CANADA LIFE ASSURANCE Co	17,121	0.03%	$634K	+6,437 (+60.2%)
134	CANADA PENSION PLAN INVESTMENT BOARD	16,500	0.03%	$612K	-7,900 (-32.4%)
135	Tidal Investments LLC	16,100	0.03%	$597K	+1,724 (+12.0%)
136	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	15,847	0.03%	$588K	—
137	FOX RUN MANAGEMENT, L.L.C.	15,622	0.03%	$580K	NEW
138	ARIZONA STATE RETIREMENT SYSTEM	15,359	0.03%	$570K	+198 (+1.3%)
139	TD Asset Management Inc	15,086	0.03%	$560K	-8,646 (-36.4%)
140	Rockefeller Capital Management L.P.	14,935	0.03%	$554K	+60 (+0.4%)
141	AlphaCentric Advisors LLC	14,173	0.02%	$526K	+202 (+1.4%)
142	Atria Investments, Inc	14,033	0.02%	$521K	+156 (+1.1%)
143	Vanguard Investments Australia, Ltd.	13,537	0.02%	$502K	—
144	INTECH INVESTMENT MANAGEMENT LLC	12,858	0.02%	$477K	-1,171 (-8.3%)
145	COMMERCE BANK	12,437	0.02%	$462K	—
146	ENVESTNET ASSET MANAGEMENT INC	12,057	0.02%	$447K	-171 (-1.4%)
147	KLP KAPITALFORVALTNING AS	11,800	0.02%	$438K	—
148	CAPTRUST FINANCIAL ADVISORS	11,351	0.02%	$421K	NEW
149	VOYA INVESTMENT MANAGEMENT LLC	11,350	0.02%	$421K	+1,354 (+13.5%)
150	Gallagher Fiduciary Advisors, LLC	11,095	0.02%	$412K	+18 (+0.2%)
151	ROYAL BANK OF CANADA	10,429	0.02%	$388K	-1,361 (-11.5%)
152	PRUDENTIAL FINANCIAL INC	9,955	0.02%	$369K	+910 (+10.1%)
153	Hudson Bay Capital Management LP	9,700	0.02%	$360K	-42,130 (-81.3%)
154	ProShare Advisors LLC	9,694	0.02%	$360K	-1,111 (-10.3%)
155	ALLSTATE CORP	9,485	0.02%	$352K	NEW
156	China Universal Asset Management Co., Ltd.	9,465	0.02%	$351K	-933 (-9.0%)
157	Brevan Howard Capital Management LP	9,290	0.02%	$345K	-15,179 (-62.0%)
158	CAPSTONE INVESTMENT ADVISORS, LLC	9,196	0.02%	$341K	NEW
159	Fiduciary Trust Co	8,250	0.01%	$306K	+3 (+0.0%)
160	E Fund Management Co., Ltd.	7,837	0.01%	$291K	-5,078 (-39.3%)
161	HSBC HOLDINGS PLC	7,717	0.01%	$293K	NEW
162	JONES FINANCIAL COMPANIES LLLP	7,628	0.01%	$289K	+3,584 (+88.6%)
163	Financiere des Professionnels - Fonds d'investissement inc.	7,505	0.01%	$279K	NEW
164	PDT Partners, LLC	7,500	0.01%	$278K	—
165	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO	6,796	0.01%	$252K	—
166	Savvy Advisors, Inc.	6,794	0.01%	$252K	—
167	TEACHER RETIREMENT SYSTEM OF TEXAS	6,475	0.01%	$240K	-652 (-9.1%)
168	VICTORY CAPITAL MANAGEMENT INC	6,441	0.01%	$239K	-12,674 (-66.3%)
169	Vanguard Personalized Indexing Management, LLC	6,172	0.01%	$229K	NEW
170	PNC Financial Services Group, Inc.	5,836	0.01%	$217K	+896 (+18.1%)
171	XPONANCE LLC	5,757	0.01%	$214K	NEW
172	Merit Financial Group, LLC	5,556	0.01%	$206K	NEW
173	Inscription Capital, LLC	5,540	0.01%	$206K	-3,055 (-35.5%)
174	Arax Advisory Partners	5,376	0.01%	$200K	+5,256 (+4380.0%)
175	Ameritas Investment Partners, Inc.	5,368	0.01%	$199K	+649 (+13.8%)
176	State of Alaska, Department of Revenue	5,000	0.01%	$185K	—
177	Mirae Asset Global Investments Co., Ltd.	2,660	0.00%	$99K	-396 (-13.0%)
178	Eurizon Capital SGR S.p.A.	2,647	0.00%	$101K	—
179	KBC Group NV	2,073	0.00%	$77K	—
180	Tower Research Capital LLC (TRC)	2,054	0.00%	$76K	-6,363 (-75.6%)
181	Versant Capital Management, Inc	2,001	0.00%	$74K	+1,583 (+378.7%)
182	Allworth Financial LP	1,971	0.00%	$73K	+1,903 (+2798.5%)
183	OSAIC HOLDINGS, INC.	1,592	0.00%	$59K	-194 (-10.9%)
184	Bayforest Capital Ltd	1,492	0.00%	$55K	-1,323 (-47.0%)
185	NISA INVESTMENT ADVISORS, LLC	1,358	0.00%	$50K	+845 (+164.7%)
186	ASSETMARK, INC	1,317	0.00%	$49K	—
187	GF FUND MANAGEMENT CO. LTD.	1,242	0.00%	$46K	-68 (-5.2%)
188	Quantbot Technologies LP	1,172	0.00%	$43K	NEW
189	Sterling Capital Management LLC	1,136	0.00%	$42K	-735 (-39.3%)
190	Pacer Advisors, Inc.	928	0.00%	$34K	NEW
191	ACADIAN ASSET MANAGEMENT LLC	876	0.00%	$31K	-4,983 (-85.0%)
192	Nykredit A/S	703	0.00%	$26K	NEW
193	Essential Partners LLC	557	0.00%	$21K	+552 (+11040.0%)
194	US BANCORP \DE\	542	0.00%	$20K	—
195	GAMMA Investing LLC	538	0.00%	$20K	-149 (-21.7%)
196	EverSource Wealth Advisors, LLC	535	0.00%	$20K	+489 (+1063.0%)
197	Kemnay Advisory Services Inc.	533	0.00%	$20K	+56 (+11.7%)
198	CITY HOLDING CO	500	0.00%	$19K	—
199	Farther Finance Advisors, LLC	484	0.00%	$18K	+282 (+139.6%)
200	FIRST HORIZON CORP	442	0.00%	$16K	-201 (-31.3%)
201	Smartleaf Asset Management LLC	424	0.00%	$16K	—
202	ROTHSCHILD INVESTMENT LLC	402	0.00%	$15K	+362 (+905.0%)
203	SIGNATUREFD, LLC	399	0.00%	$15K	—
204	True Wealth Design, LLC	306	0.00%	$11K	+294 (+2450.0%)
205	FIFTH THIRD BANCORP	281	0.00%	$10K	+72 (+34.4%)
206	THURSTON, SPRINGER, MILLER, HERD & TITAK, INC.	241	0.00%	$9K	—
207	Bell Investment Advisors, Inc	237	0.00%	$9K	—
208	IFP Advisors, Inc	233	0.00%	$9K	+231 (+11550.0%)
209	Hillsdale Investment Management Inc.	200	0.00%	$7K	—
210	Concord Wealth Partners	200	0.00%	$7K	NEW
211	SJS Investment Consulting Inc.	131	0.00%	$5K	+130 (+13000.0%)
212	Keating Financial Advisory Services, Inc.	124	0.00%	$5K	-19 (-13.3%)
213	Hurley Capital, LLC	120	0.00%	$4K	—
214	Triumph Capital Management	100	0.00%	$4K	—
215	Private Wealth Management Group, LLC	83	0.00%	$3K	—
216	JPL Wealth Management, LLC	80	0.00%	$3K	+10 (+14.3%)
217	Wealth Enhancement Trust Services, Inc.	77	0.00%	$3K	NEW
218	BESSEMER GROUP INC	76	0.00%	$3K	—
219	Larson Financial Group LLC	66	0.00%	$2K	—
220	Clearstead Advisors, LLC	63	0.00%	$2K	NEW
221	Coppell Advisory Solutions LLC	59	0.00%	$910K	NEW
222	Pinnacle Wealth Planning Services, Inc.	40	0.00%	$1K	—
223	ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/	38	0.00%	$1K	NEW
224	SBI Securities Co., Ltd.	32	0.00%	$1K	-1 (-3.0%)
225	Parkside Financial Bank & Trust	22	0.00%	$817	-40 (-64.5%)
226	Parallel Advisors, LLC	20	0.00%	$742	—
227	FEDERATED HERMES, INC.	19	0.00%	$705	—
228	Manchester Capital Management LLC	16	0.00%	$594	—
229	Covestor Ltd	12	0.00%	$0	+9 (+300.0%)
230	Global Retirement Partners, LLC	11	0.00%	$408	NEW
231	Steward Partners Investment Advisory, LLC	9	0.00%	$334	—
232	FIDUCIARY FINANCIAL ADVISORS	5	0.00%	$185	NEW
233	Fortitude Family Office, LLC	2	0.00%	$74	—
234	JFS WEALTH ADVISORS, LLC	2	0.00%	$75	—
235	Bay Harbor Wealth Management, LLC	2	0.00%	$74	—
236	Dunhill Financial, LLC	1	0.00%	$67	—
237	Rialto Wealth Management, LLC	1	0.00%	$38	—
238	Hughes Financial Services, LLC	1	0.00%	$37	NEW

Exited since 2026-03-31 (34 filers; largest 25 shown)

T. Rowe Price Investment Management, Inc.	−1,488,740
MPM BIOIMPACT LLC	−1,306,261
Frazier Life Sciences Management, L.P.	−1,256,080
Artisan Partners Limited Partnership	−481,516
Vestal Point Capital, LP	−450,000
Eversept Partners, LP	−200,000
ESSEX INVESTMENT MANAGEMENT CO LLC	−103,177
TANG CAPITAL MANAGEMENT LLC	−100,000
Woodline Partners LP	−74,423
Capital International Investors	−48,616
SIMPLEX TRADING, LLC	−37,462
Legato Capital Management LLC	−32,373
MILLENNIUM MANAGEMENT LLC	−32,144
PRELUDE CAPITAL MANAGEMENT, LLC	−29,085
JANUS HENDERSON GROUP PLC	−23,797
Virtu Financial LLC	−21,392
Balyasny Asset Management L.P.	−18,009
Caitong International Asset Management Co., Ltd	−16,222
PSP Research LLC	−15,000
Y-Intercept (Hong Kong) Ltd	−13,866
Pale Fire Capital SE	−13,650
Voleon Capital Management LP	−9,679
NOMURA HOLDINGS INC	−9,176
Ground Swell Capital, LLC	−8,347
FRANKLIN RESOURCES INC	−8,287

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Four Crossings Institutional Partners V, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Spokes, Andrew J. M.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Wehrly, Mark C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Warren, John R.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Short Daniel S.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Saito Edric C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Dapice Joshua J.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Roberts, Jr., Thomas G.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Luo Patrick (Cheng)	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Dreyfuss, Philip D.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Dunn Hannah E.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Farallon Capital (AM) Investors, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital F5 Master I, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital Institutional Partners III, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital Institutional Partners II, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital Institutional Partners, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital Management, L.L.C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Farallon Capital Offshore Investors II, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Capital Partners, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon F5 (GP), L.L.C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Healthcare Partners (GP), L.L.C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Healthcare Partners Master, L.P.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Institutional (GP) V, L.L.C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Farallon Partners, L.L.C.	SCHEDULE 13G/A	2026-08-03	2026-06-30	0	0%
Linn, Michael G.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Kim, David T.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Gehani, Varun N.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Giauque, Nicolas	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
Husen, Avner A.	SCHEDULE 13G/A	2026-08-03	2026-06-30	5,917,400	9.9%
D. E. Shaw & Co., L.P.	SCHEDULE 13G	2026-07-02	2026-06-25	3,034,031	5.1%
David E. Shaw	SCHEDULE 13G	2026-07-02	2026-06-25	3,034,031	5.1%
Armistice Capital, LLC	SCHEDULE 13G/A	2026-05-15	2026-03-31	2,716,000	4.57%
Steven Boyd	SCHEDULE 13G/A	2026-05-15	2026-03-31	2,716,000	4.57%
Lynx1 Capital Management LP	SCHEDULE 13G	2026-05-06	2026-04-29	3,013,949	5.1%
Weston Nichols	SCHEDULE 13G	2026-05-06	2026-04-29	3,013,949	5.1%
Vanguard Capital Management	SCHEDULE 13G	2026-04-29	2026-03-31	3,088,169	5.27%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Patel, Rajiv A.	SCHEDULE 13G/A	2026-02-09	2025-12-31	0	0%
Seybold, William	SCHEDULE 13G/A	2026-02-09	2025-12-31	0	0%
STATE STREET CORPORATION	SCHEDULE 13G	2026-02-09	2025-12-31	3,108,145	5.3%
Fried, Richard B	SCHEDULE 13G/A	2026-02-09	2025-12-31	0	0%
Bellevue Group AG	SCHEDULE 13G/A	2025-12-05	2025-11-19	0	0%
Bellevue Asset Management AG	SCHEDULE 13G/A	2025-12-05	2025-11-19	0	0%
Paradigm BioCapital Advisors LP	SCHEDULE 13G/A	2025-11-14	2025-09-30	2,873,555	4.9%
Senai Asefaw, M.D.	SCHEDULE 13G/A	2025-11-14	2025-09-30	2,873,555	4.9%
Paradigm BioCapital International Fund Ltd.	SCHEDULE 13G/A	2025-11-14	2025-09-30	2,536,170	4.4%
Paradigm BioCapital Advisors GP LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	2,873,555	4.9%
BlackRock, Inc.	SCHEDULE 13G/A	2025-07-17	2025-06-30	4,513,170	7.8%
Biotech Target N.V.	SCHEDULE 13G/A	2025-06-13	2025-06-01	0	0%
BB Biotech AG	SCHEDULE 13G/A	2025-06-13	2025-06-01	0	0%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.