v3.25.4
Income Taxes - Schedule of Reconciliation of Income Taxes (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Amount      
U.S. federal statutory tax rate $ 5,404 $ 2,663 $ 1,377
Statutory tax rate difference between Ireland and the U.S.   (302) (187)
Other adjustments   (239) (58)
Effect of cross-border tax laws      
Foreign-derived intangible income (334) (307) (237)
Other (149)    
Tax credits (327) (291) (258)
Nontaxable or nondeductible items:      
Non-deductible acquired IPR&D 442 566 677
Other (121)    
Income taxes $ 5,091 $ 2,090 $ 1,314
Percent      
U.S. federal statutory tax rate (in percent) 21.00%    
Effect of cross-border tax laws      
Foreign-derived intangible income (in percent) (1.30%)    
Other (in percent) (0.50%)    
Tax credits (in percent) (1.30%)    
Nontaxable or nondeductible items:      
Non-deductible acquired IPR&D (in percent) 1.70%    
Other (in percent) (0.50%)    
Income taxes (in percent) 19.80% 16.50%  
Ireland      
Amount      
Statutory tax rate difference between Ireland and the U.S. $ (346)    
Other adjustments $ 269    
Percent      
Statutory tax rate difference between Ireland and U.S. (in percent) (1.30%)    
Other adjustments (in percent) 1.00%    
Other foreign jurisdictions      
Amount      
Statutory tax rate difference between Ireland and the U.S. $ (53)    
Percent      
Statutory tax rate difference between Ireland and U.S. (in percent) (0.20%)    
United States      
Amount      
Other adjustments $ 306    
Percent      
Other adjustments (in percent) 1.20%