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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Apr. 01, 2023
Jan. 01, 2021
Mar. 31, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2017
Income Taxes [Line Items]              
Income tax expense       $ 13,584 $ 18,654 $ 393  
Tax benefit (expense) computed at the federal statutory rate       21.00% 21.00% 21.00%  
Change in enacted tax rate, amount       $ 188,900 $ 39,700    
Deferred tax liability       $ 10,912 7    
Pre-Tax Act U.S. federal net operating loss carry-forwards beginning of expiration year       2031      
Pre-Tax Act U.S. state net operating loss carry-forwards beginning of expiration year       2025      
U.S. Federal research tax credits beginning of expiration year       2032      
Deferred tax assets, valuation allowance       $ 3,611,242 2,293,361    
Gross unrecognized tax benefits, including related interest and penalties       469,697 345,328    
Net unrecognized tax benefits       469,573 344,971 $ 286,605  
Amount of tax benefit when gross unrecognized tax benefits realized       15,900      
Other Liabilities              
Income Taxes [Line Items]              
Net unrecognized tax benefits       $ 15,900 $ 11,800    
Accounting Standards Update 2020-06 | Revision of Prior Period, Accounting Standards Update, Adjustment | Convertible Notes              
Income Taxes [Line Items]              
Derecognition of deferred tax liability   $ 138,800          
Deferred tax liability   (138,800)          
Offsetting increase to valuation allowance recorded to additional paid-in capital and accumulated deficit   $ 138,800          
U.K.              
Income Taxes [Line Items]              
Tax benefit (expense) computed at the federal statutory rate     17.00% 19.00%      
Net operating loss carry-forwards       $ 3,200,000      
Percentage of taxable income limitation       50.00%      
Income tax year under examination       2020      
U.K. | Scenario Forecast              
Income Taxes [Line Items]              
Tax benefit (expense) computed at the federal statutory rate 25.00%            
Federal              
Income Taxes [Line Items]              
Net operating loss carry-forwards       $ 7,500,000      
Pre-Tax Act operating loss carry-forwards             $ 1,600,000
Post-Tax Act operating loss carry-forwards       $ 5,900,000      
Pre-Tax Act operating loss carry-forwards period             20 years
Percentage of taxable income limitation       80.00%      
Federal | Research              
Income Taxes [Line Items]              
Accumulated research tax credits       $ 476,600      
State              
Income Taxes [Line Items]              
Net operating loss carry-forwards       4,400,000      
State | Research              
Income Taxes [Line Items]              
Accumulated research tax credits       $ 292,800