Segment and Geographic Information - Summary of Reconciliation of Segment Financial Information to Loss from Operations (Detail) - USD ($) $ in Thousands |
12 Months Ended | ||
|---|---|---|---|
Dec. 31, 2022 |
Dec. 31, 2021 |
Dec. 31, 2020 |
|
| Segment Reporting Information [Line Items] | |||
| Loss from operations | $ (161,201) | $ (411,046) | $ (1,173,679) |
| Total stock-based compensation expense | 564,798 | 778,215 | 1,270,702 |
| Reconciling items | |||
| Segment Reporting Information [Line Items] | |||
| Loss from operations | (161,201) | (411,046) | (1,173,679) |
| Research and development expenses | 265,808 | 237,189 | 203,597 |
| General and administrative expenses | 365,768 | 295,071 | 293,637 |
| Total stock-based compensation expense | 564,798 | 778,215 | 1,270,702 |
| Operating Segments | |||
| Segment Reporting Information [Line Items] | |||
| Total contribution | $ 1,035,173 | $ 899,429 | $ 594,257 |