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Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.

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Debt, Credit Facilities and Commitments and Contingencies - Long-Term Debt - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended		2 Months Ended	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Jan. 31, 2023	Feb. 17, 2023	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2024	Sep. 30, 2024	Aug. 01, 2024	Jun. 30, 2024	May 31, 2024
Long-term debt
Aggregate principal amount outstanding				$ 67,144	$ 59,385	$ 67,144
Long-term debt obligations, gross				66,841		66,841
FDA Approval
Long-term debt
Payable on Funding Agreement				531		531
Senior Notes Issued in 2024
Long-term debt
Debt Issuance Costs, Gross				99		99
Debt Instrument, Unamortized Discount				37		37
Senior notes \| Senior Notes Issued in 2024
Long-term debt
Aggregate principal amount of debt				$ 15,000		$ 15,000
Senior notes \| 2.5% Convertible Senior Note
Long-term debt
Stated interest rate (as a percent)								2.50%
Senior notes \| Senior Euro Notes Due 2024 At 1.250 Percent [Member]
Long-term debt
Stated interest rate (as a percent)									1.25%
Senior notes \| Senior Notes Due 2024 at 3.850 Percent [Member]
Long-term debt
Stated interest rate (as a percent)									3.85%
Senior notes \| Senior Notes Due in 2024 At 2.60 Percent [Member]
Long-term debt
Stated interest rate (as a percent)				2.60%		2.60%
Senior notes \| Senior Euro Notes 1.375 Percent Due 2024 [Member]
Long-term debt
Stated interest rate (as a percent)										1.38%
Senior notes \| Senior Notes Due 2023 At 2.800 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt	$ 350
Stated interest rate (as a percent)	2.80%
Senior notes \| Senior Notes 2.85 Percent Due 2023 [Member]
Long-term debt
Stated interest rate (as a percent)		2.85%
Senior notes \| Senior Euro Notes Due 2023 At 1.500 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt					$ 500
Stated interest rate (as a percent)					1.50%
Senior notes \| Senior Notes Due in 2023 At 3.75 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt					$ 1,300
Stated interest rate (as a percent)					3.75%
Senior notes \| Term Loan due April 2027
Long-term debt
Stated interest rate (as a percent)				4.549%		4.549%
Term loan facilities
Long-term debt
Aggregate principal amount outstanding							$ 2,000
Term loan facilities \| Senior Euro Notes Due 2024 At 1.250 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt						$ 700
Term loan facilities \| Senior Notes Due 2024 at 3.850 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt						1,000
Term loan facilities \| Senior Notes Due in 2024 At 2.60 Percent [Member]
Long-term debt
Borrowings (repayments) of long-term debt				$ 3,800
Term loan facilities \| Senior Euro Notes 1.375 Percent Due 2024 [Member]
Long-term debt
Borrowings (repayments) of long-term debt						$ 1,500
Term loan facilities \| Floating Rate Term Loan Tranche Due May 2023 Refinanced [Member]
Long-term debt
Borrowings (repayments) of long-term debt			$ 1,000
Term loan facilities \| Senior Notes 2.85 Percent Due 2023 [Member]
Long-term debt
Borrowings (repayments) of long-term debt		$ 1,000
Term loan facilities \| Term Loan Due May 2025
Long-term debt
Borrowings (repayments) of long-term debt				2,000
Term loan facilities \| Term Loan due April 2027
Long-term debt
Borrowings (repayments) of long-term debt				$ 2,000