| Disaggregation of revenue by product and by geographic area |
Revenues were as follows (in millions): | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Three months ended September 30, | | | 2021 | | 2020 | | | U.S. | | ROW | | Total | | U.S. | | ROW | | Total | Enbrel® (etanercept) | | $ | 1,263 | | | $ | 26 | | | $ | 1,289 | | | $ | 1,289 | | | $ | 36 | | | $ | 1,325 | | Prolia® (denosumab) | | 530 | | | 273 | | | 803 | | | 478 | | | 223 | | | 701 | | Otezla® (apremilast) | | 495 | | | 114 | | | 609 | | | 439 | | | 99 | | | 538 | | XGEVA® (denosumab) | | 372 | | | 145 | | | 517 | | | 363 | | | 118 | | | 481 | | Neulasta® (pegfilgrastim) | | 360 | | | 55 | | | 415 | | | 484 | | | 71 | | | 555 | | Aranesp® (darbepoetin alfa) | | 149 | | | 247 | | | 396 | | | 158 | | | 226 | | | 384 | | Repatha® (evolocumab) | | 139 | | | 133 | | | 272 | | | 92 | | | 113 | | | 205 | | KYPROLIS® (carfilzomib) | | 198 | | | 95 | | | 293 | | | 173 | | | 87 | | | 260 | | | Other products | | 1,052 | | | 674 | | | 1,726 | | | 1,142 | | | 513 | | | 1,655 | | Total product sales(1) | | $ | 4,558 | | | $ | 1,762 | | | 6,320 | | | $ | 4,618 | | | $ | 1,486 | | | 6,104 | | | Other revenues | | | | | | 386 | | | | | | | 319 | | | Total revenues | | | | | | $ | 6,706 | | | | | | | $ | 6,423 | | | | | | | | | | | | | | | | | Nine months ended September 30, | | | 2021 | | 2020 | | | U.S. | | ROW | | Total | | U.S. | | ROW | | Total | | ENBREL | | $ | 3,270 | | | $ | 87 | | | $ | 3,357 | | | $ | 3,619 | | | $ | 105 | | | $ | 3,724 | | Prolia® | | 1,569 | | | 806 | | | 2,375 | | | 1,341 | | | 673 | | | 2,014 | | Otezla® | | 1,284 | | | 335 | | | 1,619 | | | 1,280 | | | 298 | | | 1,578 | | XGEVA® | | 1,061 | | | 412 | | | 1,473 | | | 1,036 | | | 361 | | | 1,397 | | Neulasta® | | 1,215 | | | 168 | | | 1,383 | | | 1,538 | | | 219 | | | 1,757 | | Aranesp® | | 409 | | | 709 | | | 1,118 | | | 489 | | | 704 | | | 1,193 | | Repatha® | | 421 | | | 423 | | | 844 | | | 331 | | | 303 | | | 634 | | KYPROLIS® | | 547 | | | 277 | | | 824 | | | 527 | | | 266 | | | 793 | | | Other products | | 3,059 | | | 1,974 | | | 5,033 | | | 3,164 | | | 1,652 | | | 4,816 | | Total product sales(1) | | $ | 12,835 | | | $ | 5,191 | | | 18,026 | | | $ | 13,325 | | | $ | 4,581 | | | 17,906 | | | Other revenues | | | | | | 1,107 | | | | | | | 884 | | | Total revenues | | | | | | $ | 19,133 | | | | | | | $ | 18,790 | | | | | | | | | | | | | | |
____________ (1) Hedging gains and losses, which are included in product sales, were not material for the three and nine months ended September 30, 2021 and 2020.
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