Collaborations and Other Arrangements - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
Mar. 31, 2026	Mar. 31, 2025
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue	$ 19,799	$ 12,729
Jardiance
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue	1,114	1,014
Jardiance \| Milestone Payments, Sales-based
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue	250	$ 370
Boehringer Ingelheim \| Milestone Payments, Sales-based
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements	660
Ebglyss \| Milestone Payments, Sales-based
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements	1,200
Ebglyss \| Milestone Payments, Sales-based \| Roche
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential achievements	$ 975

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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+ Details