v3.25.4
INCOME TAXES - Summary of Effective Tax Rate Reconciliation (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Amount      
Income tax expense at U.S. federal statutory tax rate $ 2,057 $ 145 $ 1,440
State taxes, net of federal benefit (138) (159) 174
Effect of cross-border tax laws:      
Global intangible low-taxed income 85 66 23
Foreign-derived intangible income (85) (133) (143)
U.S. taxation of foreign branches 9 (245) 0
Other 2 14 13
Tax credits:      
R&D tax credits (143) (144) (164)
Other (9) (13) (56)
Nontaxable or nondeductible items:      
Acquired IPR&D and related charges 65 810 88
Other 20 98 (2)
Changes in unrecognized tax benefits 61 (427) (197)
Other adjustments:      
Settlement of tax examinations 0 251 (67)
Legal entity restructuring 0 (884) 0
Income tax (benefit) expense $ 1,286 $ 211 $ 1,247
Percent      
Income tax expense at U.S. federal statutory tax rate 21.00% 21.00% 21.00%
State taxes, net of federal benefit (1.40%) (23.00%) 2.50%
Effect of cross-border tax laws:      
Global intangible low-taxed income 0.90% 9.60% 0.30%
Foreign-derived intangible income (0.90%) (19.30%) (2.10%)
U.S. taxation of foreign branches 0.10% (35.50%) 0.00%
Other 0.00% 2.00% 0.20%
Tax credits:      
R&D tax credits (1.50%) (20.90%) (2.40%)
Other (0.10%) (1.90%) (0.80%)
Nontaxable or nondeductible items:      
Acquired IPR&D and related charges 0.70% 117.40% 1.30%
Other 0.20% 14.20% 0.00%
Changes in unrecognized tax benefits 0.60% (61.90%) (2.90%)
Other adjustments:      
Settlement of tax examinations 0.00% 36.40% (1.00%)
Legal entity restructuring 0.00% (128.10%) 0.00%
Income tax expense / Effective tax rate 13.10% 30.50% 18.20%
Ireland:      
Amount      
Tax rate differential $ (118) $ (67) $ (58)
Other $ 0 $ 46 $ 69
Percent      
Tax rate differential (1.20%) (9.70%) (0.80%)
Other 0.00% 6.70% 1.00%
United Kingdom:      
Amount      
Tax rate differential     $ 5
Other     16
Intercompany asset transfer     $ 92
Percent      
Tax rate differential     0.10%
Other     0.20%
Intercompany asset transfer     1.30%
Australia:      
Amount      
Tax rate differential   $ 7  
Other   (44)  
Intercompany asset transfer   388  
Valuation allowance   $ (101)  
Percent      
Tax rate differential   1.00%  
Other   (6.40%)  
Intercompany asset transfer   56.20%  
Valuation allowance   (14.60%)  
Other foreign jurisdictions      
Amount      
Tax rate differential $ (9) $ 41 $ (30)
Percent      
Tax rate differential (0.10%) 5.90% (0.40%)
U.S.      
Amount      
Other $ 27 $ (26) $ 6
Valuation allowance $ (538) $ 588 $ 38
Percent      
Other 0.30% (3.80%) 0.10%
Valuation allowance (5.50%) 85.20% 0.60%