Segment Reporting - Schedule of Sales of Company's Products (Details) - USD ($)
$ in Millions |
12 Months Ended |
Dec. 31, 2025 |
Dec. 31, 2024 |
Dec. 31, 2023 |
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
$ 65,011
|
$ 64,168
|
$ 60,115
|
| Increase (decrease) in revenue hedging activities |
(127)
|
195
|
244
|
| Revenue related to the sale of the marketing rights |
138
|
106
|
118
|
| AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Revenue from collaborative arrangement |
1,886
|
1,481
|
1,296
|
| Alliance revenue - Lynparza | AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Revenue from collaborative arrangement |
1,450
|
1,311
|
1,199
|
| Alliance revenue - Koselugo | AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Revenue from collaborative arrangement |
436
|
170
|
97
|
| Operating Segments |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
64,496
|
63,277
|
59,208
|
| Operating Segments | Pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
58,142
|
57,400
|
53,583
|
| Operating Segments | Pharmaceutical | Keytruda |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
31,641
|
29,482
|
25,011
|
| Operating Segments | Pharmaceutical | Keytruda Qlex |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
40
|
0
|
0
|
| Operating Segments | Pharmaceutical | Alliance revenue - Lynparza |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,450
|
1,311
|
1,199
|
| Operating Segments | Pharmaceutical | Alliance revenue - Lenvima |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,053
|
1,010
|
960
|
| Operating Segments | Pharmaceutical | Welireg |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
716
|
509
|
218
|
| Operating Segments | Pharmaceutical | Alliance revenue - Reblozyl |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
525
|
371
|
212
|
| Operating Segments | Pharmaceutical | Gardasil/Gardasil 9 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
5,233
|
8,583
|
8,886
|
| Operating Segments | Pharmaceutical | ProQuad/M-M-R II/Varivax |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,451
|
2,485
|
2,368
|
| Operating Segments | Pharmaceutical | Vaxneuvance |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
825
|
808
|
665
|
| Operating Segments | Pharmaceutical | Capvaxive |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
759
|
97
|
0
|
| Operating Segments | Pharmaceutical | RotaTeq |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
673
|
711
|
769
|
| Operating Segments | Pharmaceutical | Pneumovax 23 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
166
|
263
|
412
|
| Operating Segments | Pharmaceutical | Bridion |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,841
|
1,764
|
1,842
|
| Operating Segments | Pharmaceutical | Prevymis |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
978
|
785
|
605
|
| Operating Segments | Pharmaceutical | Zerbaxa |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
312
|
252
|
218
|
| Operating Segments | Pharmaceutical | Dificid |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
247
|
340
|
302
|
| Operating Segments | Pharmaceutical | Winrevair |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,443
|
419
|
0
|
| Operating Segments | Pharmaceutical | Alliance revenue - Adempas/Verquvo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
470
|
415
|
367
|
| Operating Segments | Pharmaceutical | Adempas |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
312
|
287
|
255
|
| Operating Segments | Pharmaceutical | Ohtuvayre |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
178
|
0
|
0
|
| Operating Segments | Pharmaceutical | Lagevrio |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
380
|
964
|
1,428
|
| Operating Segments | Pharmaceutical | Isentress/Isentress HD |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
325
|
394
|
483
|
| Operating Segments | Pharmaceutical | Delstrigo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
306
|
249
|
201
|
| Operating Segments | Pharmaceutical | Pifeltro |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
171
|
163
|
142
|
| Operating Segments | Pharmaceutical | Belsomra |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
186
|
222
|
231
|
| Operating Segments | Pharmaceutical | Simponi |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
543
|
710
|
| Operating Segments | Pharmaceutical | Remicade |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
114
|
187
|
| Operating Segments | Pharmaceutical | Januvia |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,604
|
1,334
|
2,189
|
| Operating Segments | Pharmaceutical | Janumet |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
940
|
935
|
1,177
|
| Operating Segments | Pharmaceutical | Other pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,917
|
2,590
|
2,546
|
| Operating Segments | Animal Health |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
6,354
|
5,877
|
5,625
|
| Operating Segments | Animal Health | Livestock |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
3,896
|
3,462
|
3,337
|
| Operating Segments | Animal Health | Companion Animal |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,458
|
2,415
|
2,288
|
| Other |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
515
|
891
|
907
|
| United States |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
36,510
|
32,277
|
28,480
|
| United States | Operating Segments |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
36,362
|
32,151
|
28,343
|
| United States | Operating Segments | Pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
34,409
|
30,290
|
26,539
|
| United States | Operating Segments | Pharmaceutical | Keytruda |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
18,829
|
17,872
|
15,114
|
| United States | Operating Segments | Pharmaceutical | Keytruda Qlex |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
38
|
0
|
0
|
| United States | Operating Segments | Pharmaceutical | Alliance revenue - Lynparza |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
683
|
626
|
607
|
| United States | Operating Segments | Pharmaceutical | Alliance revenue - Lenvima |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
737
|
705
|
657
|
| United States | Operating Segments | Pharmaceutical | Welireg |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
603
|
466
|
209
|
| United States | Operating Segments | Pharmaceutical | Alliance revenue - Reblozyl |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
432
|
303
|
168
|
| United States | Operating Segments | Pharmaceutical | Gardasil/Gardasil 9 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,641
|
2,425
|
2,083
|
| United States | Operating Segments | Pharmaceutical | ProQuad/M-M-R II/Varivax |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,885
|
1,919
|
1,837
|
| United States | Operating Segments | Pharmaceutical | Vaxneuvance |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
459
|
461
|
561
|
| United States | Operating Segments | Pharmaceutical | Capvaxive |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
730
|
96
|
0
|
| United States | Operating Segments | Pharmaceutical | RotaTeq |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
426
|
472
|
493
|
| United States | Operating Segments | Pharmaceutical | Pneumovax 23 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
21
|
56
|
127
|
| United States | Operating Segments | Pharmaceutical | Bridion |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,631
|
1,401
|
1,156
|
| United States | Operating Segments | Pharmaceutical | Prevymis |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
475
|
371
|
264
|
| United States | Operating Segments | Pharmaceutical | Zerbaxa |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
186
|
146
|
119
|
| United States | Operating Segments | Pharmaceutical | Dificid |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
202
|
303
|
274
|
| United States | Operating Segments | Pharmaceutical | Winrevair |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,358
|
408
|
0
|
| United States | Operating Segments | Pharmaceutical | Alliance revenue - Adempas/Verquvo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
421
|
388
|
350
|
| United States | Operating Segments | Pharmaceutical | Adempas |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
0
|
0
|
| United States | Operating Segments | Pharmaceutical | Ohtuvayre |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
178
|
0
|
0
|
| United States | Operating Segments | Pharmaceutical | Lagevrio |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
101
|
176
|
10
|
| United States | Operating Segments | Pharmaceutical | Isentress/Isentress HD |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
181
|
185
|
215
|
| United States | Operating Segments | Pharmaceutical | Delstrigo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
56
|
56
|
49
|
| United States | Operating Segments | Pharmaceutical | Pifeltro |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
111
|
113
|
101
|
| United States | Operating Segments | Pharmaceutical | Belsomra |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
82
|
72
|
81
|
| United States | Operating Segments | Pharmaceutical | Simponi |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
0
|
0
|
| United States | Operating Segments | Pharmaceutical | Remicade |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
0
|
0
|
| United States | Operating Segments | Pharmaceutical | Januvia |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
999
|
469
|
1,151
|
| United States | Operating Segments | Pharmaceutical | Janumet |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
268
|
161
|
223
|
| United States | Operating Segments | Pharmaceutical | Other pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
676
|
640
|
690
|
| United States | Operating Segments | Animal Health |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,953
|
1,861
|
1,804
|
| United States | Operating Segments | Animal Health | Livestock |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
807
|
732
|
700
|
| United States | Operating Segments | Animal Health | Companion Animal |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,146
|
1,129
|
1,104
|
| United States | Other |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
148
|
126
|
137
|
| Int’l |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
28,501
|
31,891
|
31,635
|
| Int’l | Operating Segments |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
28,134
|
31,126
|
30,865
|
| Int’l | Operating Segments | Pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
23,733
|
27,110
|
27,044
|
| Int’l | Operating Segments | Pharmaceutical | Keytruda |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
12,812
|
11,610
|
9,897
|
| Int’l | Operating Segments | Pharmaceutical | Keytruda Qlex |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2
|
0
|
0
|
| Int’l | Operating Segments | Pharmaceutical | Alliance revenue - Lynparza |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
767
|
685
|
592
|
| Int’l | Operating Segments | Pharmaceutical | Alliance revenue - Lenvima |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
316
|
305
|
303
|
| Int’l | Operating Segments | Pharmaceutical | Welireg |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
113
|
43
|
10
|
| Int’l | Operating Segments | Pharmaceutical | Alliance revenue - Reblozyl |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
93
|
68
|
43
|
| Int’l | Operating Segments | Pharmaceutical | Gardasil/Gardasil 9 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,592
|
6,158
|
6,803
|
| Int’l | Operating Segments | Pharmaceutical | ProQuad/M-M-R II/Varivax |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
566
|
566
|
531
|
| Int’l | Operating Segments | Pharmaceutical | Vaxneuvance |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
366
|
347
|
103
|
| Int’l | Operating Segments | Pharmaceutical | Capvaxive |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
29
|
1
|
0
|
| Int’l | Operating Segments | Pharmaceutical | RotaTeq |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
246
|
239
|
276
|
| Int’l | Operating Segments | Pharmaceutical | Pneumovax 23 |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
146
|
207
|
285
|
| Int’l | Operating Segments | Pharmaceutical | Bridion |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
209
|
363
|
686
|
| Int’l | Operating Segments | Pharmaceutical | Prevymis |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
503
|
414
|
341
|
| Int’l | Operating Segments | Pharmaceutical | Zerbaxa |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
126
|
106
|
100
|
| Int’l | Operating Segments | Pharmaceutical | Dificid |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
45
|
37
|
28
|
| Int’l | Operating Segments | Pharmaceutical | Winrevair |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
85
|
11
|
0
|
| Int’l | Operating Segments | Pharmaceutical | Alliance revenue - Adempas/Verquvo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
49
|
27
|
16
|
| Int’l | Operating Segments | Pharmaceutical | Adempas |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
312
|
287
|
255
|
| Int’l | Operating Segments | Pharmaceutical | Ohtuvayre |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
0
|
0
|
| Int’l | Operating Segments | Pharmaceutical | Lagevrio |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
278
|
787
|
1,418
|
| Int’l | Operating Segments | Pharmaceutical | Isentress/Isentress HD |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
144
|
209
|
268
|
| Int’l | Operating Segments | Pharmaceutical | Delstrigo |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
250
|
193
|
152
|
| Int’l | Operating Segments | Pharmaceutical | Pifeltro |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
59
|
50
|
41
|
| Int’l | Operating Segments | Pharmaceutical | Belsomra |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
104
|
150
|
150
|
| Int’l | Operating Segments | Pharmaceutical | Simponi |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
543
|
710
|
| Int’l | Operating Segments | Pharmaceutical | Remicade |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
0
|
114
|
187
|
| Int’l | Operating Segments | Pharmaceutical | Januvia |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
605
|
865
|
1,039
|
| Int’l | Operating Segments | Pharmaceutical | Janumet |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
672
|
774
|
954
|
| Int’l | Operating Segments | Pharmaceutical | Other pharmaceutical |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
2,244
|
1,951
|
1,856
|
| Int’l | Operating Segments | Animal Health |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
4,401
|
4,016
|
3,821
|
| Int’l | Operating Segments | Animal Health | Livestock |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
3,089
|
2,729
|
2,637
|
| Int’l | Operating Segments | Animal Health | Companion Animal |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
1,312
|
1,287
|
1,184
|
| Int’l | Other |
|
|
|
| Segment Reporting Information [Line Items] |
|
|
|
| Sales |
$ 367
|
$ 765
|
$ 770
|