Institutional HoldersBeta

Who holds a company, from every 13F filed for the quarter, one row per filer exactly as filed, against the latest share count the company reported.

ANAPTYSBIO, INC

CIK 0001370053ANAB· quarter ending 2026-06-30

Shares outstanding

29,100,902

as of 2026-05-07 · 10-Q cover page, filed 2026-05-12

Held by 13F filers

30,132,151

103.5% of shares outstanding

Holders

213

+5 vs 2026-03-31 · 45 new, 40 exited

Value

$2.1B

shares +6.7% vs prior quarter

13F holdings exceed the share count. This is normal for heavily shorted stocks: shares lent to short sellers are reported by the lender and again by whoever bought them. Related filers occasionally report the same position twice as well.

Share classes (cover page of the 10-Q filed 2026-05-12, as of 2026-05-07)

Class	Listed	Shares outstanding	Held by 13F filers	% of class	Holders	CUSIP
Common stock	ANAB · NASDAQ	29,100,902	30,132,151	103.5%	213	032724106

Each class is compared with its own share count; classes are not added together. A class that is not exchange-listed cannot be held by 13F filers.

Securities (CUSIPs held in 13F this quarter)

tick to combine

Count	CUSIP	Class (as filers write it)	Holders	Shares held	Class shares	% of class	Value	Options	Mapped via
	032724106	COM	213	30,132,151	29,100,902	103.5%	$2.1B	4 call / 2 put	13DG	holders →

Totals combine the ticked CUSIPs and update as you tick: common-stock classes by default; preferreds, notes, warrants and depositary shares are listed but not counted. "holders →" shows a single CUSIP on its own. Bonds are held as a principal amount, not shares. Options positions are never counted as holdings.

Top holders (213 of 213 · 032724106)

change vs 2026-03-31

#	Filer	Shares	% of class	Value	Change
1	EcoR1 Capital, LLC	7,880,094	27.08%	$531.9M	—
2	BlackRock, Inc.	1,844,049	6.34%	$124.5M	+162,669 (+9.7%)
3	TANG CAPITAL MANAGEMENT LLC	1,330,879	4.57%	$89.8M	—
4	STATE STREET CORP	1,286,194	4.42%	$86.8M	+293,749 (+29.6%)
5	VANGUARD CAPITAL MANAGEMENT LLC	906,233	3.11%	$61.2M	+53,082 (+6.2%)
6	Affinity Asset Advisors, LLC	826,109	2.84%	$55.8M	-113,891 (-12.1%)
7	Sanofi	821,917	2.82%	$55.5M	—
8	MILLENNIUM MANAGEMENT LLC	807,316	2.77%	$54.5M	+331,744 (+69.8%)
9	Woodline Partners LP	717,014	2.46%	$48.4M	+372,758 (+108.3%)
10	683 Capital Management, LLC	660,000	2.27%	$44.6M	+35,000 (+5.6%)
11	GEODE CAPITAL MANAGEMENT, LLC	637,873	2.19%	$43.1M	+117,632 (+22.6%)
12	Palo Alto Investors LP	603,489	2.07%	$40.7M	-34,672 (-5.4%)
13	GOLDMAN SACHS GROUP INC	584,070	2.01%	$39.4M	+251,327 (+75.5%)
14	First Light Asset Management, LLC	582,004	2.00%	$39.3M	+16,573 (+2.9%)
15	D. E. Shaw & Co., Inc.	539,666	1.85%	$36.4M	-39,630 (-6.8%)
16	VANGUARD PORTFOLIO MANAGEMENT LLC	527,858	1.81%	$35.6M	+7,988 (+1.5%)
17	Apis Capital Advisors, LLC	497,000	1.71%	$33.5M	+259,000 (+108.8%)
18	Sofinnova Investments, Inc.	493,536	1.70%	$33.3M	+245,283 (+98.8%)
19	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	488,651	1.68%	$33.0M	-3,469 (-0.7%)
20	Nuveen, LLC	420,664	1.45%	$28.4M	+104,599 (+33.1%)
21	BANK OF AMERICA CORP /DE/	417,812	1.44%	$28.2M	-83,274 (-16.6%)
22	CITADEL ADVISORS LLC	394,373	1.36%	$26.6M	+160,923 (+68.9%)
23	FEDERATED HERMES, INC.	391,667	1.35%	$26.4M	+27,546 (+7.6%)
24	Squarepoint Ops LLC	324,446	1.11%	$21.9M	+56,743 (+21.2%)
25	TWO SIGMA INVESTMENTS, LP	262,995	0.90%	$17.8M	-202,088 (-43.5%)
26	FIRST TRUST ADVISORS LP	258,989	0.89%	$17.5M	NEW
27	MORGAN STANLEY	257,091	0.88%	$17.4M	-736,814 (-74.1%)
28	FMR LLC	240,511	0.83%	$16.2M	-232,193 (-49.1%)
29	Qube Research & Technologies Ltd	228,777	0.79%	$15.4M	-25,959 (-10.2%)
30	HSBC HOLDINGS PLC	216,949	0.75%	$14.9M	+91,232 (+72.6%)
31	Empowered Funds, LLC	206,010	0.71%	$13.9M	NEW
32	NORTHERN TRUST CORP	202,767	0.70%	$13.7M	+19,248 (+10.5%)
33	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	202,305	0.70%	$13.7M	+9,618 (+5.0%)
34	Invesco Ltd.	202,056	0.69%	$13.6M	+80,953 (+66.8%)
35	DIMENSIONAL FUND ADVISORS LP	185,444	0.64%	$12.5M	NEW
36	Greenhaven Road Investment Management, L.P.	171,059	0.59%	$11.5M	NEW
37	VICTORY CAPITAL MANAGEMENT INC	169,227	0.58%	$11.4M	+61,024 (+56.4%)
38	MACKENZIE FINANCIAL CORP	150,979	0.52%	$10.2M	+117,259 (+347.7%)
39	UBS Group AG	146,832	0.50%	$9.9M	+67,162 (+84.3%)
40	VANGUARD FIDUCIARY TRUST CO	146,724	0.50%	$9.9M	+11,642 (+8.6%)
41	Connor, Clark & Lunn Investment Management Ltd.	141,026	0.48%	$9.5M	-17,536 (-11.1%)
42	Ensign Peak Advisors, Inc	107,096	0.37%	$7.2M	-18,537 (-14.8%)
43	FRANKLIN RESOURCES INC	106,949	0.37%	$7.2M	+41,129 (+62.5%)
44	CITIGROUP INC	99,114	0.34%	$6.7M	+25,708 (+35.0%)
45	NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	93,732	0.32%	$6.3M	—
46	PRUDENTIAL FINANCIAL INC	85,932	0.30%	$5.8M	+21,882 (+34.2%)
47	DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main	83,942	0.29%	$5.7M	NEW
48	JPMORGAN CHASE & CO	80,236	0.28%	$5.3M	+68,591 (+589.0%)
49	Granahan Investment Management, LLC	75,962	0.26%	$5.1M	+9,780 (+14.8%)
50	Irenic Capital Management LP	70,447	0.24%	$4.8M	NEW
51	Eversept Partners, LP	69,983	0.24%	$4.7M	+42,894 (+158.3%)
52	SG Americas Securities, LLC	66,730	0.23%	$4.5M	+41,879 (+168.5%)
53	JACOBS LEVY EQUITY MANAGEMENT, INC	62,336	0.21%	$4.2M	+33,711 (+117.8%)
54	STATE OF WISCONSIN INVESTMENT BOARD	61,753	0.21%	$4.2M	+34,134 (+123.6%)
55	RENAISSANCE TECHNOLOGIES LLC	58,300	0.20%	$3.9M	-32,600 (-35.9%)
56	VOLORIDGE INVESTMENT MANAGEMENT, LLC	57,555	0.20%	$3.9M	-21,397 (-27.1%)
57	Bank of New York Mellon Corp	56,401	0.19%	$3.8M	+5,286 (+10.3%)
58	DEUTSCHE BANK AG\	46,884	0.16%	$3.2M	-5,154 (-9.9%)
59	AQR CAPITAL MANAGEMENT LLC	46,323	0.16%	$3.1M	+13,856 (+42.7%)
60	MARSHALL WACE, LLP	43,822	0.15%	$3.0M	-24,225 (-35.6%)
61	Bleakley Financial Group, LLC	42,761	0.15%	$2.9M	-359 (-0.8%)
62	WELLINGTON MANAGEMENT GROUP LLP	41,796	0.14%	$2.8M	-5,085 (-10.8%)
63	WELLS FARGO & COMPANY/MN	41,707	0.14%	$2.8M	+8,527 (+25.7%)
64	HighMark Wealth Management LLC	39,716	0.14%	$2.7M	-54,334 (-57.8%)
65	CAPITAL FUND MANAGEMENT S.A.	39,142	0.13%	$2.6M	NEW
66	Trexquant Investment LP	35,404	0.12%	$2.4M	-49,763 (-58.4%)
67	Atom Investors LP	33,917	0.12%	$2.3M	NEW
68	ALLIANCEBERNSTEIN L.P.	32,820	0.11%	$1.8M	+1,500 (+4.8%)
69	PRICE T ROWE ASSOCIATES INC /MD/	32,374	0.11%	$2.2M	+2,683 (+9.0%)
70	Swiss National Bank	31,700	0.11%	$2.1M	+4,100 (+14.9%)
71	Voleon Capital Management LP	31,425	0.11%	$2.1M	NEW
72	Tema ETFs LLC	31,270	0.11%	$2.1M	+201 (+0.6%)
73	Tidal Investments LLC	31,270	0.11%	$2.1M	-5,082 (-14.0%)
74	Moody Aldrich Partners LLC	30,926	0.11%	$2.1M	-8,529 (-21.6%)
75	Aquatic Capital Management LLC	30,813	0.11%	$2.1M	NEW
76	SummitTX Capital, L.P.	28,779	0.10%	$1.9M	NEW
77	RHUMBLINE ADVISERS	26,346	0.09%	$1.8M	+2,498 (+10.5%)
78	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	23,310	0.08%	$1.6M	-7,417 (-24.1%)
79	BURNEY CO/	22,557	0.08%	$1.5M	NEW
80	Rafferty Asset Management, LLC	21,864	0.08%	$1.5M	-5,385 (-19.8%)
81	XTX Topco Ltd	21,411	0.07%	$1.4M	-29,126 (-57.6%)
82	HUSSMAN STRATEGIC ADVISORS, INC.	21,000	0.07%	$1.4M	—
83	TUDOR INVESTMENT CORP ET AL	20,019	0.07%	$1.4M	+15,057 (+303.4%)
84	CREDIT AGRICOLE S A	20,000	0.07%	$1.4M	—
85	MARTINGALE ASSET MANAGEMENT L P	19,942	0.07%	$1.3M	-8,200 (-29.1%)
86	Creative Planning	18,773	0.06%	$1.3M	+1,937 (+11.5%)
87	Y-Intercept (Hong Kong) Ltd	18,468	0.06%	$1.2M	-4,233 (-18.6%)
88	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	17,629	0.06%	$1.2M	+3,629 (+25.9%)
89	LOS ANGELES CAPITAL MANAGEMENT LLC	17,536	0.06%	$1.2M	+1,872 (+12.0%)
90	VIRGINIA RETIREMENT SYSTEMS ET Al	17,250	0.06%	$1.2M	+1,200 (+7.5%)
91	Diametric Capital, LP	16,868	0.06%	$1.1M	NEW
92	CANADA PENSION PLAN INVESTMENT BOARD	16,500	0.06%	$1.1M	+1,600 (+10.7%)
93	Legal & General Group Plc	16,415	0.06%	$1.1M	+2,584 (+18.7%)
94	Russell Investments Group, Ltd.	16,301	0.06%	$1.1M	+3,013 (+22.7%)
95	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	15,870	0.05%	$1.1M	NEW
96	Cresset Asset Management, LLC	14,412	0.05%	$973K	+544 (+3.9%)
97	Vanguard Global Advisers, LLC	13,919	0.05%	$940K	+2,165 (+18.4%)
98	Zurcher Kantonalbank (Zurich Cantonalbank)	13,405	0.05%	$905K	+3,806 (+39.6%)
99	Brevan Howard Capital Management LP	13,329	0.05%	$900K	+2,301 (+20.9%)
100	SEI INVESTMENTS CO	13,161	0.05%	$888K	+5,507 (+71.9%)
101	Orion Porfolio Solutions, LLC	11,876	0.04%	$802K	-1,253 (-9.5%)
102	ACADIAN ASSET MANAGEMENT LLC	11,697	0.04%	$787K	-1,522 (-11.5%)
103	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	11,639	0.04%	$782K	+1,153 (+11.0%)
104	Universal- Beteiligungs- und Servicegesellschaft mbH	11,610	0.04%	$784K	NEW
105	Clear Harbor Asset Management, LLC	11,550	0.04%	$780K	NEW
106	MetLife Investment Management, LLC	11,548	0.04%	$779K	+1,375 (+13.5%)
107	VOYA INVESTMENT MANAGEMENT LLC	11,265	0.04%	$760K	-3,081 (-21.5%)
108	PROFUND ADVISORS LLC	11,044	0.04%	$745K	-1,158 (-9.5%)
109	Quantedge Capital Pte Ltd	10,400	0.04%	$702K	NEW
110	MANUFACTURERS LIFE INSURANCE COMPANY, THE	10,366	0.04%	$700K	+200 (+2.0%)
111	VANGUARD ASSET MANAGEMENT, Ltd	9,690	0.03%	$654K	—
112	DCF Advisers, LLC	9,114	0.03%	$615K	-9,661 (-51.5%)
113	AMERICAN CENTURY COMPANIES INC	8,877	0.03%	$599K	NEW
114	CIBC WORLD MARKET INC.	8,700	0.03%	$587K	NEW
115	NEW YORK STATE COMMON RETIREMENT FUND	8,070	0.03%	$545K	+1,082 (+15.5%)
116	BNP PARIBAS FINANCIAL MARKETS	7,967	0.03%	$538K	-89,004 (-91.8%)
117	Verition Fund Management LLC	7,500	0.03%	$506K	NEW
118	Jupiter Topco LLC	7,464	0.03%	$504K	NEW
119	Lombard Odier Asset Management (USA) Corp	7,400	0.03%	$500K	NEW
120	GLENMEDE TRUST CO NA	7,016	0.02%	$474K	+635 (+10.0%)
121	Quantinno Capital Management LP	6,547	0.02%	$442K	+463 (+7.6%)
122	Duncan Williams Asset Management, LLC	6,525	0.02%	$440K	—
123	Gotham Asset Management, LLC	6,292	0.02%	$425K	-7,680 (-55.0%)
124	Virtus Investment Advisers, LLC	5,835	0.02%	$394K	-232 (-3.8%)
125	Police & Firemen's Retirement System of New Jersey	5,828	0.02%	$393K	+891 (+18.0%)
126	Savant Capital, LLC	5,736	0.02%	$387K	-438 (-7.1%)
127	Ascent Group, LLC	5,598	0.02%	$378K	-24 (-0.4%)
128	FMB WEALTH MANAGEMENT	5,592	0.02%	$377K	—
129	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	5,526	0.02%	$373K	—
130	INTECH INVESTMENT MANAGEMENT LLC	5,397	0.02%	$364K	+311 (+6.1%)
131	ENVESTNET ASSET MANAGEMENT INC	5,328	0.02%	$360K	-523 (-8.9%)
132	Hillsdale Investment Management Inc.	5,150	0.02%	$348K	+530 (+11.5%)
133	State of New Jersey Common Pension Fund D	5,113	0.02%	$345K	+329 (+6.9%)
134	BARCLAYS PLC	5,107	0.02%	$345K	-2,333 (-31.4%)
135	Ancora Advisors LLC	5,000	0.02%	$338K	NEW
136	Marex Group Ltd	4,962	0.02%	$335K	NEW
137	Susquehanna Portfolio Strategies, LLC	4,882	0.02%	$330K	-31,066 (-86.4%)
138	China Universal Asset Management Co., Ltd.	4,631	0.02%	$313K	-1,533 (-24.9%)
139	Latash Investments, LLC	4,393	0.02%	$297K	—
140	Vinva Investment Management Ltd	4,383	0.02%	$420K	—
141	ARIZONA STATE RETIREMENT SYSTEM	4,363	0.01%	$295K	+518 (+13.5%)
142	Allen Capital Group, LLC	4,039	0.01%	$273K	-85 (-2.1%)
143	Moran Wealth Management, LLC	3,981	0.01%	$269K	-83 (-2.0%)
144	Mitsubishi UFJ Trust & Banking Corp	3,872	0.01%	$261K	NEW
145	ROYAL BANK OF CANADA	3,740	0.01%	$252K	-479 (-11.4%)
146	ADAR1 Capital Management, LLC	3,698	0.01%	$250K	—
147	PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO	3,652	0.01%	$247K	-1,212 (-24.9%)
148	Coppell Advisory Solutions LLC	3,638	0.01%	$16.6M	NEW
149	Swiss Life Asset Management Ltd	3,621	0.01%	$244K	NEW
150	Vanguard Investments Australia, Ltd.	3,575	0.01%	$241K	—
151	nVerses Capital, LLC	3,557	0.01%	$240K	NEW
152	ProShare Advisors LLC	3,544	0.01%	$239K	-340 (-8.8%)
153	Verdad Advisers, LP	3,498	0.01%	$236K	NEW
154	MANGROVE PARTNERS IM, LLC	3,475	0.01%	$235K	-233 (-6.3%)
155	E Fund Management Co., Ltd.	3,083	0.01%	$208K	NEW
156	Kestra Advisory Services, LLC	3,066	0.01%	$207K	NEW
157	Rangeley Capital, LLC	3,000	0.01%	$203K	NEW
158	KLP KAPITALFORVALTNING AS	3,000	0.01%	$203K	—
159	State of Wyoming	2,347	0.01%	$158K	NEW
160	OSAIC HOLDINGS, INC.	2,177	0.01%	$147K	+131 (+6.4%)
161	GROUP ONE TRADING LLC	2,074	0.01%	$140K	+1,709 (+468.2%)
162	Ameritas Investment Partners, Inc.	1,793	0.01%	$121K	+299 (+20.0%)
163	CANADA LIFE ASSURANCE Co	1,698	0.01%	$114K	+948 (+126.4%)
164	Larson Financial Group LLC	1,624	0.01%	$110K	-2 (-0.1%)
165	US BANCORP \DE\	1,595	0.01%	$108K	-40 (-2.4%)
166	BESSEMER GROUP INC	1,428	0.00%	$96K	—
167	Mirae Asset Global Investments Co., Ltd.	1,301	0.00%	$88K	-143 (-9.9%)
168	SIMPLEX TRADING, LLC	1,267	0.00%	$86K	NEW
169	Spire Wealth Management	1,200	0.00%	$81K	+800 (+200.0%)
170	Tower Research Capital LLC (TRC)	970	0.00%	$65K	-1,928 (-66.5%)
171	Smartleaf Asset Management LLC	840	0.00%	$55K	—
172	NISA INVESTMENT ADVISORS, LLC	610	0.00%	$41K	-39 (-6.0%)
173	GF FUND MANAGEMENT CO. LTD.	576	0.00%	$39K	-45 (-7.2%)
174	Persistent Asset Partners Ltd	575	0.00%	$39K	NEW
175	Versant Capital Management, Inc	454	0.00%	$31K	—
176	GAMMA Investing LLC	447	0.00%	$30K	+5 (+1.1%)
177	Farther Finance Advisors, LLC	395	0.00%	$27K	+11 (+2.9%)
178	Pacer Advisors, Inc.	365	0.00%	$25K	NEW
179	SIGNATUREFD, LLC	355	0.00%	$24K	-11 (-3.0%)
180	Pinnacle Wealth Planning Services, Inc.	334	0.00%	$23K	—
181	Caitong International Asset Management Co., Ltd	289	0.00%	$20K	-2,040 (-87.6%)
182	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	247	0.00%	$17K	-10 (-3.9%)
183	Silver Grove Financial Group, Inc.	205	0.00%	$14K	NEW
184	Arax Advisory Partners	176	0.00%	$12K	NEW
185	Quantbot Technologies LP	175	0.00%	$12K	-384 (-68.7%)
186	ROTHSCHILD INVESTMENT LLC	165	0.00%	$11K	—
187	Rockefeller Capital Management L.P.	153	0.00%	$10K	-173 (-53.1%)
188	Allworth Financial LP	150	0.00%	$10K	-4 (-2.6%)
189	PNC Financial Services Group, Inc.	104	0.00%	$7K	-5 (-4.6%)
190	Physician Wealth Advisors, Inc.	85	0.00%	$6K	—
191	Basecamp Wealth Advisors LLC	83	0.00%	$6K	-7 (-7.8%)
192	Sterling Capital Management LLC	69	0.00%	$5K	-49 (-41.5%)
193	EverSource Wealth Advisors, LLC	65	0.00%	$4K	-838 (-92.8%)
194	Parallel Advisors, LLC	55	0.00%	$4K	-11 (-16.7%)
195	HOLLENCREST CAPITAL MANAGEMENT	50	0.00%	$3K	—
196	Optiver Holding B.V.	45	0.00%	$3K	NEW
197	Steward Partners Investment Advisory, LLC	43	0.00%	$3K	—
198	Decker Retirement Planning Inc.	43	0.00%	$3K	NEW
199	MassMutual Private Wealth & Trust, FSB	37	0.00%	$2K	-9 (-19.6%)
200	Global Retirement Partners, LLC	36	0.00%	$2K	NEW
201	ASSETMARK, INC	36	0.00%	$2K	—
202	Quarry LP	29	0.00%	$2K	NEW
203	Parkside Financial Bank & Trust	25	0.00%	$2K	—
204	Blue Trust, Inc.	19	0.00%	$1K	—
205	Essential Partners LLC	17	0.00%	$1K	-16 (-48.5%)
206	Stone House Investment Management, LLC	12	0.00%	$810	—
207	Covestor Ltd	9	0.00%	$1K	+7 (+350.0%)
208	NATIONAL BANK OF CANADA /FI/	8	0.00%	$540	NEW
209	Avion Wealth	7	0.00%	$0	NEW
210	FIFTH THIRD BANCORP	6	0.00%	$405	NEW
211	True Wealth Design, LLC	4	0.00%	$270	—
212	IFP Advisors, Inc	1	0.00%	$68	—
213	TFC Financial Management, Inc.	1	0.00%	$68	—

Exited since 2026-03-31 (40 filers; largest 25 shown)

Synergy Asset Management, LLC	−317,106
JANE STREET GROUP, LLC	−86,038
Fisher Asset Management, LLC	−56,596
Point72 Asset Management, L.P.	−55,303
Penserra Capital Management LLC	−43,430
HRT FINANCIAL LP	−40,504
Virtu Financial LLC	−33,323
Engineers Gate Manager LP	−27,815
SUSQUEHANNA INTERNATIONAL GROUP, LLP	−26,577
Headlands Technologies LLC	−24,558
J. Goldman & Co LP	−21,205
Walleye Capital LLC	−18,425
PDT Partners, LLC	−17,595
TWINBEECH CAPITAL LP	−14,518
Brookwood Investment Group LLC	−13,362
OXFORD ASSET MANAGEMENT LLP	−12,676
Ground Swell Capital, LLC	−7,610
JANUS HENDERSON GROUP PLC	−7,464
ExodusPoint Capital Management, LP	−7,260
Soleus Capital Management, L.P.	−6,000
Integrated Quantitative Investments LLC	−5,606
Bayforest Capital Ltd	−5,244
Aster Capital Management (DIFC) Ltd	−5,218
Balyasny Asset Management L.P.	−4,905
AXQ CAPITAL, LP	−4,715

Large holders from 13D/13G (latest per reporting person, last 2 years)

Filed when a holder crosses 5% or changes materially, so often more current than the quarter-end 13F. Percentages are the filer's own, against the share count they used.

Reporting person	Form	Filed	Event	Shares	% of class
Alex Silverstein	SCHEDULE 13G/A	2026-08-14	2026-06-30	1,491,959	5%
Sirenia Capital Management LP	SCHEDULE 13G/A	2026-08-14	2026-06-30	1,491,959	5%
Point72 Asset Management, L.P.	SCHEDULE 13G/A	2026-05-15	2026-03-31	55,303	0.2%
Steven A. Cohen	SCHEDULE 13G/A	2026-05-15	2026-03-31	55,303	0.2%
Point72 Capital Advisors, Inc.	SCHEDULE 13G/A	2026-05-15	2026-03-31	55,303	0.2%
The Vanguard Group	SCHEDULE 13G/A	2026-03-26	2026-03-13	0	0%
Morgan Stanley	SCHEDULE 13G/A	2026-02-11	2025-12-31	1,006,063	3.6%
Morgan Stanley Capital Services LLC	SCHEDULE 13G/A	2026-02-11	2025-12-31	879,351	3.2%
Millennium Management LLC	SCHEDULE 13G/A	2026-01-16	2025-12-31	813,571	2.9%
Millennium Group Management LLC	SCHEDULE 13G/A	2026-01-16	2025-12-31	813,571	2.9%
Israel A. Englander	SCHEDULE 13G/A	2026-01-16	2025-12-31	813,571	2.9%
First Light Asset Management, LLC	SCHEDULE 13G/A	2025-11-14	2025-09-30	770,568	2.78%
Mathew P. Arens	SCHEDULE 13G/A	2025-11-14	2025-09-30	864,618	3.12%
THE GOLDMAN SACHS GROUP, INC.	SCHEDULE 13G/A	2025-11-12	2025-09-30	1,251,294.79	4.5%
GOLDMAN SACHS & CO. LLC	SCHEDULE 13G/A	2025-11-12	2025-09-30	1,251,294.79	4.5%
Abigail P. Johnson	SCHEDULE 13G/A	2025-06-06	2025-05-30	254,211.72	0.9%
FMR LLC	SCHEDULE 13G/A	2025-06-06	2025-05-30	254,211.72	0.9%
BlackRock, Inc.	SCHEDULE 13G/A	2025-04-17	2025-03-31	1,900,844	6.2%
FHMLSP Overage, L.L.C.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,902	0.1%
FHMLSP Overage, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,902	0.1%
FHM VII, L.L.C.	SCHEDULE 13G/A	2025-02-14	2025-01-31	155,746	0.5%
Frazier Healthcare VII-A, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	34,540	0.1%
Frazier Healthcare VII, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	121,206	0.4%
Frazier Life Sciences Public Fund, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	—	0.5%
Frazier Life Sciences Public Overage Fund, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,902	0.1%
Frazier Life Sciences XI, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	40,222	0.1%
Frazier Life Sciences X, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,715	0.1%
FHMLS X, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,715	0.1%
FHMLS X, L.L.C.	SCHEDULE 13G/A	2025-02-14	2025-01-31	18,715	0.1%
James Brush	SCHEDULE 13G/A	2025-02-14	2025-01-31	167,746	0.6%
James N. Topper	SCHEDULE 13G/A	2025-02-14	2025-01-31	463,241	1.5%
FHMLS XI, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	40,222	0.1%
FHMLS XI, L.L.C.	SCHEDULE 13G/A	2025-02-14	2025-01-31	40,222	0.1%
FHM VII, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	155,746	0.5%
FHMLSP, L.P.	SCHEDULE 13G/A	2025-02-14	2025-01-31	148,844	0.5%
FHMLSP, L.L.C.	SCHEDULE 13G/A	2025-02-14	2025-01-31	148,844	0.5%
Nader Naini	SCHEDULE 13G/A	2025-02-14	2025-01-31	155,746	0.5%
Nathan Every	SCHEDULE 13G/A	2025-02-14	2025-01-31	160,369	0.5%
Patrick J. Heron	SCHEDULE 13G/A	2025-02-14	2025-01-31	391,539	1.3%
Peter Harwin	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%
Fairmount Healthcare Fund II L.P.	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%
Fairmount Funds Management LLC	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%
Daniel Estes	SCHEDULE 13G/A	2025-02-14	2025-01-31	40,222	0.1%
Brian Morfitt	SCHEDULE 13G/A	2025-02-14	2025-01-31	161,115	0.5%
Albert Cha	SCHEDULE 13G/A	2025-02-14	2025-01-31	167,746	0.6%
Alan Frazier	SCHEDULE 13G/A	2025-02-14	2025-01-31	155,746	0.5%
Tomas Kiselak	SCHEDULE 13G/A	2025-02-14	2024-12-31	0	0%

Source: SEC Form 13F-HR information tables for the quarter ending 2026-06-30 (filed within 45 days of quarter end; amendments applied; values normalised to dollars), the share count from the company's latest 10-K/10-Q XBRL cover page, and Schedule 13D/13G filings. Each row is a legal 13F filer as filed — related entities (e.g. Vanguard's advisers) are not merged. Retail brokerage accounts are not reported on 13F, so the remainder is mostly retail and insiders.