v3.25.4
Financial Instruments (Tables)
 12 Months Ended
Dec. 31, 2025
Fair Value Disclosures [Abstract]  
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis
Financial Assets and Liabilities Measured at Fair Value on a Recurring Basis and Fair Value Hierarchy:
As of December 31, 2025As of December 31, 2024
(MILLIONS)TotalLevel 1Level 2
Level 3
TotalLevel 1Level 2
Level 3
Financial assets:
Short-term investments
Equity securities with readily determinable fair value(a)
$2,596 $— $2,596 $— $7,848 $6,456 $1,392 $— 
Available-for-sale debt securities:
Government and agency—non-U.S.4,859 — 4,859 — 6,855 — 6,855 — 
Government and agency—U.S.3,030 — 3,030 — 2,853 — 2,853 — 
Corporate and other1,294 — 1,294 — 1,173 — 1,173 — 
9,183 — 9,183 — 10,881 — 10,881 — 
Total short-term investments11,779 — 11,779 — 18,729 6,456 12,273 — 
Other current assets
Derivative assets:
Interest rate contracts— — — — — — — — 
Foreign exchange contracts416 — 416 — 1,056 — 1,056 — 
Total other current assets416 — 416 — 1,056 — 1,056 — 
Long-term investments
Equity securities with readily determinable fair values(b)
642 642 — — 1,246 1,246 — — 
Available-for-sale debt securities:
Government and agency—non-U.S.1 — 1 — — — — — 
Corporate and other— — — — — — — — 
1 — 1 — — — — — 
Total long-term investments642 642 1 — 1,246 1,246 — — 
Other noncurrent assets
Derivative assets:
Interest rate contracts52 — 52 — 13 — 13 — 
Foreign exchange contracts64 — 64 — 447 — 447 — 
Total derivative assets116 — 116 — 460 — 460 — 
Insurance contracts(c)
999 — 999 — 875 — 875 — 
Total other noncurrent assets1,115 — 1,115 — 1,335 — 1,335 — 
Total assets$13,953 $642 $13,311 $— $22,366 $7,701 $14,665 $— 
Financial liabilities:
Other current liabilities
Derivative liabilities:
Interest rate contracts$16 $— $16 $— $28 $— $28 $— 
Foreign exchange contracts412 — 412 — 217 — 217 — 
Contingent consideration liabilities(d)
95 — — 95 39 — — 39 
Total other current liabilities523 — 428 95 284 — 245 39 
Other noncurrent liabilities
Derivative liabilities:
Interest rate contracts215 — 215 — 397 — 397 — 
Foreign exchange contracts815 — 815 — 723 — 723 — 
Contingent consideration liabilities(d)
1,695 — — 1,695 477 — — 477 
Total other noncurrent liabilities2,725 — 1,030 1,695 1,598 — 1,121 477 
Total liabilities$3,248 $— $1,458 $1,790 $1,882 $— $1,366 $517 
(a)Includes money market funds primarily invested in U.S. Treasury and government debt. As of December 31, 2024, short-term equity securities included our previous investment in Haleon of $6.5 billion. In the first quarter of 2025, we sold the remaining portion of our investment in Haleon for $6.3 billion. See Note 2C.
(b)Long-term equity securities of $146 million as of December 31, 2025 and $133 million as of December 31, 2024 were held in restricted trusts for U.S. non-qualified employee benefit plans.
(c)Includes life insurance policies held in restricted trusts for U.S. non-qualified employee benefit plans. The underlying invested assets in these contracts are marketable securities, which are carried at fair value, with changes in fair value recognized in Other (income)/deductions—net (see Note 4).
(d)Includes the fair value of contingent consideration associated with the acquisition of Metsera and certain prior business combinations. Fair value is estimated by using a probability-weighted discounted cash flow approach (see Note 16D).
Schedule of Changes in Contingent Consideration Liabilities
The following provides the changes in our contingent consideration liabilities valued using significant unobservable inputs:
Year Ended December 31,
(MILLIONS)20252024
Fair value, beginning$517 $692 
Changes in estimated fair value(a)
67 (52)
Additions
1,266 — 
Payments
(59)(123)
Transfer into/(out of) Level 3— — 
Fair value, ending$1,790 $517 
(a)Reported in Other (income)/deductions––net. See Note 4.
Summary of Investments
The following summarizes our investments by classification type:
As of December 31,
(MILLIONS)20252024
Short-term investments
Equity securities with readily determinable fair values
$2,596 $7,848 
Available-for-sale debt securities9,183 10,881 
Held-to-maturity debt securities675 705 
Total Short-term investments$12,454 $19,434 
Long-term investments
Equity securities with readily determinable fair values(a)
$642 $1,246 
Available-for-sale debt securities1 — 
Held-to-maturity debt securities48 45 
Private equity securities at cost(a)
696 719 
Equity-method investments
235 217 
Total Long-term investments
$1,621 $2,228 
(a)Represent investments in the life sciences sector.
Contractual Maturities of Available-for-sale and Held-to-maturity Securities
Our investment portfolio consists of investment-grade debt securities issued across diverse governments, corporate and financial institutions:
As of December 31, 2025As of December 31, 2024
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$4,890 $3 $(34)$4,859 $4,859 $1 $— $6,970 $8 $(123)$6,855 
Government and agency––U.S.
3,030 — — 3,030 3,030 — — 2,853 — — 2,853 
Corporate and other1,295 — (1)1,294 1,294 — — 1,179 — (6)1,173 
Held-to-maturity debt securities
Time deposits and other
487 — — 487 444 7 36 697 — — 697 
Government and agency––non-U.S.
236 — — 236 231 4 1 237 — — 237 
Total debt securities$9,938 $3 $(35)$9,906 $9,858 $12 $37 $11,935 $8 $(129)$11,814 
Schedule of Available-for-sale Securities Reconciliation
Our investment portfolio consists of investment-grade debt securities issued across diverse governments, corporate and financial institutions:
As of December 31, 2025As of December 31, 2024
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$4,890 $3 $(34)$4,859 $4,859 $1 $— $6,970 $8 $(123)$6,855 
Government and agency––U.S.
3,030 — — 3,030 3,030 — — 2,853 — — 2,853 
Corporate and other1,295 — (1)1,294 1,294 — — 1,179 — (6)1,173 
Held-to-maturity debt securities
Time deposits and other
487 — — 487 444 7 36 697 — — 697 
Government and agency––non-U.S.
236 — — 236 231 4 1 237 — — 237 
Total debt securities$9,938 $3 $(35)$9,906 $9,858 $12 $37 $11,935 $8 $(129)$11,814 
Held-to-maturity Securities
Our investment portfolio consists of investment-grade debt securities issued across diverse governments, corporate and financial institutions:
As of December 31, 2025As of December 31, 2024
Gross UnrealizedMaturities (in Years)Gross Unrealized
(MILLIONS)Amortized CostGainsLossesFair ValueWithin 1Over 1
to 5		Over 5Amortized CostGainsLossesFair Value
Available-for-sale debt securities
Government and agency––non-U.S.
$4,890 $3 $(34)$4,859 $4,859 $1 $— $6,970 $8 $(123)$6,855 
Government and agency––U.S.
3,030 — — 3,030 3,030 — — 2,853 — — 2,853 
Corporate and other1,295 — (1)1,294 1,294 — — 1,179 — (6)1,173 
Held-to-maturity debt securities
Time deposits and other
487 — — 487 444 7 36 697 — — 697 
Government and agency––non-U.S.
236 — — 236 231 4 1 237 — — 237 
Total debt securities$9,938 $3 $(35)$9,906 $9,858 $12 $37 $11,935 $8 $(129)$11,814 
Schedule of Gains and Losses on Investment Securities
The following presents the calculation of the portion of unrealized (gains)/losses that relates to equity securities, excluding equity-method investments, held at the reporting date:
Year Ended December 31,
(MILLIONS)202520242023
Net (gains)/losses recognized during the period on equity securities(a)
$67 $(1,008)$(1,590)
Less: Net (gains)/losses recognized during the period on equity securities sold during the period35 (1,122)(1,754)
Net unrealized (gains)/losses during the reporting period on equity securities still held at the reporting date
$32 $114 $165 
(a)Reported in Other (income)/deductions––net. See Note 4.
Included in net unrealized (gains)/losses are observable price changes on equity securities without readily determinable fair values. As of December 31, 2025, there were cumulative impairments and downward adjustments of $433 million and upward adjustments of $225 million. Impairments, downward and upward adjustments were not material to our operations in 2025, 2024 and 2023.
Schedule of Short-term Borrowings
Short-term borrowings include:
As of December 31,
(MILLIONS)20252024
Commercial paper, principal amount(a)
$— $2,453 
Current portion of long-term debt, principal amount3,000 3,750 
Other short-term borrowings, principal amount(b)
157 755 
Total short-term borrowings, principal amount
3,157 6,957 
Net unamortized discounts, premiums and debt issuance costs(3)(12)
Total Short-term borrowings, including current portion of long-term debt, carried at historical proceeds, as adjusted
$3,154 $6,946 
(a)The weighted-average effective interest rate on commercial paper outstanding was approximately 4.94% as of December 31, 2024.
(b)Primarily includes cash collateral. See Note 7F.
Schedule of Long-term Debt Instruments
The following outlines our senior unsecured long-term debt(a) and the weighted-average stated interest rate by maturity:
As of December 31,
(MILLIONS)20252024
Notes due 2026 (3.7% for 2024)(b)
$— $6,000 
Notes due 2027 (2.9% for 2025 and 2.2% for 2024)
2,081 980 
Notes due 2027 (Secured Overnight Financing Rate “SOFR” +0.500%)
500 — 
Notes due 2028 (4.6% for 2025 and 2024)
5,660 5,660 
Notes due 2029 (3.3% for 2025 and 3.5% for 2024)
2,631 1,750 
Notes due 2030 (3.7% for 2025 and 3.6% for 2024)
6,250 5,250 
Notes due 2031-2035 (4.4% for 2025 and 4.5% for 2024)
10,424 6,750 
Notes due 2036-2040 (5.3% for 2025 and 5.4% for 2024)
10,458 9,534 
Notes due 2041-2045 (4.3% for 2025 and 2024)
7,540 6,474 
Notes due 2046-2050 (3.7% for 2025 and 2024)
4,750 4,750 
Notes due 2051-2065 (5.3% for 2025 and 2024)
11,000 10,000 
Total long-term debt, principal amount61,293 57,147 
Net fair value adjustments related to hedging and purchase accounting834 701 
Net unamortized discounts, premiums and debt issuance costs(486)(444)
Total long-term debt, carried at historical proceeds, as adjusted$61,641 $57,405 
Current portion of long-term debt, carried at historical proceeds, as adjusted (not included above (3.9% for 2025 and 2024))
$2,997 $3,747 
(a)Our long-term debt is generally redeemable by us at any time at varying redemption prices plus accrued and unpaid interest.
(b)Reclassified to the current portion of long-term debt.
Issuances
In 2025, we issued the following senior unsecured notes(a) :
(MILLIONS)Principal
Coupon RateMaturity Date
Issue Currency
As of December 31, 2025
SOFR +0.500%
November 15, 2027
U.S. dollar
$500 
3.875%November 15, 2027U.S. dollar1,000 
4.200%November 15, 2030U.S. dollar1,000 
4.500%November 15, 2032U.S. dollar1,250 
4.875%November 15, 2035U.S. dollar1,250 
5.600%November 15, 2055U.S. dollar500 
5.700%November 15, 2065U.S. dollar500 
$6,000 
(b)
2.875%May 19, 2029
Euro
€750 
3.250%May 19, 2032Euro1,000 
3.875%May 19, 2037Euro750 
4.250%May 19, 2045Euro800 
€3,300 
(c)
(a)The fixed rate notes may be redeemed by us at any time, in whole, or in part, at a make-whole redemption price plus accrued and unpaid interest.
(b)The net proceeds from the sale of the notes were used for general corporate purposes, including the acquisition of Metsera and the refinancing of existing indebtedness. The weighted average effective interest rate for the notes at issuance was 4.583%.
(c)Issued through our wholly-owned finance subsidiary, PNIF, for general corporate purposes. The notes are fully and unconditionally guaranteed on a senior unsecured basis by Pfizer Inc. PNIF has no assets or operations and will have no assets or operations, other than as related to the issuance, administration and repayment of the notes and any other debt securities that it may issue in the future. The weighted average effective interest rate for the notes at issuance was 3.605%.
Schedule of Derivative Financial Instruments
The following summarizes the fair value of the derivative financial instruments and notional amounts:
(MILLIONS)
As of December 31, 2025
As of December 31, 2024
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$22,984 $325 $1,066 $23,991 $1,250 $719 
Interest rate contracts
6,750 52 230 6,750 13 425 
377 1,296 1,263 1,144 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$22,777 155 162 $26,335 253 221 
Total$532 $1,458 $1,516 $1,366 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $5.0 billion as of December 31, 2025 and $5.0 billion as of December 31, 2024.
Schedule of Derivative Assets at Fair Value
The following summarizes the fair value of the derivative financial instruments and notional amounts:
(MILLIONS)
As of December 31, 2025
As of December 31, 2024
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$22,984 $325 $1,066 $23,991 $1,250 $719 
Interest rate contracts
6,750 52 230 6,750 13 425 
377 1,296 1,263 1,144 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$22,777 155 162 $26,335 253 221 
Total$532 $1,458 $1,516 $1,366 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $5.0 billion as of December 31, 2025 and $5.0 billion as of December 31, 2024.
Schedule of Derivative Liabilities at Fair Value
The following summarizes the fair value of the derivative financial instruments and notional amounts:
(MILLIONS)
As of December 31, 2025
As of December 31, 2024
Fair ValueFair Value
NotionalAssetLiabilityNotionalAssetLiability
Derivatives designated as hedging instruments:
Foreign exchange contracts(a)
$22,984 $325 $1,066 $23,991 $1,250 $719 
Interest rate contracts
6,750 52 230 6,750 13 425 
377 1,296 1,263 1,144 
Derivatives not designated as hedging instruments:
Foreign exchange contracts
$22,777 155 162 $26,335 253 221 
Total$532 $1,458 $1,516 $1,366 
(a)The notional amount of outstanding foreign exchange contracts hedging our intercompany forecasted inventory sales was $5.0 billion as of December 31, 2025 and $5.0 billion as of December 31, 2024.
Schedule of Gains/(Losses) Incurred to Hedge or Offset Operational Foreign Exchange or Interest Rate Risk
The following summarizes information about the gains/(losses) incurred to hedge or offset operational foreign exchange or interest rate risk exposures:
 
Gains/(Losses)
Recognized in OID(a)
Gains/(Losses)
Recognized in OCI(a)
Gains/(Losses)
Reclassified from
OCI into OID and COS(a)
Year Ended December 31,
(MILLIONS)202520242025202420252024
Derivative Financial Instruments in Cash Flow Hedge Relationships:
      
Interest rate contracts$— $— $— $— $— $— 
Foreign exchange contracts(b)
— — (270)466 211 124 
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 58 34 57 34 
Derivative Financial Instruments in Fair Value Hedge Relationships:
Interest rate contracts221 (253)— — — — 
Hedged item (221)253 — — — — 
Derivative Financial Instruments in Net Investment Hedge Relationships:
Foreign exchange contracts— — (1,361)498 — — 
Amount excluded from effectiveness testing and amortized into earnings(c)
— — 321 119 207 154 
Non-Derivative Financial Instruments in Net Investment Hedge Relationships(d):
Foreign currency long-term debt— — (101)49 — — 
Derivative Financial Instruments Not Designated as Hedges:
Foreign exchange contracts98 50 — — — — 
$98 $50 $(1,353)$1,166 $476 $313 
(a)OID = Other (income)/deductions—net, included in Other (income)/deductions—net in the consolidated statements of operations. COS = Cost of Sales, included in Cost of sales in the consolidated statements of operations. OCI = Other comprehensive income/(loss), included in the consolidated statements of comprehensive income/(loss).
(b)The amounts reclassified from OCI into COS were a net gain of $49 million in 2025 and a net gain of $119 million in 2024. The remaining amounts were reclassified from OCI into OID. Based on year-end foreign exchange rates that are subject to change, we expect to reclassify a pre-tax loss of $16 million within the next 12 months into income. The maximum length of time over which we are hedging our exposure to the variability in future foreign exchange cash flows is approximately 17 years and relates to foreign currency debt.
(c)The amounts reclassified from OCI were reclassified into OID.
(d)Long-term debt includes foreign currency borrowings which are used in net investment hedges; the related carrying values as of December 31, 2025 and December 31, 2024 were $879 million and $777 million, respectively.
Schedule of Amounts Recorded In Balance Sheet Related to Cumulative Adjustments for Fair Value Hedges
The following summarizes cumulative basis adjustments to our long-term debt in fair value hedges:
As of December 31, 2025
As of December 31, 2024
Cumulative Amount of Fair
Value Hedging Adjustment
Increase/(Decrease) to
Carrying Amount		Cumulative Amount of Fair
Value Hedging Adjustment Increase/(Decrease) to
Carrying Amount
(MILLIONS)
Carrying Amount of Hedged Assets/Liabilities(a)
Active
Hedging
Relationships		Discontinued Hedging Relationships
Carrying Amount of Hedged Assets/Liabilities(a)
Active Hedging RelationshipsDiscontinued Hedging Relationships
Long-term debt$7,110 $(163)$821 $7,154 $(384)$891 
(a)Carrying amounts exclude the cumulative amount of fair value hedging adjustments.
Schedule of Amounts Recorded In Balance Sheet Related to Cumulative Adjustments for Cash Flow Hedges
The following summarizes cumulative basis adjustments to our long-term debt in fair value hedges:
As of December 31, 2025
As of December 31, 2024
Cumulative Amount of Fair
Value Hedging Adjustment
Increase/(Decrease) to
Carrying Amount		Cumulative Amount of Fair
Value Hedging Adjustment Increase/(Decrease) to
Carrying Amount
(MILLIONS)
Carrying Amount of Hedged Assets/Liabilities(a)
Active
Hedging
Relationships		Discontinued Hedging Relationships
Carrying Amount of Hedged Assets/Liabilities(a)
Active Hedging RelationshipsDiscontinued Hedging Relationships
Long-term debt$7,110 $(163)$821 $7,154 $(384)$891 
(a)Carrying amounts exclude the cumulative amount of fair value hedging adjustments.