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Income Taxes - Summary of Reconciliation of Effective Income Tax Rate (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Effective Income Tax Rate Reconciliation, Amount [Abstract]      
Expected tax (benefit) at U.S. federal statutory rate $ (102,584) $ (247,596) $ (119,127)
State income taxes - net of federal benefit (88) 500 139
Foreign tax rate differential 870 (4,131) 25,430
Research and development tax credits (94,591) (26,294) (2,106)
Stock-based compensation (817,839) (194,730) (6,069)
Non-deductible officers' compensation 428,682 76,093 0
Change in valuation allowance 616,572 373,632 112,149
Other 863 9,890 1,959
Total provision for (benefit from) income taxes $ 31,885 $ (12,636) $ 12,375