Revenues - Schedule of Disaggregation of Revenue by Product and by Geographic Area (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Disaggregation of Revenue [Line Items]
Total revenues	$ 36,751	$ 33,424	$ 28,190
U.S.
Disaggregation of Revenue [Line Items]
Total revenues	26,419	23,863	19,806
ROW
Disaggregation of Revenue [Line Items]
Total revenues	10,332	9,561	8,384
Prolia
Disaggregation of Revenue [Line Items]
Total revenues	4,414	4,374	4,048
Prolia \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	2,978	2,885	2,733
Prolia \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,436	1,489	1,315
Repatha
Disaggregation of Revenue [Line Items]
Total revenues	3,016	2,222	1,635
Repatha \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,663	1,139	793
Repatha \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,353	1,083	842
Otezla
Disaggregation of Revenue [Line Items]
Total revenues	2,265	2,126	2,188
Otezla \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,839	1,699	1,777
Otezla \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	426	427	411
ENBREL
Disaggregation of Revenue [Line Items]
Total revenues	2,226	3,316	3,697
ENBREL \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	2,199	3,288	3,650
ENBREL \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	27	28	47
EVENITY
Disaggregation of Revenue [Line Items]
Total revenues	2,100	1,563	1,160
EVENITY \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,600	1,131	809
EVENITY \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	500	432	351
XGEVA
Disaggregation of Revenue [Line Items]
Total revenues	2,084	2,225	2,112
XGEVA \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,355	1,507	1,527
XGEVA \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	729	718	585
TEPEZZA
Disaggregation of Revenue [Line Items]
Total revenues	1,903	1,851	448
TEPEZZA \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,758	1,835	441
TEPEZZA \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	145	16	7
BLINCYTO
Disaggregation of Revenue [Line Items]
Total revenues	1,559	1,216	861
BLINCYTO \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,049	800	566
BLINCYTO \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	510	416	295
Nplate
Disaggregation of Revenue [Line Items]
Total revenues	1,524	1,456	1,477
Nplate \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,027	970	996
Nplate \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	497	486	481
TEZSPIRE
Disaggregation of Revenue [Line Items]
Total revenues	1,478	972	567
TEZSPIRE \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,478	972	567
TEZSPIRE \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	0	0	0
KYPROLIS
Disaggregation of Revenue [Line Items]
Total revenues	1,412	1,503	1,403
KYPROLIS \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	913	948	921
KYPROLIS \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	499	555	482
Aranesp
Disaggregation of Revenue [Line Items]
Total revenues	1,389	1,342	1,362
Aranesp \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	416	386	452
Aranesp \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	973	956	910
KRYSTEXXA
Disaggregation of Revenue [Line Items]
Total revenues	1,340	1,185	272
KRYSTEXXA \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	1,340	1,185	272
KRYSTEXXA \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	0	0	0
Vectibix
Disaggregation of Revenue [Line Items]
Total revenues	1,175	1,045	984
Vectibix \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	604	519	461
Vectibix \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	571	526	523
Other products
Disaggregation of Revenue [Line Items]
Total revenues	7,263	5,630	4,696
Other products \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	5,437	4,037	3,307
Other products \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	1,826	1,593	1,389
Product sales
Disaggregation of Revenue [Line Items]
Total revenues	35,148	32,026	26,910
Product sales \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	25,656	23,301	19,272
Product sales \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	9,492	8,725	7,638
Other revenues
Disaggregation of Revenue [Line Items]
Total revenues	1,603	1,398	1,280
Other revenues \| U.S.
Disaggregation of Revenue [Line Items]
Total revenues	763	562	534
Other revenues \| ROW
Disaggregation of Revenue [Line Items]
Total revenues	$ 840	$ 836	$ 746